ATE471946T1 - Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2 - Google Patents
Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2Info
- Publication number
- ATE471946T1 ATE471946T1 AT03795898T AT03795898T ATE471946T1 AT E471946 T1 ATE471946 T1 AT E471946T1 AT 03795898 T AT03795898 T AT 03795898T AT 03795898 T AT03795898 T AT 03795898T AT E471946 T1 ATE471946 T1 AT E471946T1
- Authority
- AT
- Austria
- Prior art keywords
- antibody
- binds
- fusion
- antibodies
- mouse
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/467—Igs with modifications in the FR-residues only
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43394502P | 2002-12-17 | 2002-12-17 | |
PCT/EP2003/014295 WO2004055056A1 (en) | 2002-12-17 | 2003-12-16 | Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE471946T1 true ATE471946T1 (de) | 2010-07-15 |
Family
ID=32595250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03795898T ATE471946T1 (de) | 2002-12-17 | 2003-12-16 | Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2 |
Country Status (18)
Country | Link |
---|---|
US (3) | US7169904B2 (de) |
EP (1) | EP1572748B1 (de) |
JP (1) | JP4494977B2 (de) |
KR (1) | KR101086660B1 (de) |
CN (1) | CN100432105C (de) |
AT (1) | ATE471946T1 (de) |
AU (1) | AU2003298187B2 (de) |
BR (1) | BRPI0317376B8 (de) |
CA (1) | CA2510180C (de) |
DE (1) | DE60333121D1 (de) |
DK (1) | DK1572748T3 (de) |
ES (1) | ES2346205T3 (de) |
MX (1) | MXPA05006384A (de) |
PL (1) | PL211180B1 (de) |
PT (1) | PT1572748E (de) |
RU (1) | RU2366664C2 (de) |
WO (1) | WO2004055056A1 (de) |
ZA (1) | ZA200505681B (de) |
Families Citing this family (66)
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US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
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AU7172901A (en) * | 2000-06-29 | 2002-01-14 | Lexigen Pharm Corp | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents |
EP1366067B1 (de) * | 2001-03-07 | 2012-09-26 | Merck Patent GmbH | Verfahren zur expression von proteinen mit einer hybrid-isotyp-antikörpereinheit |
WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
PT1383785E (pt) * | 2001-05-03 | 2011-06-28 | Merck Patent Gmbh | Anticorpo recombinante específico de tumores e utilização deste |
EP1454138B1 (de) * | 2001-12-04 | 2012-01-18 | Merck Patent GmbH | Immunocytokine mit modulierter selektivität |
US9371559B2 (en) | 2002-06-20 | 2016-06-21 | The Regents Of The University Of California | Compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
US10001475B2 (en) | 2002-06-20 | 2018-06-19 | The Regents Of The University Of California | Light harvesting multichromophore compositions and methods of using the same |
BRPI0317376B8 (pt) * | 2002-12-17 | 2021-05-25 | Merck Patent Gmbh | proteína de fusão de anticorpo-il2 designada como hu14.18-il2, usos da mesma, vetor e composição farmacêutica |
CN1771335A (zh) * | 2003-02-13 | 2006-05-10 | 加州大学评议会 | 使用集光多生色团检测和分析多核苷酸-结合蛋白相互作用的方法和组合物 |
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- 2003-12-16 AU AU2003298187A patent/AU2003298187B2/en not_active Expired
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- 2003-12-16 WO PCT/EP2003/014295 patent/WO2004055056A1/en active Application Filing
- 2003-12-16 AT AT03795898T patent/ATE471946T1/de active
- 2003-12-16 RU RU2005119305/13A patent/RU2366664C2/ru active
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PT1572748E (pt) | 2010-09-28 |
US7767405B2 (en) | 2010-08-03 |
RU2005119305A (ru) | 2006-01-20 |
KR20050085775A (ko) | 2005-08-29 |
PL377337A1 (pl) | 2006-01-23 |
CN1726227A (zh) | 2006-01-25 |
DK1572748T3 (da) | 2010-08-23 |
BR0317376A (pt) | 2005-11-16 |
ZA200505681B (en) | 2006-04-26 |
DE60333121D1 (de) | 2010-08-05 |
US8470991B2 (en) | 2013-06-25 |
PL211180B1 (pl) | 2012-04-30 |
WO2004055056A1 (en) | 2004-07-01 |
US20040203100A1 (en) | 2004-10-14 |
BRPI0317376B1 (pt) | 2019-12-03 |
JP4494977B2 (ja) | 2010-06-30 |
CA2510180A1 (en) | 2004-07-01 |
CN100432105C (zh) | 2008-11-12 |
ES2346205T3 (es) | 2010-10-13 |
MXPA05006384A (es) | 2005-08-29 |
US20070059282A1 (en) | 2007-03-15 |
BRPI0317376B8 (pt) | 2021-05-25 |
EP1572748A1 (de) | 2005-09-14 |
CA2510180C (en) | 2012-09-11 |
KR101086660B1 (ko) | 2011-11-24 |
AU2003298187A1 (en) | 2004-07-09 |
US20100210831A1 (en) | 2010-08-19 |
AU2003298187B2 (en) | 2010-09-16 |
US7169904B2 (en) | 2007-01-30 |
RU2366664C2 (ru) | 2009-09-10 |
JP2006521085A (ja) | 2006-09-21 |
EP1572748B1 (de) | 2010-06-23 |
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