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BR112022014568A2 - Receptores de antígeno quiméricos contra her2 e métodos de uso dos mesmos - Google Patents

Receptores de antígeno quiméricos contra her2 e métodos de uso dos mesmos

Info

Publication number
BR112022014568A2
BR112022014568A2 BR112022014568A BR112022014568A BR112022014568A2 BR 112022014568 A2 BR112022014568 A2 BR 112022014568A2 BR 112022014568 A BR112022014568 A BR 112022014568A BR 112022014568 A BR112022014568 A BR 112022014568A BR 112022014568 A2 BR112022014568 A2 BR 112022014568A2
Authority
BR
Brazil
Prior art keywords
methods
cars
chimeric antigen
antigen receptors
present disclosure
Prior art date
Application number
BR112022014568A
Other languages
English (en)
Inventor
Ian Frost Gregory
Joseph Onuffer James Jr
Kundu Anirban
M Short Jay
Frey Gerhard
Wen Chang Hwai
Original Assignee
Exuma Biotech Corp
Bioatla Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exuma Biotech Corp, Bioatla Llc filed Critical Exuma Biotech Corp
Publication of BR112022014568A2 publication Critical patent/BR112022014568A2/pt

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
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Abstract

RECEPTORES DE ANTÍGENO QUIMÉRICOS CONTRA HER2 E MÉTODOS DE USO DOS MESMOS. A presente divulgação fornece receptores de antígenos quiméricos (CARs) e ácidos nucleicos que compreendem sequências nucleotídicas que codificam os CARs, que se ligam ao HER2 e CARs biológicos condicionalmente ativos (CAB) que se ligam ao HER2. A presente divulgação fornece células geneticamente modificadas para produzir os CARs, suspensão de administração compreendendo essas células geneticamente modificadas e métodos para a produção dessas células. Os CARs da presente divulgação podem ser usados em vários métodos, que são também fornecidos, incluindo os métodos para ativação de células imunes sob certas condições e métodos para realizar terapia de células adotivas, tal como terapia de CAR, por exemplo, terapia de CAR contra o câncer.
BR112022014568A 2020-01-23 2021-01-23 Receptores de antígeno quiméricos contra her2 e métodos de uso dos mesmos BR112022014568A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062964947P 2020-01-23 2020-01-23
PCT/US2021/070073 WO2021151119A1 (en) 2020-01-23 2021-01-23 Chimeric antigen receptors to her2 and methods of use thereof

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BR112022014568A2 true BR112022014568A2 (pt) 2022-09-27

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US (1) US20230072955A1 (pt)
EP (1) EP4087867A4 (pt)
JP (1) JP2023513458A (pt)
KR (1) KR20220153578A (pt)
CN (1) CN115485293A (pt)
AU (1) AU2021210446A1 (pt)
BR (1) BR112022014568A2 (pt)
CA (1) CA3168813A1 (pt)
IL (1) IL294877A (pt)
MX (1) MX2022009049A (pt)
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CN118871471A (zh) 2022-04-08 2024-10-29 菲特治疗公司 用于肿瘤靶向的嵌合抗原受体

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EP4087867A4 (en) 2024-02-14
MX2022009049A (es) 2022-11-08
AU2021210446A1 (en) 2022-07-28
WO2021151119A1 (en) 2021-07-29
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IL294877A (en) 2022-09-01
CN115485293A (zh) 2022-12-16
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