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BR0115166A - Combinações de drogas (por exemplo, cloropromazina e pentamidina) para o tratamento de distúrbios neoplásticos - Google Patents

Combinações de drogas (por exemplo, cloropromazina e pentamidina) para o tratamento de distúrbios neoplásticos

Info

Publication number
BR0115166A
BR0115166A BR0115166-5A BR0115166A BR0115166A BR 0115166 A BR0115166 A BR 0115166A BR 0115166 A BR0115166 A BR 0115166A BR 0115166 A BR0115166 A BR 0115166A
Authority
BR
Brazil
Prior art keywords
pentamidine
chlorpromazine
treatment
drug combinations
neoplastic disorders
Prior art date
Application number
BR0115166-5A
Other languages
English (en)
Inventor
Alexis Borisy
Curtis Keith
Michael A Foley
Brent R Stockwell
Original Assignee
Combinatorx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combinatorx Inc filed Critical Combinatorx Inc
Publication of BR0115166A publication Critical patent/BR0115166A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

"COMBINAçõES DE DROGAS (POR EXEMPLO, CLOROPROMAZINA E PENTAMIDINA) PARA O TRATAMENTO DE DISTúRBIOS NEOPLáSTICOS". A presente invenção refere-se a um método para tratar um paciente tendo um câncer ou outro neoplasma, administrando-se ao paciente (i) cloropromazina ou um metabólito ou análogo desta; e (ii) pentamidina ou um metabólito ou análogo desta simultaneamente ou em 14 dias de cada uma em quantidades suficientes para inibir o crescimento do neoplasma.
BR0115166-5A 2000-11-06 2001-10-30 Combinações de drogas (por exemplo, cloropromazina e pentamidina) para o tratamento de distúrbios neoplásticos BR0115166A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/706,929 US6569853B1 (en) 2000-11-06 2000-11-06 Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
PCT/US2001/047959 WO2002058684A2 (en) 2000-11-06 2001-10-30 Combinations of drugs (e.g., chlorpromazine and pentamidine) for the treatment of neoplastic disorders

Publications (1)

Publication Number Publication Date
BR0115166A true BR0115166A (pt) 2003-12-30

Family

ID=24839666

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115166-5A BR0115166A (pt) 2000-11-06 2001-10-30 Combinações de drogas (por exemplo, cloropromazina e pentamidina) para o tratamento de distúrbios neoplásticos

Country Status (29)

Country Link
US (4) US6569853B1 (pt)
EP (1) EP1339399B1 (pt)
JP (1) JP2004517915A (pt)
KR (1) KR100720205B1 (pt)
CN (1) CN1484525A (pt)
AR (1) AR035500A1 (pt)
AT (1) ATE318590T1 (pt)
AU (1) AU2002246636B8 (pt)
BG (1) BG107831A (pt)
BR (1) BR0115166A (pt)
CA (1) CA2436799C (pt)
CY (1) CY1105501T1 (pt)
DE (1) DE60117615T2 (pt)
DK (1) DK1339399T3 (pt)
EE (1) EE200300212A (pt)
ES (1) ES2258566T3 (pt)
HR (1) HRP20030460A2 (pt)
HU (1) HUP0400529A3 (pt)
IL (1) IL155795A0 (pt)
IS (1) IS2457B (pt)
MX (1) MXPA03003960A (pt)
NO (1) NO20032036L (pt)
NZ (1) NZ525773A (pt)
PL (1) PL362690A1 (pt)
PT (1) PT1339399E (pt)
RU (1) RU2286769C2 (pt)
SK (1) SK5452003A3 (pt)
TW (1) TWI259077B (pt)
WO (1) WO2002058684A2 (pt)

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MXPA06003066A (es) 2003-09-18 2006-06-20 Combinatorx Inc Combinaciones de farmacos para el tratamiento de neoplasmas.
US20050158320A1 (en) 2003-11-12 2005-07-21 Nichols M. J. Combinations for the treatment of proliferative diseases
US20050100508A1 (en) 2003-11-12 2005-05-12 Nichols M. J. Methods for identifying drug combinations for the treatment of proliferative diseases

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US6846816B2 (en) 2005-01-25
EP1339399B1 (en) 2006-03-01
DE60117615D1 (de) 2006-04-27
US20050192274A1 (en) 2005-09-01
NO20032036D0 (no) 2003-05-06
JP2004517915A (ja) 2004-06-17
CN1484525A (zh) 2004-03-24
EE200300212A (et) 2003-08-15
US6569853B1 (en) 2003-05-27
US7148216B2 (en) 2006-12-12
TWI259077B (en) 2006-08-01
IS2457B (is) 2008-11-15
RU2286769C2 (ru) 2006-11-10
IL155795A0 (en) 2003-12-23
US20070099906A1 (en) 2007-05-03
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AU2002246636B8 (en) 2006-01-19
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DK1339399T3 (da) 2006-06-19
KR100720205B1 (ko) 2007-05-21
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HUP0400529A3 (en) 2006-02-28
WO2002058684A3 (en) 2003-04-17
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CA2436799C (en) 2007-12-18
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