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BR0013581A - Pd-1, um receptor para b7-4, e usos para isto - Google Patents

Pd-1, um receptor para b7-4, e usos para isto

Info

Publication number
BR0013581A
BR0013581A BR0013581-0A BR0013581A BR0013581A BR 0013581 A BR0013581 A BR 0013581A BR 0013581 A BR0013581 A BR 0013581A BR 0013581 A BR0013581 A BR 0013581A
Authority
BR
Brazil
Prior art keywords
immune cell
receiver
modulate
receptor
immune
Prior art date
Application number
BR0013581-0A
Other languages
English (en)
Inventor
Clive Wood
Gordon J Freeman
Original Assignee
Dana Faber Cancer Inst Inc
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26847600&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0013581(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dana Faber Cancer Inst Inc, Genetics Inst filed Critical Dana Faber Cancer Inst Inc
Publication of BR0013581A publication Critical patent/BR0013581A/pt

Links

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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
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    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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Abstract

"PD-1, UM RECEPTOR PARA B7-4, E USOS PARA ISTO". A invenção identifica PD-1 como um receptor para B7-4. B7-4 pode inibir ativação de célula imune aglutinando a um receptor inibidor em uma célula imune. Conformemente, a invenção fornece agentes para modular PD-1, B7-4, e a interação entre B7-4 e PD-1 a fim de modular um sinal co-estimulador ou um inibidor em uma célula imune resultando em modulação da resposta imune.
BR0013581-0A 1999-08-23 2000-08-23 Pd-1, um receptor para b7-4, e usos para isto BR0013581A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15039099P 1999-08-23 1999-08-23
US16489799P 1999-11-10 1999-11-10
PCT/US2000/023347 WO2001014557A1 (en) 1999-08-23 2000-08-23 Pd-1, a receptor for b7-4, and uses therefor

Publications (1)

Publication Number Publication Date
BR0013581A true BR0013581A (pt) 2002-07-02

Family

ID=26847600

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013581-0A BR0013581A (pt) 1999-08-23 2000-08-23 Pd-1, um receptor para b7-4, e usos para isto

Country Status (19)

Country Link
US (3) US6808710B1 (pt)
EP (2) EP1210428B1 (pt)
JP (6) JP4896327B2 (pt)
AU (2) AU7072700A (pt)
BR (1) BR0013581A (pt)
CA (2) CA2925551A1 (pt)
CY (3) CY2017036I1 (pt)
DK (1) DK1210428T3 (pt)
ES (1) ES2539411T3 (pt)
FR (3) FR17C1056I1 (pt)
HU (4) HU228477B1 (pt)
IL (2) IL147972A0 (pt)
LU (2) LUC00049I2 (pt)
MX (1) MXPA02001877A (pt)
NO (1) NO20020859L (pt)
NZ (1) NZ517955A (pt)
PL (1) PL354286A1 (pt)
PT (1) PT1210428E (pt)
WO (1) WO2001014557A1 (pt)

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HU228477B1 (en) * 1999-08-23 2013-03-28 Dana Farber Cancer Inst Inc Pd-1, a receptor for b7-4, and uses therefor
PL362804A1 (en) * 1999-08-23 2004-11-02 Dana-Farber Cancer Institute Novel b7-4 molecules and uses therefor
PT1234031T (pt) 1999-11-30 2017-06-26 Mayo Foundation B7-h1, uma nova molécula imunoregulatória
US7030219B2 (en) 2000-04-28 2006-04-18 Johns Hopkins University B7-DC, Dendritic cell co-stimulatory molecules
WO2001094413A2 (en) 2000-06-06 2001-12-13 Bristol-Myers Squibb Company B7-related nucleic acids and polypeptides and their uses for immunomodulation
JP2004501631A (ja) 2000-06-28 2004-01-22 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Ｐｄ−ｌ２分子：新規ｐｄ−１リガンドおよびその使用
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WO2002077208A1 (de) * 2001-03-27 2002-10-03 Genethor Gmbh Antigen-abhängige reduktion von spezifischen immunreaktionen durch beeinflussung der co-stimulation
JP2004533226A (ja) 2001-04-02 2004-11-04 ワイス Ｂ７−４に対するｐｄ−１、ａレセプター、およびその使用
AR036993A1 (es) * 2001-04-02 2004-10-20 Wyeth Corp Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
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WO2002092792A2 (de) * 2001-05-16 2002-11-21 Genethor Gmbh Antigen-abhängige reduktion von spezifischen immunreaktionen durch beeinflussung der co-stimulation
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US20040241745A1 (en) * 2001-07-31 2004-12-02 Tasuku Honjo Substance specific to pd-1
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CA2490399C (en) * 2002-06-19 2015-10-06 Raven Biotechnologies, Inc. Novel raag10 cell surface target and a family of antibodies recognizing that target
DE60334303D1 (de) 2002-07-03 2010-11-04 Tasuku Honjo Immunpotenzierende zusammensetzungen
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