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BR9912816A - Composição terapêutica à base de flavonóides, tencionada para uso no tratamento de tumores por agentes citotóxicos - Google Patents

Composição terapêutica à base de flavonóides, tencionada para uso no tratamento de tumores por agentes citotóxicos

Info

Publication number
BR9912816A
BR9912816A BR9912816-0A BR9912816A BR9912816A BR 9912816 A BR9912816 A BR 9912816A BR 9912816 A BR9912816 A BR 9912816A BR 9912816 A BR9912816 A BR 9912816A
Authority
BR
Brazil
Prior art keywords
tumors
treatment
intended
flavonoids
cytotoxic agents
Prior art date
Application number
BR9912816-0A
Other languages
English (en)
Inventor
Francis Darro
Robert Kiss
Armand Frydman
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of BR9912816A publication Critical patent/BR9912816A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Patente de Invenção: <B>"COMPOSIçãO TERAPêUTICA à BASE DE FLAVONóIDES, TENCIONADA PARA USO NO TRATAMENTO DE TUMORES POR AGENTES CITOTóXICOS"<D>. A presente invenção refere-se a composição tendo uma atividade sobre a proliferação de células clonogênicas em tumores e compreendendo uma quantidade terapeuticamente eficaz de um flavonóide, em particular um composto selecionado entre os compostos de fórmula (I) em que; R~ 1~, R~ 2~, R~ 3~ e R~ 4~, R~ 5~ e R~ 6~ são conforme definidos na reivindicação 2. A composição referida é planejada para uso no tratamento de tumores com agentes citotóxicos.
BR9912816-0A 1998-07-15 1999-07-13 Composição terapêutica à base de flavonóides, tencionada para uso no tratamento de tumores por agentes citotóxicos BR9912816A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9809058A FR2781153B1 (fr) 1998-07-15 1998-07-15 Composition therapeutique a base de flavonoides destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques
PCT/FR1999/001714 WO2000003706A1 (fr) 1998-07-15 1999-07-13 Composition therapeutique a base de flavonoïdes destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques

Publications (1)

Publication Number Publication Date
BR9912816A true BR9912816A (pt) 2001-05-08

Family

ID=9528648

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912816-0A BR9912816A (pt) 1998-07-15 1999-07-13 Composição terapêutica à base de flavonóides, tencionada para uso no tratamento de tumores por agentes citotóxicos

Country Status (12)

Country Link
EP (1) EP1096930A1 (pt)
JP (1) JP2002520356A (pt)
KR (1) KR20020003349A (pt)
CN (1) CN1139384C (pt)
AU (1) AU4789099A (pt)
BR (1) BR9912816A (pt)
CA (1) CA2337179A1 (pt)
EA (1) EA200100140A1 (pt)
FR (1) FR2781153B1 (pt)
IL (1) IL140588A0 (pt)
WO (1) WO2000003706A1 (pt)
ZA (1) ZA200100239B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069949A2 (en) * 2001-03-06 2002-09-12 Prendergast Patrick T Combination therapy for reduction of toxycity of chemotherapeutic agents
EP1808172A3 (en) * 2002-03-06 2010-05-26 Activephyto Technologies Limited Botanical extract compositions and methods of use
WO2003075943A2 (en) * 2002-03-06 2003-09-18 The Medical Research And Education Trust Botanical extract compositions with anti-cancer or phytoestrogenic activity comprising wogonin, isoliquiritigenin and/or coumestrol
US20030229136A1 (en) * 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
CN1679539A (zh) * 2005-01-20 2005-10-12 吴一心 抗肿瘤的协同药物组合物
JP2008533039A (ja) * 2005-03-11 2008-08-21 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 抗アポトーシスＢｃｌ−２ファミリーメンバーのクロメン−４−オン阻害剤およびその使用
GB0808974D0 (en) * 2008-05-16 2008-06-25 Veritron Ltd Plant extract and its therapeutic use
US9808439B2 (en) * 2015-07-29 2017-11-07 Macau University Of Science And Technology Use of tangeretin in cancer treatment
US9808477B2 (en) * 2015-07-29 2017-11-07 Macau University Of Science And Technology Use of nobiletin in cancer treatment
JP6775226B2 (ja) * 2016-06-30 2020-10-28 国立大学法人広島大学 抗癌剤作用増強物質およびそれを備えた抗癌剤キット
CN106562954A (zh) * 2016-11-11 2017-04-19 黄冈师范学院 (去甲基)多甲氧基黄酮联合紫杉醇类药物在制备治疗非小细胞肺癌的药物上的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0617304B2 (ja) * 1982-09-09 1994-03-09 理化学研究所 制癌剤
JPS5959627A (ja) * 1982-09-27 1984-04-05 Tatsuo Miyoshi 制癌剤
JPS60199817A (ja) * 1984-03-23 1985-10-09 Rikagaku Kenkyusho 制癌剤
JPS632925A (ja) * 1986-06-23 1988-01-07 Nippon Kayaku Co Ltd Ｃキナ−ゼ阻害剤および抗腫瘍剤
FR2633182B1 (fr) * 1988-06-23 1993-07-23 Beljanski Mirko Composition pharmaceutique anticancereuse et methode d'utilisation de l'invention
JPH04103532A (ja) * 1990-08-24 1992-04-06 Tatsuo Miyoshi 制癌剤
JPH04103529A (ja) * 1990-08-24 1992-04-06 Tatsuo Miyoshi 制癌剤
JP2514500B2 (ja) * 1991-09-14 1996-07-10 呉羽化学工業株式会社 多剤耐性抑制剤及び発現阻害剤
EP0642793A4 (en) * 1992-05-11 1995-03-29 Tsumura & Co. Apoptosis inducer.
WO1996031206A2 (en) * 1995-04-07 1996-10-10 Warner-Lambert Company Flavones and coumarins as agents for the treatment of atherosclerosis
DE29719198U1 (de) * 1997-10-29 1998-04-23 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke, 14558 Bergholz-Rehbrücke Flavono/Flavonoid-Zubereitung

Also Published As

Publication number Publication date
CN1139384C (zh) 2004-02-25
WO2000003706A1 (fr) 2000-01-27
JP2002520356A (ja) 2002-07-09
AU4789099A (en) 2000-02-07
FR2781153B1 (fr) 2001-08-03
FR2781153A1 (fr) 2000-01-21
EP1096930A1 (fr) 2001-05-09
KR20020003349A (ko) 2002-01-12
EA200100140A1 (ru) 2001-06-25
CA2337179A1 (en) 2000-01-27
CN1313765A (zh) 2001-09-19
IL140588A0 (en) 2002-02-10
ZA200100239B (en) 2002-01-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.