[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

BR9801744A - Derivados 5-deóxi citimida - Google Patents

Derivados 5-deóxi citimida

Info

Publication number
BR9801744A
BR9801744A BR9801744A BR9801744A BR9801744A BR 9801744 A BR9801744 A BR 9801744A BR 9801744 A BR9801744 A BR 9801744A BR 9801744 A BR9801744 A BR 9801744A BR 9801744 A BR9801744 A BR 9801744A
Authority
BR
Brazil
Prior art keywords
hydrogen atom
substituted
group
citimide
cytidine derivatives
Prior art date
Application number
BR9801744A
Other languages
English (en)
Inventor
Kazuo Hattori
Tohru Ishikawa
Hideo Ishitsuka
Yasunori Kohchi
Nobuhiro Oikawa
Nobuo Shimma
Hitomi Suda
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9801744A publication Critical patent/BR9801744A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS 5'-DEóXI CITIDINA".<D>. Novos derivados 5'-deóxi citidina representados pela fórmula geral (I) onde R^ 1^ é um átomo de hidrogênio ou um grupo facilmente hidrolisável sob condições fisiológicas; R^ 2^ é um átomo de hidrogênio, ou um grupo -CO-OR^ 4^ [onde R^ 4^ é um grupo hidrocarboneto reto ou ramificado, saturadY (onde Y é ciclo hexila ou fenila; n é um inteiro de 0 a 4)]; R^ 3^ é um átomo de hidrogênio, bromoestar substituído com átomo(s) de halogênio], um grupo vinila ou etinila [que pode estar substituído alquila, aralquila, ou anel aromático que pode tea que pode estar substituído para uso em terapia médica, especialmente terapia de tumor.
BR9801744A 1997-06-02 1998-06-01 Derivados 5-deóxi citimida BR9801744A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97108791 1997-06-02

Publications (1)

Publication Number Publication Date
BR9801744A true BR9801744A (pt) 2000-03-21

Family

ID=8226859

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9801744A BR9801744A (pt) 1997-06-02 1998-06-01 Derivados 5-deóxi citimida

Country Status (33)

Country Link
US (2) US6114520A (pt)
JP (1) JP3081185B2 (pt)
KR (1) KR100312899B1 (pt)
CN (1) CN1197871C (pt)
AR (1) AR012878A1 (pt)
AT (1) ATE440854T1 (pt)
AU (1) AU746170B2 (pt)
BR (1) BR9801744A (pt)
CA (1) CA2237368C (pt)
CO (1) CO4940436A1 (pt)
CZ (1) CZ295706B6 (pt)
DE (2) DE69841086D1 (pt)
ES (2) ES2329428T3 (pt)
FR (1) FR2763953B1 (pt)
GB (1) GB2325931B (pt)
HR (1) HRP980290A2 (pt)
HU (1) HU227852B1 (pt)
ID (1) ID19801A (pt)
IL (1) IL124661A0 (pt)
IT (1) ITMI981196A1 (pt)
MA (1) MA26503A1 (pt)
MY (1) MY128985A (pt)
NO (1) NO316609B1 (pt)
NZ (1) NZ330360A (pt)
PE (1) PE79599A1 (pt)
PL (1) PL192832B1 (pt)
RS (1) RS50010B (pt)
RU (1) RU2238278C2 (pt)
SA (1) SA98190103B1 (pt)
SG (1) SG66466A1 (pt)
TR (1) TR199800988A2 (pt)
TW (1) TW584636B (pt)
ZA (1) ZA984478B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119724A1 (en) * 1995-11-22 2003-06-26 Ts`O Paul O.P. Ligands to enhance cellular uptake of biomolecules
DE60013957T2 (de) * 1999-05-26 2006-02-23 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Vinylpyrimidinderivaten
WO2002043771A2 (en) 2000-12-01 2002-06-06 Cell Works Inc. Conjugates of glycosylated/galactosylated peptide
CN102441170A (zh) * 2004-12-03 2012-05-09 阿迪赫里克斯技术公司 与5-fu和5-fu前药组合施用dpd抑制剂的方法
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
US8741858B2 (en) 2007-09-21 2014-06-03 Zhongxu Ren Oligomer-nucleoside phosphate conjugates
WO2009082846A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
CN101469008B (zh) * 2007-12-29 2013-08-07 上海特化医药科技有限公司 卡培他滨羟基衍生物、其制备方法和用于制备卡培他滨
WO2009082844A1 (fr) * 2007-12-28 2009-07-09 Topharman Shanghai Co., Ltd Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine
WO2009094847A1 (fr) * 2007-12-28 2009-08-06 Topharman Shanghai Co., Ltd. Dérivé hydroxyle de capécitabine, procédés de préparation et d' utilisation de la capécitabine
WO2009114814A2 (en) 2008-03-14 2009-09-17 Retrotope, Inc. Therapeutic substances that modulate genome methylation
US8603999B2 (en) 2008-12-05 2013-12-10 Commonwealth Scientific And Industrial Research Organisation Amphiphile prodrugs
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
US8658618B2 (en) * 2009-10-14 2014-02-25 Adherex Technologies, Inc. Methods for preventing or reducing neurotoxicity associated with administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs
CN104926890B (zh) * 2015-06-04 2018-04-03 新乡学院 一种1,2‑o‑二乙酰基‑3,5‑o‑二苯甲酰基核糖的合成方法
PE20210367A1 (es) 2018-02-02 2021-02-26 Maverix Oncology Inc Conjugados de farmacos de molecula pequena de monofosfato de gemcitabina
CN113321694A (zh) * 2021-06-22 2021-08-31 药康众拓(江苏)医药科技有限公司 N4-羟基胞苷衍生物及其制备方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726278B2 (pt) * 1973-03-13 1982-06-03
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
CH633810A5 (en) * 1978-01-01 1982-12-31 Hoffmann La Roche Novel nucleosides and process for their preparation
US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
JPS5677226A (en) * 1979-11-27 1981-06-25 Taiho Yakuhin Kogyo Kk Antitumorigenic agent
WO1985001871A1 (en) * 1983-10-26 1985-05-09 Greer Sheldon B Method and materials for sensitizing neoplastic tissue to radiation
US5736531A (en) * 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
JP2614164B2 (ja) * 1991-05-27 1997-05-28 大鵬薬品工業株式会社 抗腫瘍効果増強のための及び腫瘍治療のための組成物
DE4123520A1 (de) * 1991-07-16 1993-01-21 Inst Molekularbiologie Ak Mittel zur regeneration des blutbildes durch foerderung der leukozytenproliferation
TW254946B (pt) * 1992-12-18 1995-08-21 Hoffmann La Roche
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
WO1994026761A1 (en) * 1993-05-14 1994-11-24 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
NZ273161A (en) * 1993-09-14 1997-11-24 Merrell Pharma Inc 5-(1-flurovinyl)-1h-pyrimidine-2,4-dione derivatives; pharmaceutical compositions
US5476932A (en) * 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
JPH10506641A (ja) * 1995-05-26 1998-06-30 エフ・ホフマン−ラ ロシュ アーゲー インターロイキン１２とピリミジンヌクレオシドの組成物

Also Published As

Publication number Publication date
TW584636B (en) 2004-04-21
PE79599A1 (es) 1999-08-25
GB2325931A (en) 1998-12-09
CN1197871C (zh) 2005-04-20
HUP9801256A3 (en) 2004-03-01
HRP980290A2 (en) 1999-04-30
FR2763953A1 (fr) 1998-12-04
HU227852B1 (en) 2012-05-02
SG66466A1 (en) 1999-07-20
MA26503A1 (fr) 2004-12-20
CZ167598A3 (cs) 1998-12-16
ZA984478B (en) 1998-12-02
TR199800988A3 (tr) 1998-12-21
US6114520A (en) 2000-09-05
DE69841086D1 (de) 2009-10-08
IL124661A0 (en) 1998-12-06
DE19823484A1 (de) 1998-12-03
SA98190103B1 (ar) 2006-04-18
AR012878A1 (es) 2000-11-22
RU2238278C2 (ru) 2004-10-20
CZ295706B6 (cs) 2005-10-12
GB9811762D0 (en) 1998-07-29
RS50010B (sr) 2008-09-29
HU9801256D0 (en) 1998-07-28
JPH10330395A (ja) 1998-12-15
AU746170B2 (en) 2002-04-18
NO316609B1 (no) 2004-03-08
PL326604A1 (en) 1998-12-07
KR100312899B1 (ko) 2002-03-08
CO4940436A1 (es) 2000-07-24
ID19801A (id) 1998-08-06
AU6798598A (en) 1998-12-03
JP3081185B2 (ja) 2000-08-28
HUP9801256A2 (hu) 1999-05-28
YU22598A (sh) 2001-12-26
FR2763953B1 (fr) 2005-01-07
NO982473D0 (no) 1998-05-29
ES2142763B1 (es) 2001-04-01
ATE440854T1 (de) 2009-09-15
ES2142763A1 (es) 2000-04-16
NO982473L (no) 1998-12-03
PL192832B1 (pl) 2006-12-29
CA2237368C (en) 2009-03-03
US6211166B1 (en) 2001-04-03
MY128985A (en) 2007-03-30
KR19990006547A (ko) 1999-01-25
GB2325931B (en) 2001-07-25
ITMI981196A1 (it) 1999-11-29
CA2237368A1 (en) 1998-12-02
ES2329428T3 (es) 2009-11-25
NZ330360A (en) 1999-03-29
TR199800988A2 (xx) 1998-12-21
CN1201037A (zh) 1998-12-09

Similar Documents

Publication Publication Date Title
BR9801744A (pt) Derivados 5-deóxi citimida
BR0014133A (pt) Uso de um composto, composto, métodos de preparação de um composto, e para inibir aurora 2 quinase em um animal de sangue quente, e, composição farmacêutica
MY126973A (en) Derivatives of 4-aminopiperidine and their use as a medicament
DE69010851D1 (de) Isoindolonderivate, ihre Herstellung und ihre Verwendung als Zwischenprodukte zur Herstellung von Substanz-P-Antagonisten.
IT1311923B1 (it) Composti farmaceutici.
HRP20010514B1 (en) Telmisartan polymorphs, methods for producing same and their use in the preparation of a medicament
TR200402083T2 (tr) Parkinson hastalığı, adhd ve mikroadenomların tedavisi için ilaçlar
FI863013A0 (fi) Bakterisida framstaellningar foer anvaendning inom veterinaermedicinen.
CO4700298A1 (es) Derivados de 3-fenilisoquinoleina-1 (2h)-ona, su preparacion y su aplicacion en la terapeutica
TR200401716T4 (tr) Yeni üç yerdeğiştirme gruplu fenil türevleri ve analogları
FR2847899B1 (fr) Derives d&#39;indole-3-carboxamide, leur preparation et leur application en therapeutique
KR900014389A (ko) 아데노신 수용체 선택성 약제
BR9714215A (pt) Derivados de benzoato de 1,4-diazabiciclo[2.2.2]oct-2-ilmetila, seu preparo e sua aplicação em terapêutica
BR0102377A (pt) Inibidores de não-nucleosìdeo transcriptase reversa
DK136987D0 (da) Selektive alfa-adrenerge receptorantagonister, fremgangsmaade til fremstilling heraf samt farmaceutiske midler indeholdende disse
DK415789A (da) Tetracykliske antidepressive midler
ES2194457T3 (es) Complejo de platino, su preparacion y aplicacion terapeutica.
KR880011155A (ko) 이미다조피리딘유도체, 그의 제법 및 치료에의 응용
BR9900179A (pt) Processo para a preparação de um composto.
BR9907672A (pt) Derivados de 5&#39;-desoxicitidina
AU2001261707A1 (en) Pirazino &#39;1$m(1)2$m(1) :1, 6! pyrido &#39;3,4-b! indole derivatives
AR009105A1 (es) Derivados de n-(benzotiazol-2-il) piperidina-1-etanamina, su preparacion y aplicacion en terapeutica
BR9812752A (pt) Derivados de 8-azabiciclo [3.2.1] octano-3-metanamina enquanto ligandos dos receptores de dopamina d2 e d3 e de serotonina 5ht1a e 5ht2
AU2001292698A1 (en) Hexahydropyrazino `1&#39;2&#39; : 1, 6!- pyrido `3, 4-b! indole-1, 4-dione derivatives for the treatment of cardiovascular disorders and erectile disfunction
PT1025101E (pt) Derivados de nafto-imidazo¬1,2-a|piridina sua preparacao e uso no tratamento de perturbacoes do sistema nervoso central

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements