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CH527194A - Process for the preparation of isoquinoline derivatives - Google Patents

Process for the preparation of isoquinoline derivatives

Info

Publication number
CH527194A
CH527194A CH10370A CH10370A CH527194A CH 527194 A CH527194 A CH 527194A CH 10370 A CH10370 A CH 10370A CH 10370 A CH10370 A CH 10370A CH 527194 A CH527194 A CH 527194A
Authority
CH
Switzerland
Prior art keywords
preparation
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
CH10370A
Other languages
German (de)
Inventor
Alfred Jr Dr Rheiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH10370A priority Critical patent/CH527194A/en
Priority to CH1011872A priority patent/CH538477A/en
Priority to SE7313623A priority patent/SE386672B/en
Priority to SE17063/70A priority patent/SE368401B/xx
Priority to DE2062001A priority patent/DE2062001C2/en
Priority to ZA708590A priority patent/ZA708590B/en
Priority to IL35916A priority patent/IL35916A/en
Priority to NLAANVRAGE7018956,A priority patent/NL171444C/en
Priority to FI703519A priority patent/FI49503C/en
Priority to IE6/71A priority patent/IE34859B1/en
Priority to GB45471A priority patent/GB1335261A/en
Priority to AT4571A priority patent/AT303041B/en
Priority to NO7121A priority patent/NO135315C/no
Priority to FR7100097A priority patent/FR2081412B1/fr
Priority to DK2571AA priority patent/DK125021B/en
Priority to ES387016A priority patent/ES387016A1/en
Priority to BE761219A priority patent/BE761219A/en
Priority to CA102,060A priority patent/CA999866A/en
Priority to JP7194A priority patent/JPS5515476B1/ja
Priority to YU19/71A priority patent/YU33660B/en
Priority to PH12087*UA priority patent/PH9682A/en
Publication of CH527194A publication Critical patent/CH527194A/en
Priority to US05/365,921 priority patent/US3947456A/en
Priority to SE7313622A priority patent/SE399879B/en
Priority to NO740554A priority patent/NO135062C/no
Priority to NO740555A priority patent/NO740555L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH10370A 1970-01-06 1970-01-06 Process for the preparation of isoquinoline derivatives CH527194A (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
CH10370A CH527194A (en) 1970-01-06 1970-01-06 Process for the preparation of isoquinoline derivatives
CH1011872A CH538477A (en) 1970-01-06 1970-01-06 Antidepressant 4-phenyl-tetrahydroquino- - lines
SE7313623A SE386672B (en) 1970-01-06 1970-12-16 INTERMEDIATE PRODUCTS FOR THE MANUFACTURE OF ISOKINOLINE DERIVATIVES
SE17063/70A SE368401B (en) 1970-01-06 1970-12-16
DE2062001A DE2062001C2 (en) 1970-01-06 1970-12-16 1,2,3,4-Tetrahydro-4-phenylisoquinoline derivatives, their acid addition salts, process for their production and pharmaceutical preparation
ZA708590A ZA708590B (en) 1970-01-06 1970-12-21 Isoquinoline derivatives
IL35916A IL35916A (en) 1970-01-06 1970-12-28 1,2,3,4-tetrahydro-4-phenyl iso-quinoline derivatives and their preparation
NLAANVRAGE7018956,A NL171444C (en) 1970-01-06 1970-12-29 PROCESS FOR THE PREPARATION OF 1,2,3,4-TETRAHYDRO-4-PHENYLISOQUINOLINE DERIVATIVES, AND METHOD FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH ANTIDEPRESSIVE PROPERTIES CONTAINING THESE DERIVATIVES
FI703519A FI49503C (en) 1970-01-06 1970-12-31 Analogous process for the preparation of 1,2,3,4-tetrahydro-4-phenylisoquinoline derivatives.
IE6/71A IE34859B1 (en) 1970-01-06 1971-01-04 Isoquinoline derivatives
AT4571A AT303041B (en) 1970-01-06 1971-01-05 Process for the production of new isoquinoline derivatives and their salts
GB45471A GB1335261A (en) 1970-01-06 1971-01-05 Isoquinoline derivatives
NO7121A NO135315C (en) 1970-01-06 1971-01-05
FR7100097A FR2081412B1 (en) 1970-01-06 1971-01-05
DK2571AA DK125021B (en) 1970-01-06 1971-01-05 Analogous process for the preparation of 1,2,3,4-tetrahydro-4-phenyl-isoquinoline derivatives or acid addition salts thereof or the corresponding optically active compounds.
ES387016A ES387016A1 (en) 1970-01-06 1971-01-05 Isoquinoline derivatives
BE761219A BE761219A (en) 1970-01-06 1971-01-05 ISOQUINOLEINE DERIVATIVES
CA102,060A CA999866A (en) 1970-01-06 1971-01-06 Isoquinoline derivatives
JP7194A JPS5515476B1 (en) 1970-01-06 1971-01-06
YU19/71A YU33660B (en) 1970-01-06 1971-01-06 Process for preparing 1, 2, 3, 4-tetrahydro-4-phenylisoquinoline derivatives
PH12087*UA PH9682A (en) 1970-01-06 1971-01-07 1,2,3,4-tetrahydro-4-phenyl-isoquinoline derivatives and pharmaceutical composition containing same
US05/365,921 US3947456A (en) 1970-01-06 1973-06-01 Substituted 4-phenyl isoquinolines
SE7313622A SE399879B (en) 1970-01-06 1973-10-05 CHEMICAL INTERMEDIATE USES FOR THE PREPARATION OF THERAPEUTIC VALUES 1,2,3,4-TETRAHYDRO-4-PHENYL-ISOKINOLINE DERIVATIVES
NO740554A NO135062C (en) 1970-01-06 1974-02-19
NO740555A NO740555L (en) 1970-01-06 1974-02-19 Isoquinoline derivatives for use as intermediates for the preparation of 2-alkyl- or 2-phenyl-lower alkyl-1,2,3,4-tetrahydro-4-isoquinoline derivatives.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH10370A CH527194A (en) 1970-01-06 1970-01-06 Process for the preparation of isoquinoline derivatives

Publications (1)

Publication Number Publication Date
CH527194A true CH527194A (en) 1972-08-31

Family

ID=4179328

Family Applications (2)

Application Number Title Priority Date Filing Date
CH1011872A CH538477A (en) 1970-01-06 1970-01-06 Antidepressant 4-phenyl-tetrahydroquino- - lines
CH10370A CH527194A (en) 1970-01-06 1970-01-06 Process for the preparation of isoquinoline derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH1011872A CH538477A (en) 1970-01-06 1970-01-06 Antidepressant 4-phenyl-tetrahydroquino- - lines

Country Status (19)

Country Link
JP (1) JPS5515476B1 (en)
AT (1) AT303041B (en)
BE (1) BE761219A (en)
CA (1) CA999866A (en)
CH (2) CH538477A (en)
DE (1) DE2062001C2 (en)
DK (1) DK125021B (en)
ES (1) ES387016A1 (en)
FI (1) FI49503C (en)
FR (1) FR2081412B1 (en)
GB (1) GB1335261A (en)
IE (1) IE34859B1 (en)
IL (1) IL35916A (en)
NL (1) NL171444C (en)
NO (1) NO135315C (en)
PH (1) PH9682A (en)
SE (3) SE386672B (en)
YU (1) YU33660B (en)
ZA (1) ZA708590B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
ZA844402B (en) * 1983-06-23 1986-01-29 Mcneil Pharmaceutical Hexahydropyrrolo(2,1-a)isoquinoline derivatives
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
CA2389300C (en) * 1999-11-03 2010-06-08 Albany Molecular Research, Inc. 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US7163949B1 (en) * 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
EP1246806B1 (en) 1999-11-03 2008-02-27 AMR Technology, Inc. Arly- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
EP1113007A1 (en) * 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
JP5132864B2 (en) 2000-07-11 2013-01-30 アルバニー モレキュラー リサーチ， インコーポレイテッド 4-Phenyl substituted tetrahydroisoquinolines and methods of use thereof
GEP20094640B (en) 2004-07-15 2009-03-10 Bristol Myers Squibb Co Aryl-and heteroaryl-substituted tetrahydro isoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
DE602006002894D1 (en) 2005-06-17 2008-11-06 Janssen Pharmaceutica Nv naphthyridine
CN101495184A (en) 2005-07-15 2009-07-29 Amr科技公司 Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (en) 2008-06-04 2010-07-28 Bristol Myers Squibb Co CRYSTAL FORM OF 6 - ((4S) -2-METHYL-4- (2-NAFTIL) -1,2,3,4-TETRAHYDROISOQUINOLIN-7-IL) PIRIDAZIN-3-AMINA
MX2011011901A (en) 2009-05-12 2012-01-20 Albany Molecular Res Inc Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof.
US8802696B2 (en) 2009-05-12 2014-08-12 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof
WO2010132487A1 (en) 2009-05-12 2010-11-18 Bristol-Myers Squibb Company CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670694B2 (en) * 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt METHOD FOR MANUFACTURING TETRAHYDROISOCHINOLINES

Also Published As

Publication number Publication date
CA999866A (en) 1976-11-16
NO135315C (en) 1977-03-23
IE34859B1 (en) 1975-09-03
IL35916A0 (en) 1971-02-25
NO135315B (en) 1976-12-13
FR2081412B1 (en) 1974-04-12
ZA708590B (en) 1971-09-29
AT303041B (en) 1972-11-10
IE34859L (en) 1971-07-06
NL171444B (en) 1982-11-01
GB1335261A (en) 1973-10-24
IL35916A (en) 1973-11-28
JPS5515476B1 (en) 1980-04-23
SE399879B (en) 1978-03-06
NL7018956A (en) 1971-07-08
YU1971A (en) 1977-06-30
NL171444C (en) 1983-04-05
YU33660B (en) 1977-12-31
DE2062001A1 (en) 1971-07-15
PH9682A (en) 1976-02-10
DE2062001C2 (en) 1986-10-16
BE761219A (en) 1971-07-05
ES387016A1 (en) 1976-05-01
SE368401B (en) 1974-07-01
CH538477A (en) 1973-06-30
DK125021B (en) 1972-12-18
FI49503C (en) 1975-07-10
SE386672B (en) 1976-08-16
FI49503B (en) 1975-04-01
FR2081412A1 (en) 1971-12-03

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Legal Events

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