BR112013000648A2 - produção biotecnológica de condroitina - Google Patents
produção biotecnológica de condroitinaInfo
- Publication number
- BR112013000648A2 BR112013000648A2 BR112013000648A BR112013000648A BR112013000648A2 BR 112013000648 A2 BR112013000648 A2 BR 112013000648A2 BR 112013000648 A BR112013000648 A BR 112013000648A BR 112013000648 A BR112013000648 A BR 112013000648A BR 112013000648 A2 BR112013000648 A2 BR 112013000648A2
- Authority
- BR
- Brazil
- Prior art keywords
- chondroitin
- biotechnological production
- fructose
- microorganism
- inactivating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01099—Sucrose:sucrose fructosyltransferase (2.4.1.99)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Enzymes And Modification Thereof (AREA)
- Materials For Medical Uses (AREA)
Abstract
produção biotecnológica de condroitina. a presente invenção refere-se a condroitina é produzida através da cultura de um micro-organismo recombinante que é obtido através da inativação de um gene codificando uma enzima responsável pela adição de resíduos de frutose ao polissacarídeo condroitina linear em um microorganismo produtor de um derivado frutosilado de condroitina.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001264A ITMI20101264A1 (it) | 2010-07-09 | 2010-07-09 | Produzione biotecnologica di condroitina |
| IT001300A ITMI20101300A1 (it) | 2010-07-15 | 2010-07-15 | Produzione biotecnologica di condroitina |
| PCT/EP2011/059069 WO2012004063A1 (en) | 2010-07-09 | 2011-06-01 | Biotechnological production of chondroitin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013000648A2 true BR112013000648A2 (pt) | 2016-05-31 |
Family
ID=45439053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013000648A BR112013000648A2 (pt) | 2010-07-09 | 2011-06-01 | produção biotecnológica de condroitina |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8609394B2 (pt) |
| EP (1) | EP2591127B1 (pt) |
| JP (1) | JP6030056B2 (pt) |
| KR (1) | KR101855062B1 (pt) |
| CN (2) | CN104974972B (pt) |
| AU (1) | AU2011275996B2 (pt) |
| BR (1) | BR112013000648A2 (pt) |
| CA (1) | CA2801843C (pt) |
| CY (1) | CY1119469T1 (pt) |
| DK (1) | DK2591127T3 (pt) |
| EA (1) | EA025126B1 (pt) |
| ES (1) | ES2644443T3 (pt) |
| GE (1) | GEP201706720B (pt) |
| HR (1) | HRP20171624T1 (pt) |
| IL (1) | IL223830B (pt) |
| LT (1) | LT2591127T (pt) |
| MX (1) | MX2013000100A (pt) |
| NO (1) | NO2591127T3 (pt) |
| NZ (1) | NZ603990A (pt) |
| PL (1) | PL2591127T3 (pt) |
| PT (1) | PT2591127T (pt) |
| SG (1) | SG186212A1 (pt) |
| SI (1) | SI2591127T1 (pt) |
| WO (1) | WO2012004063A1 (pt) |
| ZA (1) | ZA201209079B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011109438A1 (en) | 2010-03-01 | 2011-09-09 | Martek Biosciences Corporation | Compositions and methods for bacterial production of chondroitin |
| US8664196B2 (en) | 2011-05-20 | 2014-03-04 | Gnosis S.P.A. | Shark-like chondroitin sulphate and process for the preparation thereof |
| ITMI20120880A1 (it) | 2012-05-22 | 2013-11-23 | Gnosis Spa | Condroitin 6-solfato biotecnologico a basso peso molecolare dotato di attivita' antiinfiammatoria e antiartritica e suo uso nel trattamento e nella prevenzione dell'osteoartrite |
| JP6478115B2 (ja) | 2013-09-30 | 2019-03-06 | 生化学工業株式会社 | タンパク質の血中滞留性の増強方法 |
| CN106497845B (zh) * | 2016-12-14 | 2019-08-06 | 江南大学 | 一种高产软骨素的重组枯草芽孢杆菌及其应用 |
| US20220333144A1 (en) * | 2019-09-10 | 2022-10-20 | Rensselaer Polytechnic Institute | Recombinant microorganisms for in vivo production of sulfated glycosaminoglycans |
| IT202000004564A1 (it) | 2020-03-04 | 2021-09-04 | Lesaffre & Cie | Processo per la solfatazione diretta di polisaccaridi in solvente ecologicamente accettabile |
| CN112625147A (zh) * | 2020-12-22 | 2021-04-09 | 荣成万盈水产科技有限公司 | 一种利用鱿鱼软骨制备硫酸软骨素的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7642071B2 (en) | 1999-04-01 | 2010-01-05 | The Board Of Regents Of The University Of Oklahoma | Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts |
| AU2003100886B4 (en) | 2003-05-05 | 2004-07-29 | Agnes Chan | A multipurpose garment |
| JP5081629B2 (ja) | 2005-12-15 | 2012-11-28 | 生化学工業株式会社 | 長鎖コンドロイチン糖鎖及びその製造方法並びにコンドロイチン合成の促進方法 |
| CN104974973B (zh) * | 2007-04-24 | 2022-07-26 | 生化学工业株式会社 | 生产软骨素的细菌及生产软骨素的方法 |
| WO2011109438A1 (en) | 2010-03-01 | 2011-09-09 | Martek Biosciences Corporation | Compositions and methods for bacterial production of chondroitin |
-
2011
- 2011-06-01 KR KR1020137003182A patent/KR101855062B1/ko active IP Right Grant
- 2011-06-01 PL PL11722468T patent/PL2591127T3/pl unknown
- 2011-06-01 NO NO11722468A patent/NO2591127T3/no unknown
- 2011-06-01 NZ NZ603990A patent/NZ603990A/en unknown
- 2011-06-01 PT PT117224683T patent/PT2591127T/pt unknown
- 2011-06-01 AU AU2011275996A patent/AU2011275996B2/en active Active
- 2011-06-01 SI SI201131328T patent/SI2591127T1/sl unknown
- 2011-06-01 MX MX2013000100A patent/MX2013000100A/es active IP Right Grant
- 2011-06-01 CN CN201510177998.7A patent/CN104974972B/zh active Active
- 2011-06-01 BR BR112013000648A patent/BR112013000648A2/pt not_active Application Discontinuation
- 2011-06-01 ES ES11722468.3T patent/ES2644443T3/es active Active
- 2011-06-01 JP JP2013517135A patent/JP6030056B2/ja active Active
- 2011-06-01 SG SG2012089918A patent/SG186212A1/en unknown
- 2011-06-01 CA CA2801843A patent/CA2801843C/en active Active
- 2011-06-01 CN CN201180033969.3A patent/CN103228781B/zh active Active
- 2011-06-01 LT LTEP11722468.3T patent/LT2591127T/lt unknown
- 2011-06-01 WO PCT/EP2011/059069 patent/WO2012004063A1/en active Application Filing
- 2011-06-01 EP EP11722468.3A patent/EP2591127B1/en active Active
- 2011-06-01 GE GEAP201112993A patent/GEP201706720B/en unknown
- 2011-06-01 EA EA201291455A patent/EA025126B1/ru not_active IP Right Cessation
- 2011-06-01 DK DK11722468.3T patent/DK2591127T3/da active
- 2011-06-24 US US13/168,289 patent/US8609394B2/en active Active
-
2012
- 2012-11-30 ZA ZA2012/09079A patent/ZA201209079B/en unknown
- 2012-12-24 IL IL223830A patent/IL223830B/en active IP Right Grant
-
2013
- 2013-11-13 US US14/078,809 patent/US8771992B2/en active Active
-
2017
- 2017-10-16 CY CY20171101081T patent/CY1119469T1/el unknown
- 2017-10-24 HR HRP20171624TT patent/HRP20171624T1/hr unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B25G | Requested change of headquarter approved |
Owner name: GNOSIS S.P.A. (IT) |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |