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BR112014007721A2 - processos para preparar compostos úteis como inibidores de atr quinase - Google Patents

processos para preparar compostos úteis como inibidores de atr quinase

Info

Publication number
BR112014007721A2
BR112014007721A2 BR112014007721A BR112014007721A BR112014007721A2 BR 112014007721 A2 BR112014007721 A2 BR 112014007721A2 BR 112014007721 A BR112014007721 A BR 112014007721A BR 112014007721 A BR112014007721 A BR 112014007721A BR 112014007721 A2 BR112014007721 A2 BR 112014007721A2
Authority
BR
Brazil
Prior art keywords
compounds
processes
inhibitors
relates
preparing
Prior art date
Application number
BR112014007721A
Other languages
English (en)
Other versions
BR112014007721B1 (pt
Inventor
Urbina Armando
Joseph Littler Benjamenin
Andrew Siesel David
Yvonne Theodora Marie Pierard Francoise
Charrier Jean-Damien
Studley John
Angell Paul
Michael Hughes Robert
John Durrant Steven
Shi Yi
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BR112014007721A2 publication Critical patent/BR112014007721A2/pt
Publication of BR112014007721B1 publication Critical patent/BR112014007721B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

abstract [00282] the present invention relates to processes and intermediates for preparing compounds useful as inhibitors of atr kinase, such as aminopyrazine-isoxazole derivatives and related molecules. the present invention also relates to compounds useful as inhibitors of atr protein kinase. the invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. [00283] the compounds of this invention have formula i or ii: i ii wherein the variables are as defined herein. -------------------------------------------------------------------------- tradução do resumo resumo patente de invenção "processos para preparar compostos úteis como inibidores de atr quinase". a presente invenção refere-se a processos e intermediários para preparar compostos úteis como inibidores de atr quinase, tais como derivados aminopirazina-isoxazol e moléculas relacionadas. a presente invenção refere-se também a compostos úteis como inibidores de atr proteína quinase. ta invenção refere-se a compo¬sições farmaceuticamente aceitáveis que compreendem os compostos desta invenção; métodos para tratamento de várias doenças, distúr¬bios e condições com o uso de compostos desta invenção; processos para preparar os compostos desta invenção; intermediários para a preparação dos compostos desta invenção; e formas sólidas dos compostos desta invenção. os compostos desta invenção têm fórmula i ou ii: i ii em que as variáveis são como definidas aqui.
BR112014007721-5A 2011-09-30 2012-09-28 Processos para preparar compostos úteis como inibidores de atr quinase BR112014007721B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161541865P 2011-09-30 2011-09-30
US61/541,865 2011-09-30
PCT/US2012/058127 WO2013049726A2 (en) 2011-09-30 2012-09-28 Processes for making compounds useful as inhibitors of atr kinase

Publications (2)

Publication Number Publication Date
BR112014007721A2 true BR112014007721A2 (pt) 2017-04-25
BR112014007721B1 BR112014007721B1 (pt) 2022-11-01

Family

ID=47019163

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014007721-5A BR112014007721B1 (pt) 2011-09-30 2012-09-28 Processos para preparar compostos úteis como inibidores de atr quinase

Country Status (24)

Country Link
US (4) US9035053B2 (pt)
EP (4) EP2751097A2 (pt)
JP (4) JP6212045B2 (pt)
KR (2) KR102013133B1 (pt)
CN (2) CN106496173A (pt)
AR (1) AR088092A1 (pt)
AU (3) AU2012315615A1 (pt)
BR (1) BR112014007721B1 (pt)
CA (2) CA2850566C (pt)
ES (1) ES2751741T3 (pt)
HK (2) HK1201259A1 (pt)
HR (1) HRP20191641T1 (pt)
HU (1) HUE046429T2 (pt)
IL (3) IL231771A0 (pt)
IN (1) IN2014KN00929A (pt)
MX (1) MX353461B (pt)
PL (1) PL2940017T3 (pt)
PT (1) PT2940017T (pt)
RS (1) RS59337B1 (pt)
RU (2) RU2677292C2 (pt)
SG (2) SG10201606774UA (pt)
TW (3) TWI625328B (pt)
WO (1) WO2013049726A2 (pt)
ZA (1) ZA201402625B (pt)

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WO2013071094A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
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US8841337B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
CA2869309C (en) 2012-04-05 2021-02-09 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase and combination therapies thereof
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US8912198B2 (en) 2012-10-16 2014-12-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
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