[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

BR9909130A - Variantes de protease de serina tendo substituições de amino-ácido - Google Patents

Variantes de protease de serina tendo substituições de amino-ácido

Info

Publication number
BR9909130A
BR9909130A BR9909130-5A BR9909130A BR9909130A BR 9909130 A BR9909130 A BR 9909130A BR 9909130 A BR9909130 A BR 9909130A BR 9909130 A BR9909130 A BR 9909130A
Authority
BR
Brazil
Prior art keywords
amino acid
variants
serine protease
acid substitutions
acid sequence
Prior art date
Application number
BR9909130-5A
Other languages
English (en)
Inventor
Donn Nelton Rubingh
Elizabeth Ellen Sikorski
Paul Elliott Correa
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BR9909130A publication Critical patent/BR9909130A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"VARIANTES DE PROTEASE DE SERINA TENDO SUBSTITUIçõES DE AMINO-áCIDO". A presente invenção refere-se a variantes de proteases de serina tendo imunogenicidade reduzida em relação às suas proteases correspondentes do tipo selvagem. Mais particularmente a presente invenção se refere a variantes que possuem uma seq³ência de amino-ácido modificada de uma seq³ência de amino-ácido em posições especificamente identificadas, em que as seq³ência de amino-ácido modificada compreende uma substituição de uma substituição ou mais posições mais especificamente identificadas, correspondentes à subtilisina BPN' . A invenção se refere ainda a genes mutantes codificando tais variantes e a composições para tratamento pessoal e de limpeza que compreendem tais variantes.
BR9909130-5A 1998-03-26 1999-03-25 Variantes de protease de serina tendo substituições de amino-ácido BR9909130A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7939798P 1998-03-26 1998-03-26
PCT/IB1999/000518 WO1999049056A1 (en) 1998-03-26 1999-03-25 Serine protease variants having amino acid substitutions

Publications (1)

Publication Number Publication Date
BR9909130A true BR9909130A (pt) 2000-12-19

Family

ID=22150284

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909130-5A BR9909130A (pt) 1998-03-26 1999-03-25 Variantes de protease de serina tendo substituições de amino-ácido

Country Status (10)

Country Link
US (1) US6569663B1 (pt)
EP (1) EP1082442A1 (pt)
JP (1) JP2002507426A (pt)
KR (1) KR20010034697A (pt)
CN (1) CN1301305A (pt)
AR (1) AR023020A1 (pt)
AU (1) AU2742499A (pt)
BR (1) BR9909130A (pt)
CA (1) CA2325568A1 (pt)
WO (1) WO1999049056A1 (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2368718T3 (es) * 1997-10-23 2011-11-21 Danisco Us Inc. Variantes de subtilisina con múltiples sustituciones.
BR9909130A (pt) 1998-03-26 2000-12-19 Procter & Gamble Variantes de protease de serina tendo substituições de amino-ácido
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
US6495136B1 (en) 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
CA2324422A1 (en) * 1998-03-26 1999-09-30 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
CZ2002212A3 (cs) 1999-07-22 2002-07-17 The Procter & Gamble Company Varianty subtilisinové proteasy mající aminokyselinové substituce v definovaných epitopových oblastech
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
CA2379729A1 (en) 1999-07-22 2001-02-01 The Procter & Gamble Company Protease conjugates having sterically protected clip sites
CA2379712A1 (en) 1999-07-22 2001-02-01 The Procter & Gamble Company Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions
US6803222B2 (en) 2000-11-22 2004-10-12 Kao Corporation Alkaline proteases
EP1373296B1 (en) 2001-03-23 2011-10-05 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
EP1554378A4 (en) * 2001-12-31 2006-01-11 Genencor Int PROTEASES PRODUCING MODIFIED IMMUNOGEN RESPONSE AND METHODS OF PRODUCTION AND USE
JP2005514026A (ja) * 2001-12-31 2005-05-19 ジェネンコー・インターナショナル・インク 免疫反応の変化を生じるプロテアーゼ、ならびにその製造および利用方法
CA2472723C (en) * 2002-01-16 2013-12-17 Genencor International, Inc. Multiply-substituted protease variants
US6835385B2 (en) * 2002-06-14 2004-12-28 Carol J. Buck Compositions and methods for softening, thinning and removing hyperkeratotic tissue
JP4694966B2 (ja) 2002-07-30 2011-06-08 ジェネンコー・インターナショナル・インク エアロゾル生成を低減する製剤
US7888093B2 (en) 2002-11-06 2011-02-15 Novozymes A/S Subtilase variants
EP2500423B1 (en) 2003-02-26 2015-06-17 Danisco US Inc. Amylases producing an altered immunogenic response and methods of making and using the same
WO2004078960A1 (en) 2003-02-26 2004-09-16 Genencor International, Inc. Amylases producing an altered immunogenic response and methods of making and using the same
AU2003901917A0 (en) * 2003-04-22 2003-05-08 Novapharm Research (Australia) Pty Ltd Endoscope cleaning pad
US20090060933A1 (en) * 2004-06-14 2009-03-05 Estell David A Proteases producing an altered immunogenic response and methods of making and using the same
EP1700904A1 (en) 2005-03-11 2006-09-13 Unilever N.V. Liquid detergent composition
EP1700907A1 (en) 2005-03-11 2006-09-13 Unilever N.V. Liquid bleaching composition
CN100445388C (zh) * 2005-03-16 2008-12-24 云南大学 一个可降解线虫体壁的碱性丝氨酸蛋白酶及其应用
KR100639008B1 (ko) * 2005-04-13 2006-10-25 삼성에스디아이 주식회사 평판형 개질기 및 이를 채용한 연료 전지 시스템
US20070161531A1 (en) * 2005-07-08 2007-07-12 Novozymes A/S Subtilase variants
US8936796B2 (en) * 2008-02-25 2015-01-20 The Procter & Gamble Company Hair care compositions comprising sucrose polyesters
ES2461892T3 (es) * 2009-02-02 2014-05-21 The Procter & Gamble Company Composición detergente líquida para lavado de vajillas a mano
RU2011131109A (ru) * 2009-02-02 2013-03-10 Дзе Проктер Энд Гэмбл Компани Жидкий моющий состав для мытья посуды ручным способом
EP2216390B1 (en) * 2009-02-02 2013-11-27 The Procter and Gamble Company Hand dishwashing method
EP2213715A1 (en) * 2009-02-02 2010-08-04 The Procter & Gamble Company Liquid hand dishwashing detergent composition
EP2216391A1 (en) * 2009-02-02 2010-08-11 The Procter & Gamble Company Liquid hand dishwashing detergent composition
EP2216392B1 (en) * 2009-02-02 2013-11-13 The Procter and Gamble Company Liquid hand dishwashing detergent composition
JP2012524542A (ja) * 2009-04-24 2012-10-18 ダニスコ・ユーエス・インク 修飾されたプロ（ｐｒｏ）領域をもつプロテアーゼ
CN101880668B (zh) * 2010-05-07 2012-05-23 广西大学 一种编码丝氨酸蛋白酶抑制剂的基因及其应用
WO2013095439A1 (en) * 2011-12-21 2013-06-27 Colgate-Palmolive Company Oral care compositions
CN106132995A (zh) * 2014-03-28 2016-11-16 诺维信公司 蛋白质晶体在低pH下的再增溶

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795238A (fr) 1972-02-09 1973-08-09 Schering Ag Derives d'insuline reticules de maniere intramoleculaire, leur procede de preparation et leur utilisation
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2631656C2 (de) 1976-07-14 1983-02-10 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung eines Hydroxysuccinimidoester-Derivats zur Bindung von biologisch aktiven Proteinen aneinander und/oder an flüssige oder feste Trägerstoffe
FR2430453B1 (fr) 1978-07-04 1986-04-18 Novo Industri As Produit proteasique a pouvoir allergisant reduit
US4556554A (en) 1981-06-01 1985-12-03 Germaine Monteil Cosmetiques Corp. Immobilized enzymes
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5972682A (en) * 1984-05-29 1999-10-26 Genencor International, Inc. Enzymatically active modified subtilisins
US4732863A (en) 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US4844897A (en) 1985-09-13 1989-07-04 Hiroshi Maeda Anti-tumor protease preparations
JP2599946B2 (ja) 1986-01-15 1997-04-16 アムジェン，インコーポレイテツド ズブチリシン類似体
EP0260299A4 (en) 1986-02-12 1988-11-24 Genex Corp MUTAGENESIS AND SCREENING PROCESS AND PRODUCT OBTAINED.
US4990452A (en) * 1986-02-12 1991-02-05 Genex Corporation Combining mutations for stabilization of subtilisin
US4980288A (en) 1986-02-12 1990-12-25 Genex Corporation Subtilisin with increased thermal stability
IE65767B1 (en) 1986-04-30 1995-11-15 Genencor Int Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors
EP0353250B1 (en) 1987-04-06 1999-09-08 Novo Nordisk A/S The engineering of electrostatic interactions at metal ion binding sites for the stabilization of proteins
US4853871A (en) 1987-04-06 1989-08-01 Genex Corporation Computer-based method for designing stablized proteins
US4914031A (en) 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
US5543302A (en) 1988-05-27 1996-08-06 Solvay Enzymes, Inc. Proteases of altered stability to autolytic degradation
JPH02219571A (ja) 1989-02-20 1990-09-03 Kanebo Ltd 修飾プロテアーゼ及びその製造法
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
AU618675B2 (en) 1989-05-17 1992-01-02 Amgen, Inc. Multiply mutated subtilisins
DE69034159T2 (de) 1989-06-26 2005-02-17 Unilever N.V. Enzymatische Waschmittelzusammensetzungen
US5658871A (en) 1989-07-07 1997-08-19 Lever Brothers Company, Division Of Conopco, Inc. Microbial lipase muteins and detergent compositions comprising same
DK97190D0 (da) 1990-04-19 1990-04-19 Novo Nordisk As Oxidationsstabile detergentenzymer
US5230891A (en) 1990-08-20 1993-07-27 Kanebo Limited Modified protease, method of producing the same and cosmetic products containing the modified protease
US5133968A (en) 1990-08-20 1992-07-28 Kanebo, Ltd. Modified protease, method of producing the same and cosmetic products containing the modified protease
BR9107206A (pt) * 1990-12-05 1993-11-03 Novo Nordisk As Processo para produzir uma variante de proteina que evoca uma resposta imunogenica diminuida em animais,produtos obtidos,composicao e uso
ES2090481T3 (es) 1991-05-01 1996-10-16 Unilever Nv Composiciones detergentes que contienen enzimas estabilizadas.
US5414135A (en) 1991-12-30 1995-05-09 Sterling Winthrop Inc. Vinyl sulfone coupling of polyoxyalkylenes to proteins
IT1260468B (it) 1992-01-29 1996-04-09 Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
GB9207280D0 (en) 1992-04-02 1992-05-13 Unilever Plc Skin care method and composition
GB9207288D0 (en) 1992-04-02 1992-05-13 Unilever Plc Cosmetic composition
WO1994004193A1 (en) 1992-08-21 1994-03-03 Enzon, Inc. Novel attachment of polyalkylene oxides to bio-effecting substances
CA2101361A1 (en) 1992-08-27 1994-02-28 Robert A. Snow Low diol polyalkylene oxide biologically active proteinaceous substances
DE4231726A1 (de) * 1992-09-23 1994-03-24 Cognis Bio Umwelt Mutierte subtilisinartige Serinproteasen
US5567601A (en) * 1993-06-01 1996-10-22 University Of Maryland Subtilisin mutants lacking a primary calcium binding site
US6436690B1 (en) 1993-09-15 2002-08-20 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
WO1995007991A2 (en) 1993-09-15 1995-03-23 The Procter & Gamble Company Subtilisin bpn' variants with decreased adsorption and increased hydrolysis
MA23346A1 (fr) 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
HU219851B (hu) * 1993-10-14 2001-08-28 The Procter And Gamble Company Proteáz tartalmú tisztítókészítmények
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
ZA952220B (en) 1994-05-02 1995-12-14 Procter & Gamble Bpn' variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
US5629384A (en) 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
JPH10509324A (ja) 1994-11-24 1998-09-14 ノボ ノルディスク アクティーゼルスカブ 抑制されたアレルゲン性を有するポリペプチドの製造のための方法
CN1168694A (zh) 1994-12-07 1997-12-24 诺沃挪第克公司 具有减弱的变应原性的多肽
DE69631329T2 (de) 1995-03-10 2004-11-18 Sumitomo Pharmaceuticals Co., Ltd. Menschlicher wachstumsfaktor (hgf), verändert durch polyethylenglykol
AU5893796A (en) 1995-06-07 1996-12-30 Novo Nordisk A/S Modification of polypeptides
WO1996040791A1 (en) 1995-06-07 1996-12-19 Novo Nordisk A/S Modification of polypeptides
DE19530816A1 (de) 1995-08-23 1997-02-27 Cognis Bio Umwelt Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten
WO1997024427A1 (en) 1995-12-29 1997-07-10 The Procter & Gamble Company Detergent compositions comprising immobilized enzymes
EP0874893A2 (en) 1995-12-29 1998-11-04 The Procter & Gamble Company Detergent compositions comprising immobilized enzymes
EP0894128A1 (en) 1996-02-15 1999-02-03 Novo Nordisk A/S Conjugation of polypeptides
US6946280B1 (en) 1996-03-29 2005-09-20 Genencor International, Inc. Enzyme multimer and process of producing same
EP0942962B1 (en) 1996-11-26 2006-12-27 Genencor International, Inc. Chemically modified enzymes
WO1998030682A1 (en) 1997-01-10 1998-07-16 Novo Nordisk A/S Enzyme coupled with polymeric molecules for skin care
CN1246891A (zh) 1997-02-06 2000-03-08 诺沃挪第克公司 添加和/或除去了连接基团的多肽－聚合物偶联物
EP1002064B1 (en) 1997-06-25 2007-10-10 Novozymes A/S A modified polypeptide
DK1047445T3 (da) 1998-01-23 2013-11-11 Univ Toronto Modificerede enzymer og anvendelse heraf til peptidsyntese
BR9909130A (pt) 1998-03-26 2000-12-19 Procter & Gamble Variantes de protease de serina tendo substituições de amino-ácido
US6495136B1 (en) 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
ATE433485T1 (de) 1998-11-10 2009-06-15 Univ Toronto Chemisch modifizierte mutante serinhydrolasen
ATE438724T1 (de) 1998-12-21 2009-08-15 Genencor Int Chemisch modifizierte enzymen mit mehrfachgeladenen varianten

Also Published As

Publication number Publication date
CA2325568A1 (en) 1999-09-30
EP1082442A1 (en) 2001-03-14
CN1301305A (zh) 2001-06-27
WO1999049056A1 (en) 1999-09-30
JP2002507426A (ja) 2002-03-12
US6569663B1 (en) 2003-05-27
KR20010034697A (ko) 2001-04-25
AR023020A1 (es) 2002-09-04
AU2742499A (en) 1999-10-18

Similar Documents

Publication Publication Date Title
BR9909130A (pt) Variantes de protease de serina tendo substituições de amino-ácido
BR9813266A (pt) Composições alvejantes compreendendo variantesde protease múltiplas substituições
BR0012660A (pt) Variante de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal
AU2002302564A1 (en) Alkaline protease variants and detergents and cleaning agents containing said alkaline protease variants
BR9406565A (pt) Variante de protease,processo de estabilização de uma variante de protease composição e aditivo detergentes
MX9605357A (es) Variantes de subtilisina bpn' que tiene absorcion reducida e hidrolisis incrementada.
DE69738942D1 (de) Genetische sequenzen, welche für enzyme des flavonoid-stoffwechselweges kodieren und deren anwendungen
MX9605358A (es) Variantes de subtilicina 309 con absorcion disminuida e hidrolisis aumentada.
BR9909129A (pt) Conjugados de proteases
WO2004003186A3 (en) Subtilases and subtilase variants having altered immunogenicity
BR9407833A (pt) Composições alvejantes compreendendo enzimas protease
BR9407825A (pt) Variante de hidrolase de carbonila tendo uma sequência de aminoácidos não encontrada na natureza derivada de uma hidrolase de carbonila precursora variante de subtilisina DNA vetor de expressão e célula hospedeira
NO961067L (no) Subtilisin BPN' varianter med senket adsorpsjon og öket hydrolyse
ATE450606T1 (de) Mehrfachsubstituierte proteasevarianten
BR0012693A (pt) Variante, de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal
BR9909147A (pt) Variantes de serina protease com deleções e substituições de aminoácidos
BR9815469A (pt) Inibidores de protease
DE69933551D1 (de) Menschliche protease und verwendung davon für pharmazeutischen anwendungen und zur reduktion der allergisierenden wirkung von nicht-menschlichen proteinen
BR9911891A (pt) Proteases fundidas com variantes de inibidor de subtilisina de streptomyces
BR9912519A (pt) Variantes estabilizadas de inibidor de subtilisina de streptomyces
BR0315055A (pt) Diamidas de ácido pirimidin-4,6-dicarboxìilco para a inibição seletiva de colagenases
WO2001081556A3 (en) Enzyme variants having one or more d-amino acid substitutions
ATE281522T1 (de) Sentrin-spezifische menschliche protease senp1
BR9809405A (pt) Proteinase de streptococcus pneumoniae que degrada complemento humano c3
ATE280782T1 (de) Serinprotease-inhibitor

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A,9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1990 DE 25/02/2009.

B15K Others concerning applications: alteration of classification

Ipc: A61Q 19/00 (2006.01), A61K 8/02 (2006.0