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NO20030471L - Carboxamide compounds and their use as antagonists for an 11CBY receptor - Google Patents

Carboxamide compounds and their use as antagonists for an 11CBY receptor

Info

Publication number
NO20030471L
NO20030471L NO20030471A NO20030471A NO20030471L NO 20030471 L NO20030471 L NO 20030471L NO 20030471 A NO20030471 A NO 20030471A NO 20030471 A NO20030471 A NO 20030471A NO 20030471 L NO20030471 L NO 20030471L
Authority
NO
Norway
Prior art keywords
optionally substituted
antagonists
heterocyclic ring
carboxamide compounds
hydroxyl
Prior art date
Application number
NO20030471A
Other languages
Norwegian (no)
Other versions
NO20030471D0 (en
Inventor
Christopher Norbert Johnson
Martin Jones
Catherine Anne O'toole
Geoffrey Stemp
Kevin Michael Thewlis
David Witty
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0018758.3A external-priority patent/GB0018758D0/en
Priority claimed from GB0112544A external-priority patent/GB0112544D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of NO20030471D0 publication Critical patent/NO20030471D0/en
Publication of NO20030471L publication Critical patent/NO20030471L/en

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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Abstract

Forbindelser med formel (1) hvor: hver A uavhengig er hydrogen, Ci-6 alkyl eventuelt substituert med hydroksyl, Ci-6 alkoksy, Ci.6 alkenyl eller Ci.6 acyl eller et halogenatom eller hydroksyl, CN eller CF; R3 er hydrogen, metyl eller etyl, R4 er en eventuelt substituert aromatisk karbocyklisk eller heterocyklisk ring, Z er et O- eller S-atom, eller en NH- eller CH-gruppe eller en enkeltbinding, i 3- eller 4-stilling av R4 i forhold til karbonylgruppen, R5 er en eventuelt substituert aromatisk karbocyklisk eller heterocyklisk ring eller en i eventuelt substituert, mettet eller umettet, karbocyklisk eller heterocyklisk ring; og Q er (a) hvor X, Y, RI og R2 er som definert i krav 1, er antagonister av en human 1 lCBy-reseptor.Compounds of formula (1) wherein: each A is independently hydrogen, C 1-6 alkyl optionally substituted with hydroxyl, C 1-6 alkoxy, C 1-6 alkenyl or C 1-6 acyl or a halogen atom or hydroxyl, CN or CF; R 3 is hydrogen, methyl or ethyl, R 4 is an optionally substituted aromatic carbocyclic or heterocyclic ring, Z is an O or S atom, or an NH or CH group or a single bond, in the 3- or 4-position of R 4 relative to the carbonyl group, R 5 is an optionally substituted aromatic carbocyclic or heterocyclic ring or an optionally substituted, saturated or unsaturated, carbocyclic or heterocyclic ring; and Q is (a) wherein X, Y, R 1 and R 2 are as defined in claim 1, are antagonists of a human 11CBy receptor.

NO20030471A 2000-07-31 2003-01-30 Carboxamide compounds and their use as antagonists for an 11CBY receptor NO20030471L (en)

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