BG106074A - N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists - Google Patents

N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists

Info

Publication number: BG106074A
Authority: BG; Bulgaria
Prior art keywords: neurokinin; alkyl; hydrogen; optionally substituted; phenyl
Prior art date: 1999-04-06

Application number

BG106074A

Other languages

Bulgarian (bg)

English (en)

Inventor

Peter Bernstein

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-06

Filing date

2001-11-01

Publication date

2002-05-31

2001-11-01 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2002-05-31 Publication of BG106074A publication Critical patent/BG106074A/xx

Links

VFTQJCVZNTYOKM-UHFFFAOYSA-N n-(4-amino-2-phenylbutyl)naphthalene-1-carboxamide Chemical class C=1C=CC2=CC=CC=C2C=1C(=O)NCC(CCN)C1=CC=CC=C1 VFTQJCVZNTYOKM-UHFFFAOYSA-N 0.000 title 1
239000002742 neurokinin 1 receptor antagonist Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
101000831616 Homo sapiens Protachykinin-1 Proteins 0.000 abstract 2
102100024304 Protachykinin-1 Human genes 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 abstract 2
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
102000003141 Tachykinin Human genes 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
108060008037 tachykinin Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Rheumatology (AREA)
Psychology (AREA)
Cardiology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG106074A 1999-04-06 2001-11-01 N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists BG106074A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9907571.5A GB9907571D0 (en)	1999-04-06	1999-04-06	Compounds
PCT/GB2000/001252 WO2000059873A1 (en)	1999-04-06	2000-04-03	N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists

Publications (1)

Publication Number	Publication Date
BG106074A true BG106074A (en)	2002-05-31

Family

ID=10850835

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG106074A BG106074A (en)	1999-04-06	2001-11-01	N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists

Country Status (25)

Country	Link
US (3)	US6476077B1 (ko)
EP (1)	EP1169302B1 (ko)
JP (1)	JP2002541137A (ko)
KR (1)	KR20010102580A (ko)
CN (2)	CN1534017A (ko)
AT (1)	ATE277893T1 (ko)
AU (1)	AU3569200A (ko)
BG (1)	BG106074A (ko)
BR (1)	BR0009582A (ko)
CA (1)	CA2368240A1 (ko)
CZ (1)	CZ20013574A3 (ko)
DE (1)	DE60014343T2 (ko)
EE (1)	EE200100520A (ko)
GB (1)	GB9907571D0 (ko)
HK (1)	HK1044145A1 (ko)
HU (1)	HUP0200707A3 (ko)
IL (1)	IL145645A0 (ko)
IS (1)	IS6087A (ko)
NO (1)	NO20014855L (ko)
PL (1)	PL350568A1 (ko)
SK (1)	SK13012001A3 (ko)
TR (1)	TR200102875T2 (ko)
UA (1)	UA67839C2 (ko)
WO (1)	WO2000059873A1 (ko)
ZA (1)	ZA200108176B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9907571D0 (en) *	1999-04-06	1999-05-26	Zeneca Ltd	Compounds
GB0019008D0 (en) *	2000-08-04	2000-09-27	Astrazeneca Ab	Therapeutic compounds
SE0201938D0 (sv) *	2002-06-20	2002-06-20	Astrazeneca Ab	New process
ATE387385T1 (de) *	2002-11-05	2008-03-15	Astrazeneca Ab	Verriegelungsanordnung für einen verschluss auf einen behälter und entsprechender behälter
WO2004056771A1 (en) *	2002-12-20	2004-07-08	Astrazeneca Ab	Piperidine amine compounds and their use
US20080045610A1 (en) *	2004-09-23	2008-02-21	Alexander Michalow	Methods for regulating neurotransmitter systems by inducing counteradaptations
JP2008514612A (ja) *	2004-09-23	2008-05-08	ミシャロウ、アレクサンダー	対抗適応を誘発することにより神経伝達物質系を調節する方法
WO2013004766A1 (en)	2011-07-04	2013-01-10	Ferrari Giulio	Nk-1 receptor antagonists for treating corneal neovascularisation
BR112017024852B1 (pt)	2015-05-18	2023-10-31	KaNDy Therapeutics Limited	Usos de um composto antagonista do receptor nk-1/nk-3 duplo e de uma composição farmacêutica compreendendo dito composto para o tratamento de sintomas vasomotores associados com menopausa
US20210015834A1 (en)	2018-02-26	2021-01-21	Ospedale San Raffaele S.R.L.	Nk-1 antagonists for use in the treatment of ocular pain
EA202092131A1 (ru)	2018-03-14	2020-11-27	Кэнди Терапьютикс Лимитед	Новый фармацевтический препарат, содержащий двойные антагонисты рецептора nk-1/nk-3
RU2697414C1 (ru)	2018-05-11	2019-08-14	Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс"	Новый антагонист тахикининовых рецепторов и его применение
US20230134843A1 (en)	2020-03-11	2023-05-04	Ospedale San Raffaele S.R.L.	Treatment of stem cell deficiency

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI97540C (fi)	1989-11-06	1997-01-10	Sanofi Sa	Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
EP0702681A1 (en) *	1993-06-07	1996-03-27	Merck & Co. Inc.	Spiro-substituted azacycles as neurokinin antagonists
DK0777659T3 (da) *	1994-08-15	2001-09-03	Merck Sharp & Dohme	Morpholinderivater og deres anvendelse som terapeutiske midler
WO1998025617A1 (en) *	1996-12-13	1998-06-18	Merck & Co., Inc.	Substituted aryl piperazines as modulators of chemokine receptor activity
GB9907571D0 (en) *	1999-04-06	1999-05-26	Zeneca Ltd	Compounds
IL157456A0 (en) *	2001-03-21	2004-03-28	Pharmacopeia Inc Pharmacopeia	Aryl and biaryl compounds having mch modulatory activity

1999
- 1999-04-06 GB GBGB9907571.5A patent/GB9907571D0/en not_active Ceased
2000
- 2000-03-04 UA UA2001117535A patent/UA67839C2/uk unknown
- 2000-04-03 JP JP2000609386A patent/JP2002541137A/ja active Pending
- 2000-04-03 CN CNA2004100053467A patent/CN1534017A/zh active Pending
- 2000-04-03 KR KR1020017012692A patent/KR20010102580A/ko not_active Application Discontinuation
- 2000-04-03 AT AT00914298T patent/ATE277893T1/de not_active IP Right Cessation
- 2000-04-03 EP EP00914298A patent/EP1169302B1/en not_active Expired - Lifetime
- 2000-04-03 IL IL14564500A patent/IL145645A0/xx unknown
- 2000-04-03 TR TR2001/02875T patent/TR200102875T2/xx unknown
- 2000-04-03 PL PL00350568A patent/PL350568A1/xx unknown
- 2000-04-03 CN CN00805623A patent/CN1345307A/zh active Pending
- 2000-04-03 CA CA002368240A patent/CA2368240A1/en not_active Abandoned
- 2000-04-03 BR BR0009582-6A patent/BR0009582A/pt not_active IP Right Cessation
- 2000-04-03 DE DE60014343T patent/DE60014343T2/de not_active Expired - Fee Related
- 2000-04-03 EE EEP200100520A patent/EE200100520A/xx unknown
- 2000-04-03 US US09/937,981 patent/US6476077B1/en not_active Expired - Fee Related
- 2000-04-03 CZ CZ20013574A patent/CZ20013574A3/cs unknown
- 2000-04-03 AU AU35692/00A patent/AU3569200A/en not_active Abandoned
- 2000-04-03 SK SK1301-2001A patent/SK13012001A3/sk unknown
- 2000-04-03 HU HU0200707A patent/HUP0200707A3/hu unknown
- 2000-04-03 WO PCT/GB2000/001252 patent/WO2000059873A1/en not_active Application Discontinuation
2001
- 2001-09-26 IS IS6087A patent/IS6087A/is unknown
- 2001-10-04 ZA ZA200108176A patent/ZA200108176B/en unknown
- 2001-10-05 NO NO20014855A patent/NO20014855L/no not_active Application Discontinuation
- 2001-11-01 BG BG106074A patent/BG106074A/xx unknown
2002
- 2002-06-26 HK HK02104758.2A patent/HK1044145A1/zh unknown
- 2002-11-01 US US10/286,624 patent/US6586432B2/en not_active Expired - Fee Related
2003
- 2003-06-30 US US10/611,052 patent/US6821973B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR0009582A (pt)	2001-12-26
IS6087A (is)	2001-09-26
US20030092713A1 (en)	2003-05-15
DE60014343D1 (de)	2004-11-04
EP1169302B1 (en)	2004-09-29
JP2002541137A (ja)	2002-12-03
WO2000059873A1 (en)	2000-10-12
AU3569200A (en)	2000-10-23
CN1534017A (zh)	2004-10-06
EE200100520A (et)	2002-12-16
KR20010102580A (ko)	2001-11-15
HK1044145A1 (zh)	2002-10-11
US20040106610A1 (en)	2004-06-03
PL350568A1 (en)	2002-12-16
US6586432B2 (en)	2003-07-01
GB9907571D0 (en)	1999-05-26
NO20014855L (no)	2001-12-06
UA67839C2 (uk)	2004-07-15
US6476077B1 (en)	2002-11-05
US6821973B2 (en)	2004-11-23
CN1345307A (zh)	2002-04-17
ZA200108176B (en)	2003-01-06
HUP0200707A3 (en)	2002-11-28
HUP0200707A2 (en)	2002-06-29
CA2368240A1 (en)	2000-10-12
CZ20013574A3 (cs)	2002-05-15
EP1169302A1 (en)	2002-01-09
TR200102875T2 (tr)	2002-01-21
DE60014343T2 (de)	2006-03-02
ATE277893T1 (de)	2004-10-15
NO20014855D0 (no)	2001-10-05
IL145645A0 (en)	2002-06-30
SK13012001A3 (sk)	2002-04-04

Publication	Publication Date	Title
BG106074A (en)	2002-05-31	N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists
CY1105899T1 (el)	2011-02-02	Πυριδινοϋλοπιπepιδινες ως 5-ht1f αγωνιστες
KR20050085991A (en)	2005-08-29	Compounds exhibiting thrombopoietin receptor agonism
EA200200942A1 (ru)	2003-02-27	Фармацевтические композиции, содержащие производные 3-аминоазетидина, новые производные и способ их получения
IL176247A0 (en)	2006-10-05	Cyclopropane compounds and pharmaceutical use thereof
AU2001272476A1 (en)	2001-12-24	Piperidines for use as orexin receptor antagonists
HUT76476A (en)	1997-09-29	Morpholine and thiomorpholine derivatives, process for the preparation thereof and pharmaceutical compositions containing them
EA200400981A1 (ru)	2005-02-24	Новые гетероциклические соединения, активные в качестве ингибиторов бета-лактамаз
TR200400541T4 (tr)	2004-04-21	Terapide faydalı tropan türevleri.
RS20060143A (en)	2008-06-05	Phenyl or pyridil amide compounds as prostaglandin e2 antagonists
CA2284795A1 (en)	1998-10-08	Novel pyrimidine derivatives and processes for the preparation thereof
NZ331060A (en)	2000-01-28	Quinoxalinediones, preparation and pharmaceutical compositions thereof
WO2002051819A3 (en)	2002-12-05	Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them
ATE175661T1 (de)	1999-01-15	Benzamid-derivate als vasopressin-antagonisten
EA200500087A1 (ru)	2005-06-30	Производные пиперазина
AU3415599A (en)	1999-10-18	Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor agents
HUP9903758A2 (hu)	2000-06-28	Benzoxazinon dopamin D4 receptor antagonisták és az ezeket tartalmazó gyógyszerkészítmények
PE20040682A1 (es)	2004-10-07	Derivados de ciclobutano como antagonistas de nk1
RS51126B (sr)	2010-10-31	Postupak za pripremanje mezilata piperazin derivata
MY134226A (en)	2007-11-30	1,2-dihydropyrazol-3-ones which control inflammatory cyctokines
RS50085B (sr)	2009-01-22	Novi derivati morfolina, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže
IL136510A (en)	2005-09-25	Acylated hetero-alicyclic derivatives and pharmaceutical compositions containing the same
EP1559707A4 (en)	2006-08-02	SPIRO COMPOUNDS, MEDICINAL COMPOSITIONS CONTAINING THE SAID COMPOUNDS AND INTERMEDIATES THEREOF
DK0630893T3 (da)	1999-02-01	N,N'-disubstitueret amidderivat
PL324197A1 (en)	1998-05-11	Derivatives of hydroxylamine and pharmaceutic agents against ischaemia