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BR112019006918A2 - proteínas actriib variantes e usos das mesmas - Google Patents

proteínas actriib variantes e usos das mesmas

Info

Publication number
BR112019006918A2
BR112019006918A2 BR112019006918A BR112019006918A BR112019006918A2 BR 112019006918 A2 BR112019006918 A2 BR 112019006918A2 BR 112019006918 A BR112019006918 A BR 112019006918A BR 112019006918 A BR112019006918 A BR 112019006918A BR 112019006918 A2 BR112019006918 A2 BR 112019006918A2
Authority
BR
Brazil
Prior art keywords
actriib
methods
present
actriib proteins
compositions
Prior art date
Application number
BR112019006918A
Other languages
English (en)
Inventor
Grinberg Asya
M Vogan Erik
Kumar Ravindra
Original Assignee
Acceleron Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of BR112019006918A2 publication Critical patent/BR112019006918A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

em determinados aspectos, a presente invenção proporciona composições e métodos para modular (promover ou inibir) o crescimento de glóbulos vermelhos ou um tecido, tal como tecido ósseo, cartilaginoso, muscular, gorduroso e/ou neuronal. a presente invenção também proporciona métodos para triar compostos que modulam a atividade de uma proteína actriib e/ou um ligante actriib. as composições e métodos proporcionados no presente documento são úteis para tratar doenças associadas à atividade anormal de uma proteína actriib e/ou um ligante actriib.
BR112019006918A 2016-10-05 2017-10-05 proteínas actriib variantes e usos das mesmas BR112019006918A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662404718P 2016-10-05 2016-10-05
PCT/US2017/055421 WO2018067874A1 (en) 2016-10-05 2017-10-05 Variant actriib proteins and uses thereof

Publications (1)

Publication Number Publication Date
BR112019006918A2 true BR112019006918A2 (pt) 2019-06-25

Family

ID=61831930

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019006918A BR112019006918A2 (pt) 2016-10-05 2017-10-05 proteínas actriib variantes e usos das mesmas

Country Status (10)

Country Link
US (2) US11267865B2 (pt)
EP (1) EP3523328A4 (pt)
JP (2) JP7280182B2 (pt)
KR (2) KR102595559B1 (pt)
CN (1) CN110036025B (pt)
AU (3) AU2017338916B2 (pt)
BR (1) BR112019006918A2 (pt)
CA (1) CA3039525A1 (pt)
MA (1) MA46471A (pt)
WO (1) WO2018067874A1 (pt)

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Also Published As

Publication number Publication date
KR20230152811A (ko) 2023-11-03
EP3523328A1 (en) 2019-08-14
JP7280182B2 (ja) 2023-05-23
JP2019536440A (ja) 2019-12-19
AU2022201698A1 (en) 2022-04-07
US11267865B2 (en) 2022-03-08
US20220306724A1 (en) 2022-09-29
KR20190073414A (ko) 2019-06-26
AU2017338916B2 (en) 2022-03-24
AU2024200684A1 (en) 2024-02-22
KR102595559B1 (ko) 2023-10-30
JP2023033573A (ja) 2023-03-10
MA46471A (fr) 2021-05-19
WO2018067874A1 (en) 2018-04-12
US20200055919A1 (en) 2020-02-20
AU2017338916A1 (en) 2019-04-18
CN110036025A (zh) 2019-07-19
EP3523328A4 (en) 2020-04-01
CN110036025B (zh) 2024-03-22
CA3039525A1 (en) 2018-04-12

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