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BR0015243A - Heterociclos de nitrogênio bicìclico substituìdos por heteroalquilamino como inibidores da proteìna cinase p38 - Google Patents

Heterociclos de nitrogênio bicìclico substituìdos por heteroalquilamino como inibidores da proteìna cinase p38

Info

Publication number
BR0015243A
BR0015243A BR0015243-9A BR0015243A BR0015243A BR 0015243 A BR0015243 A BR 0015243A BR 0015243 A BR0015243 A BR 0015243A BR 0015243 A BR0015243 A BR 0015243A
Authority
BR
Brazil
Prior art keywords
inhibitors
heteroalkylamino
protein kinase
nitrogen heterocycles
bicyclic nitrogen
Prior art date
Application number
BR0015243-9A
Other languages
English (en)
Inventor
James Patrick Dunn
Lawrence Emerson Fisher
David Michael Goldstein
William Harris
Christopher Huw Hill
Ian Edward David Smith
Teresa Rosanne Welch
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0015243A publication Critical patent/BR0015243A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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Abstract

"HETEROCICLOS DE NITROGêNIO BICìCLICO SUBSTITUìDOS POR HETEROALQUILAMINO COMO INIBIDORES DA PROTEìNA CINASE P38". A invenção fornece compostos representados pela fórmula (I) em que R^ 1^, R^ 2^, R^ 3^, R^ 4^, e n são como definidos no pedido; e isómeros individuais, misturas racêmicas ou não racêmicas de isómeros, e sais farmaceuticamente aceitáveis destes. Os compostos são inibidores de p38 e podem ser usados no tratamento de artrite, doença de Crohn, síndrome do intestino sensível, síndrome da angústia respiratória do adulto, doença pulmonar obstrutiva crónica, osteoporose, ou doença de Alzheimer.
BR0015243-9A 1999-10-21 2000-10-13 Heterociclos de nitrogênio bicìclico substituìdos por heteroalquilamino como inibidores da proteìna cinase p38 BR0015243A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16080399P 1999-10-21 1999-10-21
US21374300P 2000-06-22 2000-06-22
PCT/EP2000/010088 WO2001029042A1 (en) 1999-10-21 2000-10-13 Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase

Publications (1)

Publication Number Publication Date
BR0015243A true BR0015243A (pt) 2002-07-16

Family

ID=26857240

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015243-9A BR0015243A (pt) 1999-10-21 2000-10-13 Heterociclos de nitrogênio bicìclico substituìdos por heteroalquilamino como inibidores da proteìna cinase p38

Country Status (27)

Country Link
US (1) US6451804B1 (pt)
EP (1) EP1228070B1 (pt)
JP (1) JP3961830B2 (pt)
KR (1) KR100523120B1 (pt)
CN (1) CN1171889C (pt)
AR (1) AR026084A1 (pt)
AT (1) ATE353329T1 (pt)
AU (1) AU776250B2 (pt)
BR (1) BR0015243A (pt)
CA (1) CA2388142C (pt)
CZ (1) CZ20021744A3 (pt)
DE (1) DE60033307T2 (pt)
ES (1) ES2280247T3 (pt)
HK (1) HK1051039A1 (pt)
HR (1) HRP20020328A2 (pt)
HU (1) HUP0203564A3 (pt)
IL (1) IL149100A0 (pt)
MA (1) MA26837A1 (pt)
MX (1) MXPA02003950A (pt)
NO (1) NO20021781L (pt)
NZ (1) NZ518119A (pt)
PE (1) PE20010758A1 (pt)
PL (1) PL357502A1 (pt)
RU (1) RU2265606C2 (pt)
TR (1) TR200201057T2 (pt)
WO (1) WO2001029042A1 (pt)
YU (1) YU29102A (pt)

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