BR9808923B1 - processos para fazer compostos inibidores de ciclooxigenase-2, e, compostos intermediÁrios para fazer inibidores de ciclooxigenase-2. - Google Patents

processos para fazer compostos inibidores de ciclooxigenase-2, e, compostos intermediÁrios para fazer inibidores de ciclooxigenase-2.

Info

Publication number: BR9808923B1
Authority: BR; Brazil
Prior art keywords: cyclooxygenase; making; compounds; inhibitors; processes
Prior art date: 1997-04-18

Application number

BRPI9808923-4A

Other languages

English (en)

Other versions

BR9808923A (pt

Inventor

Philip J Pye

Ashok Maliakal

Kai Rossen

Ralph P Volante

Jess Sager

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-18

Filing date

1998-04-14

Publication date

2010-08-24

1997-05-13 Priority claimed from GBGB9709686.1A external-priority patent/GB9709686D0/en

1998-04-14 Application filed filed Critical

2000-08-01 Publication of BR9808923A publication Critical patent/BR9808923A/pt

2010-08-24 Publication of BR9808923B1 publication Critical patent/BR9808923B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/52—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI9808923-4A 1997-04-18 1998-04-14 processos para fazer compostos inibidores de ciclooxigenase-2, e, compostos intermediÁrios para fazer inibidores de ciclooxigenase-2. BR9808923B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US4564297P	1997-04-18	1997-04-18
GBGB9709686.1A GB9709686D0 (en)	1997-05-13	1997-05-13	Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors
PCT/US1998/008312 WO1998047871A1 (en)	1997-04-18	1998-04-14	Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors

Publications (2)

Publication Number	Publication Date
BR9808923A BR9808923A (pt)	2000-08-01
BR9808923B1 true BR9808923B1 (pt)	2010-08-24

Family

ID=26311530

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9808923-4A BR9808923B1 (pt)	1997-04-18	1998-04-14	processos para fazer compostos inibidores de ciclooxigenase-2, e, compostos intermediÁrios para fazer inibidores de ciclooxigenase-2.

Country Status (22)

Country	Link
EP (1)	EP0975596B1 (pt)
JP (1)	JP3300369B2 (pt)
KR (1)	KR20010006546A (pt)
CN (1)	CN1182117C (pt)
AT (1)	ATE270275T1 (pt)
AU (1)	AU729730B2 (pt)
BR (1)	BR9808923B1 (pt)
CA (1)	CA2287482C (pt)
CZ (1)	CZ293246B6 (pt)
DE (1)	DE69824839T2 (pt)
EA (1)	EA002190B1 (pt)
ES (1)	ES2223128T3 (pt)
HK (1)	HK1023771A1 (pt)
HR (1)	HRP980206B1 (pt)
HU (1)	HU226999B1 (pt)
NZ (1)	NZ500390A (pt)
PL (1)	PL190265B1 (pt)
RS (1)	RS49901B (pt)
SK (1)	SK285037B6 (pt)
TW (1)	TW492959B (pt)
UA (1)	UA66792C2 (pt)
WO (1)	WO1998047871A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100446324B1 (ko) *	1999-01-14	2004-08-30	론자 아게	1-(6-메틸피리딘-3-일)-2-[4-(메틸술포닐)페닐]에타논 및이의 제조 방법
SK284903B6 (sk) *	1999-01-14	2006-02-02	Lonza Ag	Spôsob výroby 1-(6-metylpyridín-3-yl)-2-[(4- (metylsulfonyl)fenyl]etanónu a medziprodukty
US6566527B1 (en)	1999-07-27	2003-05-20	Merck & Co., Inc.	Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-methylsulphonyl)-phenyl]ethanone
DK1198455T3 (da) *	1999-07-27	2004-04-05	Lonza Ag	Fremgangsmåde til fremstilling af 1-(6-methylpyridin-3-yl)-2-[(4-(methylsulfonyl)phenyl]ethanon
KR20020067574A (ko)	1999-12-23	2002-08-22	니트로메드 인코포레이티드	니트로소화 및 니트로실화된 사이클로옥시게나아제-2억제제, 조성물 및 그 이용방법
JP2001261647A (ja) *	2000-03-22	2001-09-26	Sankio Chemical Co Ltd	ピリジン誘導体の製造方法
ES2290157T3 (es)	2000-07-20	2008-02-16	Lauras As	Uso de inhibidores de cox-2 como inmunoestimulantes en el tratamiento de vih o sida.
ES2683125T3 (es) *	2010-06-16	2018-09-25	Glenmark Generics Limited	Proceso para la preparación de piridinas 2,3-diaril-5-sustituidas y sus compuestos intermedios
ES2603640T3 (es) *	2010-11-15	2017-02-28	Virdev Intermediates Pvt. Ltd.	Un proceso para inhibidor selectivo de ciclooxigenasa-2
CN103204803A (zh)	2012-01-13	2013-07-17	阿尔弗雷德·E·蒂芬巴赫尔有限责任两合公司	用于合成依托考昔的方法
WO2014114352A1 (en) *	2013-01-25	2014-07-31	Synthon Bv	Process for making etoricoxib
WO2015036550A1 (en)	2013-09-13	2015-03-19	Synthon B.V.	Process for making etoricoxib

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH561716A5 (pt) *	1971-05-10	1975-05-15	Ciba Geigy Ag
US5474995A (en) *	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
US5686470A (en) *	1995-02-10	1997-11-11	Weier; Richard M.	2, 3-substituted pyridines for the treatment of inflammation
RU2200158C2 (ru) *	1995-02-13	2003-03-10	Джи.Ди.Сирл энд Ко.	Замещенные изоксазолы, фармацевтические композиции на их основе и способ подавления воспалений
US5643933A (en) *	1995-06-02	1997-07-01	G. D. Searle & Co.	Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5677318A (en) *	1996-07-11	1997-10-14	Merck Frosst Canada, Inc.	Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents
EP0912518B1 (en) *	1996-07-18	2003-09-10	Merck Frosst Canada & Co.	Substituted pyridines as selective cyclooxygenase-2 inhibitors

1998
- 1998-04-09 TW TW087105349A patent/TW492959B/zh not_active IP Right Cessation
- 1998-04-14 CA CA002287482A patent/CA2287482C/en not_active Expired - Fee Related
- 1998-04-14 NZ NZ500390A patent/NZ500390A/en unknown
- 1998-04-14 CZ CZ19993690A patent/CZ293246B6/cs not_active IP Right Cessation
- 1998-04-14 SK SK1436-99A patent/SK285037B6/sk not_active IP Right Cessation
- 1998-04-14 ES ES98919881T patent/ES2223128T3/es not_active Expired - Lifetime
- 1998-04-14 PL PL98336298A patent/PL190265B1/pl not_active IP Right Cessation
- 1998-04-14 AU AU72571/98A patent/AU729730B2/en not_active Ceased
- 1998-04-14 DE DE69824839T patent/DE69824839T2/de not_active Expired - Lifetime
- 1998-04-14 BR BRPI9808923-4A patent/BR9808923B1/pt not_active IP Right Cessation
- 1998-04-14 JP JP54636798A patent/JP3300369B2/ja not_active Expired - Fee Related
- 1998-04-14 KR KR1019997009636A patent/KR20010006546A/ko not_active IP Right Cessation
- 1998-04-14 HU HU0003155A patent/HU226999B1/hu not_active IP Right Cessation
- 1998-04-14 WO PCT/US1998/008312 patent/WO1998047871A1/en active IP Right Grant
- 1998-04-14 EA EA199900948A patent/EA002190B1/ru not_active IP Right Cessation
- 1998-04-14 EP EP98919881A patent/EP0975596B1/en not_active Expired - Lifetime
- 1998-04-14 CN CNB988061864A patent/CN1182117C/zh not_active Expired - Fee Related
- 1998-04-14 RS YUP-536/99A patent/RS49901B/sr unknown
- 1998-04-14 AT AT98919881T patent/ATE270275T1/de not_active IP Right Cessation
- 1998-04-14 UA UA99116266A patent/UA66792C2/uk unknown
- 1998-04-16 HR HR980206A patent/HRP980206B1/xx not_active IP Right Cessation
2000
- 2000-05-16 HK HK00102924A patent/HK1023771A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ293246B6 (cs)	2004-03-17
CN1260782A (zh)	2000-07-19
HK1023771A1 (en)	2000-09-22
BR9808923A (pt)	2000-08-01
CA2287482C (en)	2004-02-17
HRP980206B1 (en)	2002-02-28
CZ369099A3 (cs)	2000-04-12
UA66792C2 (uk)	2004-06-15
YU53699A (sh)	2001-12-26
EP0975596A1 (en)	2000-02-02
EA199900948A1 (ru)	2000-04-24
JP3300369B2 (ja)	2002-07-08
PL190265B1 (pl)	2005-11-30
RS49901B (sr)	2008-08-07
HUP0003155A2 (hu)	2001-06-28
ES2223128T3 (es)	2005-02-16
EA002190B1 (ru)	2002-02-28
SK285037B6 (sk)	2006-05-04
WO1998047871A1 (en)	1998-10-29
EP0975596B1 (en)	2004-06-30
NZ500390A (en)	2001-08-31
PL336298A1 (en)	2000-06-19
CN1182117C (zh)	2004-12-29
HRP980206A2 (en)	1998-12-31
DE69824839T2 (de)	2005-07-07
TW492959B (en)	2002-07-01
KR20010006546A (ko)	2001-01-26
ATE270275T1 (de)	2004-07-15
AU729730B2 (en)	2001-02-08
HU226999B1 (en)	2010-04-28
DE69824839D1 (de)	2004-08-05
JP2000513018A (ja)	2000-10-03
SK143699A3 (en)	2000-07-11
CA2287482A1 (en)	1998-10-29
HUP0003155A3 (en)	2002-01-28
AU7257198A (en)	1998-11-13

Publication	Publication Date	Title
YU64100A (sh)	2002-11-15	Postupak za sintetizovanje cox-2 inhibitora
BR9812837A (pt)	2000-08-08	Processo para fazer um composto, e, composto
PT971713E (pt)	2003-09-30	Utilizacao de inibidores da colinesterase para tratamento de desordens da atencao
UA49809C2 (uk)	2002-10-15	Спосіб одержання фенільних гетероциклів, які використовуються як інгібітори цог-2, а також сполуки, одержані цим способом
WO2002030353A3 (en)	2002-06-27	NF-λB INHIBITORS
TW200510397A (en)	2005-03-16	Conjugated complement cascade inhibitors
BR0008625A (pt)	2002-02-19	Processo para tratamento de asma induzida por exercìcio
BR9808923B1 (pt)	2010-08-24	processos para fazer compostos inibidores de ciclooxigenase-2, e, compostos intermediÁrios para fazer inibidores de ciclooxigenase-2.
AU2001260880A1 (en)	2001-11-20	Pharmaceutical compounds for treating copd
ATE193526T1 (de)	2000-06-15	Alkylierte styrole als prodrugs zu cox-2- inhibitoren
DK0996435T3 (da)	2003-01-27	Aminosyrederivater anvendelige til behandling af slagtilfælde
NO983511D0 (no)	1998-07-30	Difenylstilbener som pro-legemidler for COX-2-inhibitorer
NO20033921L (no)	2003-11-05	Inhibitor av monoaminopptak
PL330227A1 (en)	1999-05-10	Method of obtaining phenylheterocyclic compounds suitable as cox-2 inhibitors
DE69930844D1 (de)	2006-05-24	Inhibitoren von mycobakterien
DE60010934D1 (de)	2004-06-24	Medikamente geeignet zur Behandlung von proliferativen Erkrankungen
ATE409066T1 (de)	2008-10-15	Einzeldosis aromatase hemmer zur behandlung von unfruchtbarkeit
MY140504A (en)	2009-12-31	Statin-mmp inhibitor combinations
WO1999025327A3 (en)	1999-09-23	Small molecule intervention in hiv-1 replication
EP1351680B8 (fr)	2005-08-17	Utilisation de l'anethole-dithiolethione dans la prevention et le traitement de la tenotoxicite induite par un medicament
DK1366033T3 (da)	2005-08-15	Kemiske forbindelser
DK0971714T3 (da)	2002-11-04	Metode til anvendelse af cyklooxygenase-2-inhibitorer til behandling og forebyggelse af demens
DE60215947D1 (de)	2006-12-21	Pyridin-2-yl-methylamin-derivate zur behandlung von opiatsucht
PT1315491E (pt)	2006-10-31	Utilizacao de pirazoles substituidos para o fabrico de um medicamento para o tratamento de alergias

Legal Events

Date	Code	Title	Description
2007-06-19	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2008-01-02	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2009-12-08	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2010-08-24	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/08/2010, OBSERVADAS AS CONDICOES LEGAIS.
2011-04-05	B25D	Requested change of name of applicant approved	Owner name: MERCK SHARP AND DOHME CORP. (US) Free format text: NOME ALTERADO DE: MERCK AND CO., INC.
2015-12-01	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE AS 15A, 16A E 17A ANUIDADES.
2016-03-29	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.