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BR9911871A - Derivados de ácido fenoxiacético e composições medicinais contendo os mesmos - Google Patents

Derivados de ácido fenoxiacético e composições medicinais contendo os mesmos

Info

Publication number
BR9911871A
BR9911871A BR9911871-8A BR9911871A BR9911871A BR 9911871 A BR9911871 A BR 9911871A BR 9911871 A BR9911871 A BR 9911871A BR 9911871 A BR9911871 A BR 9911871A
Authority
BR
Brazil
Prior art keywords
phenoxyacetic acid
compositions containing
same
medicinal compositions
derivatives
Prior art date
Application number
BR9911871-8A
Other languages
English (en)
Other versions
BR9911871B1 (pt
Inventor
Nobuyuki Tanaka
Tetsuro Tamai
Harunobu Mukaiyama
Akihito Hirabayashi
Hideyuki Muranaka
Masaakisato
Masuo Akahane
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of BR9911871A publication Critical patent/BR9911871A/pt
Publication of BR9911871B1 publication Critical patent/BR9911871B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Maintenance And Inspection Apparatuses For Elevators (AREA)

Abstract

"DERIVADOS DE áCIDO FENOXIACéTICO E COMPOSIçõES MEDICINAIS CONTENDO OS MESMOS" A presente invenção proporciona novos derivados de ácido fenoxiacético, representados pela fórmula geral acima descrita, e os sais farmaceuticamente aceitáveis dos mesmos, os quais têm excelentes efeitos estimulantes do adrenoceptor <225>~ 3~ e são úteis como agentes para a prevenção ou o tratamento de obesidade, hiperglicemia, das doenças causadas por hipermotilidade intestinal, polaciúria, incontinência urinária, depressão, ou das doenças causadas por cálculos biliares ou hipermotilidade do trato biliar. (Na fórmula geral, R¹ representa um grupo hidróxi etc.; um de R² e R³ é um átomo de hidrogênio, um átomo de halogênio etc., enquanto que o outro é um átomo de hidrogênio; R^ 4^ representa um átomo de halogênio etc.)
BRPI9911871-8A 1998-07-08 1999-07-05 derivados de ácido fenoxiacético e composições farmacêuticas contendo os mesmos. BR9911871B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22850198 1998-07-08
PCT/JP1999/003611 WO2000002846A1 (en) 1998-07-08 1999-07-05 Phenoxyacetic acid derivatives and medicinal compositions containing the same

Publications (2)

Publication Number Publication Date
BR9911871A true BR9911871A (pt) 2001-03-27
BR9911871B1 BR9911871B1 (pt) 2010-10-19

Family

ID=16877446

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9911871-8A BR9911871B1 (pt) 1998-07-08 1999-07-05 derivados de ácido fenoxiacético e composições farmacêuticas contendo os mesmos.

Country Status (28)

Country Link
US (1) US6538152B1 (pt)
EP (1) EP1095932B1 (pt)
JP (2) JP4132010B2 (pt)
KR (1) KR100516277B1 (pt)
CN (1) CN1242983C (pt)
AR (1) AR029600A1 (pt)
AT (1) ATE267161T1 (pt)
AU (1) AU771200B2 (pt)
BR (1) BR9911871B1 (pt)
CA (1) CA2336853C (pt)
CO (1) CO5070574A1 (pt)
CZ (1) CZ302727B6 (pt)
DE (1) DE69917459T2 (pt)
DK (1) DK1095932T3 (pt)
ES (1) ES2221390T3 (pt)
HK (1) HK1039480A1 (pt)
HU (1) HUP0103008A3 (pt)
IL (1) IL140498A (pt)
MY (1) MY126489A (pt)
NO (1) NO327770B1 (pt)
NZ (1) NZ509203A (pt)
PE (1) PE20000758A1 (pt)
PL (1) PL197453B1 (pt)
PT (1) PT1095932E (pt)
SA (1) SA99200411B1 (pt)
TW (1) TW432040B (pt)
WO (1) WO2000002846A1 (pt)
ZA (1) ZA200100135B (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ585000A0 (en) * 2000-02-28 2000-03-16 Fujisawa Pharmaceutical Co., Ltd. Aminoalcohol derivatives
UA77000C2 (en) * 2001-09-13 2006-10-16 Kissei Pharmaceutical Crystalline form of hydroxynorephedrine derivative
UA79498C2 (en) 2002-09-05 2007-06-25 Kissei Pharmaceutical Intermediates for preparation of phenoxy-acetic derivates and processes of their preparation
USRE44872E1 (en) 2002-11-07 2014-04-29 Astellas Pharma Inc. Remedy for overactive bladder comprising acetic acid anilide derivative as the active ingredient
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
DK1620085T3 (da) * 2003-05-05 2008-11-24 Kissei Pharmaceutical Anvendelse af phenoxyacetatsyrederivater til behandling af hyperaktiv blære
DE10351271A1 (de) * 2003-10-31 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Zusammensetzung zur Behandlung der Stressinkontinenz und/oder Mischinkontinenz
CA2544100A1 (en) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Pharmaceutical composition, containing a beta-3-adrenoceptor agonist and an alpha antagonist and/or a 5-alpha-reductase inhibitor
DE10352132A1 (de) * 2003-11-04 2005-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Zusammensetzung aus einem Beta-3-Adrenozeptor-Agonisten und einem Alpha Agonisten
DE10356112A1 (de) * 2003-11-27 2005-06-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Zusammensetzung aus einem Beta-3-Adrenozeptor-Agonisten und einem in den Prostglandinstoffwechsel eingreifendem Wirkstoff
JP4808613B2 (ja) * 2004-03-24 2011-11-02 キッセイ薬品工業株式会社 頻尿または尿失禁の予防または治療用医薬
WO2005092321A1 (ja) * 2004-03-24 2005-10-06 Kissei Pharmaceutical Co., Ltd. 頻尿または尿失禁の予防または治療用医薬組成物
EP1804778A1 (de) * 2004-10-18 2007-07-11 Boehringer Ingelheim International GmbH Verwendung eines beta-3-agonisten zur behandlung von beschwerden der prostata und des unteren urogenitaltrakts
DE102004050952A1 (de) * 2004-10-18 2006-04-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Zusammensetzung zur Behandlung von Beschwerden, die mit krankhaften Veränderungen oder Irritationen der Prostata verbunden sind
JP2008517886A (ja) 2004-10-26 2008-05-29 キッセイ薬品工業株式会社 フェノキシ酢酸誘導体の合成
TWI356699B (en) * 2004-11-10 2012-01-21 Kissei Pharmaceutical Agent for treating interstitial cystitis and agent
LT5282B (lt) 2005-02-28 2005-10-25 Kissei Pharmaceutical Co., Ltd. Tarpiniai junginiai fenoksiacto rūgšties darinių gamyboje ir jų panaudojimo būdas
JPWO2006118087A1 (ja) * 2005-04-26 2008-12-18 キッセイ薬品工業株式会社 ヒドロキシノルエフェドリン誘導体塩酸塩・１／４水和物の結晶
US7763654B2 (en) * 2005-04-26 2010-07-27 Kissei Pharmaceutical Co., Ltd. Crystal polymorph of hydroxynorephedrin derivative hydrochloride
BRPI0615339A2 (pt) * 2005-08-29 2011-05-17 Kissei Pharmaceutical Combinação farmacêutica para a prevenção ou tratamento de doenças associadas com a diminuição de lágrimas
EP1769792A1 (de) * 2005-09-30 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co.KG Verwendung eines beta-3-Adrenozeptor-Agonisten zur Behandlung von Nieren- und Blasenbeschwerden
WO2007083640A1 (ja) * 2006-01-18 2007-07-26 Kyorin Pharmaceutical Co., Ltd. 頻尿及び尿失禁の予防又は治療剤
TWI478712B (zh) 2008-09-30 2015-04-01 Astellas Pharma Inc 釋控性醫藥組成物
PL2554168T3 (pl) 2010-03-29 2018-05-30 Astellas Pharma Inc. Kompozycja farmaceutyczna do kontrolowanego uwalniania
WO2014108449A1 (en) 2013-01-08 2014-07-17 Atrogi Ab A screening method, a kit, a method of treatment and a compound for use in a method of treatment
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses
US12097189B1 (en) 2024-02-09 2024-09-24 Astellas Pharma Inc. Pharmaceutical composition for modified release

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6401871A (pt) * 1964-02-27 1965-08-30
ATE1994T1 (de) 1979-06-16 1982-12-15 Beecham Group Plc Aethanamin-derivate, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen.
GB8418472D0 (en) * 1984-07-19 1984-08-22 Beecham Group Plc Compounds
US5776983A (en) * 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
AU4320297A (en) 1996-09-26 1998-04-17 Kissei Pharmaceutical Co. Ltd. 2-amino-1-(4-hydroxy-2-methylphenyl)propanol derivatives
ID24062A (id) 1997-07-25 2000-07-06 Kissei Pharmaceutical Turunan-turunan asam aminoetilfenoksiasetat dan obat untuk mengurangi nyeri dan membantu penyingkiran dalam litiasis saluran air kencing

Also Published As

Publication number Publication date
CN1242983C (zh) 2006-02-22
ES2221390T3 (es) 2004-12-16
ZA200100135B (en) 2001-12-10
PE20000758A1 (es) 2000-09-04
AR029600A1 (es) 2003-07-10
KR100516277B1 (ko) 2005-09-21
CA2336853A1 (en) 2000-01-20
JP4132010B2 (ja) 2008-08-13
NO20010078D0 (no) 2001-01-05
IL140498A (en) 2004-06-20
IL140498A0 (en) 2002-02-10
AU771200B2 (en) 2004-03-18
PL345730A1 (en) 2002-01-02
SA99200411B1 (ar) 2006-09-09
NO327770B1 (no) 2009-09-21
HK1039480A1 (en) 2002-04-26
PT1095932E (pt) 2004-09-30
HUP0103008A2 (hu) 2001-12-28
CZ302727B6 (cs) 2011-09-29
MY126489A (en) 2006-10-31
CA2336853C (en) 2009-03-10
KR20010071772A (ko) 2001-07-31
ATE267161T1 (de) 2004-06-15
TW432040B (en) 2001-05-01
US6538152B1 (en) 2003-03-25
JP2008273965A (ja) 2008-11-13
JP4871321B2 (ja) 2012-02-08
CN1308603A (zh) 2001-08-15
BR9911871B1 (pt) 2010-10-19
WO2000002846A1 (en) 2000-01-20
CO5070574A1 (es) 2001-08-28
NO20010078L (no) 2001-03-08
HUP0103008A3 (en) 2002-12-28
CZ200173A3 (cs) 2002-01-16
EP1095932A4 (en) 2002-10-16
PL197453B1 (pl) 2008-04-30
AU4397399A (en) 2000-02-01
DE69917459D1 (de) 2004-06-24
EP1095932B1 (en) 2004-05-19
DE69917459T2 (de) 2005-05-12
EP1095932A1 (en) 2001-05-02
DK1095932T3 (da) 2004-09-20
NZ509203A (en) 2003-03-28

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