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BR0112856A - Method for treating the disorder, compound or a salt or solvate thereof, process for preparing the disorder, pharmaceutical composition, method of treatment and / or prophylaxis of one or more of the disorders, use of a compound, and method for treatment of diabetes, major depression, manic depression, anxiety, schizophrenia, and sleep disorders in human and non-human mammals - Google Patents

Method for treating the disorder, compound or a salt or solvate thereof, process for preparing the disorder, pharmaceutical composition, method of treatment and / or prophylaxis of one or more of the disorders, use of a compound, and method for treatment of diabetes, major depression, manic depression, anxiety, schizophrenia, and sleep disorders in human and non-human mammals

Info

Publication number
BR0112856A
BR0112856A BR0112856-6A BR0112856A BR0112856A BR 0112856 A BR0112856 A BR 0112856A BR 0112856 A BR0112856 A BR 0112856A BR 0112856 A BR0112856 A BR 0112856A
Authority
BR
Brazil
Prior art keywords
treatment
compound
disorder
human
disorders
Prior art date
Application number
BR0112856-6A
Other languages
Portuguese (pt)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0018758.3A external-priority patent/GB0018758D0/en
Priority claimed from GB0112544A external-priority patent/GB0112544D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BR0112856A publication Critical patent/BR0112856A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Abstract

"MéTODO PARA O TRATAMENTO DOS DISTúRBIOS, COMPOSTO OU UM SAL OU SOLVATO DESTE, PROCESSO PARA A PREPARAçãO DOS MESMOS, COMPOSIçãO FARMACêUTICA, MéTODO DE TRATAMENTO E/OU PROFILAXIA DE UM OU MAIS DOS DISTúRBIOS, USO DE UM COMPOSTO, E, MéTODO PARA O TRATAMENTO DE DIABETES, GRANDE DEPRESSãO, DEPRESSãO MANìACA, ANSIEDADE, ESQUIZOFRENIA E DISTúRBIOS DO SONO, EM MAMìFEROS HUMANOS E NãO HUMANOS". Os compostos da fórmula (I) é independentemente hidrogênio, alquila C~ 1-6~ opcionalmente substituída pelo grupo hidroxila, alcóxi C~ 1-6~, alquenila C~ 1-6~ ou acila C~ 1-6~ ou um átomo de halogênio ou hidroxila, grupo CN ou CF~ 3~; R3 é hidrogênio, metila ou etila; R4 é um anel carbocíclico ou heterocíclico aromático opcionalmente substituído; Z é um átomo de O ou S ou um grupo NH ou CH~ 2~, ou uma ligação simples, na posição 3 ou 4 do R4 em relação ao grupo carbonila; R5 é um anel carbocíclico ou heterocíclico aromático opcionalmente substituído, ou um anel carbocíclico ou heterocíclico saturado ou insaturado opcionalmente substituído e Q é (a) Quando X, Y, R1 e R2 forem como definidos na reivindicação 1; são antagonistas de um receptor 11CBy humano."METHOD FOR THE TREATMENT OF DISTURBES, COMPOUND OR A SALT OR SOLVATT OF THIS PROCESS FOR PREPARING THEREOF, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT AND / OR PROPHYLAXIS, USE OF THE COMPOUND AND THE DISORDER, USE OF TREATMENT OF DIABETES, BIG DEPRESSION, MANIC DEPRESSION, ANXIETY, SCHIZOPHRENIA AND SLEEP DISORDERS IN HUMAN AND NON-HUMAN MAMMERS ". The compounds of formula (I) are independently hydrogen, C 1-6 alkyl, optionally substituted by hydroxyl, C 1-6 alkoxy, C 1-6 alkenyl or C 1-6 acyl or an atom halogen or hydroxyl, CN or CF-3 ~ group; R3 is hydrogen, methyl or ethyl; R4 is an optionally substituted aromatic carbocyclic or heterocyclic ring; Z is an O or S atom or an NH or CH 2 - group, or a single bond, at the 3 or 4 position of R 4 with respect to the carbonyl group; R5 is an optionally substituted aromatic carbocyclic or heterocyclic ring or an optionally substituted saturated or unsaturated carbocyclic or heterocyclic ring and Q is (a) When X, Y, R1 and R2 are as defined in claim 1; they are antagonists of a human 11CBy receptor.

BR0112856-6A 2000-07-31 2001-07-26 Method for treating the disorder, compound or a salt or solvate thereof, process for preparing the disorder, pharmaceutical composition, method of treatment and / or prophylaxis of one or more of the disorders, use of a compound, and method for treatment of diabetes, major depression, manic depression, anxiety, schizophrenia, and sleep disorders in human and non-human mammals BR0112856A (en)

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GBGB0018758.3A GB0018758D0 (en) 2000-07-31 2000-07-31 Novel use and compunds
GB0112544A GB0112544D0 (en) 2001-05-23 2001-05-23 Novel use and compounds
PCT/EP2001/008637 WO2002010146A1 (en) 2000-07-31 2001-07-26 Carboxamide compounds and their use as antagonists of a human 11cby receptor

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