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BR0314380A - Ativação de metaloprotease de miostatina e métodos de modulação da atividade de miostatina - Google Patents

Ativação de metaloprotease de miostatina e métodos de modulação da atividade de miostatina

Info

Publication number
BR0314380A
BR0314380A BR0314380-5A BR0314380A BR0314380A BR 0314380 A BR0314380 A BR 0314380A BR 0314380 A BR0314380 A BR 0314380A BR 0314380 A BR0314380 A BR 0314380A
Authority
BR
Brazil
Prior art keywords
myostatin
metalloprotease
activation
agent
methods
Prior art date
Application number
BR0314380-5A
Other languages
English (en)
Inventor
Neil M Wolfman
Kathy Tomkinson
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0314380A publication Critical patent/BR0314380A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"ATIVAçãO DE METALOPROTEASE DE MIOSTATINA E MéTODOS DE MODULAçãO DA ATIVIDADE DE MIOSTATINA". A presente invenção refere-se à clivagem de metaloprotease de um pró-peptídeo de miostatina que resulta em ativação de uma miostatina inativa latente para uma forma ativa. Conseq³entemente, os métodos de identificação de agentes que modulam a ativação de miostatina mediata por metaloprotease são fornecidos, da mesma forma que são identificados agentes empregando-se tais métodos. São também fornecidos métodos de modulação de crescimento muscular em um organismo aumentando-se ou diminuindo-se clivagem de um pró-peptídeo de miostatina mediada por metaloprotease.
BR0314380-5A 2002-09-16 2003-09-16 Ativação de metaloprotease de miostatina e métodos de modulação da atividade de miostatina BR0314380A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41113302P 2002-09-16 2002-09-16
US43916403P 2003-01-09 2003-01-09
US48686303P 2003-07-10 2003-07-10
PCT/US2003/028907 WO2004024092A2 (en) 2002-09-16 2003-09-16 Metalloprotease activation of myostatin, and methods of modulating myostatin activity

Publications (1)

Publication Number Publication Date
BR0314380A true BR0314380A (pt) 2005-07-19

Family

ID=31999236

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0314270-1A BR0314270A (pt) 2002-09-16 2003-09-16 Ativação de miostatina com metaloprotease e processos de modulação da atividade da miostatina
BR0314380-5A BR0314380A (pt) 2002-09-16 2003-09-16 Ativação de metaloprotease de miostatina e métodos de modulação da atividade de miostatina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0314270-1A BR0314270A (pt) 2002-09-16 2003-09-16 Ativação de miostatina com metaloprotease e processos de modulação da atividade da miostatina

Country Status (12)

Country Link
US (3) US7572599B2 (pt)
EP (3) EP2192129A1 (pt)
JP (3) JP4547561B2 (pt)
AT (1) ATE461275T1 (pt)
AU (3) AU2003267246A1 (pt)
BR (2) BR0314270A (pt)
CA (2) CA2498044A1 (pt)
DE (1) DE60331778D1 (pt)
ES (1) ES2344734T3 (pt)
IL (1) IL166651A (pt)
MX (2) MXPA05002648A (pt)
WO (2) WO2004024890A2 (pt)

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WO2003072714A2 (en) 2002-02-21 2003-09-04 Wyeth Follistatin domain containing proteins
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Also Published As

Publication number Publication date
AU2003272394A1 (en) 2004-04-30
JP2010248195A (ja) 2010-11-04
EP1578928A2 (en) 2005-09-28
JP2006517525A (ja) 2006-07-27
DE60331778D1 (de) 2010-04-29
WO2004024092A2 (en) 2004-03-25
JP4547561B2 (ja) 2010-09-22
BR0314270A (pt) 2005-08-02
US20060275280A1 (en) 2006-12-07
EP1549747A4 (en) 2006-08-23
CA2496213C (en) 2013-11-19
WO2004024890A3 (en) 2006-07-27
EP2192129A1 (en) 2010-06-02
IL166651A0 (en) 2006-01-15
WO2004024092A3 (en) 2004-08-26
CA2496213A1 (en) 2004-03-25
US20040138118A1 (en) 2004-07-15
JP2006507356A (ja) 2006-03-02
AU2010201977A1 (en) 2010-06-03
EP1578928B1 (en) 2010-03-17
EP1578928A4 (en) 2007-01-03
MXPA05002968A (es) 2005-09-08
EP1549747A2 (en) 2005-07-06
MXPA05002648A (es) 2005-08-19
ATE461275T1 (de) 2010-04-15
IL166651A (en) 2013-12-31
US7572599B2 (en) 2009-08-11
US20050043232A1 (en) 2005-02-24
JP5369044B2 (ja) 2013-12-18
ES2344734T3 (es) 2010-09-06
WO2004024890A2 (en) 2004-03-25
CA2498044A1 (en) 2004-03-25
AU2003267246A1 (en) 2004-04-30

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A , 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2069 DE 31/08/2010.