[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

AU2001277731A1 - Fused bicyclic amide compounds and medicinal use thereof - Google Patents

Fused bicyclic amide compounds and medicinal use thereof

Info

Publication number
AU2001277731A1
AU2001277731A1 AU2001277731A AU7773101A AU2001277731A1 AU 2001277731 A1 AU2001277731 A1 AU 2001277731A1 AU 2001277731 A AU2001277731 A AU 2001277731A AU 7773101 A AU7773101 A AU 7773101A AU 2001277731 A1 AU2001277731 A1 AU 2001277731A1
Authority
AU
Australia
Prior art keywords
fused bicyclic
amide compounds
medicinal use
bicyclic amide
medicinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001277731A
Inventor
Kenji Chiba
Takafumi Kawaguchi
Youichiro Naito
Makio Ohtsuki
Naoki Sugiyama
Hiroyuki Ushio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Publication of AU2001277731A1 publication Critical patent/AU2001277731A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001277731A 2000-08-09 2001-08-09 Fused bicyclic amide compounds and medicinal use thereof Abandoned AU2001277731A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000241934 2000-08-09
JP2000-241934 2000-08-09
PCT/JP2001/006852 WO2002012189A1 (en) 2000-08-09 2001-08-09 Fused bicyclic amide compounds and medicinal use thereof

Publications (1)

Publication Number Publication Date
AU2001277731A1 true AU2001277731A1 (en) 2002-02-18

Family

ID=18733040

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001277731A Abandoned AU2001277731A1 (en) 2000-08-09 2001-08-09 Fused bicyclic amide compounds and medicinal use thereof

Country Status (4)

Country Link
US (1) US7112594B2 (en)
EP (1) EP1310488A4 (en)
AU (1) AU2001277731A1 (en)
WO (1) WO2002012189A1 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US6825228B2 (en) * 2001-06-13 2004-11-30 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
DE60330847D1 (en) * 2002-03-28 2010-02-25 Mitsubishi Tanabe Pharma Corp benzofuran
EP1497278B1 (en) * 2002-04-11 2010-05-26 Boehringer Ingelheim Pharmaceuticals Inc. Heterocyclic amide derivatives as cytokine inhibitors
WO2004018461A2 (en) * 2002-08-23 2004-03-04 Pharmacia & Upjohn Company Llc Antibacterial benzoic acid derivatives
JP2005104838A (en) 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd Condensed furan compound
CN1809531B (en) 2003-04-30 2010-05-26 诺瓦提斯公司 Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators
TW200512181A (en) 2003-09-26 2005-04-01 Tanabe Seiyaku Co Amide-type carboxamide derivatives
TW200524915A (en) 2003-09-26 2005-08-01 Tanabe Seiyaku Co Carbamoyl-type benzofuran derivatives
US7417063B2 (en) * 2004-04-13 2008-08-26 Bristol-Myers Squibb Company Bicyclic heterocycles useful as serine protease inhibitors
KR20070006889A (en) * 2004-05-03 2007-01-11 노파르티스 아게 Combinations comprising a s1p receptor agonist and a jak3 kinase inhibitor
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
PT1773816E (en) * 2004-06-24 2015-04-29 Vertex Pharma Modulators of atp-binding cassette transporters
CA2587664A1 (en) * 2004-12-21 2006-06-29 Devgen N.V. Compounds with kv4 ion channel activity
SE0403171D0 (en) * 2004-12-23 2004-12-23 Astrazeneca Ab New compounds
JPWO2006137350A1 (en) * 2005-06-22 2009-01-15 キッセイ薬品工業株式会社 Novel furopyridine derivatives, pharmaceutical compositions containing them and their use
EP1979367A2 (en) * 2005-12-24 2008-10-15 Vertex Pharmaceuticals Incorporated Quinolin-4-one derivatives as modulators of abc transporters
PL1993360T3 (en) * 2005-12-28 2017-08-31 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
DE102006039038A1 (en) 2006-08-19 2008-02-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg New manufacturing process
TW200900408A (en) * 2007-03-02 2009-01-01 Kyowa Hakko Kogyo Kk Fused pyridine derivative
AU2008266883B2 (en) * 2007-06-20 2014-01-30 Merck Sharp & Dohme Corp. Inhibitors of janus kinases
AU2008286946B2 (en) * 2007-08-10 2013-11-21 H. Lundbeck A/S Heteroaryl amide analogues
EP2237784A1 (en) * 2008-01-11 2010-10-13 The Regents of the University of California Activators of executioner procaspases 3, 6 and 7
EP2161266A1 (en) * 2008-08-22 2010-03-10 EVOTEC Neurosciences GmbH Benzofuran derivatives as orexin receptor antagonists
ES2483690T3 (en) 2008-10-23 2014-08-07 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
JP2012517448A (en) * 2009-02-11 2012-08-02 リアクション バイオロジー コープ． Selective kinase inhibitor
SG174410A1 (en) 2009-03-20 2011-11-28 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
PE20121326A1 (en) 2009-08-26 2012-10-11 Takeda Pharmaceutical DERIVATIVES OF FUSED HETEROCYCLIC RING AND USE OF THE SAME
US8614208B2 (en) 2009-08-26 2013-12-24 Takeda Pharmaceutical Company Limited Fused heterocyclic ring derivative and use thereof
WO2011024869A1 (en) 2009-08-26 2011-03-03 武田薬品工業株式会社 Fused heterocyclic ring derivative and use thereof
EP2471791B1 (en) 2009-08-26 2014-11-12 Takeda Pharmaceutical Company Limited Fused heterocyclic ring derivative and use thereof
EP3252057B1 (en) 2009-12-04 2024-03-27 Sunovion Pharmaceuticals Inc. Multicyclic compounds and methods of use thereof
KR20140000695A (en) * 2010-10-14 2014-01-03 미쓰비시 타나베 파마 코퍼레이션 Amide derivative and use thereof
US9198911B2 (en) 2010-11-02 2015-12-01 The Trustees Of Columbia University In The City Of New York Methods for treating hair loss disorders
AU2011330850B2 (en) * 2010-11-15 2016-01-28 Viiv Healthcare Uk Limited Inhibitors of HIV replication
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US20120184548A1 (en) * 2011-01-19 2012-07-19 Romyr Dominique Carboxylic acid aryl amides
IL265430B2 (en) 2012-02-27 2024-08-01 Vertex Pharma Pharmaceutical compositions containing a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamode and uses thereof
JP5925723B2 (en) * 2012-04-13 2016-05-25 田辺三菱製薬株式会社 Pharmaceutical use of amide derivatives
AU2013247671A1 (en) 2012-04-13 2014-10-23 Mitsubishi Tanabe Pharma Corporation Amidopyridine derivative, and use thereof
WO2016009253A1 (en) * 2014-07-16 2016-01-21 Anil Mishra Recombinant interleukin-15 is a therapeutic agent for the treatment of airway hyperactivity, resistance (obstruction) and fibrosis in chronic asthma
ES2702288T3 (en) 2014-10-07 2019-02-28 Vertex Pharma Co-crystals of transmembrane conductance regulator modulators of cystic fibrosis
US10045981B2 (en) 2015-11-24 2018-08-14 Jakpharm, Llc Selective kinase inhibitors
CN116514761A (en) 2016-07-29 2023-08-01 赛诺维信制药公司 Compounds, compositions and uses thereof
CA3032141A1 (en) 2016-07-29 2018-02-01 Vadim ALEXANDROV Compounds and compositions and uses thereof
IL268694B2 (en) 2017-02-16 2023-10-01 Sunovion Pharmaceuticals Inc Treatment of schizophrenia
WO2019018441A1 (en) * 2017-07-17 2019-01-24 Massachusetts Institute Of Technology Cell atlas of healthy and diseased barrier tissues
US10780074B2 (en) 2017-08-02 2020-09-22 Sunovion Pharmaceuticals Inc. Compounds and uses thereof
CN118406063A (en) 2018-02-16 2024-07-30 赛诺维信制药公司 Salt, crystal forms and preparation method thereof
EP3938045A1 (en) 2019-03-14 2022-01-19 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
MX2022012833A (en) 2020-04-14 2022-11-07 Sunovion Pharmaceuticals Inc (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders.

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB760750A (en) * 1953-05-28 1956-11-07 Bayer Ag Water insoluble monoazo dyestuffs
US3413308A (en) * 1966-09-02 1968-11-26 Dow Chemical Co Substituted benzo(b)thiophene-2-carboxanilides
US3479348A (en) * 1967-11-14 1969-11-18 Sumitomo Chemical Co Quinoxaline derivatives
US4179578A (en) * 1971-12-24 1979-12-18 Sandoz Ltd. Para-phenyl stilbene derivatives
DK408574A (en) * 1973-09-06 1975-05-05 Ciba Geigy Ag
US4145364A (en) * 1977-11-30 1979-03-20 Merck & Co., Inc. Preparation of fluorinated anilines
US4191775A (en) 1977-12-15 1980-03-04 Imperial Chemical Industries Limited Amide derivatives
DE3063878D1 (en) * 1979-07-13 1983-07-28 Thomae Gmbh Dr K Derivatives of carboxylic acids, their preparation and medicaments containing them
DE2948056A1 (en) * 1979-11-29 1981-06-04 Boehringer Mannheim Gmbh, 6800 Mannheim NEW AMINOPROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4800211A (en) * 1986-08-18 1989-01-24 Merck & Co., Inc. 5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors
US5268389A (en) * 1989-10-16 1993-12-07 Uniroyal Chemical Company, Inc. Thiocarboxylate ester compounds compositions containing the same
US5023265A (en) 1990-06-01 1991-06-11 Schering Corporation Substituted 1-H-pyrrolopyridine-3-carboxamides
GB9816837D0 (en) * 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
US5356926A (en) 1992-02-24 1994-10-18 Warner-Lambert Company 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
DE4319041A1 (en) * 1992-10-23 1994-04-28 Bayer Ag Trisubstituted biphenyls
JPH06298732A (en) * 1993-02-16 1994-10-25 Taisho Pharmaceut Co Ltd Indole derivative
DE69412538T2 (en) 1993-05-18 1998-12-24 Takeda Chemical Industries, Ltd., Osaka Benzopyran derivatives and their use
DE4317076A1 (en) * 1993-05-21 1994-11-24 Bayer Ag Benzothiophene carboxamide S-oxide
US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US5631280A (en) 1995-03-29 1997-05-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6514996B2 (en) * 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
DE19612506A1 (en) * 1996-03-29 1997-10-02 Wella Ag Oxidation hair dyes containing 2,5-diaminobenzonitriles and new 2,5-diaminobenzonitriles
PL329922A1 (en) 1996-05-20 1999-04-26 Darwin Discovery Ltd Quinoline carboxamides as inhibitors of the tumour necrosis factor and of phosphodiesterase
IL126558A (en) * 1996-05-20 2002-07-25 Darwin Discovery Ltd Benzofuran carboxamides and pharmaceutical compositions containing them
EP2223920A3 (en) 1996-06-19 2011-09-28 Aventis Pharma Limited Substituted azabicyclic compounds
ID21775A (en) * 1996-10-25 1999-07-22 Yoshitomi Pharmaceutical COMPOUND 1-PHENILPIRAZOL COMPOUNDS AND THE USE OF PHARMACIES
US6069151A (en) * 1996-11-06 2000-05-30 Darwin Discovery, Ltd. Quinolines and their therapeutic use
AU711587B2 (en) 1996-11-06 1999-10-14 Darwin Discovery Limited Quinolines and their therapeutic use
WO1998022452A1 (en) 1996-11-19 1998-05-28 Kyowa Hakko Kogyo Co., Ltd. Benzofuran derivatives
AUPO395396A0 (en) * 1996-12-02 1997-01-02 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives
JP2001509145A (en) * 1996-12-23 2001-07-10 デュポン ファーマシューティカルズ カンパニー Heterocyclic aromatic compounds containing nitrogen as factor Xa inhibitors
UY24949A1 (en) * 1997-04-08 2001-04-30 Smithkline Beecham Corp CALCILITE COMPOUNDS
AUPO941497A0 (en) * 1997-09-24 1997-10-16 Fujisawa Pharmaceutical Co., Ltd. Novel compounds
CO4980854A1 (en) * 1998-02-10 2000-11-27 Novartis Ag PARTICULARLY AMIDED B-CELL INHIBITORS, THE PROCESS FOR THEIR PRODUCTION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU2641299A (en) 1998-03-04 1999-09-20 Kyowa Hakko Kogyo Co. Ltd. Benzofuran derivatives
TW555759B (en) * 1998-06-08 2003-10-01 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
US6399656B1 (en) 1998-07-28 2002-06-04 Smithkline Beecham Corporation Compounds and methods
EP1102750A1 (en) 1998-08-04 2001-05-30 AstraZeneca AB Amide derivatives useful as inhibitors of the production of cytokines
JP2000095767A (en) 1998-09-28 2000-04-04 Takeda Chem Ind Ltd Antagonist for gonadotrophic hormone-releasing hormone
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
DE60045474D1 (en) 1999-01-13 2011-02-17 Univ New York State Res Found NEW METHOD FOR CREATING PROTEIN KINASE INHIBITORS
ES2234564T3 (en) * 1999-02-10 2005-07-01 Mitsubishi Pharma Corporation AMIDA TYPE COMPOUNDS AND THEIR USE IN MEDICINE.
WO2001021615A1 (en) 1999-09-17 2001-03-29 Yamanouchi Pharmaceutical Co., Ltd. Benzimidazole derivatives
KR100312685B1 (en) * 1999-09-28 2001-11-03 김순택 Beam index type cathode ray tube and method for making photodetector compatible with this cathode ray tube
ES2235970T3 (en) 1999-10-19 2005-07-16 MERCK & CO. INC. THYROSINE KINASE INHIBITORS.

Also Published As

Publication number Publication date
EP1310488A4 (en) 2005-08-10
WO2002012189A1 (en) 2002-02-14
EP1310488A1 (en) 2003-05-14
US7112594B2 (en) 2006-09-26
US20030203909A1 (en) 2003-10-30

Similar Documents

Publication Publication Date Title
AU2001277731A1 (en) Fused bicyclic amide compounds and medicinal use thereof
EP1367060A4 (en) Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof
EP1364957A4 (en) Glycopyranosyloxypyrazole derivatives and medicinal use thereof
EP1364958A4 (en) Glycopyranosyloxypyrazole derivatives and medicinal use thereof
HUP0303103A3 (en) Fused pyrrolocarbazoles, pharmaceutical compositions containing them and use of the compounds
HUP0402236A3 (en) Heterocyclic compounds pharmaceutical compounds containing thereof and use thereof
AU2001264313A1 (en) Pyrazolopyridine compounds and use thereof as drugs
MXPA03004936A (en) Fused cyclic compounds and medicinal use thereof.
AU2001277741A1 (en) 2-aminopyridine compounds and use thereof as drugs
HK1040995A1 (en) 2-oxoquinoline compounds and medicinal uses thereof
AU2003291310A1 (en) Fused heterocyclic compounds and use thereof
AUPQ969800A0 (en) Pyrazolopyridine compound and pharmaceutical use thereof
AU2002218502A1 (en) Lactam compounds and medicinal use thereof
AU2002308891A1 (en) Novel heterocyclic derivatives and medicinal use thereof
AU2001227084A1 (en) N-arylhydrazide compounds and use thereof as drugs
AU2001261375A1 (en) Human caspase-12 materials and methods
AU2002308889A1 (en) Novel heterocyclic compound and medicinal use thereof
HK1069385A1 (en) Heterocyclic compound and medicinal use thereof
AU2001264273A1 (en) Amide compounds and use thereof
GB0119025D0 (en) Compounds and their therapeutic use
AU2001290641A1 (en) Substituted fused pyrroleimines and pyrazoleimines
AU4432001A (en) Trityl-type compounds and their use
AU2000231564A1 (en) Phosphororganic compounds and the use thereof
AU6866700A (en) Biscyclopropanecarboxylic acid amide compounds and medicinal use thereof
AUPR548601A0 (en) Pyrazolopyrazinecompound and pharmaceutical use thereof