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BR0015307A - Compound, composition, pharmaceutical composition, methods to treat a disorder that is created by or is dependent on the decreased availability of serotonin, norepinephrine or dopamine, and to inhibit the absorption of synaptic norepinephrine, synaptic serotonin and synaptic dopamine in a patient in need of these, and together - Google Patents

Compound, composition, pharmaceutical composition, methods to treat a disorder that is created by or is dependent on the decreased availability of serotonin, norepinephrine or dopamine, and to inhibit the absorption of synaptic norepinephrine, synaptic serotonin and synaptic dopamine in a patient in need of these, and together

Info

Publication number
BR0015307A
BR0015307A BR0015307-9A BR0015307A BR0015307A BR 0015307 A BR0015307 A BR 0015307A BR 0015307 A BR0015307 A BR 0015307A BR 0015307 A BR0015307 A BR 0015307A
Authority
BR
Brazil
Prior art keywords
synaptic
serotonin
norepinephrine
dopamine
composition
Prior art date
Application number
BR0015307-9A
Other languages
Portuguese (pt)
Inventor
James P Beck
Mark A Smith
Original Assignee
Albany Molecular Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albany Molecular Res Inc filed Critical Albany Molecular Res Inc
Publication of BR0015307A publication Critical patent/BR0015307A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTO, COMPOSIçãO, COMPOSIçãO FARMACêUTICA, MéTODOS PARA TRATAR UM DISTúRBIO QUE é CRIADO PELA OU é DEPENDENTE DA DISPONIBILIDADE DIMINUìDA DE SEROTONINA, NOREPINEFRINA OU DOPAMINA, E PARA INIBIR A ABSORçãO DE NOREPINEFRINA SINáPTICA, DE SEROTONINA SINáPTICA E DE DOPAMINA SINáPTICA EM UM PACIENTE EM NECESSIDADE DESTAS, E, CONJUNTO". São aqui fornecidos compostos das fórmulas de IA a IF. Aqui são providos compostos da fórmula IA-IF. Estes compostos são tetraidroisoquinolinas da estrutura (A), em que R^ 1^ a R^ 8^ para os compostos de cada uma das fórmulas IA, IB, IC, ID, IE e IF são como aqui descritos. Os ditos compostos são particularmente úteis no tratamento de vários distúrbios neurológicos e psiquiátricos, por exemplo, ADHD."COMPOUND, COMPOSITION, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING A DISORDER THAT IS CREATED BY OR IS DEPENDENT ON THE DECLINED AVAILABILITY OF SEROTONIN, NOREPINEPHRINE OR DOPAMINE, AND TO INHIBIT THE SYNTHINE EMPTY, NEPTINE SYNTHINE, NEED THESE, AND, TOGETHER ". Compounds of formulas IA to IF are provided herein. Here, compounds of the formula IA-IF are provided. These compounds are tetrahydroisoquinolines of structure (A), wherein R 1 to R 2 8 for the compounds of each of the formulas IA, IB, IC, ID, IE and IF are as described herein. Said compounds are particularly useful in the treatment of various neurological and psychiatric disorders, for example, ADHD.

BR0015307-9A 1999-11-03 2000-11-03 Compound, composition, pharmaceutical composition, methods to treat a disorder that is created by or is dependent on the decreased availability of serotonin, norepinephrine or dopamine, and to inhibit the absorption of synaptic norepinephrine, synaptic serotonin and synaptic dopamine in a patient in need of these, and together BR0015307A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16327099P 1999-11-03 1999-11-03
PCT/US2000/030328 WO2001032624A1 (en) 1999-11-03 2000-11-03 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin

Publications (1)

Publication Number Publication Date
BR0015307A true BR0015307A (en) 2002-07-09

Family

ID=22589231

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015307-9A BR0015307A (en) 1999-11-03 2000-11-03 Compound, composition, pharmaceutical composition, methods to treat a disorder that is created by or is dependent on the decreased availability of serotonin, norepinephrine or dopamine, and to inhibit the absorption of synaptic norepinephrine, synaptic serotonin and synaptic dopamine in a patient in need of these, and together

Country Status (11)

Country Link
EP (1) EP1246805A1 (en)
JP (1) JP4907817B2 (en)
KR (2) KR20080065707A (en)
CN (1) CN100436420C (en)
AU (1) AU784280B2 (en)
BR (1) BR0015307A (en)
CA (1) CA2389300C (en)
MX (1) MXPA02004329A (en)
NZ (1) NZ519146A (en)
RU (1) RU2293728C2 (en)
WO (1) WO2001032624A1 (en)

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DE10154689A1 (en) * 2001-11-09 2003-05-22 Probiodrug Ag Substituted amino ketone compounds
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
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US6703405B2 (en) 2001-12-22 2004-03-09 Aventis Pharma Deutschland Gmbh Substituted 4-phenyltetrahydroisoquinolinium salts, process for their preparation, their use as a medicament, and medicament containing them
EP1572659A2 (en) * 2002-12-02 2005-09-14 Pharmacia & Upjohn Company LLC The use of 4-phenyl substituted tetrahydroisoquinolines in the treatment of pain, migraine and urinary incontinence
AU2003280137A1 (en) * 2002-12-02 2004-06-23 Pharmacia & Upjohn Company Llc The use of 4-phenyl-substituted tetrahydroisoquinolines in the treatment of pain, migraine headaches and urinary incontinence
AU2003283646A1 (en) * 2002-12-02 2004-06-23 Pharmacia & Upjohn Company Llc The use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence
DE10312963A1 (en) * 2003-03-24 2004-10-07 Aventis Pharma Deutschland Gmbh Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as medicament, and medicament containing them
US7241775B2 (en) 2003-03-24 2007-07-10 Sanofi-Aventis Deutschland Gmbh Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines
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Also Published As

Publication number Publication date
CA2389300C (en) 2010-06-08
JP2004501860A (en) 2004-01-22
EP1246805A1 (en) 2002-10-09
MXPA02004329A (en) 2005-08-26
NZ519146A (en) 2004-02-27
CN100436420C (en) 2008-11-26
CN1413197A (en) 2003-04-23
KR100878855B1 (en) 2009-01-15
AU1459601A (en) 2001-05-14
AU784280B2 (en) 2006-03-02
CA2389300A1 (en) 2001-05-10
RU2293728C2 (en) 2007-02-20
KR20020081211A (en) 2002-10-26
WO2001032624A1 (en) 2001-05-10
KR20080065707A (en) 2008-07-14
JP4907817B2 (en) 2012-04-04

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