ATE549021T1 - Kombinationstherapien zur behandlung von morbus alzheimer mit dimebon und donepezil - Google Patents
Kombinationstherapien zur behandlung von morbus alzheimer mit dimebon und donepezilInfo
- Publication number
- ATE549021T1 ATE549021T1 AT07867284T AT07867284T ATE549021T1 AT E549021 T1 ATE549021 T1 AT E549021T1 AT 07867284 T AT07867284 T AT 07867284T AT 07867284 T AT07867284 T AT 07867284T AT E549021 T1 ATE549021 T1 AT E549021T1
- Authority
- AT
- Austria
- Prior art keywords
- alzheimer
- disease
- dimebon
- combination therapies
- donepezil
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85486606P | 2006-10-27 | 2006-10-27 | |
PCT/US2007/022645 WO2008051599A2 (en) | 2006-10-27 | 2007-10-26 | Combination therapies for treating alzheimer's disease using i. a. dimebon and dolepezil |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE549021T1 true ATE549021T1 (de) | 2012-03-15 |
Family
ID=39315586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07867284T ATE549021T1 (de) | 2006-10-27 | 2007-10-26 | Kombinationstherapien zur behandlung von morbus alzheimer mit dimebon und donepezil |
Country Status (15)
Country | Link |
---|---|
US (1) | US20100152108A1 (de) |
EP (2) | EP2086538B1 (de) |
JP (1) | JP2010507672A (de) |
KR (1) | KR20090087009A (de) |
CN (1) | CN101631547A (de) |
AT (1) | ATE549021T1 (de) |
AU (1) | AU2007309390A1 (de) |
BR (1) | BRPI0718437A2 (de) |
CA (1) | CA2667553A1 (de) |
IL (2) | IL198405A0 (de) |
MX (1) | MX2009004516A (de) |
NO (1) | NO20092051L (de) |
RU (1) | RU2009120048A (de) |
SG (1) | SG178000A1 (de) |
WO (1) | WO2008051599A2 (de) |
Families Citing this family (62)
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DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
RU2334514C1 (ru) * | 2006-12-01 | 2008-09-27 | Институт физиологически активных веществ Российской Академии наук | СРЕДСТВО ДЛЯ УЛУЧШЕНИЯ КОГНИТИВНЫХ ФУНКЦИЙ И ПАМЯТИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО (4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
CA2683453C (en) * | 2007-04-05 | 2013-06-11 | Alla Chem, Llc | Substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-.beta.]indoles, methods for the production and use thereof |
US20090221627A1 (en) | 2007-09-20 | 2009-09-03 | Alexey Aksinenko | Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use |
RU2007139634A (ru) * | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
CN104387382A (zh) | 2008-03-24 | 2015-03-04 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚和应用方法 |
EP2274307B1 (de) | 2008-03-24 | 2015-07-29 | Medivation Technologies, Inc. | Verbrückte heterocyclische verbindungen und anwendungsverfahren |
US20110172262A1 (en) * | 2008-09-15 | 2011-07-14 | Biovista, Inc. | Compositions and methods for treating epilepsy |
TW201018694A (en) | 2008-09-29 | 2010-05-16 | Abbott Lab | Indole and indoline derivatives and methods of use thereof |
US9625475B2 (en) | 2008-09-29 | 2017-04-18 | Abbvie Inc. | Indole and indoline derivatives and methods of use thereof |
CA2742320A1 (en) | 2008-10-31 | 2010-05-06 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles containing rigid moieties |
WO2010051503A1 (en) | 2008-10-31 | 2010-05-06 | Medivation Technologies, Inc. | Azepino [4, 5-b] indoles and methods of use |
WO2010057104A2 (en) * | 2008-11-17 | 2010-05-20 | Auspex Pharmaceuticals, Inc. | Pyridoindole modulators of nmda receptor and acetylcholinesterase |
EP2381955A4 (de) * | 2008-12-30 | 2013-01-16 | Univ Ramot | Kombinationstherapien mit nap |
BRPI1008020A2 (pt) | 2009-02-11 | 2016-03-15 | Sunovion Pharmaceuticals Inc | antagonistas e agonistas inversos h3 da histamina e métodos de uso dos mesmos |
EP2417973B1 (de) | 2009-04-10 | 2013-08-28 | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. | Retardzusammensetzung mit tetrahydropyrido[4, 3-b]indol-derivat |
EP2424366B1 (de) | 2009-04-29 | 2016-02-17 | Medivation Technologies, Inc. | Pyrido-[4,3-b-]indole und verwendungsverfahren dafür |
WO2010127177A1 (en) * | 2009-04-29 | 2010-11-04 | Medivation Technologies, Inc. | Pyrido [4,3-b] indoles and methods of use |
US20120172350A1 (en) * | 2009-09-11 | 2012-07-05 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
EP2480078A4 (de) | 2009-09-23 | 2013-03-06 | Medivation Technologies Inc | Pyrido-[4,3-b-]indole und verwendungsverfahren dafür |
WO2011038163A1 (en) | 2009-09-23 | 2011-03-31 | Medivation Technologies, Inc. | Pyrido[3,4-b]indoles and methods of use |
EP2480081A4 (de) | 2009-09-23 | 2013-03-06 | Medivation Technologies Inc | Gebrückte heterocyclische verbindungen und verfahren zu ihrer verwendung |
WO2011039675A2 (en) * | 2009-09-30 | 2011-04-07 | Pfizer Inc. | Latrepirdine transdermal therapeutic dosage forms |
JP6082250B2 (ja) | 2010-02-09 | 2017-02-15 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 認知機能を改善するための方法および組成物 |
TR201001117A1 (tr) * | 2010-02-15 | 2011-09-21 | Sanovel İlaç San.Ve Ti̇c.A.Ş. | Dimebolin ve memantin kombinasyonları |
WO2011103485A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
WO2011103433A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
WO2011103430A1 (en) | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
WO2012016708A1 (en) * | 2010-08-06 | 2012-02-09 | Ratiopharm Gmbh | Oral dosage form comprising dimebolin and donepezil |
PE20131394A1 (es) | 2010-09-23 | 2014-01-11 | Abbvie Inc | Monohidrato de derivados de aza-adamantano |
US20140303144A1 (en) | 2011-02-18 | 2014-10-09 | Medivation Technologies, Inc. | Compounds and methods of treating hypertension |
AU2012254158B2 (en) | 2011-02-18 | 2016-02-04 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
US20140155384A1 (en) | 2011-02-18 | 2014-06-05 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
WO2012112964A2 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE |
WO2012122405A2 (en) * | 2011-03-08 | 2012-09-13 | The Trustees Of Columbia University In The City Of New York | Screening assays using stem cells and stem cell-derived neurons from mouse models of alzheimer's disease |
DE102012003065A1 (de) * | 2012-02-13 | 2013-08-14 | Friedrich-Schiller-Universität Jena | Neue bivalente Gammacarbolinderivate sowie deren Herstellung und Verwendung als Antidementiva |
WO2013130422A1 (en) | 2012-02-27 | 2013-09-06 | Biovista, Inc. | Compositions and methods for treating mitochondrial diseases |
EP3666272A1 (de) * | 2012-05-08 | 2020-06-17 | Forum Pharmaceuticals Inc. | Verwendung von encenicline bei der behandlung von kognitiver behinderung, alzheimer-krankheit, speicherdefizit |
EP2866894A4 (de) * | 2012-06-27 | 2016-03-16 | Univ Miami | Zusammensetzung und verfahren zur behandlung von morbus alzheimer |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
RU2496465C1 (ru) * | 2012-11-15 | 2013-10-27 | Борис Николаевич Анисимов | Способ профилактики развития и прогрессирования болезни альцгеймера на курортном этапе |
WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
WO2016179217A1 (en) * | 2015-05-06 | 2016-11-10 | Ohio University | Metal ion chelation for enhancing the effect of tissue plasminogen activator (tpa) in thromobolysis |
CN112843005B (zh) | 2015-05-22 | 2023-02-21 | 艾吉因生物股份有限公司 | 左乙拉西坦的延时释放药物组合物 |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
US10639315B1 (en) | 2019-05-21 | 2020-05-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating Alzheimer's disease |
US11690849B2 (en) | 2019-04-12 | 2023-07-04 | LA PharmaTech Inc. | Method of treating dementia |
US10966989B2 (en) | 2019-04-12 | 2021-04-06 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders |
US11938139B2 (en) | 2019-04-12 | 2024-03-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders |
US11744833B2 (en) | 2019-04-12 | 2023-09-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of insomnia |
US11389458B2 (en) | 2019-04-12 | 2022-07-19 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating parkinson's and huntington's disease |
US11318144B2 (en) | 2019-04-12 | 2022-05-03 | LA PharmaTech Inc. | Compositions and methods for treating Alzheimer's disease and Parkinson's disease |
US10898493B2 (en) | 2019-04-12 | 2021-01-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for psychiatric symptoms of patients with Alzheimer's disease |
US10639314B1 (en) | 2019-04-30 | 2020-05-05 | LA PharmaTech Inc. | Method of treating Alzheimer's disease |
JP2022529476A (ja) | 2019-04-17 | 2022-06-22 | コンパス パスファインダー リミテッド | 不安障害、頭痛障害、及び摂食障害をサイロシビンで治療するための方法 |
CN114072945A (zh) * | 2019-05-21 | 2022-02-18 | La药研科技公司 | 用于治疗精神障碍、行为障碍、认知障碍的新型药物组合物和方法 |
CA3187020A1 (en) * | 2020-06-12 | 2021-12-16 | Beckley Psytech Limited | Composition comprising a benzoate salt of 5-methoxy-n,n-dimethyltryptamine |
US11351179B1 (en) | 2021-08-05 | 2022-06-07 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of psychiatric disorders |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
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DE1813229A1 (de) | 1967-12-08 | 1970-08-20 | Sumitomo Chemical Co | gamma-Carboline und ihre Salze und Verfahren zu ihrer Herstellung |
DE1952800C3 (de) | 1969-10-20 | 1974-04-18 | Nautschno-Issledowatelskij Institut Farmakologii I Chimioterapii, Moskau | 3,6-Dimethyl-l,2,3,4,4a,9a-hexahydro-gamma-carbolin-dihydrochlorid |
US3718657A (en) | 1970-12-03 | 1973-02-27 | Abbott Lab | Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines |
IL74497A (en) | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
US4663318A (en) | 1986-01-15 | 1987-05-05 | Bonnie Davis | Method of treating Alzheimer's disease |
NL195004C (nl) | 1987-03-04 | 2003-11-04 | Novartis Ag | Fenylcarbamaat bevattend farmaceutisch preparaat. |
FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
ES2059602T3 (es) | 1989-04-14 | 1994-11-16 | Merz & Co Gmbh & Co | Uso de derivados de adamantano para la prevencion y tratamiento de isquemia cerebral. |
US5614560A (en) | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
RU2106864C1 (ru) | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
WO1997046526A1 (en) | 1996-06-07 | 1997-12-11 | Eisai Co., Ltd. | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
TW513409B (en) | 1996-06-07 | 2002-12-11 | Eisai Co Ltd | Polymorphs of donepezil hydrochloride |
TW506836B (en) | 1996-06-14 | 2002-10-21 | Janssen Pharmaceutica Nv | Fast-dissolving galanthamine hydrobromide tablet |
JPH10259126A (ja) * | 1997-01-17 | 1998-09-29 | Takeda Chem Ind Ltd | アルツハイマー病治療・予防剤 |
PT1048653E (pt) | 1997-12-05 | 2004-07-30 | Eisai Co Ltd | Policristais de donepezil e processo para a sua producao |
DK1086706T3 (da) | 1999-03-31 | 2004-03-08 | Eisai Co Ltd | Stabiliserede sammensætninger indeholdende nootropiske lægemidler |
EP1633786A4 (de) | 2002-10-09 | 2007-07-25 | Rinat Neuroscience Corp | Verfahren zur behandlung der alzheimer-krankheit mit antikörpern gegen amyloid-beta-peptid und zusammensetzungen daraus |
WO2004037234A2 (en) * | 2002-10-24 | 2004-05-06 | Merz Pharma Gmbh & Co. Kgaa | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
RU2006101225A (ru) * | 2003-06-16 | 2006-06-10 | Аллерган, Инк. (Us) | Пероральные лекарственные формы мемантина |
RU2283108C2 (ru) | 2003-12-08 | 2006-09-10 | Сергей Олегович Бачурин | ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
RS51822B (en) * | 2005-04-04 | 2012-02-29 | Eisai R. &D. Management Co. Ltd. | DIHYDROPYRIDINE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES AND Dementia |
-
2007
- 2007-10-26 US US12/447,448 patent/US20100152108A1/en not_active Abandoned
- 2007-10-26 AU AU2007309390A patent/AU2007309390A1/en not_active Abandoned
- 2007-10-26 RU RU2009120048/15A patent/RU2009120048A/ru not_active Application Discontinuation
- 2007-10-26 WO PCT/US2007/022645 patent/WO2008051599A2/en active Application Filing
- 2007-10-26 EP EP07867284A patent/EP2086538B1/de not_active Not-in-force
- 2007-10-26 AT AT07867284T patent/ATE549021T1/de active
- 2007-10-26 JP JP2009534657A patent/JP2010507672A/ja active Pending
- 2007-10-26 SG SG2012004289A patent/SG178000A1/en unknown
- 2007-10-26 CN CN200780048266A patent/CN101631547A/zh active Pending
- 2007-10-26 KR KR1020097010803A patent/KR20090087009A/ko not_active Application Discontinuation
- 2007-10-26 BR BRPI0718437-9A2A patent/BRPI0718437A2/pt not_active Application Discontinuation
- 2007-10-26 CA CA002667553A patent/CA2667553A1/en not_active Abandoned
- 2007-10-26 MX MX2009004516A patent/MX2009004516A/es not_active Application Discontinuation
- 2007-10-26 EP EP11181674A patent/EP2420235A1/de not_active Withdrawn
-
2009
- 2009-04-26 IL IL198405A patent/IL198405A0/en unknown
- 2009-05-26 NO NO20092051A patent/NO20092051L/no not_active Application Discontinuation
-
2012
- 2012-05-10 IL IL219709A patent/IL219709A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2086538B1 (de) | 2012-03-14 |
BRPI0718437A2 (pt) | 2013-11-19 |
WO2008051599A2 (en) | 2008-05-02 |
JP2010507672A (ja) | 2010-03-11 |
KR20090087009A (ko) | 2009-08-14 |
EP2086538A2 (de) | 2009-08-12 |
MX2009004516A (es) | 2009-08-12 |
NO20092051L (no) | 2009-07-22 |
EP2420235A1 (de) | 2012-02-22 |
AU2007309390A1 (en) | 2008-05-02 |
SG178000A1 (en) | 2012-02-28 |
IL198405A0 (en) | 2010-02-17 |
CN101631547A (zh) | 2010-01-20 |
IL219709A0 (en) | 2012-06-28 |
CA2667553A1 (en) | 2008-05-02 |
US20100152108A1 (en) | 2010-06-17 |
WO2008051599A3 (en) | 2008-07-24 |
RU2009120048A (ru) | 2010-12-10 |
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