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ATE8874T1 - Therapeutisch nuetzliche 1-alkyl-2-amino-tetralin- derivate. - Google Patents

Therapeutisch nuetzliche 1-alkyl-2-amino-tetralin- derivate.

Info

Publication number
ATE8874T1
ATE8874T1 AT82850102T AT82850102T ATE8874T1 AT E8874 T1 ATE8874 T1 AT E8874T1 AT 82850102 T AT82850102 T AT 82850102T AT 82850102 T AT82850102 T AT 82850102T AT E8874 T1 ATE8874 T1 AT E8874T1
Authority
AT
Austria
Prior art keywords
carbon atoms
group
alkyl
alkyl group
compounds
Prior art date
Application number
AT82850102T
Other languages
English (en)
Inventor
Folke Lars-Erik Arvidsson
Per Arvid Emil Carlsson
Uli Alf Hacksell
John Stephan Mikael Hjorth
Anette Margareta Johansson
Per Lennart Lindberg
John Lars Gunnar Nilsson
Domingo Sanchez
Hakan Vilhelm Wikstroem
Original Assignee
Astra Laekemedel Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Laekemedel Aktiebolag filed Critical Astra Laekemedel Aktiebolag
Application granted granted Critical
Publication of ATE8874T1 publication Critical patent/ATE8874T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
AT82850102T 1981-05-08 1982-05-06 Therapeutisch nuetzliche 1-alkyl-2-amino-tetralin- derivate. ATE8874T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8102908 1981-05-08
EP82850102A EP0064964B1 (de) 1981-05-08 1982-05-06 Therapeutisch nützliche 1-Alkyl-2-amino-tetralin-Derivate

Publications (1)

Publication Number Publication Date
ATE8874T1 true ATE8874T1 (de) 1984-08-15

Family

ID=20343779

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82850102T ATE8874T1 (de) 1981-05-08 1982-05-06 Therapeutisch nuetzliche 1-alkyl-2-amino-tetralin- derivate.

Country Status (16)

Country Link
US (1) US4876284A (de)
EP (1) EP0064964B1 (de)
JP (1) JPS57192344A (de)
AT (1) ATE8874T1 (de)
AU (2) AU554206B2 (de)
CA (1) CA1236113A (de)
DE (1) DE3260529D1 (de)
DK (1) DK164937C (de)
ES (4) ES511986A0 (de)
FI (1) FI78067C (de)
GR (1) GR77121B (de)
IE (1) IE53143B1 (de)
IL (1) IL65501A (de)
NO (1) NO152902C (de)
NZ (1) NZ200526A (de)
PH (2) PH18065A (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65501A (en) * 1981-05-08 1986-04-29 Astra Laekemedel Ab 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
US4722933A (en) * 1985-12-20 1988-02-02 Nelson Research & Development Co. Substituted 2-aminotetralins
US4657925A (en) * 1984-08-13 1987-04-14 Nelson Research & Development Co. Method and compositions for reducing the intraocular pressure of mammals
US4743618A (en) * 1983-01-03 1988-05-10 Nelson Research & Development Co. Substituted 2-aminotetralins
GB2157950B (en) * 1984-05-04 1988-11-02 Nelson Res & Dev Selective d-2 dopamine receptor agonist
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
EP0168505B1 (de) * 1984-05-22 1989-08-09 Whitby Research Incorporated Substituierte 2-Aminotetraline und Verfahren zur Herstellung
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
EP0451145A1 (de) * 1988-07-29 1991-10-16 Schering Corporation Verfahren zur enantiospezifischen herstellung von zwischenprodukten für hexahydro-benzo-[d]naphtho[2,1-biazepine
US5091526A (en) * 1988-07-29 1992-02-25 Schering Corporation Process for the enantiospecific synthesis of intermediates for hexahydro-benzo[d]-naphtho[2,1-b]azepines
CA1335106C (en) * 1989-02-27 1995-04-04 John Mehnert Schaus Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
SE8901889D0 (sv) * 1989-05-26 1989-05-26 Astra Ab Novel 8-substituted-2-aminotetralines
ATE172712T1 (de) * 1989-05-31 1998-11-15 Upjohn Co Zns-wirksame 8-heterocyclyl-2-aminotetralin derivate
IT1232160B (it) * 1989-07-31 1992-01-25 Sigma Tau Ind Farmaceuti 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono
EP0507863A4 (en) * 1989-12-28 1993-07-07 Virginia Commonwealth University Sigma receptor ligands and the use thereof
DK0471515T3 (da) * 1990-08-15 1997-07-21 Lilly Co Eli Ringsubstituerede 2-amino-1,2,3,4-tetrahydronphtalener, 3-aminochromaner og 3-aminothiochromaner
JPH06506951A (ja) * 1991-04-26 1994-08-04 ジ・アップジョン・カンパニー 物質乱用の治療／予防方法
WO1993000313A2 (en) * 1991-06-27 1993-01-07 Virginia Commonwealth University Sigma receptor ligands and the use thereof
IT1251877B (it) * 1991-09-26 1995-05-26 Zambon Spa Processo per la preparazione di 2-ammino-5,6 dimetossi-tetralina
WO1994022495A1 (en) * 1993-03-31 1994-10-13 The Trustees Of The University Of Pennsylvania Dopamine d-3 and serotonin (5-ht1a) receptor ligands and imaging agents
US6087346A (en) * 1993-06-23 2000-07-11 Cambridge Neuroscience, Inc. Sigma receptor ligands and the use thereof
GB9315566D0 (en) * 1993-07-28 1993-09-08 Smithkline Beecham Plc Medicaments
JPH11503116A (ja) * 1995-03-27 1999-03-23 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 二環式アミン誘導体および抗精神病薬としてのそれらの使用
US5646188A (en) * 1995-07-05 1997-07-08 Teva Pharmaceutical Industries, Ltd. Polyamine derivatives of 1-aminoindan
JP2002526521A (ja) 1998-10-07 2002-08-20 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 神経ペプチドｙのｙ５受容体のリガンドとしてのｎ−アラルキルアミノテトラリン
JP2005526137A (ja) 2002-05-17 2005-09-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アミノテトラリン−誘動尿素のバニロイドｖｒ１受容体調節剤
EP2098511A1 (de) 2008-03-07 2009-09-09 Solvias AG Verfahren zur Herstellung von Verbindungen mit einer Hydronaphtalinstruktur mit einem asymmetrisch substituierten Benzolring
DE102010020553A1 (de) 2010-05-14 2011-11-17 Bayer Schering Pharma Aktiengesellschaft Substituierte 8-Alkoxy-2-aminotetralin-Derivate und ihre Verwendung
EA028918B9 (ru) 2012-07-20 2018-07-31 Байер Фарма Акциенгезельшафт Производные 5-аминотетрагидрохинолин-2-карбоновых кислот и их применение в качестве активатора растворимой гуанилатциклазы
WO2014012935A1 (de) 2012-07-20 2014-01-23 Bayer Pharma Aktiengesellschaft Substituierte aminoindan- und aminotetralin-carbonsäuren und ihre verwendung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1017359A (en) * 1972-07-03 1977-09-13 Frederic P. Hauck Substituted cyclic polymethylene phenols
JPS5124508B2 (de) * 1972-08-14 1976-07-24
DE2752659A1 (de) * 1976-12-07 1978-06-08 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
DE3062971D1 (en) * 1979-09-14 1983-06-09 Sandoz Ag Derivatives of tetraline, their preparation and medicaments containing these compounds
AU7179781A (en) * 1980-05-29 1981-12-21 Astra Lakemedel Aktiebolag Therapeutically useful tetralin derivatives
IL65501A (en) * 1981-05-08 1986-04-29 Astra Laekemedel Ab 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
FR2512814A1 (fr) * 1981-09-16 1983-03-18 Synthelabo Derives d'amino-2 tetrahydro-1,2,3,4 naphtalene, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
NZ200526A (en) 1985-09-13
ES535882A0 (es) 1985-12-01
ES8504666A1 (es) 1985-05-01
ES519615A0 (es) 1985-05-01
NO152902C (no) 1985-12-11
AU572497B2 (en) 1988-05-12
PH18065A (en) 1985-03-18
NO152902B (no) 1985-09-02
AU554206B2 (en) 1986-08-14
FI821598A0 (fi) 1982-05-06
ES529311A0 (es) 1985-08-01
ES8306708A1 (es) 1983-06-01
IE53143B1 (en) 1988-07-20
FI821598L (fi) 1982-11-09
IL65501A0 (en) 1982-07-30
IL65501A (en) 1986-04-29
DK164937C (da) 1993-02-01
DE3260529D1 (en) 1984-09-13
AU8340982A (en) 1982-11-11
ES511986A0 (es) 1983-06-01
PH19585A (en) 1986-05-26
JPH0419221B2 (de) 1992-03-30
US4876284A (en) 1989-10-24
EP0064964A1 (de) 1982-11-17
ES8506591A1 (es) 1985-08-01
ES8602603A1 (es) 1985-12-01
IE821076L (en) 1982-11-08
DK202882A (da) 1982-11-09
AU2587984A (en) 1984-06-28
NO821494L (no) 1982-11-09
EP0064964B1 (de) 1984-08-08
JPS57192344A (en) 1982-11-26
FI78067B (fi) 1989-02-28
DK164937B (da) 1992-09-14
GR77121B (de) 1984-09-07
FI78067C (fi) 1989-06-12
CA1236113A (en) 1988-05-03

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