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BR0113408A - Derivados de aminociclohexano - Google Patents

Derivados de aminociclohexano

Info

Publication number
BR0113408A
BR0113408A BR0113408-6A BR0113408A BR0113408A BR 0113408 A BR0113408 A BR 0113408A BR 0113408 A BR0113408 A BR 0113408A BR 0113408 A BR0113408 A BR 0113408A
Authority
BR
Brazil
Prior art keywords
prophylaxis
compounds
treatment
pharmaceutically acceptable
aminocyclohexane derivatives
Prior art date
Application number
BR0113408-6A
Other languages
English (en)
Inventor
Jean Ackermann
Johannes Aebi
Denise Blum
Alexander Chucholowski
Henrietta Dehmlow
Hans-Peter Maerki
Olivier Morand
Rene Trussardi
Der Mark Elizabeth Von
Sabine Wallbaum
Thomas Weller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0113408A publication Critical patent/BR0113408A/pt

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/52—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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Abstract

"DERIVADOS DE AMINOCICLOHEXANO". A presente invenção refere-se a compostos de fórmula (I), em que U, V, W, A^ 1^, A^ 2^, A^ 3^, A^ 4^, A^ 5^, A^ 6^, m e n são como definido na descrição e reivindicações e os sais farmaceuticamente aceitáveis e/ou ésteres farmaceuticamente aceitáveis destes. Os compostos são úteis para o tratamento e/ou profilaxia de doenças que são associadas com ciclase de 2,3-oxidoesqualeno-lanosterol, tal como hipercolesterolemia, hiperlipemia, arteriosclerose, doenças vasculares, micoses, cálculos biliares, tumores o/ou distúrbios hiperproliferativos, e tratamento e/ou profilaxia de tolerância prejudicada à glicose e diabetes.
BR0113408-6A 2000-08-16 2001-08-08 Derivados de aminociclohexano BR0113408A (pt)

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PCT/EP2001/009174 WO2002014267A1 (en) 2000-08-16 2001-08-08 Novel aminocyclohexane derivatives

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EP1558591B1 (en) * 2002-10-07 2014-05-07 The Regents of The University of California Modulation of anxiety through blockade of anandamide hydrolysis
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RU2449988C1 (ru) * 2011-04-29 2012-05-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Физиологически Активных Веществ Российской Академии Наук (Ифав Ран) 2,2,2-трифтор-1-трифторметилэтиловый эфир циклогексилкарбаминовой кислоты в качестве эффективного средства для селективного необратимого ингибирования карбоксилэстеразы
CN102584618A (zh) * 2012-01-18 2012-07-18 浙江工业大学 一种4-取代酰氨基环己酮的制备方法
CN113600163B (zh) * 2021-09-13 2022-06-14 厦门大学 一种光催化剂及其应用、n-烷基哌嗪及其衍生物的制备方法
CN115780487B (zh) * 2023-01-05 2023-05-05 河北东丽新材料有限公司 一种萃取剂及利用其处理4,4`-联苯醚二酐生产固废的方法

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NZ523879A (en) 2004-09-24
KR20030048010A (ko) 2003-06-18
RU2225393C1 (ru) 2004-03-10
AU2001293744B2 (en) 2007-05-10
CZ2003451A3 (cs) 2003-10-15
CN1468214A (zh) 2004-01-14
PA8525101A1 (es) 2002-07-30
US20020045777A1 (en) 2002-04-18
AU9374401A (en) 2002-02-25
PE20020367A1 (es) 2002-05-11
CA2418744A1 (en) 2002-02-21
HRP20030086A2 (en) 2005-02-28
KR100566175B1 (ko) 2006-03-29
HUP0303105A3 (en) 2005-05-30
JP4244139B2 (ja) 2009-03-25
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AR030712A1 (es) 2003-09-03
MA26941A1 (fr) 2004-12-20
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US6858651B2 (en) 2005-02-22
UY26891A1 (es) 2002-02-28
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ATE403646T1 (de) 2008-08-15
WO2002014267A1 (en) 2002-02-21
PL361783A1 (en) 2004-10-04
JP2004506037A (ja) 2004-02-26
CA2418744C (en) 2010-04-20
YU12003A (sh) 2006-05-25
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