BR0111058A - Formas de sólidos de 11 beta-[4e-(hidroxiiminometil)-fenil]-17 alfa-metoximetil-17 beta-metóxi-estra-4,9-dien-3-ona de mesoprogestina - Google Patents
Formas de sólidos de 11 beta-[4e-(hidroxiiminometil)-fenil]-17 alfa-metoximetil-17 beta-metóxi-estra-4,9-dien-3-ona de mesoprogestinaInfo
- Publication number
- BR0111058A BR0111058A BR0111058-6A BR0111058A BR0111058A BR 0111058 A BR0111058 A BR 0111058A BR 0111058 A BR0111058 A BR 0111058A BR 0111058 A BR0111058 A BR 0111058A
- Authority
- BR
- Brazil
- Prior art keywords
- beta
- hydroxyiminomethyl
- dien
- phenyl
- solid body
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 5
- -1 hydroxyiminomethyl Chemical group 0.000 title abstract 3
- 150000002923 oximes Chemical class 0.000 abstract 2
- 230000037237 body shape Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"FORMAS DE SóLIDOS DE 11 BETA-[4E-(HIDROXIIMINOMETIL)-FENIL]-17 ALFA-METOXIMETIL-17 BETA-METóXI-ESTRA-4,9-DIEN-3-ONA DE MESOPROGESTINA". A invenção refere-se a novas formas de corpo sólido de 11<225>-[4E-(hidroxiiminometil)fenil]-17<244>-metoximetil-17<225>- metóxi-estra-4,9-dien-3-ona de mesoprogestina (oxima J867), particularmente uma forma altamente cristalina ou amorfa altamente pura e estável (não-solvato/ não-hidrato) do composto J867. A invenção também refere a métodos para produzir referidas novas formas de corpo sólido e ao emprego desta em composições farmacêuticas. As novas formas de corpo sólido são caracterizadas pela exibição de um grau elevado de estabilidade. As formas de corpo sólido de oxima J867 podem, em particular, ser empregadas na área de controle de fertilidade e na terapia de reposição hormonal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00110887A EP1157996A1 (de) | 2000-05-23 | 2000-05-23 | Neue Festkörperformen des Mesoprogestins 11Beta-[4E-(Hydroxyiminomethyl)-phenyl]-17Alpha-methoxymethyl-17Beta-methoxy-estra-4,9-dien-3-on |
| PCT/EP2001/005237 WO2001090137A2 (de) | 2000-05-23 | 2001-05-09 | NEUE FESTKÖRPERFORMEN DES MESOPROGESTINS 11β-[4E-(HYDROXYIMINOMETHYL)-PHENYL]-17α-METHOXYMETHYL-17β-METHOXY-ESTRA-4,9-DIEN-3-ON |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0111058A true BR0111058A (pt) | 2003-04-15 |
Family
ID=8168805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0111058-6A BR0111058A (pt) | 2000-05-23 | 2001-05-09 | Formas de sólidos de 11 beta-[4e-(hidroxiiminometil)-fenil]-17 alfa-metoximetil-17 beta-metóxi-estra-4,9-dien-3-ona de mesoprogestina |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7799770B2 (pt) |
| EP (3) | EP1157996A1 (pt) |
| JP (1) | JP2003534350A (pt) |
| KR (1) | KR100553292B1 (pt) |
| CN (1) | CN100384867C (pt) |
| AT (1) | ATE397617T1 (pt) |
| AU (2) | AU2001256344B2 (pt) |
| BG (1) | BG65968B1 (pt) |
| BR (1) | BR0111058A (pt) |
| CA (1) | CA2409869C (pt) |
| CZ (1) | CZ2003620A3 (pt) |
| DE (1) | DE50114012D1 (pt) |
| DK (1) | DK1292607T3 (pt) |
| EA (1) | EA005623B1 (pt) |
| EC (2) | ECSP024358A (pt) |
| ES (1) | ES2307613T3 (pt) |
| HR (2) | HRP20021032B1 (pt) |
| HU (1) | HUP0301956A3 (pt) |
| IL (2) | IL152868A0 (pt) |
| ME (1) | MEP15608A (pt) |
| MX (1) | MXPA02011524A (pt) |
| NO (1) | NO327004B1 (pt) |
| NZ (1) | NZ522768A (pt) |
| PL (1) | PL358789A1 (pt) |
| PT (1) | PT1292607E (pt) |
| RS (1) | RS50493B (pt) |
| SK (1) | SK2922003A3 (pt) |
| UA (1) | UA73988C2 (pt) |
| WO (1) | WO2001090137A2 (pt) |
| ZA (1) | ZA200209322B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10218109A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| DE10218107A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Steroiden, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| EP1838717A2 (en) * | 2005-01-18 | 2007-10-03 | Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság | Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same |
| US20090054387A1 (en) | 2006-04-18 | 2009-02-26 | Detlef Grawe | Method for preparing 4-[17beta-methoxy-17alpha-methoxymethyl-3-oxestra-4,9-dien-11beta-yl]benzaldehyde (E)-oxime (asoprisnil) |
| DE102006018888A1 (de) * | 2006-04-18 | 2007-10-25 | Bayer Schering Pharma Ag | Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil) |
| EP1862468A1 (de) * | 2006-06-02 | 2007-12-05 | Bayer Schering Pharma Aktiengesellschaft | Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on |
| DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| DE102009034362A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034525A1 (de) | 2009-07-21 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
| DE102010007722A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4332283A1 (de) * | 1993-09-20 | 1995-04-13 | Jenapharm Gmbh | Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19610667C2 (de) * | 1996-03-08 | 1998-04-09 | Schering Ag | (Z)-11ß-[4-(Dimethylamino)phenyl]17ß-hydroxy-17alpha-(3-hydroxy-1-propenyl)estr-4-en-3-on als kristallines Ansolvat |
| EP1204656A2 (en) * | 1999-07-29 | 2002-05-15 | Eli Lilly And Company | A crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene hydrochloride |
-
2000
- 2000-05-23 EP EP00110887A patent/EP1157996A1/de not_active Withdrawn
-
2001
- 2001-05-09 ES ES01929632T patent/ES2307613T3/es not_active Expired - Lifetime
- 2001-05-09 RS YUP-887/02A patent/RS50493B/sr unknown
- 2001-05-09 US US10/296,463 patent/US7799770B2/en active Active
- 2001-05-09 CZ CZ2003620A patent/CZ2003620A3/cs unknown
- 2001-05-09 SK SK292-2003A patent/SK2922003A3/sk not_active Application Discontinuation
- 2001-05-09 PL PL01358789A patent/PL358789A1/xx not_active IP Right Cessation
- 2001-05-09 EP EP07115136A patent/EP1862469A2/de not_active Withdrawn
- 2001-05-09 NZ NZ522768A patent/NZ522768A/en unknown
- 2001-05-09 DK DK01929632T patent/DK1292607T3/da active
- 2001-05-09 ME MEP-156/08A patent/MEP15608A/xx unknown
- 2001-05-09 PT PT01929632T patent/PT1292607E/pt unknown
- 2001-05-09 CA CA002409869A patent/CA2409869C/en not_active Expired - Lifetime
- 2001-05-09 AU AU2001256344A patent/AU2001256344B2/en not_active Ceased
- 2001-05-09 IL IL15286801A patent/IL152868A0/xx unknown
- 2001-05-09 DE DE50114012T patent/DE50114012D1/de not_active Expired - Lifetime
- 2001-05-09 AT AT01929632T patent/ATE397617T1/de not_active IP Right Cessation
- 2001-05-09 MX MXPA02011524A patent/MXPA02011524A/es active IP Right Grant
- 2001-05-09 WO PCT/EP2001/005237 patent/WO2001090137A2/de active Application Filing
- 2001-05-09 HU HU0301956A patent/HUP0301956A3/hu unknown
- 2001-05-09 EA EA200201192A patent/EA005623B1/ru not_active IP Right Cessation
- 2001-05-09 JP JP2001586324A patent/JP2003534350A/ja active Pending
- 2001-05-09 EP EP01929632A patent/EP1292607B1/de not_active Expired - Lifetime
- 2001-05-09 AU AU5634401A patent/AU5634401A/xx active Pending
- 2001-05-09 BR BR0111058-6A patent/BR0111058A/pt not_active IP Right Cessation
- 2001-05-09 CN CNB018099394A patent/CN100384867C/zh not_active Expired - Fee Related
- 2001-05-09 KR KR1020027015762A patent/KR100553292B1/ko not_active IP Right Cessation
- 2001-09-05 UA UA20021210147A patent/UA73988C2/uk unknown
-
2002
- 2002-11-14 IL IL152868A patent/IL152868A/en not_active IP Right Cessation
- 2002-11-15 ZA ZA200209322A patent/ZA200209322B/en unknown
- 2002-11-22 NO NO20025613A patent/NO327004B1/no not_active IP Right Cessation
- 2002-11-22 EC EC2002004358A patent/ECSP024358A/es unknown
- 2002-12-23 HR HR20021032A patent/HRP20021032B1/xx not_active IP Right Cessation
-
2003
- 2003-02-14 BG BG107557A patent/BG65968B1/bg unknown
-
2008
- 2008-08-29 HR HR20080423A patent/HRP20080423A2/xx not_active Application Discontinuation
- 2008-10-22 EC EC2008004358A patent/ECSP084358A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2156 DE 02/05/2012. |