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ATE496634T1 - Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung - Google Patents

Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung

Info

Publication number
ATE496634T1
ATE496634T1 AT03078355T AT03078355T ATE496634T1 AT E496634 T1 ATE496634 T1 AT E496634T1 AT 03078355 T AT03078355 T AT 03078355T AT 03078355 T AT03078355 T AT 03078355T AT E496634 T1 ATE496634 T1 AT E496634T1
Authority
AT
Austria
Prior art keywords
pref
iii
pertussis
toxoid
agg
Prior art date
Application number
AT03078355T
Other languages
English (en)
Inventor
John R Vose
Raafat E Fahim
Gail E D Jackson
Larry U L Tan
Andrew Herbert
Leslie Boux
Luis Barreto
John Thipphawong
Michael H Klein
Original Assignee
Sanofi Pasteur Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/433,646 external-priority patent/US5877298A/en
Application filed by Sanofi Pasteur Ltd filed Critical Sanofi Pasteur Ltd
Application granted granted Critical
Publication of ATE496634T1 publication Critical patent/ATE496634T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT03078355T 1995-05-04 1996-05-02 Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung ATE496634T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/433,646 US5877298A (en) 1995-05-04 1995-05-04 Acellular pertussis vaccines and methods of preparing thereof
US50174395A 1995-07-12 1995-07-12

Publications (1)

Publication Number Publication Date
ATE496634T1 true ATE496634T1 (de) 2011-02-15

Family

ID=27029924

Family Applications (3)

Application Number Title Priority Date Filing Date
AT03078355T ATE496634T1 (de) 1995-05-04 1996-05-02 Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung
AT96911887T ATE221081T1 (de) 1995-05-04 1996-05-02 Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung
AT96911886T ATE228851T1 (de) 1995-05-04 1996-05-02 Azelluläre pertussis impfstoffe und verfahren zur herstellung

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT96911887T ATE221081T1 (de) 1995-05-04 1996-05-02 Azelluläre pertussis-impfstoffe und verfahren zu deren herstellung
AT96911886T ATE228851T1 (de) 1995-05-04 1996-05-02 Azelluläre pertussis impfstoffe und verfahren zur herstellung

Country Status (18)

Country Link
US (1) US6399076B2 (de)
EP (7) EP0824358B1 (de)
CN (2) CN100387618C (de)
AT (3) ATE496634T1 (de)
AU (2) AU710538B2 (de)
BR (2) BR9608115A (de)
CA (3) CA2433502A1 (de)
DE (3) DE69638326D1 (de)
DK (3) DK1393744T3 (de)
ES (2) ES2182971T3 (de)
FR (1) FR16C0015I2 (de)
HK (1) HK1016191A1 (de)
LU (1) LU93036I2 (de)
MX (1) MX9708481A (de)
NL (1) NL300804I2 (de)
NZ (2) NZ306392A (de)
PT (3) PT824358E (de)
WO (2) WO1996034883A1 (de)

Families Citing this family (34)

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FR2646776B1 (fr) * 1989-05-12 1994-06-03 Pasteur Institut Utilisation de preparations vaccinantes a base d'adenyl cyclase ou de bacteries les produisant en tant qu'antigenes protecteurs contre les effets des bordetella
CA2188424A1 (en) * 1994-04-28 1995-11-09 Akihiro Suehara Method of separating protective components of bordetella pertussis
US6696065B1 (en) * 1995-05-04 2004-02-24 Aventis Pastuer Limited Acellular pertussis vaccines and methods of preparation thereof
GB9611501D0 (en) * 1996-06-03 1996-08-07 Smithkline Beecham Biolog Vaccine compositions
CN100408095C (zh) * 1996-07-02 2008-08-06 康诺特实验室有限公司 多价dtp-polio疫苗
WO2000023107A1 (fr) * 1998-10-21 2000-04-27 The Kitasato Institute Preparations de vaccin contenant des toxines attenuees
CN1906307B (zh) * 2003-11-20 2011-08-24 圣诺菲·帕斯图尔公司 纯化百日咳毒素的方法及其中有用的肽
NZ555889A (en) * 2004-12-17 2009-07-31 Staat Der Nederlanden Vert Doo Deacylation of LPS in gram negative bacteria
US8124397B2 (en) * 2005-08-08 2012-02-28 Oregon Health & Science University Inactivating pathogens with oxidizing agents for vaccine production
EP1867638A1 (de) * 2006-06-16 2007-12-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren zur kovalenten Verknüpfung zweier Moleküle mittels Diels-Alder-Reaktion mit inversem Elektronenbedarf
EP2066344B2 (de) 2006-09-07 2016-06-29 GlaxoSmithKline Biologicals S.A. Inaktiviertes Poliovirus Mischimpfstoff
CN100537767C (zh) * 2007-04-29 2009-09-09 中国药品生物制品检定所 百日咳疫苗保护性抗原的重组表达及其应用
GB0822633D0 (en) * 2008-12-11 2009-01-21 Novartis Ag Formulation
US20100330158A1 (en) * 2009-03-31 2010-12-30 Innopharma, Llc Protein-assisted drug delivery system for the targeted administration of active agents
EP2430040A1 (de) 2009-05-11 2012-03-21 Novartis AG Antigenaufreinigungs­verfahren für pertactinantigen
EP2758429A4 (de) * 2011-09-20 2015-09-02 Bio Rad Laboratories Entfernung von virustötenden substanzen aus biomolekülpräparaten
WO2013049535A2 (en) 2011-09-30 2013-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Influenza vaccine
CN102584958A (zh) * 2012-02-08 2012-07-18 北京天坛生物制品股份有限公司 百日咳杆菌69kd外膜蛋白的纯化方法
CN102793915B (zh) * 2012-07-25 2013-10-23 天津康希诺生物技术有限公司 一种无细胞百日咳疫苗的生产方法
DK2863943T3 (en) 2013-03-08 2016-11-07 Janssen Vaccines & Prevention Bv acellular pertussis vaccines
BR112017026193B1 (pt) 2015-06-05 2021-09-14 W.R. Grace & Co-Conn Adsorventes, método de produção dos adsorventes e uso dos adsorventes
CN105106947A (zh) * 2015-07-21 2015-12-02 华兰生物工程股份有限公司 过氧化氢脱毒的无细胞百日咳疫苗及其制备方法
EP3518968B1 (de) 2016-10-03 2022-01-05 The U.S.A. as represented by the Secretary, Department of Health and Human Services Hiv-1-env-fusionspeptid-immunogene und deren verwendung
WO2018081832A1 (en) 2016-10-31 2018-05-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Peptide fragments from filoviruses and their uses
US11235056B2 (en) 2017-03-24 2022-02-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Glycan-masked engineered outer domains of HIV-1 gp120 and their use
KR102426041B1 (ko) * 2017-08-01 2022-07-29 주식회사 녹십자 냉동 및 해동 과정을 포함하는 백일해균 유래 단백질 수득 방법
US11136356B2 (en) 2017-10-16 2021-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Recombinant HIV-1 envelope proteins and their use
WO2020061564A1 (en) 2018-09-23 2020-03-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv-1 env fusion peptide nanoparticle carrier conjugates and their use
CA3117390A1 (en) 2018-10-22 2020-04-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Recombinant gp120 protein with v1-loop deletion
CN110358802B (zh) * 2019-08-16 2021-06-18 长春百克生物科技股份公司 一种去除百日咳组分菌毛蛋白2/3内毒素的方法
CN112094354B (zh) * 2020-11-05 2021-02-02 苏州世诺生物技术有限公司 副鸡禽杆菌基因工程亚单位疫苗、其制备方法及应用
US20240277829A1 (en) 2021-08-03 2024-08-22 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection
WO2023192835A1 (en) 2022-03-27 2023-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Base-covered hiv-1 envelope ectodomains and their use
CN117417419B (zh) * 2023-01-10 2024-04-19 康希诺生物股份公司 一种百日咳毒素脱毒方法及无细胞百白破联合疫苗

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4258029A (en) 1979-04-23 1981-03-24 Connaught Laboratories Limited Synthetic adjuvants for stimulation of antigenic responses
DE3521994A1 (de) 1985-06-20 1987-01-02 Bayer Ag N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
GB8601279D0 (en) * 1986-01-20 1986-02-26 Public Health Lab Service Purification of pertussis antigens
US4705686A (en) 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
WO1989001976A1 (en) * 1987-09-04 1989-03-09 Amgen Inc. Recombinant dna-derived bordetella toxin subunit analogs
GB8727489D0 (en) 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
GB8807860D0 (en) 1988-04-05 1988-05-05 Connaught Lab Pertussis vaccine
US4967176A (en) * 1988-07-15 1990-10-30 Raychem Corporation Assemblies of PTC circuit protection devices
US5101014A (en) 1989-02-10 1992-03-31 United States Of America Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis
WO1990012086A1 (en) * 1989-03-31 1990-10-18 Washington University Bordetella vaccines
US5276142A (en) 1989-12-11 1994-01-04 American Cyanamid Company Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis
GB9007657D0 (en) * 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
EP0484621A3 (en) * 1990-07-11 1992-08-26 American Cyanamid Company Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens
CA2188424A1 (en) 1994-04-28 1995-11-09 Akihiro Suehara Method of separating protective components of bordetella pertussis
FR2728170A1 (fr) * 1994-12-15 1996-06-21 Pasteur Institut Vaccin de type acellulaire anti-bordetella
US5877298A (en) * 1995-05-04 1999-03-02 Connaught Lab Acellular pertussis vaccines and methods of preparing thereof

Also Published As

Publication number Publication date
EP1233022A1 (de) 2002-08-21
EP1234580A1 (de) 2002-08-28
NZ306392A (en) 1999-04-29
CA2220063A1 (en) 1996-11-07
BR9608115A (pt) 2004-07-13
CA2220048C (en) 2006-03-07
US20010009666A1 (en) 2001-07-26
CA2220048A1 (en) 1996-11-07
DE69638326D1 (de) 2011-03-10
PT824358E (pt) 2003-02-28
DE69622555D1 (de) 2002-08-29
AU5494096A (en) 1996-11-21
EP0824358B1 (de) 2002-12-04
HK1016191A1 (en) 1999-10-29
CA2433502A1 (en) 1996-11-07
EP1233022B1 (de) 2015-12-09
US6399076B2 (en) 2002-06-04
BR9608114A (pt) 2000-10-31
PT1393744E (pt) 2011-05-03
FR16C0015I1 (de) 2016-06-10
PT826001E (pt) 2002-12-31
DE69625191T2 (de) 2003-07-10
WO1996034623A1 (en) 1996-11-07
EP1393744A1 (de) 2004-03-03
DK0826001T3 (da) 2002-11-18
CN1193324A (zh) 1998-09-16
WO1996034883A1 (en) 1996-11-07
DE69622555T2 (de) 2003-03-27
ATE221081T1 (de) 2002-08-15
EP0826001B1 (de) 2002-07-24
CN100387618C (zh) 2008-05-14
EP0826001A1 (de) 1998-03-04
FR16C0015I2 (fr) 2017-06-09
AU715417B2 (en) 2000-02-03
EP1234579A1 (de) 2002-08-28
DE69625191D1 (de) 2003-01-16
LU93036I2 (fr) 2016-06-21
EP0824358A1 (de) 1998-02-25
CN1198099A (zh) 1998-11-04
NZ306391A (en) 1999-03-29
NL300804I2 (de) 2016-11-01
EP1393744B1 (de) 2011-01-26
DK0824358T3 (da) 2003-01-27
AU710538B2 (en) 1999-09-23
AU5494196A (en) 1996-11-21
ATE228851T1 (de) 2002-12-15
EP1405643A1 (de) 2004-04-07
MX9708481A (es) 1998-02-28
ES2180758T3 (es) 2003-02-16
CA2220063C (en) 2003-08-26
DK1393744T3 (da) 2011-05-30
ES2182971T3 (es) 2003-03-16

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