[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE531805T1 - Transgene ananaspflanzen mit modifiziertem carotinoidgehalt und verfahren zu ihrer herstellung - Google Patents

Transgene ananaspflanzen mit modifiziertem carotinoidgehalt und verfahren zu ihrer herstellung

Info

Publication number
ATE531805T1
ATE531805T1 AT03790354T AT03790354T ATE531805T1 AT E531805 T1 ATE531805 T1 AT E531805T1 AT 03790354 T AT03790354 T AT 03790354T AT 03790354 T AT03790354 T AT 03790354T AT E531805 T1 ATE531805 T1 AT E531805T1
Authority
AT
Austria
Prior art keywords
modified
production
pineapple plants
carotinoid content
transgenic pineapple
Prior art date
Application number
AT03790354T
Other languages
English (en)
Inventor
Thomas Young
Ebrahim Firoozabady
Original Assignee
Del Monte Fresh Produce Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Del Monte Fresh Produce Company filed Critical Del Monte Fresh Produce Company
Application granted granted Critical
Publication of ATE531805T1 publication Critical patent/ATE531805T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/825Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A01H4/008Methods for regeneration to complete plants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8202Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
    • C12N15/8205Agrobacterium mediated transformation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Environmental Sciences (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Fruits And Vegetables (AREA)
AT03790354T 2002-12-06 2003-12-05 Transgene ananaspflanzen mit modifiziertem carotinoidgehalt und verfahren zu ihrer herstellung ATE531805T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43132302P 2002-12-06 2002-12-06
PCT/US2003/038664 WO2004052085A1 (en) 2002-12-06 2003-12-05 Transgenic pineapple plants with modified carotenoid levels and methods of their production

Publications (1)

Publication Number Publication Date
ATE531805T1 true ATE531805T1 (de) 2011-11-15

Family

ID=32507709

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03790354T ATE531805T1 (de) 2002-12-06 2003-12-05 Transgene ananaspflanzen mit modifiziertem carotinoidgehalt und verfahren zu ihrer herstellung

Country Status (11)

Country Link
US (1) US8049067B2 (de)
EP (2) EP1589807B1 (de)
JP (1) JP2006508681A (de)
KR (2) KR101209345B1 (de)
AT (1) ATE531805T1 (de)
AU (2) AU2003293407B2 (de)
DK (1) DK1589807T3 (de)
ES (1) ES2376868T3 (de)
IL (2) IL168840A (de)
PT (1) PT1589807E (de)
WO (2) WO2004052085A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1589807T3 (da) 2002-12-06 2012-02-13 Del Monte Fresh Produce Company Transgene ananasplanter med modificerede carotenoidniveauer og fremgangsmåder til deres fremstilling
US7663021B2 (en) 2002-12-06 2010-02-16 Del Monte Fresh Produce Company Transgenic pineapple plants with modified carotenoid levels and methods of their production
WO2006069610A2 (en) 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
EP2199304A1 (de) * 2004-12-17 2010-06-23 Metanomics GmbH Verfahren zur Steuerung der Chemikalienherstellung
WO2006113709A2 (en) 2005-04-15 2006-10-26 Del Monte Fresh Produce Company Plant promoters, terminators, genes, vectors and related transformed plants
US8581035B2 (en) 2006-08-31 2013-11-12 Monsanto Technology Llc Plant transformation without selection
CN101407807B (zh) * 2008-11-19 2013-11-06 暨南大学 对染色体进行处理而改变细胞遗传特性的方法及其应用
CN101979584B (zh) * 2010-07-15 2012-05-30 华中农业大学 β-胡萝卜素羟化酶基因DSM2在控制水稻抗旱性中的应用
ITRM20110491A1 (it) * 2011-09-19 2013-03-20 Aep Advanced Ecopower Patents Sa Pianta oleaginosa transgenica.
US20130205443A1 (en) * 2012-01-27 2013-08-08 The Texas A&M University System Pathogen resistant citrus compositions, organisms, systems, and methods
USPP25763P3 (en) 2012-06-04 2015-08-04 Del Monte Fresh Produce Pineapple plant named ‘Rosé’
KR101979878B1 (ko) * 2015-11-18 2019-05-17 씨제이브리딩 주식회사 신품종 배추 식물
CN109006488A (zh) * 2018-10-15 2018-12-18 四川农业大学 一种基于以芽繁芽的红苞凤梨培育方法
CN110129291B (zh) * 2019-04-16 2021-06-08 扬州大学 大麦耐湿调控基因HvACO1、蛋白及其在育种中的应用
CN110463607A (zh) * 2019-09-09 2019-11-19 新疆农业大学 野生欧洲李叶片组织培养的方法

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
AU6137986A (en) 1985-07-16 1987-02-10 Salk Institute For Biological Studies, The Genetic alteration of plants with retroviruses
JPS62291904A (ja) 1986-06-12 1987-12-18 Namiki Precision Jewel Co Ltd 永久磁石の製造方法
EP0262972A3 (de) 1986-10-01 1990-08-29 The Plant Cell Research Institute Inc. Genetische Transformation und kontrollierte Regenerierung von Cucumis SP in vitro
NZ230375A (en) 1988-09-09 1991-07-26 Lubrizol Genetics Inc Synthetic gene encoding b. thuringiensis insecticidal protein
BR9007159A (pt) 1989-02-24 1991-12-10 Monsanto Co Genes sinteticos de plantas e processo para a preparacao dos mesmos
US5034323A (en) 1989-03-30 1991-07-23 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
JP2950888B2 (ja) * 1989-04-21 1999-09-20 麒麟麦酒株式会社 カロチノイドの合成に有用なdna鎖
US5429939A (en) * 1989-04-21 1995-07-04 Kirin Beer Kabushiki Kaisha DNA sequences useful for the synthesis of carotenoids
GB8928179D0 (en) * 1989-12-13 1990-02-14 Ici Plc Dna,constructs,cells and plants derived therefrom
US5618988A (en) * 1990-03-02 1997-04-08 Amoco Corporation Enhanced carotenoid accumulation in storage organs of genetically engineered plants
US5530188A (en) * 1990-03-02 1996-06-25 Amoco Corporation Beta-carotene biosynthesis in genetically engineered hosts
EP0471056B1 (de) * 1990-03-02 2001-10-17 BP Corporation North America Inc. Biosynthese von carotinoiden in genetisch hergestellten wirtszellen
US5684238A (en) * 1990-03-02 1997-11-04 Amoco Corporation Biosynthesis of zeaxanthin and glycosylated zeaxanthin in genetically engineered hosts
US5530189A (en) * 1990-03-02 1996-06-25 Amoco Corporation Lycopene biosynthesis in genetically engineered hosts
CA2080584C (en) 1990-04-18 2000-09-05 Marc Cornelissen Modified bacillus thuringiensis insecticidal-crystal protein genes and their expression in plant cells
US5262316A (en) * 1991-11-22 1993-11-16 Dna Plant Technology Corporation Genetically transformed pepper plants and methods for their production
US5591616A (en) * 1992-07-07 1997-01-07 Japan Tobacco, Inc. Method for transforming monocotyledons
FR2709496B1 (fr) * 1993-08-30 1995-11-03 Limagrain Holding Groupe Procédé de production de plantes transgéniques, entièrement transformées en génération T0, à partir de méristèmes.
US7939328B1 (en) 1993-09-03 2011-05-10 Japan Tobacco Inc. Method of transforming monocotyledons using scutella of immature embryos
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
US5792903A (en) * 1993-10-25 1998-08-11 Yissum Research Development Company Of Hebrew University Of Jerusalem Lycopene cyclase gene
US5545817A (en) 1994-03-11 1996-08-13 Calgene, Inc. Enhanced expression in a plant plastid
AU5897796A (en) * 1995-05-17 1996-11-29 Centre National De La Recherche Scientifique Dna sequences encoding a lycopene cyclase, antisense sequenc es derived therefrom and their use for the modification of c arotenoids levels in plants
US6087563A (en) * 1996-01-29 2000-07-11 Arizona Board Of Regents On Behalf Of The University Of Arizona Cloned arabidopsis p-hydroxyphenyl pyruvic acid dioxygenase DNA
US5744341A (en) * 1996-03-29 1998-04-28 University Of Maryland College Park Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes
US6642021B2 (en) * 1996-03-29 2003-11-04 University Of Maryland Methods of producing carotenoids by the expression of plant ε-cyclase genes
AUPN958296A0 (en) * 1996-05-01 1996-05-23 Golden Circle Limited Novel acc synthase genes from pineapple
GB9611981D0 (en) * 1996-06-07 1996-08-07 Zeneca Ltd Enhancement of gene expression
US5955269A (en) * 1996-06-20 1999-09-21 Rutgers, The State University Of New Jersey Methods of screening foods for nutraceuticals
WO1998006862A1 (en) * 1996-08-09 1998-02-19 Calgene Llc Methods for producing carotenoid compounds and speciality oils in plant seeds
US6429356B1 (en) * 1996-08-09 2002-08-06 Calgene Llc Methods for producing carotenoid compounds, and specialty oils in plant seeds
US6242257B1 (en) * 1996-10-29 2001-06-05 Council Of Scientific & Industrial Research Tissue culture process for producing a large number of viable cotton plants in vitro
US5908771A (en) * 1997-01-31 1999-06-01 R. J. Reynolds Tobacco Company Method for regeneration of salvia species
PT900279E (pt) * 1997-02-20 2005-01-31 Bayer Bioscience Nv Processo melhorado de transformacao de plantas
US5952543A (en) * 1997-02-25 1999-09-14 Dna Plant Technology Corporation Genetically transformed pineapple plants and methods for their production
US6140555A (en) * 1997-06-06 2000-10-31 Mississippi State University Methods for maize transformation coupled with adventitious regeneration utilizing nodal section explants and mature zygotic embryos
US6133035A (en) * 1997-07-16 2000-10-17 Dna Plant Technology Corporation Method of genetically transforming banana plants
EP1017268A1 (de) * 1997-09-24 2000-07-12 The Regents Of The University Of California Verfahren und zusammensetzung für die transformation von getreiden mittels kultivierten triebmeristemgewebe
US5948956A (en) * 1997-10-16 1999-09-07 Oms Investments, Inc. Transgenic plants and method for node segment transformation
JP3032841B2 (ja) * 1997-12-02 2000-04-17 農林水産省果樹試験場長 β−カロテンハイドロキシラーゼ遺伝子
US6653530B1 (en) * 1998-02-13 2003-11-25 Calgene Llc Methods for producing carotenoid compounds, tocopherol compounds, and specialty oils in plant seeds
WO1999058644A1 (en) * 1998-05-14 1999-11-18 University Of Hawaii Compositions and methods for genetic transformation of pineapple
US6037522A (en) * 1998-06-23 2000-03-14 Rhone-Poulenc Agro Agrobacterium-mediated transformation of monocots
US6252141B1 (en) * 1998-08-14 2001-06-26 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Tomato gene B polynucleotides coding for lycopene cyclase
JP2002525062A (ja) * 1998-09-15 2002-08-13 ジェネシス リサーチ アンド デベロップメント コーポレイション リミテッド 遺伝的に改変された植物の作成方法並びにこれにより生産された遺伝的改変植物、植物性材料及び植物製品
US6043072A (en) * 1998-11-05 2000-03-28 Washington State University Research Foundation Nucleic acids encoding Taxus geranylgeranyl diphosphate synthase, and methods of use
US6835540B2 (en) * 2001-03-16 2004-12-28 Mendel Biotechnology, Inc. Biosynthetic pathway transcription factors
CA2367408A1 (en) * 1999-04-07 2000-10-12 Mendel Biotechnology, Inc. Genetic trait breeding method
USPP12861P2 (en) * 1999-07-15 2002-08-20 Cirad Pineapple plant named ‘RL 41’
WO2001012828A1 (en) 1999-08-18 2001-02-22 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
AUPQ388399A0 (en) * 1999-11-05 1999-12-02 State Of Queensland Through Its Department Of Primary Industries, The A method of transformation
MXPA02004882A (es) * 1999-11-17 2004-04-05 Mendel Biotechnology Inc Genes de desarrollo de la planta.
DE10015458A1 (de) 2000-03-29 2001-10-11 Inst Pflanzengenetik & Kultur Verfahren zur raschen Herstellung von transgenen, markergen-freien Pflanzen
IT1317038B1 (it) * 2000-06-05 2003-05-26 Vitroplant Vivai Di Zuccherell Metodo per la rigenerazione di piante e suoi usi per lamoltiplicazione e/o la trasformazione di piante.
EP1360300A2 (de) * 2000-07-31 2003-11-12 Frederick M. Hahn Manipulation der in der mevalonsäure- und isoprenoid-biosynthese verantwortlichen gene zur herstellung von geänderten merkmalen in transgenen organismen
AU8980001A (en) * 2000-08-11 2002-02-25 Syngenta Participations Ag Methods for stable transformation of plants
AUPR143100A0 (en) 2000-11-10 2000-12-07 Bureau Of Sugar Experiment Stations Plant transformation
AU2002232757A1 (en) 2000-12-22 2002-07-08 Monsanto Technology Llc Plant transformation process with selection and early identification of germline events
DE10102338A1 (de) 2001-01-19 2002-07-25 Basf Plant Science Gmbh Verfahren zur Expression von Biosynthesegenen in pflanzlichen Samen unter Verwendung von neuen multiplen Expressionskonstrukten
DK1589807T3 (da) 2002-12-06 2012-02-13 Del Monte Fresh Produce Company Transgene ananasplanter med modificerede carotenoidniveauer og fremgangsmåder til deres fremstilling

Also Published As

Publication number Publication date
IL168840A (en) 2010-12-30
EP1571899A4 (de) 2006-08-30
AU2003302775B2 (en) 2010-05-27
AU2003293407A1 (en) 2004-06-30
US20060130171A1 (en) 2006-06-15
IL168921A (en) 2013-07-31
AU2003302775A1 (en) 2004-06-30
KR20110066979A (ko) 2011-06-17
JP2006508681A (ja) 2006-03-16
AU2003293407B2 (en) 2010-03-04
KR101209345B1 (ko) 2012-12-07
ES2376868T3 (es) 2012-03-20
KR20050084157A (ko) 2005-08-26
WO2004053082A3 (en) 2004-10-14
EP1589807B1 (de) 2011-11-02
EP1571899A2 (de) 2005-09-14
EP1589807A1 (de) 2005-11-02
WO2004052085A1 (en) 2004-06-24
PT1589807E (pt) 2012-02-02
WO2004053082A2 (en) 2004-06-24
US8049067B2 (en) 2011-11-01
DK1589807T3 (da) 2012-02-13
EP1589807A4 (de) 2007-09-12

Similar Documents

Publication Publication Date Title
ATE531805T1 (de) Transgene ananaspflanzen mit modifiziertem carotinoidgehalt und verfahren zu ihrer herstellung
MY148081A (en) Cultivated agarwood
NO20073846L (no) Ladet termoplastisk resin-basert bitumlinos mastik
DE602004020538D1 (de) Verfahren und Vorrichtung zur Laserbestrahlung, sowie Verfahren zur Herstellung von Halbleiter.
ATE419260T1 (de) C-aryl-glucosid-sglt2-inhibitoren und verfahren zu ihrer herstellung
ATE284865T1 (de) Benzoylcyclohexandione, verfahren zu ihrer herstellung und ihre verwendung als herbizide und pflanzenwachstumsregulatoren
ATE520780T1 (de) Pflanzen mit veränderten wachstumseigenschaften und verfahren zur deren herstellung
DE60133905D1 (de) Brennstofzellenanordnung und verfahren zu ihrer herstellung
DE60332953D1 (de) Gleichmässiges faservlies und verfahren zu dessen herstellung
ATE497008T1 (de) Verfahren zur herstellung transgener pflanzen
DE60233058D1 (de) Silsesquioxanderivate und verfahren zu ihrer herstellung
DE60125366D1 (de) Perfluorpolyether und verfahren zur ihrer herstellung
ATE520781T1 (de) Verfahren zur veränderung des gehalts von speicherstoffen in pflanzen
DE50310782D1 (de) Piezoaktor und verfahren zu dessen herstellung
DE60311103D1 (de) Auf norbornenester basierendes polymerisat und verfahren zu seiner herstellung
WO2004016742A3 (en) α(1,3)-GALACTOSYLTRANSFERASE NULL CELLS, METHODS OF SELECTING AND α(1,3)-GALACTOSYLTRANSFERASE NULL SWINE PRODUCED THEREFROM
ATE497509T1 (de) Elektrosterisch stabilisierte wässrige polyurethan-harze, verfahren zu ihrer herstellung und deren verwendung
ATE505535T1 (de) Verfahren zur herstellung stabiler b-lymphozyten
DE50310019D1 (de) Membranmodul zur wasserstoffabtrennung und verfahren zu dessen herstellung
DE60234678D1 (de) Leiterplatte und verfahren zu ihrer herstellung
DE60333840D1 (de) Geformte absorbierende auflagen und verfahren zur dessen herstellung
ATE369418T1 (de) Mykotoxin-resistente transgene weizenpflanze, verfahren zur herstellung und verwendung derselben
NO20063117L (no) Fremgangsmate for forskyving av surgassandeler inne i et naturgassnettverk
DE60225508D1 (de) Leiterplatte und verfahren zu ihrer herstellung
DE602004031350D1 (de) Penamkristall und verfahren zu dessen herstellung