BR112015011111A2 - proteína multifuncional e formulação farmacêutica - Google Patents
proteína multifuncional e formulação farmacêuticaInfo
- Publication number
- BR112015011111A2 BR112015011111A2 BR112015011111A BR112015011111A BR112015011111A2 BR 112015011111 A2 BR112015011111 A2 BR 112015011111A2 BR 112015011111 A BR112015011111 A BR 112015011111A BR 112015011111 A BR112015011111 A BR 112015011111A BR 112015011111 A2 BR112015011111 A2 BR 112015011111A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical formulation
- multifunctional protein
- multifunctional
- protein
- formulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12195094 | 2012-11-30 | ||
| PCT/EP2013/074759 WO2014083004A1 (en) | 2012-11-30 | 2013-11-26 | Removal of cancer cells by circulating virus-specific cytotoxic t-cells using cancer cell targeted mhc class i comprising multi-function proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015011111A2 true BR112015011111A2 (pt) | 2017-11-14 |
Family
ID=47227715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015011111A BR112015011111A2 (pt) | 2012-11-30 | 2013-11-26 | proteína multifuncional e formulação farmacêutica |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20160083477A1 (pt) |
| EP (1) | EP2925780B1 (pt) |
| JP (1) | JP2015537043A (pt) |
| KR (1) | KR20150088881A (pt) |
| CN (1) | CN104781279A (pt) |
| AR (1) | AR093641A1 (pt) |
| BR (1) | BR112015011111A2 (pt) |
| CA (1) | CA2887486A1 (pt) |
| HK (1) | HK1211949A1 (pt) |
| MX (1) | MX354660B (pt) |
| RU (1) | RU2015125639A (pt) |
| WO (1) | WO2014083004A1 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201504558TA (en) | 2012-12-11 | 2015-07-30 | Einstein Coll Med | Methods for high throughput receptor:ligand identification |
| CN106132428B (zh) * | 2014-01-21 | 2021-08-06 | 阿尔伯特爱因斯坦医学院 | 用于快速和全面t细胞免疫监测的细胞平台 |
| CN113248624A (zh) * | 2014-06-18 | 2021-08-13 | 阿尔伯特爱因斯坦医学院 | Syntac多肽及其用途 |
| AU2017268348A1 (en) | 2016-05-18 | 2018-10-25 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| AU2017266905B2 (en) | 2016-05-18 | 2022-12-15 | Albert Einstein College Of Medicine, Inc. | Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof |
| EP4360647A3 (en) | 2016-12-22 | 2024-07-24 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| AU2018234628B2 (en) | 2017-03-15 | 2023-07-20 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| WO2019012138A1 (en) | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | POLYPEPTIDE MOLECULE WITH IMPROVED DOUBLE-SPECIFICITY |
| DE102017115966A1 (de) * | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
| CN111886241A (zh) | 2018-01-09 | 2020-11-03 | 库尔生物制药有限公司 | 多聚体t细胞调节多肽及其使用方法 |
| EP3755711A4 (en) * | 2018-02-20 | 2021-11-24 | Technion Research & Development Foundation Limited | IMMUNOTHERAPEUTIC COMPOSITION FOR THE TREATMENT OF CANCER |
| WO2020056152A1 (en) * | 2018-09-12 | 2020-03-19 | Chang Liu | Single chain constructs |
| EP3902560A1 (en) | 2018-12-28 | 2021-11-03 | F. Hoffmann-La Roche AG | A peptide-mhc-i-antibody fusion protein for therapeutic use in a patient with amplified immune response |
| CA3169949A1 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| EP4211149A4 (en) | 2020-09-09 | 2024-10-09 | Cue Biopharma Inc | MHC CLASS II T-CELL MODULATING MULTIMER POLYPEPTIDES FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF |
| WO2023126544A1 (en) * | 2022-01-03 | 2023-07-06 | Aarhus Universitet | Proteinaceous compound for generating specific cytotoxic t-cell effect |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3825615A1 (de) * | 1988-07-28 | 1990-02-01 | Behringwerke Ag | Antigenkonstrukte von "major histocompatibility complex" klasse i antigenen mit spezifischen traegermolekuelen, ihre herstellung und verwendung |
| US6268411B1 (en) * | 1997-09-11 | 2001-07-31 | The Johns Hopkins University | Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses |
| CA2406378A1 (en) * | 2000-04-12 | 2001-10-25 | University Of Rochester | Targeted vaccine delivery systems |
| US20030017134A1 (en) * | 2001-06-19 | 2003-01-23 | Technion Research And Development Foundation Ltd. | Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer |
| WO2005099361A2 (en) * | 2003-07-10 | 2005-10-27 | Vaccinex, Inc. | MHC CLASS I - PEPTIDE-ANTIBODY CONJUGATES WITH MODIFIED β2-MICROGLOBULIN |
| ES2549128T3 (es) * | 2006-05-19 | 2015-10-23 | Technion Research And Development Foundation Ltd. | Proteínas de fusión, usos de las mismas y procesos para producir las mismas |
| US10611818B2 (en) * | 2007-09-27 | 2020-04-07 | Agilent Technologies, Inc. | MHC multimers in tuberculosis diagnostics, vaccine and therapeutics |
| SG10201604160WA (en) * | 2011-02-10 | 2016-07-28 | Roche Glycart Ag | Mutant Interleukin-2 Polypeptides |
| PE20141212A1 (es) * | 2011-06-22 | 2014-09-19 | Hoffmann La Roche | Eliminacion de celulas diana por parte de celulas t citotoxicas especificas de virus utilizando complejos que comprenden mhc de clase 1 |
| CA2889788A1 (en) * | 2012-12-21 | 2014-06-26 | F. Hoffmann-La Roche Ag | Disulfide-linked multivalent mhc class i comprising multi-function proteins |
| EP3291832A4 (en) * | 2015-05-06 | 2018-09-12 | UTI Limited Partnership | Nanoparticle compositions for sustained therapy |
-
2013
- 2013-11-26 KR KR1020157017126A patent/KR20150088881A/ko not_active Application Discontinuation
- 2013-11-26 MX MX2015006755A patent/MX354660B/es active IP Right Grant
- 2013-11-26 WO PCT/EP2013/074759 patent/WO2014083004A1/en active Application Filing
- 2013-11-26 CN CN201380058062.1A patent/CN104781279A/zh active Pending
- 2013-11-26 EP EP13795771.8A patent/EP2925780B1/en not_active Not-in-force
- 2013-11-26 CA CA 2887486 patent/CA2887486A1/en not_active Abandoned
- 2013-11-26 JP JP2015544443A patent/JP2015537043A/ja not_active Ceased
- 2013-11-26 RU RU2015125639A patent/RU2015125639A/ru not_active Application Discontinuation
- 2013-11-26 BR BR112015011111A patent/BR112015011111A2/pt not_active Application Discontinuation
- 2013-11-28 AR ARP130104385A patent/AR093641A1/es unknown
-
2015
- 2015-05-28 US US14/724,571 patent/US20160083477A1/en not_active Abandoned
- 2015-12-24 HK HK15112675.0A patent/HK1211949A1/xx unknown
-
2018
- 2018-07-30 US US16/049,201 patent/US20190169309A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014083004A1 (en) | 2014-06-05 |
| MX354660B (es) | 2018-03-14 |
| RU2015125639A (ru) | 2017-01-10 |
| US20190169309A1 (en) | 2019-06-06 |
| KR20150088881A (ko) | 2015-08-03 |
| JP2015537043A (ja) | 2015-12-24 |
| EP2925780A1 (en) | 2015-10-07 |
| US20160083477A1 (en) | 2016-03-24 |
| EP2925780B1 (en) | 2017-10-18 |
| HK1211949A1 (en) | 2016-06-03 |
| CA2887486A1 (en) | 2014-06-05 |
| MX2015006755A (es) | 2016-01-15 |
| AR093641A1 (es) | 2015-06-17 |
| CN104781279A (zh) | 2015-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL286784A (en) | Compositions of protein and antibody | |
| BR112015011111A2 (pt) | proteína multifuncional e formulação farmacêutica | |
| LTPA2018511I1 (lt) | Policikliniai karbamoilpiridino junginiai ir jų farmacinis panaudojimas | |
| DK3181128T3 (da) | Farmaceutisk nilotinib-sammensætning | |
| DK2903600T3 (da) | Virusholdig formulering og anvendelse deraf | |
| DK2858671T3 (da) | Antistofformulering | |
| DK2890397T3 (da) | Antiprolactinreceptor-antistofformulering | |
| BR112015003125A2 (pt) | ingrediente hidrante cosmético ou7 farmacêutico | |
| BR112014029403A2 (pt) | conjugados, anticorpo e formulação farmacêutica | |
| DK2920197T3 (da) | Prolinlåste sammenhæftede peptider og anvendelser deraf | |
| DK2844222T3 (da) | Lægemiddelformulering med forsinket udløsning | |
| BR112015001211A2 (pt) | novos ácidos 5-aminotetra-hidroquinolina-2-carboxílicos e sua utilização | |
| DK2922877T3 (da) | Forbedrede peptidlægemidler | |
| BR112013014644A2 (pt) | composição farmacêutica e complexo | |
| DK2897594T3 (da) | Farmaceutisk sammensætning | |
| CY2200004T2 (el) | Σκευασματα δαπτομυκινης και χρησεις αυτων | |
| DK2868318T4 (da) | Injicerbar formulering | |
| CL2014003283A1 (es) | Formulación farmacéutica. | |
| BR112015003116A2 (pt) | preparação farmacêutica sólida contendo levotiroxina | |
| CO7091176A2 (es) | Diagnóstico farmacéutico | |
| DK3473255T3 (da) | Farmaceutisk formulering omfattende ciclesonid | |
| DK2735305T3 (da) | Stabiliserede flydende farmaceutiske præparater | |
| BR112015002646A2 (pt) | composto e composição farmacêutica | |
| DK2869845T3 (da) | Dimert protein med tredobbelte mutationer | |
| DK3003401T3 (da) | Farmaceutisk præparat |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |