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BE2015C017I2 - - Google Patents

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Publication number
BE2015C017I2
BE2015C017I2 BE2015C017C BE2015C017C BE2015C017I2 BE 2015C017 I2 BE2015C017 I2 BE 2015C017I2 BE 2015C017 C BE2015C017 C BE 2015C017C BE 2015C017 C BE2015C017 C BE 2015C017C BE 2015C017 I2 BE2015C017 I2 BE 2015C017I2
Authority
BE
Belgium
Application number
BE2015C017C
Other languages
French (fr)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of BE2015C017I2 publication Critical patent/BE2015C017I2/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
BE2015C017C 2002-07-29 2015-03-26 BE2015C017I2 (xx)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39995602P 2002-07-29 2002-07-29
PCT/US2003/021977 WO2004014295A2 (en) 2002-07-29 2003-07-15 Tiacumicin production

Publications (1)

Publication Number Publication Date
BE2015C017I2 true BE2015C017I2 (xx) 2022-09-22

Family

ID=31715689

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2015C017C BE2015C017I2 (xx) 2002-07-29 2015-03-26

Country Status (18)

Country Link
US (4) US7507564B2 (xx)
EP (2) EP2860241A1 (xx)
JP (3) JP2005534332A (xx)
KR (1) KR100972542B1 (xx)
CN (1) CN100519757C (xx)
AU (1) AU2003251902B2 (xx)
BE (1) BE2015C017I2 (xx)
CA (1) CA2494742C (xx)
CY (1) CY2015015I1 (xx)
DK (1) DK1539977T3 (xx)
ES (1) ES2527052T3 (xx)
FR (1) FR15C0028I2 (xx)
HU (1) HUS1500016I1 (xx)
LU (1) LU92684I2 (xx)
NL (1) NL300727I2 (xx)
PT (1) PT1539977E (xx)
SI (1) SI1539977T1 (xx)
WO (1) WO2004014295A2 (xx)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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US20070105791A1 (en) * 2002-07-29 2007-05-10 Optimer Pharmaceuticals, Inc. Method of treating clostridium difficile-associated diarrhea
PT1539977E (pt) * 2002-07-29 2015-01-14 Optimer Pharmaceuticals Inc Produção de tiacumicina
US7906489B2 (en) * 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
CA2566687C (en) 2004-05-14 2012-07-24 Optimer Pharmaceuticals, Inc. The use of tiacumicin b in the treatment of antibiotic resistant staphylococcus or vancomycin-resistant enterococci infections
AU2012200784B2 (en) * 2005-01-31 2013-07-11 Merck Sharp & Dohme Llc 18-membered macrocycles and analogs thereof
US7378508B2 (en) 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
JP5166040B2 (ja) * 2005-01-31 2013-03-21 オプティマー ファーマシューティカルズ、インコーポレイテッド 18員大環状化合物及びその類似化合物
CA2626698C (en) * 2005-10-21 2015-12-01 Optimer Pharmaceuticals, Inc. Method of treating clostridium difficile-associated diarrhea
US20080176927A1 (en) * 2007-01-19 2008-07-24 Optimer Pharmaceuticals, Inc. Compositions of stable tiacumicins
KR100891313B1 (ko) * 2007-08-17 2009-03-31 (주) 제노텍 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법
TWI326284B (en) * 2007-10-26 2010-06-21 Echem Hightech Co Ltd Derivatives of tiacumicin b as anti-cancer agents
TWI523654B (zh) 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法
CA2789928C (en) * 2010-02-15 2020-03-10 Abbvie Inc. Process for the preparation of scyllo-inositol
EP2663540A1 (en) 2010-10-13 2013-11-20 Elan Pharmaceuticals, Inc. Methods of synthesis of scyllitol and related compounds
CN102115757B (zh) * 2010-12-14 2015-10-28 中国科学院南海海洋研究所 台勾霉素的生物合成基因簇及其应用
ITMI20120560A1 (it) 2012-04-05 2013-10-06 Olon Spa Procedimento per la purificazione della tiacumicina b
ITMI20120559A1 (it) * 2012-04-05 2013-10-06 Olon Spa Procedimento migliorato per la produzione di tiacumicina b
EA201492059A1 (ru) * 2012-05-10 2015-02-27 Тева Фармасьютикал Уоркс Лтд. Твердые формы фидаксомицина и способы их получения
ITMI20130856A1 (it) * 2013-05-27 2014-11-28 Olon Spa Procedimento per la produzione di tiacumicina b
IN2015DN00928A (xx) * 2012-08-07 2015-06-12 Olon Spa
ITMI20121406A1 (it) * 2012-08-07 2014-02-08 Olon Spa Procedimento per la produzione di tiacumicina b
CN102993251B (zh) * 2012-12-17 2016-03-16 苏州纳微科技有限公司 一种用高效液相色谱纯化台勾霉素b的方法
JO3464B1 (ar) 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd التركيبات الخاصة بمركبات التياكوميسين
US10119158B2 (en) * 2013-04-23 2018-11-06 Concord Biotech Limited Process for the preparation of fidaxomicin
CN103275152B (zh) * 2013-05-29 2015-11-18 华北制药集团新药研究开发有限责任公司 一种高纯度非达霉素的制备方法
CN103275153B (zh) * 2013-06-27 2016-03-23 华北制药集团新药研究开发有限责任公司 一种非达霉素晶体的制备方法
CN104418925B (zh) * 2013-09-05 2018-09-28 重庆乾泰生物医药有限公司 一种制备高纯度非达霉素的方法
CN104513286B (zh) * 2013-09-27 2018-08-17 博瑞生物医药(苏州)股份有限公司 一种分离纯化非达米星的方法
CN104560766B (zh) * 2013-10-16 2017-07-28 浙江海正药业股份有限公司 一种游动放线菌菌株及其应用
CN104561198B (zh) * 2013-10-18 2019-04-12 重庆乾泰生物医药有限公司 一种发酵生产非达霉素的方法
SI3083976T1 (sl) * 2013-12-20 2020-10-30 Xellia Pharmaceuticals Aps Postopek priprave tiakumicina B
CN104846044B (zh) * 2014-02-17 2019-02-01 上海医药工业研究院 一种提高非达霉素产量的发酵培养基
WO2015127955A1 (en) 2014-02-25 2015-09-03 Olon S.P.A. A new polymorph of tiacumicin b and process for preparation thereof
KR20160134719A (ko) 2014-03-18 2016-11-23 셀리아 파마슈티칼즈 에이피에스 신규한 다형체 및 신규한 고체 상태의 티아쿠미신 b
CN104946708B (zh) * 2014-03-28 2018-06-12 上海医药工业研究院 一种生产非达霉素的发酵培养基以及发酵方法
CN103880904B (zh) * 2014-03-28 2016-08-24 华北制药集团新药研究开发有限责任公司 非达霉素晶型i及其制备方法
MD4695C1 (ro) 2014-05-09 2021-02-28 Astellas Pharma Europe Ltd Compus tiacumicinic şi regim de tratament asociat
CN104098637B (zh) * 2014-07-09 2017-01-04 浙江海正药业股份有限公司 一种纯化非达霉素的方法
CA2990961A1 (en) 2015-07-03 2017-01-12 Astellas Pharma Europe Ltd. Novel dosage regimen tiacumicin compound
IL251499B (en) * 2017-04-02 2019-02-28 Efraty Avi Reverse osmosis installation in a closed circuit with a hydraulic arm for desalination with low energy consumption and a high recovery ratio
CN107236686B (zh) * 2017-06-21 2019-10-15 杭州华东医药集团新药研究院有限公司 一种桔橙指孢囊菌及其在调控微生物代谢物非达霉素中的应用
CN114084964B (zh) * 2020-08-24 2023-02-24 中国石油化工股份有限公司 一种芳香有机化合物废水生物处理促进剂及制备方法和应用

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PT1539977E (pt) * 2002-07-29 2015-01-14 Optimer Pharmaceuticals Inc Produção de tiacumicina

Also Published As

Publication number Publication date
KR20050053598A (ko) 2005-06-08
JP2010178760A (ja) 2010-08-19
US7507564B2 (en) 2009-03-24
NL300727I2 (xx) 2016-05-17
CA2494742A1 (en) 2004-02-19
JP5907931B2 (ja) 2016-04-26
AU2003251902A1 (en) 2004-02-25
US20130123477A1 (en) 2013-05-16
HUS1500016I1 (hu) 2017-10-30
CA2494742C (en) 2015-05-12
JP5729919B2 (ja) 2015-06-03
WO2004014295A2 (en) 2004-02-19
DK1539977T3 (en) 2014-11-17
CN100519757C (zh) 2009-07-29
US20140296498A1 (en) 2014-10-02
CY2015015I1 (el) 2020-05-29
EP1539977A2 (en) 2005-06-15
FR15C0028I1 (xx) 2015-05-15
SI1539977T1 (sl) 2015-01-30
CN1688707A (zh) 2005-10-26
JP2013208131A (ja) 2013-10-10
US20100028970A1 (en) 2010-02-04
EP1539977A4 (en) 2006-10-11
FR15C0028I2 (fr) 2015-11-13
EP1539977B1 (en) 2014-10-08
EP2860241A1 (en) 2015-04-15
KR100972542B1 (ko) 2010-07-28
US8728796B2 (en) 2014-05-20
US20060257981A1 (en) 2006-11-16
ES2527052T3 (es) 2015-01-20
WO2004014295A3 (en) 2005-04-14
JP2005534332A (ja) 2005-11-17
PT1539977E (pt) 2015-01-14
LU92684I2 (fr) 2015-11-02
AU2003251902B2 (en) 2008-03-06

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