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BE1000355A3 - WATER-SOLUBLE PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL-CYSTEINE AND CITRIC ACID. - Google Patents

WATER-SOLUBLE PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL-CYSTEINE AND CITRIC ACID. Download PDF

Info

Publication number
BE1000355A3
BE1000355A3 BE8700816A BE8700816A BE1000355A3 BE 1000355 A3 BE1000355 A3 BE 1000355A3 BE 8700816 A BE8700816 A BE 8700816A BE 8700816 A BE8700816 A BE 8700816A BE 1000355 A3 BE1000355 A3 BE 1000355A3
Authority
BE
Belgium
Prior art keywords
citric acid
cysteine
acetyl
pharmaceutical composition
water
Prior art date
Application number
BE8700816A
Other languages
French (fr)
Inventor
Annibale Gazzaniga
Valter Gianesello
Federico Stroppolo
Original Assignee
Inpharzam Internat Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inpharzam Internat Sa filed Critical Inpharzam Internat Sa
Application granted granted Critical
Publication of BE1000355A3 publication Critical patent/BE1000355A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Il est décrit une composition pharmaceutique, sous forme de granulé ou de comprimé effervescent hydrosoluble, constituée (en pourcentages en poids) par : N-acétyl-cystéine 6-32%;Acide citrique 35-50%;NaHCO3 26-37%;Aspartame 1-1,5%;Substance sapide 5-7%;le total s'élevant à 100% et le rapport en poids entre l'acide citrique et NaHCO3 étant compris entre 1,2 et 1,4.It is described a pharmaceutical composition, in the form of granule or effervescent water-soluble tablet, constituted (in percentages by weight) by: N-acetyl-cysteine 6-32%; Citric acid 35-50%; NaHCO3 26-37%; Aspartame 1-1.5%; Substance sapid 5-7%; the total amounting to 100% and the weight ratio between citric acid and NaHCO3 being between 1.2 and 1.4.

BE8700816A 1986-07-24 1987-07-23 WATER-SOLUBLE PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL-CYSTEINE AND CITRIC ACID. BE1000355A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2975/86A CH667590A5 (en) 1986-07-24 1986-07-24 WATER-SOLUBLE EFFERVESCENT PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL-CISTEIN. .

Publications (1)

Publication Number Publication Date
BE1000355A3 true BE1000355A3 (en) 1988-11-08

Family

ID=4245841

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8700816A BE1000355A3 (en) 1986-07-24 1987-07-23 WATER-SOLUBLE PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL-CYSTEINE AND CITRIC ACID.

Country Status (8)

Country Link
BE (1) BE1000355A3 (en)
CH (1) CH667590A5 (en)
DE (1) DE3723735A1 (en)
FR (1) FR2601876B1 (en)
GB (1) GB2192790B (en)
IT (1) IT1222104B (en)
NL (1) NL194067C (en)
SE (1) SE500494C2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1217445B (en) * 1988-04-29 1990-03-22 Altergon Sa SOLUBLE PHARMACEUTICAL COMPOSITION CONTAINING ACETYLCISTEIN
DE3822096A1 (en) * 1988-06-30 1990-01-04 Klinge Co Chem Pharm Fab STABILIZED DRUG PREPARATION
SE462779B (en) * 1988-10-10 1990-09-03 Lejus Medical Ab PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYL CYSTEIN IN A CERNA COATED WITH HYDROXIPROPYLMETHYL CELLULOS AGREEMENT
DE3909049A1 (en) * 1989-03-18 1990-09-20 Arthur Boskamp PREPARATION AND THEIR USE
IT1231012B (en) * 1989-07-27 1991-11-08 Zambon Spa PHARMACEUTICAL COMPOSITION FOR ORAL USE CONTAINING NAC.
DK0497724T3 (en) * 1991-01-26 1996-04-29 Senju Pharma Co Means for the disintegration of gallstones
DE4103360A1 (en) * 1991-02-05 1992-08-06 Koehler Peter Use of acetyl-cysteine and isotonic sodium chloride (0.9 per cent) - for treating bronchial asthma and bronchitis-induced spasms
US5296500A (en) * 1991-08-30 1994-03-22 The Procter & Gamble Company Use of N-acetyl-cysteine and derivatives for regulating skin wrinkles and/or skin atrophy
IT1256616B (en) * 1992-12-02 1995-12-12 Zambon Spa SYRUP CONTAINING N-ACETYL-CISTEIN
DE4406261C2 (en) * 1993-08-31 1996-07-04 Deutsches Krebsforsch Use of thiol compounds to reduce body fat
BE1007926A3 (en) * 1994-01-31 1995-11-21 Zambon Int Pharma Pharmaceutical composition containing n-acetyl-cysteine.
US5451405A (en) * 1994-04-25 1995-09-19 Chesebrough-Pond's Usa Co. Skin treatment composition
DE19509856C2 (en) * 1995-03-17 1997-09-11 Schwabe Willmar Gmbh & Co Use of an effervescent composition with Ginkgo biloba dry extract for the treatment of peripheral and cerebral circulatory disorders
CN1324234A (en) 1998-09-25 2001-11-28 格利科克斯有限公司 Fructosamine oxidase: antagonists and inhibitors
EP1115842A4 (en) 1998-09-25 2002-08-21 Glycox Corp Ltd Fructosamine oxidase assay: methods and materials
WO2003077901A1 (en) 2002-03-08 2003-09-25 Protemix Corporation Limited Preventing and/or treating cardiovascular disease and/or associated heart failure
CA3011023A1 (en) 2002-08-20 2004-03-04 Philera New Zealand Limited Composition comprising triethylenetramine salts for treating tissue damage
CA3050047A1 (en) 2004-07-19 2006-03-16 Philera New Zealand Limited Synthesis of triethylenetetramines
TR200900881A2 (en) * 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Stable pharmaceutical compositions masked by taste and odor
TR200900882A2 (en) * 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Pharmaceutical compositions with high bioavailability, masked by taste and odor.
IT1399492B1 (en) 2010-04-13 2013-04-19 Alpex Pharma Sa EFFERVESCENT PHARMACEUTICAL COMPOSITIONS CONTAINING N-ACETYLCISTEIN.
CN102233139B (en) * 2010-04-21 2012-09-05 重庆健能医药开发有限公司 Acetylcysteine effervescent tablet and preparation method and application thereof
EP2571499A1 (en) * 2010-05-18 2013-03-27 Mahmut Bilgic Pharmaceutical composition comprising n- acetylcysteine and a xanthine
CN101947211A (en) * 2010-08-28 2011-01-19 浙江金华康恩贝生物制药有限公司 Method for preparing acetylcysteine effervescent tablet
TR201104738A2 (en) * 2011-05-16 2012-12-21 Bi̇lgi̇ç Mahmut Pharmaceutical combination containing N-Acetylcysteine.
US8747894B2 (en) * 2012-05-08 2014-06-10 Alpex Pharma S.A. Effervescent compositions containing N-acetylcysteine
WO2015117987A1 (en) 2014-02-05 2015-08-13 Sanovel Ilac Sanayi Ve Ticaret A.S. Effervescent formulations comprising ibuprofen and n-acetylcystein
CN113559078A (en) * 2021-07-02 2021-10-29 安徽省先锋制药有限公司 Preparation method of acetylcysteine effervescent tablets

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2470M (en) * 1962-03-13 1964-04-20 Mead Johnson & Co Therapeutic composition.
FR2145590A1 (en) * 1971-07-12 1973-02-23 Hoffmann La Roche

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3317558A1 (en) * 1983-05-13 1984-11-15 Dietrich Dr.med. Sta. Eulalia Ibiza Reichert Oral antisnoring composition
DE3317530A1 (en) * 1983-05-13 1984-11-15 Dietrich Dr.med. Sta. Eulalia Ibiza Reichert Antisnoring composition
IT1170268B (en) * 1983-12-21 1987-06-03 Zambon Spa USE OF ACETYLCISTEIN TO REDUCE THE INCREASE IN THE PROLIEFERATION OF THE BASAL CELLS OF THE RESPIRATORY THRACHEO-BRONCHIAL EPITHELIUM INDUCED BY TOBACCO SMOKE IN MAMMALS
DE3514995A1 (en) * 1985-04-25 1986-10-30 Protopharma Ltd., 7831 Malterdingen Use of sulfhydryl pharmaceuticals for combating damage to the gastric mucosa

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2470M (en) * 1962-03-13 1964-04-20 Mead Johnson & Co Therapeutic composition.
FR2145590A1 (en) * 1971-07-12 1973-02-23 Hoffmann La Roche

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DICTIONNAIRE VIDAL, 61ième édition, 1985, page 944, OVP, Paris, FR; "Mucomyst forme orale" *

Also Published As

Publication number Publication date
GB2192790B (en) 1990-01-31
DE3723735C2 (en) 1992-05-21
FR2601876A1 (en) 1988-01-29
GB2192790A (en) 1988-01-27
GB8717582D0 (en) 1987-09-03
CH667590A5 (en) 1988-10-31
SE8702940L (en) 1988-01-25
SE8702940D0 (en) 1987-07-23
NL194067B (en) 2001-02-01
NL8701743A (en) 1988-02-16
DE3723735A1 (en) 1988-02-04
IT8721411A0 (en) 1987-07-23
NL194067C (en) 2001-06-05
SE500494C2 (en) 1994-07-04
IT1222104B (en) 1990-08-31
FR2601876B1 (en) 1989-10-13

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: S.A. *INPHARZAM

Effective date: 20070723