AU567392B2 - Carbacyclin analogs - Google Patents

Carbacyclin analogs

Info

Publication number: AU567392B2
Authority: AU; Australia
Prior art keywords: carbacyclin analogs; carbacyclin; analogs
Prior art date: 1980-02-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

AU38208/85A

Other versions

AU3820885A (en

Inventor

Paul Adrian Aristoff

Robert Charles Kelly

Norman Allan Nelson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-02-28

Filing date

1985-01-30

Publication date

1987-11-19

1980-02-28 Priority claimed from US06/125,608 external-priority patent/US4338457A/en

1985-01-30 Application filed by Upjohn Co filed Critical Upjohn Co

1985-06-20 Publication of AU3820885A publication Critical patent/AU3820885A/en

1987-11-19 Application granted granted Critical

1987-11-19 Publication of AU567392B2 publication Critical patent/AU567392B2/en

1997-04-24 Assigned to PHARMACIA & UPJOHN COMPANY reassignment PHARMACIA & UPJOHN COMPANY Request to Amend Deed and Register Assignors: UPJOHN COMPANY, THE

2001-01-23 Anticipated expiration legal-status Critical

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)
Indole Compounds (AREA)

AU38208/85A 1980-02-28 1985-01-30 Carbacyclin analogs Expired AU567392B2 (en)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
US06/125,608 US4338457A (en)	1980-02-28	1980-02-28	Composition and process
US125608		1980-02-28
US13505580A	1980-03-28	1980-03-28
US135055		1980-03-28
US14054680A	1980-04-15	1980-04-15
US140546		1980-04-15
US14295380A	1980-04-23	1980-04-23
US142953		1980-04-23

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
AU66606/81A Division AU542861B2 (en)	1980-02-28	1981-01-23	Carbacyclin analogs

Publications (2)

Publication Number	Publication Date
AU3820885A AU3820885A (en)	1985-06-20
AU567392B2 true AU567392B2 (en)	1987-11-19

Family

ID=27494588

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU66606/81A Expired AU542861B2 (en)	1980-02-28	1981-01-23	Carbacyclin analogs
AU38208/85A Expired AU567392B2 (en)	1980-02-28	1985-01-30	Carbacyclin analogs

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AU66606/81A Expired AU542861B2 (en)	1980-02-28	1981-01-23	Carbacyclin analogs

Country Status (12)

Country	Link
JP (2)	JPH02167248A (en)
AU (2)	AU542861B2 (en)
CA (1)	CA1201712A (en)
CH (2)	CH655308A5 (en)
DE (4)	DE3153474C2 (en)
FR (1)	FR2484413B1 (en)
GB (1)	GB2070596B (en)
HK (1)	HK6989A (en)
IL (1)	IL61936A (en)
IT (1)	IT1144901B (en)
NL (1)	NL8100959A (en)
SE (6)	SE453594B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3237200A1 (en) *	1982-10-05	1984-04-05	Schering AG, 1000 Berlin und 4709 Bergkamen	5-FLUORCARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
CA1201712A (en) *	1980-02-28	1986-03-11	Paul A. Aristoff	Carbacyclin analogs
DE3048906A1 (en) *	1980-12-19	1982-07-15	Schering Ag, 1000 Berlin Und 4619 Bergkamen	NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE3142733A1 (en) *	1981-10-23	1983-05-05	Schering Ag, 1000 Berlin Und 4619 Bergkamen	METHOD FOR PRODUCING CARBACYCLIN INTERMEDIATE PRODUCTS
DE3146278C2 (en) *	1981-11-21	1984-10-31	Grünenthal GmbH, 5190 Stolberg	cis-bicyclo [3.3.0] octane derivatives, medicaments containing them and processes for the preparation of these compounds
IL67332A (en) *	1981-12-01	1985-12-31	Chinoin Gyogyszer Es Vegyeszet	Inter-m-phenylene-prostacyclin analogues,process for the preparation thereof and pharmaceutical compositions containing them
DE3204443A1 (en) *	1982-02-08	1983-08-18	Schering Ag, 1000 Berlin Und 4619 Bergkamen	NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US4487961A (en) *	1982-02-16	1984-12-11	The Upjohn Company	9-Substituted carbacyclin analogs
US4533749A (en) *	1982-02-16	1985-08-06	The Upjohn Company	9-Substituted carbacyclin analogs
US4486598A (en) *	1982-02-22	1984-12-04	The Upjohn Company	Carbacyclin analogs
US4490555A (en) *	1982-03-19	1984-12-25	The Upjohn Company	9-Substituted carbacyclin analogs
US4487960A (en) *	1982-04-19	1984-12-11	The Upjohn Company	9-Substituted carbacyclin analogs
HU190007B (en) *	1982-05-06	1986-08-28	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu	Process for producing new aromatic prostacylin analogues
DE3225288A1 (en) *	1982-07-02	1984-01-19	Schering AG, 1000 Berlin und 4709 Bergkamen	NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE3225287A1 (en) *	1982-07-02	1984-01-05	Schering AG, 1000 Berlin und 4709 Bergkamen	NEW CARBACYCLINAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE3408699A1 (en) *	1984-03-08	1985-09-12	Schering AG, 1000 Berlin und 4709 Bergkamen	NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US4683330A (en) *	1984-03-08	1987-07-28	The Upjohn Company	Interphenylene carbacyclin derivatives
US4668814A (en) *	1984-03-08	1987-05-26	The Upjohn Company	Interphenylene carbacyclin derivatives
EP0175450B1 (en) *	1984-07-18	1989-03-22	The Upjohn Company	An interphenylene-carbacyclin compound
DE3428266A1 (en) *	1984-07-27	1986-01-30	Schering AG, 1000 Berlin und 4709 Bergkamen	NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE19722849A1 (en) *	1997-05-23	1998-11-26	Schering Ag	Leukotriene B¶4¶ antagonists, especially 3-oxa-tetra-hydronaphthalene LTB¶4¶ antagonists
US6700025B2 (en) *	2001-01-05	2004-03-02	United Therapeutics Corporation	Process for stereoselective synthesis of prostacyclin derivatives
CA2959852A1 (en)	2003-05-22	2005-01-27	United Therapeutics Corporation	Compounds and methods for delivery of prostacyclin analogs
KR101161889B1 (en) *	2003-12-16	2012-07-02	유나이티드 쎄러퓨틱스 코포레이션	Use of treprostinil to treat and prevent ischemic lesions
US20090124697A1 (en)	2003-12-16	2009-05-14	United Therapeutics Corporation	Inhalation formulations of treprostinil
CA2710725C (en)	2010-07-22	2017-08-01	Alphora Research Inc.	Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation
CA2726599C (en)	2010-12-30	2017-07-25	Alphora Research Inc.	Process for treprostinil salt preparation
CA3212313A1 (en)	2013-03-14	2014-10-02	United Therapeutics Corporation	Solid forms of treprostinil
KR101830693B1 (en)	2016-04-28	2018-02-21	연성정밀화학(주)	Process for Preparing Treprostinil and Intermediate Therefor
HU231212B1 (en)	2018-04-16	2021-11-29	CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt.	Process for production of iloprost

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2017699A (en) *	1978-03-31	1979-10-10	Ono Pharmaceutical Co	6,9-methano-pgi2 analogues
AU8407282A (en) *	1981-05-22	1982-11-25	Schering Aktiengesellschaft	Carbocyclic prostacyclin alcohol analogs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5495552A (en) *	1978-01-06	1979-07-28	Sankyo Co Ltd	Prostacyline derivative and its preparation
JPS54119441A (en) *	1978-03-09	1979-09-17	Sumitomo Chem Co Ltd	Novel bicyclooctane derivative
US4180657A (en) *	1978-08-14	1979-12-25	The Upjohn Company	Acyl-substituted phenyl esters of prostacyclin-type compounds
US4192891A (en) *	1979-04-25	1980-03-11	E. R. Squibb & Sons, Inc.	Prostacyclin analogs and their use in inhibition of arachidonic acid-induced platelet aggregation and bronchoconstriction
CA1201712A (en) *	1980-02-28	1986-03-11	Paul A. Aristoff	Carbacyclin analogs
US4338457A (en) *	1980-02-28	1982-07-06	The Upjohn Company	Composition and process

1981
- 1981-01-16 CA CA000368710A patent/CA1201712A/en not_active Expired
- 1981-01-20 IL IL61936A patent/IL61936A/en unknown
- 1981-01-23 AU AU66606/81A patent/AU542861B2/en not_active Expired
- 1981-01-28 SE SE8100564A patent/SE453594B/en not_active IP Right Cessation
- 1981-01-30 GB GB8102901A patent/GB2070596B/en not_active Expired
- 1981-02-16 DE DE3153474A patent/DE3153474C2/de not_active Expired - Lifetime
- 1981-02-16 DE DE3153460A patent/DE3153460C2/de not_active Expired - Lifetime
- 1981-02-16 DE DE3153390A patent/DE3153390C2/de not_active Expired
- 1981-02-16 DE DE3105588A patent/DE3105588A1/en active Granted
- 1981-02-17 CH CH1786/84A patent/CH655308A5/en not_active IP Right Cessation
- 1981-02-17 CH CH1038/81A patent/CH648017A5/en not_active IP Right Cessation
- 1981-02-26 IT IT20019/81A patent/IT1144901B/en active
- 1981-02-27 FR FR8103965A patent/FR2484413B1/en not_active Expired
- 1981-02-27 NL NL8100959A patent/NL8100959A/en active Search and Examination
1985
- 1985-01-30 AU AU38208/85A patent/AU567392B2/en not_active Expired
- 1985-10-04 SE SE8504616A patent/SE8504616D0/en not_active Application Discontinuation
- 1985-10-04 SE SE8504615A patent/SE8504615L/en not_active Application Discontinuation
- 1985-10-04 SE SE8504619A patent/SE8504619L/en not_active Application Discontinuation
- 1985-10-04 SE SE8504617A patent/SE8504617L/en not_active Application Discontinuation
- 1985-10-04 SE SE8504618A patent/SE8504618D0/en not_active Application Discontinuation
1989
- 1989-01-19 HK HK69/89A patent/HK6989A/en not_active IP Right Cessation
- 1989-10-24 JP JP1275132A patent/JPH02167248A/en active Granted
1993
- 1993-01-22 JP JP5025993A patent/JPH06145085A/en active Pending

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2017699A (en) *	1978-03-31	1979-10-10	Ono Pharmaceutical Co	6,9-methano-pgi2 analogues
AU8407282A (en) *	1981-05-22	1982-11-25	Schering Aktiengesellschaft	Carbocyclic prostacyclin alcohol analogs

Also Published As

Publication number	Publication date
JPH048427B2 (en)	1992-02-17
FR2484413A1 (en)	1981-12-18
AU542861B2 (en)	1985-03-21
FR2484413B1 (en)	1986-05-23
IT1144901B (en)	1986-10-29
JPH06145085A (en)	1994-05-24
HK6989A (en)	1989-01-27
DE3105588A1 (en)	1981-12-10
DE3153390C2 (en)	1989-09-14
NL8100959A (en)	1981-10-01
IL61936A0 (en)	1981-02-27
SE8504618L (en)	1985-10-04
IT8120019A0 (en)	1981-02-26
DE3153460A1 (en)	1988-08-11
DE3153460C2 (en)	1990-08-16
CA1201712A (en)	1986-03-11
SE8504616L (en)	1985-10-04
DE3105588C2 (en)	1989-04-13
CH648017A5 (en)	1985-02-28
CH655308A5 (en)	1986-04-15
IL61936A (en)	1986-08-31
SE8504616D0 (en)	1985-10-04
SE453594B (en)	1988-02-15
DE3153474C2 (en)	1990-05-31
AU6660681A (en)	1981-09-03
SE8504617D0 (en)	1985-10-04
AU3820885A (en)	1985-06-20
SE8504619D0 (en)	1985-10-04
SE8100564L (en)	1981-08-29
SE8504615D0 (en)	1985-10-04
JPH02167248A (en)	1990-06-27
GB2070596B (en)	1984-02-08
SE8504619L (en)	1985-10-04
SE8504617L (en)	1985-10-04
GB2070596A (en)	1981-09-09
SE8504615L (en)	1985-10-04
SE8504618D0 (en)	1985-10-04

Publication	Publication Date	Title
AU542861B2 (en)	1985-03-21	Carbacyclin analogs
AU582020B2 (en)	1989-03-09	Prostaglandins
AU546358B2 (en)	1985-08-29	Piperazinylbenzoheterocyclic compounds
AU536754B2 (en)	1984-05-24	Imidodisulfamides
ZA81807B (en)	1982-03-31	Carbacyclin analogs
AU536416B2 (en)	1984-05-10	Prostacyclin analogs
AU3206284A (en)	1984-11-29	2-guanidno-4-heteroarylthiazoles
AU527275B2 (en)	1983-02-24	Auto-diaphragm hemodialyser
AU1626983A (en)	1984-01-05	Prostaglandin d analogues
AU542949B2 (en)	1985-03-28	Prostanoid compounds
AU542975B2 (en)	1985-03-28	13-oxa prostaglandin analogs
AU534814B2 (en)	1984-02-16	Showstand
AU537073B2 (en)	1984-06-07	Haloacetanilide
AU517843B2 (en)	1981-08-27	Guanylamidines
AU7409281A (en)	1982-02-18	Polyazaheterocyclic compounds
AU548782B2 (en)	1986-01-02	11-deoxy-11-methyl-15-acetoxy pge compounds
AU525004B2 (en)	1982-10-14	Phthalimidoguanidines
AU522849B2 (en)	1982-07-01	Sulfonium compounds
AU537618B2 (en)	1984-07-05	Haloacetamilide
AU526844B2 (en)	1983-02-03	Surf-ski
AU523877B2 (en)	1982-08-19	6,9-epoxy prostaglandin analogues
IE810402L (en)	1981-08-28	Carbacyclin analogues
GB2122202B (en)	1985-01-03	Carbacyclin intermediates
AU535926B2 (en)	1984-04-12	Prostacyclins
IE851045L (en)	1981-08-28	Carbacyclin intermediates

Legal Events

Date	Code	Title	Description
2001-08-23	MK14	Patent ceased section 143(a) (annual fees not paid) or expired