BG51046A3 - Method for the preparation of pyrido (1, 2- a) pyrazine derivatives - Google Patents

Method for the preparation of pyrido (1, 2- a) pyrazine derivatives Download PDF

Info

Publication number: BG51046A3
Authority: BG; Bulgaria
Prior art keywords: pyrido; preparation; pyrazine derivatives; imidoradical; chn
Prior art date: 1989-01-23

Application number

BG090949A

Other languages

Bulgarian (bg)

English (en)

Inventor

Kishor Desai

Gene Bright

Original Assignee

Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-23

Filing date

1990-01-18

Publication date

1993-01-15

1990-01-18 Application filed by Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware filed Critical Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware

1993-01-15 Publication of BG51046A3 publication Critical patent/BG51046A3/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

BG090949A 1989-01-23 1990-01-18 Method for the preparation of pyrido (1, 2- a) pyrazine derivatives BG51046A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/000275 WO1990008148A1 (en)	1989-01-23	1989-01-23	Bis-aza-bicyclic anxiolytic agents
PCT/US1989/003811 WO1990008144A1 (en)	1989-01-23	1989-09-01	Bis-aza-bicyclic anxiolytic agents

Publications (1)

Publication Number	Publication Date
BG51046A3 true BG51046A3 (en)	1993-01-15

Family

ID=22214801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG090949A BG51046A3 (en)	1989-01-23	1990-01-18	Method for the preparation of pyrido (1, 2- a) pyrazine derivatives

Country Status (38)

Country	Link
US (1)	US5122525A (bs)
EP (1)	EP0380217B1 (bs)
JP (1)	JPH0643427B2 (bs)
KR (1)	KR910009289B1 (bs)
CN (1)	CN1022186C (bs)
AP (1)	AP128A (bs)
AR (1)	AR246969A1 (bs)
AT (1)	ATE82574T1 (bs)
AU (1)	AU614214B2 (bs)
BA (1)	BA98302A (bs)
BG (1)	BG51046A3 (bs)
CA (1)	CA2008108C (bs)
CZ (1)	CZ277698B6 (bs)
DD (1)	DD291560A5 (bs)
DE (1)	DE69000467T2 (bs)
DK (1)	DK0380217T3 (bs)
EG (1)	EG19306A (bs)
ES (1)	ES2053094T3 (bs)
FI (1)	FI95381C (bs)
GR (1)	GR3006925T3 (bs)
HU (1)	HU215154B (bs)
IE (1)	IE62670B1 (bs)
IL (1)	IL93073A (bs)
IS (1)	IS1667B (bs)
MA (1)	MA21735A1 (bs)
MX (1)	MX19222A (bs)
MY (1)	MY104861A (bs)
NO (1)	NO175978C (bs)
NZ (1)	NZ232168A (bs)
OA (1)	OA10041A (bs)
PL (1)	PL163836B1 (bs)
PT (1)	PT92919B (bs)
RO (1)	RO110142B1 (bs)
RU (1)	RU2015977C1 (bs)
SK (1)	SK279339B6 (bs)
WO (2)	WO1990008148A1 (bs)
YU (1)	YU47554B (bs)
ZA (1)	ZA90430B (bs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990008148A1 (en) *	1989-01-23	1990-07-26	Pfizer Inc.	Bis-aza-bicyclic anxiolytic agents
WO1992000075A1 (en) *	1990-06-29	1992-01-09	Pfizer Inc.	Pyridopyrazine derivatives for treating substance abuse and addiction
JP2609410B2 (ja) *	1991-01-31	1997-05-14	ファイザー・インコーポレーテッド	（７Ｓ，トランス）−２−（２−ピリミジニル）−７−（ヒドロキシメチル）オクタヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジンの製造
US5185449A (en) *	1991-02-27	1993-02-09	Pfizer Inc.	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
CA2195622C (en) *	1991-02-27	1999-08-17	Frank J. Urban	Process for preparing trans-piperidine-2,5-dicarboxylates
US5157034A (en) *	1991-02-27	1992-10-20	Pfizer Inc.	Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US5311195A (en) *	1991-08-30	1994-05-10	Etak, Inc.	Combined relative and absolute positioning method and apparatus
CA2118936A1 (en) *	1991-09-25	1993-04-01	Gene M. Bright	Neuroleptic 2-substituted perhydro-1-h-pyrido[1,2-a]pyrazines
ATE185565T1 (de) *	1992-06-16	1999-10-15	Pfizer	Verfahren und zwischenprodukte zur herstellung von bis-aza-bicyclischen anxiolytica
AU5291793A (en) *	1992-09-24	1994-04-12	National Institutes Of Health	Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A (en) *	1993-01-25	1997-11-20	Israel State	Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) *	1993-08-20	1997-06-10	Pfizer Inc.	Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) *	1993-10-13	1995-10-03	Pfizer Inc.	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) *	1993-11-01	1999-06-20	Israel State	Controlled cryogenic contact system
US6231833B1 (en) *	1999-08-05	2001-05-15	Pfizer Inc	2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
ES2166830T3 (es) *	1994-09-30	2002-05-01	Pfizer	Derivados 2,7-sustituidos de octahidro-1h-pirido(1,2-a)pirazina.
US5731307A (en) *	1994-09-30	1998-03-24	Pfizer, Inc.	Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
HUP9900611A3 (en) *	1995-12-21	2000-09-28	Pfizer	2,7-substituted octahydro-pyrrolo[1,2-a]pyrazine derivatives, pharmaceutical compositions containing them and intermediates for the preparation of the compounds
CN1221418A (zh) *	1996-07-01	1999-06-30	辉瑞大药厂	(7s,反)－2－(2－嘧啶基)－7－(羟甲基)八氢－2h－吡啶并[1,2－a)吡嗪的制备
PA8469101A1 (es) *	1998-04-09	2000-09-29	Pfizer Prod Inc	Ligandos azabiciclicos de receptores 5ht1
US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (es) *	1998-09-21	2000-11-11	Pfizer Prod Inc	Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 (en) *	2000-07-31	2002-02-07	Coe Jotham Wadsworth	Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en)	2000-11-29	2003-12-30	Pfizer Inc.	Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
JP3910627B2 (ja) *	2003-03-12	2007-04-25	ファイザー・プロダクツ・インク	ピリジルオキシメチルおよびベンゾイソオキサゾールのアザビシクロ環の誘導体
WO2004092173A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	A2a adenosine receptor antagonists
ES2347152T3 (es) *	2003-11-26	2010-10-26	Pfizer Products Inc.	Derivados de aminopirazol como inhibidores de gsk-3.
JP2008500325A (ja) *	2004-05-27	2008-01-10	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	注意欠陥多動性障害の治療用の組合せ
US7658206B2 (en)	2006-12-05	2010-02-09	Kohler Co.	Plumbing valve with stick control handle

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3388128A (en) *	1965-09-03	1968-06-11	Allan R. Day	Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) *	1978-05-22	1980-01-08	Mead Johnson & Company	Buspirone anti-anxiety method
US4339579A (en) *	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) *	1982-05-07	1983-08-23	American Home Products Corporation	2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) *	1982-05-25	1983-11-08	American Home Products Corporation	4-Substituted-piperidino carboxamides
US4517187A (en) *	1982-10-18	1985-05-14	Pennwalt Corporation	1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3409440A1 (de) *	1984-03-15	1985-09-26	Bayer Ag, 5090 Leverkusen	Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
IT1204803B (it) *	1986-02-17	1989-03-10	Acraf	Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
JP2668259B2 (ja) *	1988-02-18	1997-10-27	塩野義製薬株式会社	複素環化合物および抗潰瘍剤
WO1990008148A1 (en) *	1989-01-23	1990-07-26	Pfizer Inc.	Bis-aza-bicyclic anxiolytic agents

1989
- 1989-01-23 WO PCT/US1989/000275 patent/WO1990008148A1/en unknown
- 1989-01-23 MX MX1922290A patent/MX19222A/es unknown
- 1989-09-01 RO RO148053A patent/RO110142B1/ro unknown
- 1989-09-01 WO PCT/US1989/003811 patent/WO1990008144A1/en active IP Right Grant
- 1989-09-01 HU HU40/90A patent/HU215154B/hu not_active IP Right Cessation
- 1989-12-13 IS IS3529A patent/IS1667B/is unknown
1990
- 1990-01-12 EP EP90300362A patent/EP0380217B1/en not_active Expired - Lifetime
- 1990-01-12 DK DK90300362.2T patent/DK0380217T3/da active
- 1990-01-12 DE DE9090300362T patent/DE69000467T2/de not_active Expired - Fee Related
- 1990-01-12 ES ES90300362T patent/ES2053094T3/es not_active Expired - Lifetime
- 1990-01-12 AT AT90300362T patent/ATE82574T1/de not_active IP Right Cessation
- 1990-01-16 IL IL9307390A patent/IL93073A/en not_active IP Right Cessation
- 1990-01-18 BG BG090949A patent/BG51046A3/xx unknown
- 1990-01-19 AR AR90315971A patent/AR246969A1/es active
- 1990-01-19 CA CA002008108A patent/CA2008108C/en not_active Expired - Fee Related
- 1990-01-19 NZ NZ232168A patent/NZ232168A/xx unknown
- 1990-01-19 MY MYPI90000101A patent/MY104861A/en unknown
- 1990-01-21 EG EG3290A patent/EG19306A/xx active
- 1990-01-22 CZ CS90299A patent/CZ277698B6/cs not_active IP Right Cessation
- 1990-01-22 PT PT92919A patent/PT92919B/pt not_active IP Right Cessation
- 1990-01-22 MA MA21996A patent/MA21735A1/fr unknown
- 1990-01-22 SK SK299-90A patent/SK279339B6/sk unknown
- 1990-01-22 DD DD90337249A patent/DD291560A5/de not_active IP Right Cessation
- 1990-01-22 KR KR1019900000701A patent/KR910009289B1/ko not_active Expired
- 1990-01-22 IE IE22590A patent/IE62670B1/en not_active IP Right Cessation
- 1990-01-22 AP APAP/P/1990/000158A patent/AP128A/en active
- 1990-01-22 AU AU48679/90A patent/AU614214B2/en not_active Ceased
- 1990-01-22 ZA ZA90430A patent/ZA90430B/xx unknown
- 1990-01-22 YU YU11190A patent/YU47554B/sh unknown
- 1990-01-22 CN CN90100291A patent/CN1022186C/zh not_active Expired - Fee Related
- 1990-01-22 PL PL90283395A patent/PL163836B1/pl not_active IP Right Cessation
- 1990-01-23 JP JP2013459A patent/JPH0643427B2/ja not_active Expired - Fee Related
- 1990-01-23 OA OA59727A patent/OA10041A/en unknown
1991
- 1991-07-09 US US07/721,537 patent/US5122525A/en not_active Expired - Lifetime
- 1991-07-22 NO NO912863A patent/NO175978C/no unknown
- 1991-07-22 FI FI913510A patent/FI95381C/fi not_active IP Right Cessation
- 1991-07-22 RU SU915001279A patent/RU2015977C1/ru not_active IP Right Cessation
1993
- 1993-01-28 GR GR930400172T patent/GR3006925T3/el unknown
1998
- 1998-03-30 BA BA980302A patent/BA98302A/bs unknown

Also Published As

Publication number	Publication date
NO912863D0 (no)	1991-07-22
CZ277698B6 (en)	1993-03-17
BA98302A (bs)	2001-09-14
AR246969A1 (es)	1994-10-31
IS1667B (is)	1997-11-14
EP0380217A1 (en)	1990-08-01
AP128A (en)	1991-03-20
WO1990008148A1 (en)	1990-07-26
YU11190A (sh)	1993-05-28
KR900011774A (ko)	1990-08-02
AP9000158A0 (en)	1990-01-31
IE62670B1 (en)	1995-03-08
FI95381C (fi)	1996-01-25
US5122525A (en)	1992-06-16
IE900225L (en)	1990-07-23
AU4867990A (en)	1990-07-26
NZ232168A (en)	1991-08-27
RO110142B1 (ro)	1995-10-30
FI95381B (fi)	1995-10-13
NO175978C (no)	1995-01-11
EP0380217B1 (en)	1992-11-19
GR3006925T3 (bs)	1993-06-30
DE69000467D1 (de)	1992-12-24
CA2008108C (en)	1995-08-08
OA10041A (en)	1996-10-14
AU614214B2 (en)	1991-08-22
CA2008108A1 (en)	1990-07-23
FI913510A0 (fi)	1991-07-22
HUT63163A (en)	1993-07-28
RU2015977C1 (ru)	1994-07-15
PT92919B (pt)	1995-12-29
HU215154B (hu)	2000-09-28
ATE82574T1 (de)	1992-12-15
ES2053094T3 (es)	1994-07-16
EG19306A (en)	1995-01-31
ZA90430B (en)	1991-08-28
DD291560A5 (de)	1991-07-04
IS3529A7 (is)	1990-07-24
CN1022186C (zh)	1993-09-22
PT92919A (pt)	1990-07-31
MX19222A (es)	1993-12-01
PL163836B1 (pl)	1994-05-31
CS29990A3 (en)	1992-11-18
DE69000467T2 (de)	1993-04-01
NO912863L (no)	1991-07-22
JPH02233681A (ja)	1990-09-17
JPH0643427B2 (ja)	1994-06-08
YU47554B (sh)	1995-10-03
KR910009289B1 (ko)	1991-11-09
IL93073A (en)	1994-05-30
SK279339B6 (sk)	1998-10-07
NO175978B (no)	1994-10-03
MY104861A (en)	1994-06-30
WO1990008144A1 (en)	1990-07-26
CN1044464A (zh)	1990-08-08
DK0380217T3 (da)	1992-12-14
MA21735A1 (fr)	1990-10-01

Publication	Publication Date	Title
BG51046A3 (en)	1993-01-15	Method for the preparation of pyrido (1, 2- a) pyrazine derivatives
ATE188965T1 (de)	2000-02-15	Neue pyrazincarboxamidderivate, ihre herstellung und ihre verwendung in arzneimitteln
EP0221041A3 (en)	1987-10-28	Benzimidazole derivatives, process for their preparation and their pharmaceutical use
NZ217958A (en)	1989-02-24	Derivatives of imidazo benzazepine and pharmaceutical compositions
ATE84032T1 (de)	1993-01-15	Benzimidazolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
ATE126708T1 (de)	1995-09-15	Echokontrastmittel.
DE3854854D1 (de)	1996-02-15	3-Desmethyl-mevalonsäurederivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen, ihre Verwendung sowie Zwischenprodukte
RU92004368A (ru)	1995-03-27	Замещенные пиримидины, способ их получения, фармацевтическая композиция
GR3006091T3 (bs)	1993-06-21
IT8419308A0 (it)	1984-01-25	Procedimento per la preparazione di formulazioni galeniche particolarmente per uso farmaceutico, dietetico, cosmetico e diagnostico.
DK0598770T3 (da)	1997-12-15	Pyrazinderivater samt fremstilling og anvendelse deraf
ES2123511T3 (es)	1999-01-16	Derivados imidazopiridina, procedimiento de preparacion y aplicaciones.
NO883074D0 (no)	1988-07-08	Fremgangsmaate til fremstilling av 3-desmetyl-4-fluor-mevalonsyrederivater.
PT77309A (de)	1983-10-01	Isochinolinderivate verfahren zu ihrer herstellung pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
SE8700555L (sv)	1987-08-15	Purinderivat, deras framstellning och lekemedel innehallande dessa
HUT46214A (en)	1988-10-28	Process for producing medical preparation suitable for treatment of peptic ulcer
BG90414A (bg)	1993-12-24	2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им
ATE184875T1 (de)	1999-10-15	Imidazo(1,2-a>indeno(1,2-e>pyrazin-2-carbonsäur derivate, ihre herstellung und sie enthaltende arzneimittel
ATE62226T1 (de)	1991-04-15	Neue 3-pyridylmethylnaphthylderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE4216T1 (de)	1983-08-15	3-hydrocarbylthio-2-acyloxypropyl 2trimethylammonioethyl phosphate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen.
ATE89563T1 (de)	1993-06-15	Oxiran-pseudooligosaccharide, verfahren zu deren herstellung, deren verwendung und pharmazeutische praeparate.
IT1251496B (it)	1995-05-15	Derivati imidazotiadiazolici ad attivita' diuretica, procedimenti per la loro preparazione e composizioni che li contengono
DE3778858D1 (de)	1992-06-11	17-benzylspartein-derivate enthaltende positiv inotrop wirksame pharmazeutische zubereitungen.
JO1519B1 (en)	1989-01-25	New compounds (new benzimidazole derivatives are effective as ulcers)
SE8704049D0 (sv)	1987-10-16	Novel pharmacological compounds