BR112015000534A2 - método para a preparação de 2,4-dihidroxibutirato, microrganismo, organismo e uso - Google Patents

método para a preparação de 2,4-dihidroxibutirato, microrganismo, organismo e uso

Info

Publication number: BR112015000534A2
Authority: BR; Brazil
Prior art keywords: dihydroxybutyrate; microorganism; organism; preparation
Prior art date: 2012-07-11

Application number

BR112015000534A

Other languages

English (en)

Other versions

BR112015000534B1 (pt

BR112015000534A8 (pt

Inventor

Dressaire Clémentine

Cordier Hélene

Marie Francois Jean

Huet Robert

Walther Thomas

Original Assignee

Adisseo France Sas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-07-11

Filing date

2013-07-10

Publication date

2017-12-19

2013-07-10 Application filed by Adisseo France Sas filed Critical Adisseo France Sas

2017-12-19 Publication of BR112015000534A2 publication Critical patent/BR112015000534A2/pt

2023-01-03 Publication of BR112015000534A8 publication Critical patent/BR112015000534A8/pt

2023-02-28 Publication of BR112015000534B1 publication Critical patent/BR112015000534B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01028—D-Lactate dehydrogenase (1.1.1.28)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01037—Malate dehydrogenase (1.1.1.37)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01082—Malate dehydrogenase (NADP+) (1.1.1.82)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01272—(R)-2-Hydroxyacid dehydrogenase (1.1.1.272)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01299—Malate dehydrogenase (NAD(P)+)(1.1.1.299)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01001—Aspartate transaminase (2.6.1.1), i.e. aspartate-aminotransferase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01042—Branched-chain-amino-acid transaminase (2.6.1.42)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01057—Aromatic-amino-acid transaminase (2.6.1.57)

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Mycology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Botany (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BR112015000534-9A 2012-07-11 2013-07-10 Método para a preparação de 2,4-dihidroxibutirato, microrganismo modificado e método de produção de 2,4-dhb BR112015000534B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201261670405P	2012-07-11	2012-07-11
US61/670,405		2012-07-11
PCT/EP2013/064619 WO2014009435A1 (en)	2012-07-11	2013-07-10	Method for the preparation of 2,4-dihydroxybutyrate

Publications (3)

Publication Number	Publication Date
BR112015000534A2 true BR112015000534A2 (pt)	2017-12-19
BR112015000534A8 BR112015000534A8 (pt)	2023-01-03
BR112015000534B1 BR112015000534B1 (pt)	2023-02-28

Family

ID=48748274

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR112015000534-9A BR112015000534B1 (pt)	2012-07-11	2013-07-10	Método para a preparação de 2,4-dihidroxibutirato, microrganismo modificado e método de produção de 2,4-dhb

Country Status (11)

Country	Link
US (2)	US10570422B2 (pt)
EP (1)	EP2872640B1 (pt)
JP (1)	JP6293746B2 (pt)
KR (1)	KR102093172B1 (pt)
CN (1)	CN104471069B (pt)
AR (1)	AR091726A1 (pt)
BR (1)	BR112015000534B1 (pt)
ES (1)	ES2800341T3 (pt)
IN (1)	IN2014DN10637A (pt)
RU (1)	RU2645260C2 (pt)
WO (1)	WO2014009435A1 (pt)

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US10190101B2 (en)	2014-04-11	2019-01-29	String Bio Private Limited	Production of lactic acid from organic waste or biogas or methane using recombinant methanotrophic bacteria
WO2015195710A1 (en) *	2014-06-16	2015-12-23	Invista Technlogies S.A.R.L.	Process for producing glutarate and glutaric acid methyl ester
US10385322B2 (en)	2014-10-03	2019-08-20	Metabolic Explorer	Mutant glutamate dehydrogenase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate
ES2811337T3 (es)	2015-04-07	2021-03-11	Metabolic Explorer Sa	Microorganismo modificado para la producción optimizada de 2,4-dihidroxibutirato con eflujo de 2,4- dihidroxibutirato aumentado
CN107690482B (zh) *	2015-04-07	2022-11-29	代谢探索者公司	用于2,4-二羟基丁酸的优化生产的经修饰的微生物
MX2017015668A (es)	2015-06-04	2018-08-15	Basf Se	Microorganismos recombinante para la produccion mejorada de quimicos finos.
EP3307902A1 (en) *	2015-06-12	2018-04-18	Basf Se	Recombinant microorganism for improved production of alanine
BR112017027815B1 (pt)	2015-06-25	2021-12-21	Dynamic Food Ingredients Corporation	Método de produção de 2,4-dihidroxibutirato
KR102149044B1 (ko) *	2017-07-12	2020-08-28	울산과학기술원	2-히드록시 감마 부티로락톤 또는 2,4-디히드록시-부티레이트 의 제조 방법
EP3470512A1 (en)	2017-10-10	2019-04-17	Metabolic Explorer	Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate
CN108866017B (zh) *	2018-08-24	2020-07-03	浙江华睿生物技术有限公司	一种酶法制备β-羟基-β-甲基丁酸的方法
AU2020262490A1 (en)	2019-04-25	2021-11-25	Zymochem, Inc.	Production of chemicals from renewable sources
CN110577961B (zh) *	2019-09-23	2021-05-04	安徽师范大学	一种热稳定性苹果酸脱氢酶基因的构建方法、编码蛋白及其应用
DE102021101004B3 (de)	2021-01-19	2022-03-10	Technische Universität Dresden, Körperschaft des öffentlichen Rechts	Verfahren zur Herstellung von 2,4-Dihydroxybutyrat oder L-Threonin unter Nutzung eines mikrobiellen Stoffwechselweges
CN113106029A (zh) *	2021-04-20	2021-07-13	南京工业大学	一种过表达aro8基因的酿酒酵母工程菌及其构建方法与应用
WO2023230399A1 (en) *	2022-05-23	2023-11-30	The Regents Of The University Of California	Novel carbon fixation pathway
CN115948482B (zh) *	2023-02-07	2024-02-09	中国科学院天津工业生物技术研究所	一种2，4-二羟基丁酸生物合成途径的构建方法及应用
EP4431609A1 (en)	2023-03-14	2024-09-18	Adisseo France S.A.S.	Method for improving 2, 4 dihydroxybutyric acid production and yield

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2013
- 2013-07-10 ES ES13734811T patent/ES2800341T3/es active Active
- 2013-07-10 JP JP2015520978A patent/JP6293746B2/ja active Active
- 2013-07-10 RU RU2014153354A patent/RU2645260C2/ru active
- 2013-07-10 US US14/414,331 patent/US10570422B2/en active Active
- 2013-07-10 CN CN201380036661.3A patent/CN104471069B/zh active Active
- 2013-07-10 KR KR1020147036006A patent/KR102093172B1/ko active IP Right Grant
- 2013-07-10 BR BR112015000534-9A patent/BR112015000534B1/pt active IP Right Grant
- 2013-07-10 WO PCT/EP2013/064619 patent/WO2014009435A1/en active Application Filing
- 2013-07-10 IN IN10637DEN2014 patent/IN2014DN10637A/en unknown
- 2013-07-10 EP EP13734811.6A patent/EP2872640B1/en active Active
- 2013-07-11 AR ARP130102456 patent/AR091726A1/es active IP Right Grant
2020
- 2020-01-13 US US16/740,598 patent/US11505811B2/en active Active

Also Published As

Publication number	Publication date
KR102093172B1 (ko)	2020-03-25
AR091726A1 (es)	2015-02-25
EP2872640B1 (en)	2020-03-25
KR20150035726A (ko)	2015-04-07
RU2014153354A (ru)	2016-08-27
CN104471069A (zh)	2015-03-25
US20200131542A1 (en)	2020-04-30
RU2645260C2 (ru)	2018-02-19
IN2014DN10637A (pt)	2015-09-11
JP2015524253A (ja)	2015-08-24
JP6293746B2 (ja)	2018-03-14
US10570422B2 (en)	2020-02-25
US20150147793A1 (en)	2015-05-28
BR112015000534B1 (pt)	2023-02-28
BR112015000534A8 (pt)	2023-01-03
US11505811B2 (en)	2022-11-22
WO2014009435A1 (en)	2014-01-16
CN104471069B (zh)	2018-06-01
EP2872640A1 (en)	2015-05-20
ES2800341T3 (es)	2020-12-29

Publication	Publication Date	Title
BR112015000534A2 (pt)	2017-12-19	método para a preparação de 2,4-dihidroxibutirato, microrganismo, organismo e uso
BR112014031262A2 (pt)	2017-06-27	composições biocatalisadoras inovadoras e processos para uso.
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ZA201404625B (en)	2015-11-25	Polycyclic derivatives, preparation method and medical uses thereof
BR112014026149A2 (pt)	2017-07-18	método para a preparação de 2,4-ácido dihidroxibutírico (2,4-dhb) e microrganismo.
HK1193100A1 (zh)	2014-09-12	苯基- -氮雜-雙環己- -基-甲酮及其作為藥物的用途
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BR112014026564A2 (pt)	2017-06-27	formulação, uso de uma formulação, e, processo para a preparação de uma formulação
EP3059304A4 (en)	2017-07-05	Novel microorganism and use thereof
BR112014026565A2 (pt)	2017-06-27	formulação, uso de uma formulação, e, processo para produzir uma formulação
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