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BR112016004437A2 - métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit - Google Patents

métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit

Info

Publication number
BR112016004437A2
BR112016004437A2 BR112016004437A BR112016004437A BR112016004437A2 BR 112016004437 A2 BR112016004437 A2 BR 112016004437A2 BR 112016004437 A BR112016004437 A BR 112016004437A BR 112016004437 A BR112016004437 A BR 112016004437A BR 112016004437 A2 BR112016004437 A2 BR 112016004437A2
Authority
BR
Brazil
Prior art keywords
antibodies
immunotest
kit
cell line
line selection
Prior art date
Application number
BR112016004437A
Other languages
English (en)
Inventor
C Krawitz Denise
Gunawan Feny
H Yuk Inn
Zhu-Shimoni Judith
S Lin Margaret
Vanderlaan Martin
Vij Rajesh
Hsiao Yi-Chun
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112016004437A2 publication Critical patent/BR112016004437A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)
    • G01N2333/92—Triglyceride splitting, e.g. by means of lipase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

são fornecidos anticorpos monoclonais e policlonais que ligam fosfolipase similar a b 2 de hamster. também são fornecidos métodos de detecção e quantificação de fosfolipase similar a b 2 de hamster, por exemplo, em preparações de polipeptídeos recombinantes, bem como kits de condução desses métodos. também são fornecidos métodos de seleção de linhagens de células hospedeiras ou linhagens de células que expressam polipeptídeos recombinantes e expressam baixos níveis de fosfolipase similar a b 2 de hamster.
BR112016004437A 2013-09-13 2014-09-12 métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit BR112016004437A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361877503P 2013-09-13 2013-09-13
US201461991228P 2014-05-09 2014-05-09
PCT/US2014/055382 WO2015038884A2 (en) 2013-09-13 2014-09-12 Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products

Publications (1)

Publication Number Publication Date
BR112016004437A2 true BR112016004437A2 (pt) 2017-10-17

Family

ID=52666515

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016004437A BR112016004437A2 (pt) 2013-09-13 2014-09-12 métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit

Country Status (13)

Country Link
US (3) US9945858B2 (pt)
EP (2) EP4163633A1 (pt)
JP (2) JP6546178B2 (pt)
KR (2) KR102260855B1 (pt)
CN (1) CN105722992B (pt)
BR (1) BR112016004437A2 (pt)
CA (2) CA2920686C (pt)
ES (1) ES2915378T3 (pt)
HK (1) HK1226107A1 (pt)
MX (2) MX2016002799A (pt)
PL (1) PL3044323T3 (pt)
RU (1) RU2016107435A (pt)
WO (1) WO2015038884A2 (pt)

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BR112016004437A2 (pt) 2013-09-13 2017-10-17 Genentech Inc métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit
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SG11201707186YA (en) * 2015-03-06 2017-10-30 Genentech Inc Ultrapurified dsba and dsbc and methods of making and using the same
CN105021824A (zh) * 2015-07-06 2015-11-04 上海优者生物科技有限公司 用于定量检测生物医药制品中残留cho宿主细胞蛋白的elisa试剂盒及其使用方法
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CN109307771A (zh) * 2018-09-14 2019-02-05 北京三元基因药业股份有限公司 亲和层析定量检测重组人α干扰素工艺中间体含量的方法
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