ATE419863T1 - Pyy3-36 zur zur reduzierung oder vorbeugung von fettleibigkeit - Google Patents
Pyy3-36 zur zur reduzierung oder vorbeugung von fettleibigkeitInfo
- Publication number
- ATE419863T1 ATE419863T1 AT02768992T AT02768992T ATE419863T1 AT E419863 T1 ATE419863 T1 AT E419863T1 AT 02768992 T AT02768992 T AT 02768992T AT 02768992 T AT02768992 T AT 02768992T AT E419863 T1 ATE419863 T1 AT E419863T1
- Authority
- AT
- Austria
- Prior art keywords
- pyy3
- reducing
- preventing obesity
- subject
- decreasing
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title 1
- 235000020824 obesity Nutrition 0.000 title 1
- 235000019577 caloric intake Nutrition 0.000 abstract 2
- 230000003247 decreasing effect Effects 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 235000019789 appetite Nutrition 0.000 abstract 1
- 230000036528 appetite Effects 0.000 abstract 1
- 235000012631 food intake Nutrition 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Birds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Liquid Developers In Electrophotography (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Plural Heterocyclic Compounds (AREA)
- Fats And Perfumes (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Lasers (AREA)
- Toilet Supplies (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32440601P | 2001-09-24 | 2001-09-24 | |
GBGB0200507.2A GB0200507D0 (en) | 2002-01-10 | 2002-01-10 | Appetite suppression |
US39210902P | 2002-06-28 | 2002-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE419863T1 true ATE419863T1 (de) | 2009-01-15 |
Family
ID=27256373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02768992T ATE419863T1 (de) | 2001-09-24 | 2002-09-24 | Pyy3-36 zur zur reduzierung oder vorbeugung von fettleibigkeit |
Country Status (19)
Country | Link |
---|---|
US (2) | US7459432B2 (de) |
EP (2) | EP2050460A1 (de) |
JP (3) | JP2005508324A (de) |
KR (1) | KR100989647B1 (de) |
CN (1) | CN100350968C (de) |
AT (1) | ATE419863T1 (de) |
AU (1) | AU2002332054B2 (de) |
BR (1) | BR0212985A (de) |
CA (1) | CA2461345A1 (de) |
DE (1) | DE60230818D1 (de) |
DK (1) | DK1499277T3 (de) |
ES (1) | ES2320979T3 (de) |
HK (1) | HK1070281A1 (de) |
HU (1) | HU228621B1 (de) |
IL (3) | IL160983A0 (de) |
MX (1) | MXPA04002751A (de) |
NZ (1) | NZ532427A (de) |
PL (1) | PL205971B1 (de) |
WO (1) | WO2003026591A2 (de) |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
US7745216B2 (en) | 1999-02-10 | 2010-06-29 | Curis, Inc. | Methods and reagents for treating glucose metabolic disorders |
JP2003518914A (ja) | 1999-02-10 | 2003-06-17 | キュリス インコーポレイテッド | グルコース代謝障害を治療する方法および試薬 |
US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
EP1349563B1 (de) | 2000-12-14 | 2009-12-02 | Amylin Pharmaceuticals, Inc. | Peptid pyy[3-36] zur behandlung von stoffwechselkrankheiten |
GB0121709D0 (en) | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
CN100350968C (zh) | 2001-09-24 | 2007-11-28 | 皇家创新有限公司 | 饮食行为的改进 |
WO2003027637A2 (en) | 2001-09-24 | 2003-04-03 | Oregon Health And Science University | Assessment of neurons in the arcuate nucleus to screen for agents that modify feeding behavior |
US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
WO2004056314A2 (en) * | 2002-12-17 | 2004-07-08 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity |
US7166575B2 (en) * | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
US7229966B2 (en) * | 2002-12-17 | 2007-06-12 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity |
US7186692B2 (en) * | 2002-12-17 | 2007-03-06 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
GB0300571D0 (en) | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
CN1964630A (zh) | 2003-02-13 | 2007-05-16 | 耶希瓦大学艾伯塔·爱恩斯坦医学院 | 通过控制下丘脑的长链脂肪酰基-辅酶A(LC-CoA)的水平来调控食物摄取和葡萄糖产生 |
US8008255B2 (en) | 2003-05-30 | 2011-08-30 | Amylin Pharmaceuticals, Inc. | Methods and compositions for enhanced transmucosal delivery of peptides and proteins |
CA2539548A1 (en) | 2003-09-18 | 2005-03-31 | Conforma Therapeutics Corporation | Novel heterocyclic compounds as hsp90-inhibitors |
WO2005077072A2 (en) | 2004-02-11 | 2005-08-25 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
EP2335716A3 (de) * | 2004-02-11 | 2011-10-19 | Amylin Pharmaceuticals Inc. | Pankreas-polypeptidfamilienmotive und diese enthaltende polypeptide |
EP1718671A2 (de) * | 2004-02-23 | 2006-11-08 | Rheoscience A/S | Peptid-yy-analoga |
EP1734963A4 (de) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | Verfahren zur behandlung von menschen mit metabolischen und anthropometrischen störungen |
GB0411014D0 (en) * | 2004-05-18 | 2004-06-23 | Haptogen Ltd | Methods for the control treatment and management of obesity |
US20070213270A1 (en) * | 2004-06-16 | 2007-09-13 | Costantino Henry R | Peptide yy formulations having increased stability and resistance to microbial agents |
EP1791553B1 (de) * | 2004-07-12 | 2013-10-23 | Emisphere Technologies, Inc. | Zusammensetzungen zur abgabe von peptid yy und pyy agonisten |
US20060210655A1 (en) * | 2004-10-07 | 2006-09-21 | Martin Grigorov | Bioactive compositions, natural methods of producing them and computational methods for designing natural production processes |
WO2006042242A2 (en) | 2004-10-08 | 2006-04-20 | Amylin Pharmaceuticals, Inc. | Amylin family polypeptide- 6 (afp- 6) analogs and methods of making and using them |
WO2006059106A2 (en) | 2004-12-02 | 2006-06-08 | Domantis Limited | Bispecific domain antibodies targeting serum albumin and glp-1 or pyy |
EP3000826A1 (de) | 2004-12-13 | 2016-03-30 | Amylin Pharmaceuticals, LLC | Motive der bauchspeicheldrüsen-polypeptid familie, polypeptide und methoden unter verwendung derselben |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US8052996B2 (en) | 2005-02-03 | 2011-11-08 | Intarcia Therapeutics, Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
PA8660701A1 (es) * | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
NZ561361A (en) | 2005-02-11 | 2010-02-26 | Amylin Pharmaceuticals Inc | GIP hybrid polypeptides with at least two hormonal activities |
US20090286723A1 (en) | 2005-02-11 | 2009-11-19 | Amylin Pharmaceuticals, Inc. | Hybrid Polypeptides with Selectable Properties |
US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
GB0504857D0 (en) | 2005-03-09 | 2005-04-13 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
GB0511986D0 (en) * | 2005-06-13 | 2005-07-20 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
EP2330125A3 (de) | 2005-08-11 | 2012-12-12 | Amylin Pharmaceuticals, Inc. | Hybridpolypeptide mit auswählbaren Eigenschaften |
EP1934254A1 (de) | 2005-09-21 | 2008-06-25 | 7TM Pharma A/S | Selektive y4 rezeptor agonisten für therapeutische eingriffe |
US7851590B2 (en) | 2005-09-21 | 2010-12-14 | 7Tm Pharma A/S | Y2 selective receptor agonists for therapeutic interventions |
BRPI0616463A2 (pt) | 2005-09-29 | 2011-06-21 | Merck & Co Inc | composto, composição farmacêutica, e, uso de um composto |
WO2007039318A2 (en) * | 2005-10-06 | 2007-04-12 | Bayer Schering Pharma Aktiengesellschaft | Neuropeptide y analogs |
US20080255084A1 (en) | 2005-10-21 | 2008-10-16 | Randy Lee Webb | Combination of Organic Compounds |
US20070232537A1 (en) * | 2005-12-19 | 2007-10-04 | Nastech Pharmaceutical Company Inc. | Intranasal pyy formulations with improved transmucosal pharmacokinetics |
WO2007085887A1 (en) * | 2006-01-27 | 2007-08-02 | Pfizer Products Inc. | Pyy agonists and uses thereof |
US8977517B2 (en) * | 2006-06-05 | 2015-03-10 | Creighton University | System and methods for evaluating efficacy of appetite-affecting drugs |
GB0613196D0 (en) | 2006-07-03 | 2006-08-09 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
PL2359808T3 (pl) | 2006-08-09 | 2013-10-31 | Intarcia Therapeutics Inc | Osmotyczne systemy dostawcze i zespoły tłokowe |
US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
EP2946778A1 (de) | 2006-09-22 | 2015-11-25 | Merck Sharp & Dohme Corp. | Behandlungsverfahren mit verwendung von fettsäuresyntheseinhibitoren |
TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
CA2682727C (en) | 2007-04-02 | 2016-03-22 | Banyu Pharmaceutical Co., Ltd. | Indoledione derivative |
IL290847B2 (en) | 2007-04-23 | 2024-11-01 | Intarcia Therapeutics Inc | Suspension formulations of insulinotropic peptides and their uses |
JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US7814038B1 (en) * | 2007-12-06 | 2010-10-12 | Dominic John Repici | Feedback-tolerant method and device producing weight-adjustment factors for pre-synaptic neurons in artificial neural networks |
EP2247743B1 (de) * | 2008-02-08 | 2016-04-06 | Ambrx, Inc. | Modifizierte leptin-polypeptide und deren verwendungen |
US8343140B2 (en) * | 2008-02-13 | 2013-01-01 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
EP2810951B1 (de) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase |
EP3241839B1 (de) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
US8410284B2 (en) | 2008-10-22 | 2013-04-02 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
CN102271509A (zh) | 2008-10-31 | 2011-12-07 | 默沙东公司 | 用于抗糖尿病药的新型环苯并咪唑衍生物 |
WO2010090876A2 (en) | 2009-01-21 | 2010-08-12 | University Of Florida Research Foundation, Inc. | Satiation peptide administration |
US9260500B2 (en) | 2009-07-02 | 2016-02-16 | Takeda Pharmaceutical Company Limited | Peptide and use thereof |
RU2753280C2 (ru) | 2009-09-28 | 2021-08-12 | Интарсия Терапьютикс, Инк. | Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства |
GB201001333D0 (en) | 2010-01-27 | 2010-03-17 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
CA2786314A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
PT2651398T (pt) | 2010-12-16 | 2018-03-09 | Novo Nordisk As | Composições sólidas compreendendo um agonista de glp-1 e um sal de ácido n-(8-(2-hidroxibenzoil)amino) caprílico |
GB201101459D0 (en) * | 2011-01-27 | 2011-03-16 | Imp Innovations Ltd | Novel compounds and thier effects on fedding behaviour |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
CN103476258B (zh) | 2011-02-25 | 2017-04-26 | 默沙东公司 | 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物 |
CA2834288A1 (en) | 2011-04-25 | 2012-11-01 | Advanced Bioscience Laboratories, Inc. | Truncated hiv envelope proteins (env), methods and compositions related thereto |
ES2690553T3 (es) | 2012-03-22 | 2018-11-21 | Novo Nordisk A/S | Composiciones de péptidos GLP-1 y preparación de estas |
US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
CA2880901A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
US9011365B2 (en) | 2013-03-12 | 2015-04-21 | Medibotics Llc | Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food |
US9067070B2 (en) | 2013-03-12 | 2015-06-30 | Medibotics Llc | Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type |
EP2970119B1 (de) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Neuartige indolderivate als antidiabetika |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
EP2968439A2 (de) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Zusammensetzungen zur behandlung von magen-darm-störungen |
DK2983690T3 (da) * | 2013-04-10 | 2019-05-20 | Univ Copenhagen | Neuropeptid Y-afledte peptider |
WO2014178018A1 (en) * | 2013-05-02 | 2014-11-06 | Glaxosmithkline Intellectual Property Development Limited | Therapeutic peptides |
US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
EP4424697A2 (de) | 2013-06-05 | 2024-09-04 | Bausch Health Ireland Limited | Ultrareine agonisten der guanylatcyclase c, verfahren zur herstellung und verwendung davon |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
JP6629198B2 (ja) | 2013-11-15 | 2020-01-15 | ノヴォ ノルディスク アー/エス | 35位にβ−ホモアルギニン置換を有するHPYY(1−36) |
SI3068421T1 (sl) | 2013-11-15 | 2019-08-30 | Novo Nordisk A/S | Selektivne spojine PYY in njihova uporaba |
US20170137486A1 (en) | 2014-05-23 | 2017-05-18 | Imperial Innovations Limited | Peptide yy (pyy) analogues |
WO2016030534A1 (en) | 2014-08-29 | 2016-03-03 | Tes Pharma S.R.L. | INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
CN107920884B (zh) | 2015-06-03 | 2021-08-27 | 因塔西亚制药公司 | 植入物放置和移除系统 |
EP3307768A1 (de) | 2015-06-12 | 2018-04-18 | Novo Nordisk A/S | Selektive pyy-verbindungen und verwendungen davon |
KR101604212B1 (ko) * | 2015-07-17 | 2016-03-17 | 울산대학교 산학협력단 | Nad를 함유하는 비만 또는 내당능장애의 예방 및 치료용 조성물 |
US20170174614A1 (en) | 2015-12-22 | 2017-06-22 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
CA3007286A1 (en) | 2015-12-22 | 2017-06-29 | Zogenix International Limited | Fenfluramine compositions and methods of preparing the same |
US11311633B2 (en) | 2016-04-16 | 2022-04-26 | University Of Florida Research Foundation, Incorporated | Satiation peptides for weight loss and altered taste sensitivity |
WO2017200943A1 (en) | 2016-05-16 | 2017-11-23 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
MX2019001799A (es) | 2016-08-24 | 2019-06-13 | Zogenix International Ltd | Formulacion para inhibir la formacion de agonistas de 5-ht2b y metodos de utilizacion de la misma. |
AU2017342083A1 (en) | 2016-10-14 | 2019-04-11 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
WO2018129058A1 (en) | 2017-01-03 | 2018-07-12 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug |
EP3625247A4 (de) * | 2017-05-16 | 2021-03-24 | The University of Chicago | Zusammensetzungen und verfahren zur behandlung und/oder vorbeugung von pathogenen pilzinfektionen und zur aufrechterhaltung von mikrobiomkommensalismus |
US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
GB201720188D0 (en) | 2017-12-04 | 2018-01-17 | Imperial Innovations Ltd | Analogues of PYY |
AU2019211322A1 (en) | 2018-01-23 | 2020-07-23 | Gila Therapeutics, Inc. | Peptide YY pharmaceutical formulations, compositions, and methods |
SG11202006595RA (en) | 2018-02-02 | 2020-08-28 | Novo Nordisk As | Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant |
GB2573145A (en) * | 2018-04-26 | 2019-10-30 | Univ Ulster | Peptides for metabolic disease |
WO2019216919A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
CN113302189A (zh) | 2018-11-20 | 2021-08-24 | Tes制药有限责任公司 | α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂 |
US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
CN113092427A (zh) * | 2021-04-02 | 2021-07-09 | 南京中医药大学 | 异硫氰酸荧光素在标记β内啡肽中的应用 |
Family Cites Families (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4175122A (en) | 1975-04-15 | 1979-11-20 | Burroughs Wellcome Co. | Biologically active amides |
US4223017A (en) | 1975-04-15 | 1980-09-16 | Burroughs Wellcome Co. | Biologically active amides |
GB1560933A (en) | 1975-04-15 | 1980-02-13 | Wellcome Found | Biologically activy polypeptides |
US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
US4220653A (en) * | 1979-01-24 | 1980-09-02 | Vivino A Earl | Administration of cimetidine to reduce appetite and facilitate weight loss in persons suffering from excessive weight |
US4229389A (en) | 1979-03-16 | 1980-10-21 | Thompson Marine Corporation | Gas diffuser, aerator, or sparger apparatus |
DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
JPS58118008A (ja) | 1982-01-06 | 1983-07-13 | Nec Corp | デ−タ処理装置 |
DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
JPS607934A (ja) | 1983-06-29 | 1985-01-16 | Dai Ichi Seiyaku Co Ltd | リポソ−ムの製造方法 |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
DE3483949D1 (de) * | 1983-09-26 | 1991-02-21 | Udo Dr Med Ehrenfeld | Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr. |
EP0143949B1 (de) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmazeutische Zusammensetzung mit Gehalt an Urokinase |
US4701441A (en) | 1985-02-11 | 1987-10-20 | University Of Florida | Methods and compositions for stimulation of appetite |
US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
CA1257199A (en) | 1986-05-20 | 1989-07-11 | Paul Y. Wang | Preparation containing bioactive macromolecular substance for multi-months release in vivo |
HU196755B (en) | 1986-09-16 | 1989-01-30 | Gyogyszerkutato Intezet | Process for production of new substituated amilid derivatives and medical compositions containing them |
IE63869B1 (en) | 1986-11-06 | 1995-06-14 | Res Dev Foundation | Aerosols containing liposomes and method for their preparation |
JP2887325B2 (ja) | 1988-06-28 | 1999-04-26 | ラ ホヤ キャンサー リサーチ ファウンデーション | デコリンによる細胞増殖の抑制 |
US5026685A (en) | 1988-07-15 | 1991-06-25 | The Salk Institute For Biological Studies | NPY peptide analogs |
US5349052A (en) | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
DE68925966T2 (de) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
SE9002278L (sv) | 1990-06-28 | 1991-12-29 | Perstorp Ab | Anvaendning av inositoltrisfosfat foer framstaellning av ett laekemedel |
IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
US5571695A (en) | 1991-11-06 | 1996-11-05 | Garvan Institute Of Medical Research | Human neuropeptide Y-Y1 receptor |
DK39892D0 (da) | 1992-03-25 | 1992-03-25 | Bernard Thorens | Peptid |
EP0619332B1 (de) | 1992-10-28 | 1998-02-25 | Kuraray Co., Ltd. | Polyurethan sowie daraus hergestellte lederähnliche folie |
JP2961045B2 (ja) * | 1993-02-24 | 1999-10-12 | 日清製粉株式会社 | 腸管粘膜増強促進剤 |
PL310897A1 (en) | 1993-03-29 | 1996-01-08 | Univ Cincinnati | Analogues of yy peptide and their application |
WO1995000162A1 (en) | 1993-06-21 | 1995-01-05 | Enzon, Inc. | Site specific synthesis of conjugated peptides |
GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5965566A (en) | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5545549A (en) | 1994-02-03 | 1996-08-13 | Synaptic Pharmaceutical Corporation | DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof |
US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
US5696093A (en) | 1994-10-28 | 1997-12-09 | Crc For Biopharmaceutical Research Pty Limited | Method of treating nasal congestion using neuropeptide Y Y2 agonist peptides |
WO1996014336A1 (fr) | 1994-11-07 | 1996-05-17 | Kyowa Hakko Kogyo Co., Ltd. | Nouvelle oxyntomoduline |
US6001970A (en) | 1994-11-07 | 1999-12-14 | Merck & Co., Inc | Modified human neuropeptide Y1 Receptors |
US5574010A (en) | 1994-11-14 | 1996-11-12 | The Regents Of The University Of California | Treatment of pancreatic tumors with peptide YY and analogs thereof |
US5602024A (en) | 1994-12-02 | 1997-02-11 | Synaptic Pharmaceutical Corporation | DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof |
US5989920A (en) * | 1994-12-02 | 1999-11-23 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5 |
US5907030A (en) | 1995-01-25 | 1999-05-25 | University Of Southern California | Method and compositions for lipidization of hydrophilic molecules |
US5912227A (en) | 1995-01-27 | 1999-06-15 | North Carolina State University | Method of enhancing nutrient uptake |
US6558708B1 (en) * | 1995-05-17 | 2003-05-06 | Cedars-Sinai Medical Center | Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia |
US5635503A (en) | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Company | Dihydropyridine npy antagonists: piperazine derivatives |
US5668151A (en) | 1995-06-07 | 1997-09-16 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: piperidine derivatives |
AU1328197A (en) | 1995-12-01 | 1997-06-19 | Synaptic Pharmaceutical Corporation | Aryl sulfonamide and sulfamide derivatives and uses thereof |
BR9707336B1 (pt) | 1996-02-02 | 2009-01-13 | dispositivo de embebição de fluido adequado para dosagem de leuprolida em um ambiente fluido de uso. | |
US5962270A (en) | 1996-02-06 | 1999-10-05 | Bionebraska, Inc. | Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs |
US5965392A (en) | 1996-04-08 | 1999-10-12 | Bayer Corporation | Neuropeptide Y receptor Y5 and nucleic acid sequences |
US5919901A (en) * | 1996-04-08 | 1999-07-06 | Bayer Corporation | Neuropeptide Y receptor Y5 and nucleic acid sequences |
US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
AUPO029096A0 (en) | 1996-06-05 | 1996-07-04 | Crc For Biopharmaceutical Research Pty Ltd | Npy y2 agonists |
US6355478B1 (en) | 1996-06-17 | 2002-03-12 | Eli Lilly And Company | Rhesus monkey neuropeptide Y Y2 receptor |
US6268343B1 (en) * | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
US6458924B2 (en) * | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
CN1271086C (zh) | 1996-08-30 | 2006-08-23 | 诺沃挪第克公司 | Glp-1衍生物 |
UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
ATE366584T1 (de) | 1996-11-12 | 2007-08-15 | Novo Nordisk As | Verwendung von glp-1 peptiden |
JP2000505105A (ja) | 1996-11-13 | 2000-04-25 | ユニヴァーシティ・オブ・シンシナティ | ペプチドyyのアナログおよびその使用 |
WO1998030231A1 (en) * | 1997-01-07 | 1998-07-16 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the reduction of food intake |
AU5773798A (en) | 1997-01-29 | 1998-08-18 | Polymasc Pharmaceuticals Plc | Pegylation process |
US6048900A (en) | 1998-02-13 | 2000-04-11 | Bayer Corporation | Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists |
US6001836A (en) | 1997-05-28 | 1999-12-14 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: cyanoguanidine derivatives |
US5889016A (en) | 1997-06-26 | 1999-03-30 | Bristol-Myers Squibb Company | Dihydropyrimidone derivatives as NPY antagonists |
US6093692A (en) | 1997-09-25 | 2000-07-25 | The University Of Southern California | Method and compositions for lipidization of hydrophilic molecules |
EP0920864A1 (de) | 1997-12-03 | 1999-06-09 | Pfizer Products Inc. | Kombinationstherapie durch einen spezifischen beta-3 Agonisten und einen Appetithemmer |
EP2433623A1 (de) * | 1998-02-02 | 2012-03-28 | Trustees Of Tufts College | Verwendung von Dipetidylpeptidasehemmer zur Regulierung des Glukosemetabolismus |
FR2774674B1 (fr) | 1998-02-10 | 2000-03-24 | Atochem Elf Sa | Procede de preparation d'une solution aqueuse de peroxyde d'hydrogene directement a partir d'hydrogene et d'oxygene et dispositif permettant sa mise en oeuvre |
DE69942307D1 (de) | 1998-02-27 | 2010-06-10 | Novo Nordisk As | N-terminal veränderte glp-1 abkömmlinge |
US6046167A (en) | 1998-03-25 | 2000-04-04 | University Of Cincinnati | Peptide YY analogs |
FR2777283B1 (fr) | 1998-04-10 | 2000-11-24 | Adir | Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5993414A (en) | 1998-04-23 | 1999-11-30 | Medtronic, Inc. | Implantable device |
NZ507763A (en) | 1998-04-29 | 2003-06-30 | Ortho Mcneil Pharm Inc | N-substituted aminotetralin sulphonamide derivatives useful as ligands for the neuropeptide Y Y5 receptor used in the treatment of obesity and other disorders |
CA2346363A1 (en) | 1998-10-07 | 2000-04-13 | Ortho-Mcneil Pharmaceutical, Inc. | N-aralkylaminotetralins as ligands for the neuropeptide y y5 receptor |
TWI242000B (en) | 1998-12-10 | 2005-10-21 | Univ Southern California | Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use |
JP2002534512A (ja) | 1999-01-15 | 2002-10-15 | ノボ ノルディスク アクティーゼルスカブ | 非ペプチドglp−1アゴニスト |
JP2003518914A (ja) * | 1999-02-10 | 2003-06-17 | キュリス インコーポレイテッド | グルコース代謝障害を治療する方法および試薬 |
US6407120B1 (en) | 1999-02-18 | 2002-06-18 | Pfizer Inc. | Neuropeptide Y antagonists |
CA2369549A1 (en) | 1999-04-02 | 2000-10-12 | Robert W. Desimone | Aryl and heteroaryl fused aminoalkyl-imidazole derivatives and their use as antidiabetics |
US6218408B1 (en) | 1999-06-30 | 2001-04-17 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (bicyclics) |
US6340683B1 (en) | 1999-04-22 | 2002-01-22 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (triazines) |
AU4659200A (en) | 1999-05-05 | 2000-11-21 | Ortho-Mcneil Pharmaceutical, Inc. | 3a,4,5,9b-tetrahydro-1h-benz(e)indol-2-yl amine-derived neuropeptide Y receptors ligands useful in the treatment of obesity and other disorders |
US7601691B2 (en) * | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
ATE372782T1 (de) | 1999-06-21 | 2007-09-15 | Lilly Co Eli | Synergitische verwendung von thiazolidinedionen und glucagon-ähnlichem peptid-1 und dessen agonisten für die behandlung von nicht-insulin- abhängigen diabetes |
US6225330B1 (en) | 1999-06-30 | 2001-05-01 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (tricyclics) |
EP1076066A1 (de) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptide zur Senkung des Blutglukosespiegels |
US6399631B1 (en) | 1999-07-23 | 2002-06-04 | Pfizer Inc. | Carbazole neuropeptide Y5 antagonists |
EP1493742A1 (de) | 1999-07-28 | 2005-01-05 | Ortho-Mcneil Pharmaceutical, Inc. | Amine und Amide als Liganden für den Neuropeptid-Y Y5 Rezeptor, und ihre Verwendung zur Herstellung von Fettleibigkeit und anderen Erkrankungen |
EP1207161B1 (de) | 1999-08-25 | 2006-01-18 | Banyu Pharmaceutical Co., Ltd. | Isoindolderivate |
CA2381111A1 (en) | 1999-08-26 | 2001-03-01 | Leah M. Giupponi | Npy antagonists: spiroisoquinolinone derivatives |
WO2001014368A1 (en) | 1999-08-26 | 2001-03-01 | Viropharma Incorporated | Compounds, compositions and methods for treating influenza |
CA2379585C (en) | 1999-09-30 | 2006-06-20 | James W. Darrow | Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines |
EP1239871A1 (de) | 1999-11-12 | 2002-09-18 | Novo Nordisk A/S | Verwendung von glp-1-agonisten zur hemmung der degeneration von beta-zellen |
US6436091B1 (en) | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
CN101898982B (zh) * | 1999-11-26 | 2012-07-04 | 盐野义制药株式会社 | Npy y5拮抗剂 |
ES2227115T5 (es) | 2000-01-10 | 2014-10-30 | Amylin Pharmaceuticals, Inc. | Utilización de exendinas y sus agonistas para el tratamiento de la hipertrigliceridemia |
AU2001237254A1 (en) | 2000-03-08 | 2001-09-17 | Novo-Nordisk A/S | Lowering serum lipids |
AU2001254686A1 (en) | 2000-03-16 | 2001-09-24 | Bayer Aktiengesellschaft | Regulation of human neuropeptide y-like g protein-coupled receptor |
IL142707A0 (en) * | 2000-04-27 | 2002-03-10 | Pfizer Prod Inc | Methods of treating obesity using a neurotensin receptor ligand |
US6444675B2 (en) | 2000-05-10 | 2002-09-03 | Bristol-Myers Squibb Company | 4-alkyl and 4-cycloalkyl derivatives of dihydropyridine NPY antagonists |
US6432960B2 (en) | 2000-05-10 | 2002-08-13 | Bristol-Myers Squibb Company | Squarate derivatives of dihydropyridine NPY antagonists |
WO2001087335A2 (en) | 2000-05-17 | 2001-11-22 | Eli Lilly And Company | Method for selectively inhibiting ghrelin action |
US6256216B1 (en) * | 2000-05-18 | 2001-07-03 | Integrated Device Technology, Inc. | Cam array with minimum cell size |
US6391881B2 (en) | 2000-05-19 | 2002-05-21 | Bristol-Myers Squibb Company | Thiourea derivatives of dihydropyridine NPY antagonists |
CA2407784C (en) | 2000-05-19 | 2014-08-26 | Bionebraska, Inc. | Treatment of acute coronary syndrome with glp-1 |
CN101301294A (zh) | 2000-07-06 | 2008-11-12 | 症变治疗公司 | Fbp酶抑制剂与抗糖尿病药联合用于治疗糖尿病 |
US6420352B1 (en) | 2000-07-19 | 2002-07-16 | W. Roy Knowles | Hair loss prevention |
US6586403B1 (en) * | 2000-07-20 | 2003-07-01 | Salpep Biotechnology, Inc. | Treating allergic reactions and inflammatory responses with tri-and dipeptides |
US6900226B2 (en) * | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
US20020156010A1 (en) * | 2000-11-20 | 2002-10-24 | Lustig Robert H. | Method of treating obesity in adult patients exhibiting primary insulin hypersecretion |
EP1349563B1 (de) * | 2000-12-14 | 2009-12-02 | Amylin Pharmaceuticals, Inc. | Peptid pyy[3-36] zur behandlung von stoffwechselkrankheiten |
WO2002066479A1 (fr) | 2001-02-23 | 2002-08-29 | Banyu Pharmaceutical Co.,Ltd. | Derives de l'isoindole |
WO2002067918A1 (fr) | 2001-02-27 | 2002-09-06 | Banyu Pharmaceutical Co., Ltd. | Nouveau derive de diallylmethylamine |
JP2005500338A (ja) * | 2001-07-26 | 2005-01-06 | シェーリング コーポレイション | 置換尿素神経ペプチドyy5レセプターアンタゴニスト |
GB0121709D0 (en) | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
CN100350968C (zh) | 2001-09-24 | 2007-11-28 | 皇家创新有限公司 | 饮食行为的改进 |
EP2329839B1 (de) | 2002-01-10 | 2015-09-16 | Imperial Innovations Limited | Änderung des Fütterverhaltens durch GLP-1 und PYY |
US8058233B2 (en) * | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
US7166575B2 (en) * | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
GB0300571D0 (en) * | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
ES2512499T3 (es) * | 2003-04-08 | 2014-10-24 | Yeda Research And Development Co., Ltd. | Fármacos pegilados reversibles |
CN1220702C (zh) | 2003-07-30 | 2005-09-28 | 北京中科亚光生物科技有限公司 | 促胰岛素分泌肽及其用途 |
WO2005035761A1 (en) | 2003-10-16 | 2005-04-21 | Compugen Ltd. | Splice variants of preproglucagon, glucagon-like peptide-1 and oxyntomodulin |
KR20070039911A (ko) | 2004-06-01 | 2007-04-13 | 도만티스 리미티드 | 증강된 혈청 반감기를 가지는 이특이성 융합 항체 |
PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
GB0504857D0 (en) | 2005-03-09 | 2005-04-13 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
KR101349808B1 (ko) | 2005-06-13 | 2014-02-13 | 임페리얼 이노베이션스 리미티드 | 섭취행동에 관한 신규 화합물들 및 이들의 효능 |
WO2007056362A2 (en) | 2005-11-07 | 2007-05-18 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting physiological solubility and stability |
CA2638800A1 (en) | 2006-02-22 | 2007-09-07 | Merck & Co., Inc. | Oxyntomodulin derivatives |
CA2654055A1 (en) | 2006-06-07 | 2007-12-21 | Human Genome Sciences, Inc. | Albumin fusion proteins |
GB0613196D0 (en) | 2006-07-03 | 2006-08-09 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
-
2002
- 2002-09-24 CN CNB028185846A patent/CN100350968C/zh not_active Expired - Fee Related
- 2002-09-24 KR KR1020097023184A patent/KR100989647B1/ko not_active IP Right Cessation
- 2002-09-24 MX MXPA04002751A patent/MXPA04002751A/es active IP Right Grant
- 2002-09-24 AT AT02768992T patent/ATE419863T1/de not_active IP Right Cessation
- 2002-09-24 HU HU0600337A patent/HU228621B1/hu not_active IP Right Cessation
- 2002-09-24 JP JP2003530230A patent/JP2005508324A/ja active Pending
- 2002-09-24 DK DK02768992T patent/DK1499277T3/da active
- 2002-09-24 DE DE60230818T patent/DE60230818D1/de not_active Expired - Lifetime
- 2002-09-24 US US10/490,776 patent/US7459432B2/en not_active Expired - Fee Related
- 2002-09-24 NZ NZ532427A patent/NZ532427A/en not_active IP Right Cessation
- 2002-09-24 ES ES02768992T patent/ES2320979T3/es not_active Expired - Lifetime
- 2002-09-24 BR BR0212985-0A patent/BR0212985A/pt not_active Application Discontinuation
- 2002-09-24 CA CA002461345A patent/CA2461345A1/en not_active Abandoned
- 2002-09-24 EP EP20080022583 patent/EP2050460A1/de not_active Withdrawn
- 2002-09-24 IL IL16098302A patent/IL160983A0/xx unknown
- 2002-09-24 PL PL374270A patent/PL205971B1/pl not_active IP Right Cessation
- 2002-09-24 EP EP02768992A patent/EP1499277B1/de not_active Expired - Lifetime
- 2002-09-24 AU AU2002332054A patent/AU2002332054B2/en not_active Ceased
- 2002-09-24 WO PCT/US2002/031944 patent/WO2003026591A2/en active Application Filing
-
2004
- 2004-03-21 IL IL160983A patent/IL160983A/en not_active IP Right Cessation
-
2005
- 2005-04-08 HK HK05103004.3A patent/HK1070281A1/xx not_active IP Right Cessation
-
2008
- 2008-08-29 US US12/202,197 patent/US8217001B2/en not_active Expired - Fee Related
-
2009
- 2009-06-15 IL IL199364A patent/IL199364A/en not_active IP Right Cessation
-
2010
- 2010-01-08 JP JP2010003242A patent/JP2010111694A/ja active Pending
-
2012
- 2012-11-29 JP JP2012260485A patent/JP6124565B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE419863T1 (de) | Pyy3-36 zur zur reduzierung oder vorbeugung von fettleibigkeit | |
WO2003057235A3 (en) | Modification of feeding behavior | |
DE60140693D1 (en) | Ankheiten | |
ATE427724T1 (de) | Systeme zum verschieben und/oder zuruckhalten von gewebe in den oberen atemwegen | |
HRP20041180A2 (en) | 11-beta-hidroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | |
ITMI20042132A1 (it) | Dispositivo e metodo per la terapia dell'obesita' | |
FI952060A (fi) | Menetelmä atsitromysiinin annostamiseksi | |
AU2003221684A1 (en) | Cancer treatment method comprising administering an erb-family inhibitor and a raf and/or ras inhibitor | |
AU2003252182A8 (en) | Therapeutic treatment for the metabolic syndrome and type 2 diabetes | |
ZA200500719B (en) | The use of the combination of ciclesonide and antihitamines for the treatment of allergic rhinitis. | |
MY122838A (en) | Treating allergic and inflammatory conditions | |
IS7417A (is) | Ambroxól til að meðhöndla kvalafullt ástand í munni og koki | |
AU2003272608A8 (en) | Modulating vesicular monoamine transporter trafficking and function: a novel approach for the treatment of parkinson's disease | |
AU2003218462A8 (en) | Treatment of obesity and other disorders associated with excessive food intake | |
HK1077755A1 (en) | Use of a paralpha agonist and metformin for the treatment of obesity ppar-alpha | |
WO2005009337A3 (en) | Treating severe acute respiratory syndrome | |
USD562460S1 (en) | Orthopedic bench | |
BRPI0412288A (pt) | uso de aivlosina para o tratamento, prevenção ou controle de doenças em virtude de brachyspira pilosicoli em porcos e ornithobacterium rhinotracheale em aves | |
NZ516651A (en) | 17-beta-decanoate-4estrene-3-one and 17-beta-cyclohexylpropionate-4-estrene-3-one for treating aggression and stimulating appetite in stags (deer) during puberty especially for promoting and obtaining stag's horn | |
TW200833336A (en) | Method of treatment of obesity | |
ES1048340U (es) | Dispositivo para evitar el ronquido y la apnea del sueño. | |
AU2003223528A1 (en) | Treatment for type 1 diabetes before and after expression of predisposition markers. | |
EP1487427A4 (de) | Verfahren zur prävention und behandlung von peripherer neuropathie durch verabreichung von desmethylselegilin | |
RU2002105274A (ru) | Способ иммунореабилитации больных хроническим бронхитом | |
BR9301908A (pt) | Aparelho contra apneia e ronco |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |