ATE448189T1 - Glycerin-peg-derivate als inhibitoren der cyclooxigenase-2 und der phospholipase-a2 - Google Patents
Glycerin-peg-derivate als inhibitoren der cyclooxigenase-2 und der phospholipase-a2Info
- Publication number
- ATE448189T1 ATE448189T1 AT02756086T AT02756086T ATE448189T1 AT E448189 T1 ATE448189 T1 AT E448189T1 AT 02756086 T AT02756086 T AT 02756086T AT 02756086 T AT02756086 T AT 02756086T AT E448189 T1 ATE448189 T1 AT E448189T1
- Authority
- AT
- Austria
- Prior art keywords
- phospholipase
- group
- cyclooxigenase
- glycerin
- inhibitors
- Prior art date
Links
- 102100037611 Lysophospholipase Human genes 0.000 title abstract 2
- 108010058864 Phospholipases A2 Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000002632 lipids Chemical class 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/30—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with trihydroxylic compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27825701P | 2001-03-23 | 2001-03-23 | |
US09/877,334 US6495596B1 (en) | 2001-03-23 | 2001-06-07 | Compounds and methods for inhibition of phospholipase A2 and cyclooxygenase-2 |
PCT/US2002/011155 WO2002102757A1 (en) | 2001-03-23 | 2002-03-22 | Glycerol-peg-derivatives as inhibitors of cyclooxygenase-2 and phospholipase-a2 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE448189T1 true ATE448189T1 (de) | 2009-11-15 |
Family
ID=26959001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02756086T ATE448189T1 (de) | 2001-03-23 | 2002-03-22 | Glycerin-peg-derivate als inhibitoren der cyclooxigenase-2 und der phospholipase-a2 |
Country Status (6)
Country | Link |
---|---|
US (1) | US6495596B1 (de) |
EP (1) | EP1381587B1 (de) |
AT (1) | ATE448189T1 (de) |
CA (1) | CA2447811C (de) |
DE (1) | DE60234329D1 (de) |
WO (1) | WO2002102757A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IS4518A (is) * | 1997-07-09 | 1999-01-10 | Lyfjathroun Hf, The Icelandic Bio Pharmaceutical Group | Nýtt lyfjaform fyrir bóluefni |
US6998421B2 (en) * | 2001-06-07 | 2006-02-14 | Biozone Laboratories, Inc. | Compounds and methods for inhibition of phospholipase A2 and cyclooxygenase - 2 |
EP1441715B1 (de) * | 2001-11-06 | 2013-02-27 | The Brigham And Women's Hospital, Inc. | Lipoxine und durch aspirin ausgelöste lipoxine und ihre stabilen analoga zur behandlung von asthma und entzündlichen atemkrankheiten |
CA2477321A1 (en) * | 2002-02-25 | 2003-08-28 | Lyfjathroun Hf | Absorption enhancing agent |
EA200401565A1 (ru) * | 2002-05-24 | 2005-04-28 | Неофарм, Инк. | Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты) |
CA2486967A1 (en) * | 2002-05-24 | 2003-12-04 | Neopharm, Inc. | Cardiolipin compositions their methods of preparation and use |
US6855332B2 (en) * | 2002-07-03 | 2005-02-15 | Lyfjathroun Hf. | Absorption promoting agent |
US20050277611A1 (en) * | 2002-10-16 | 2005-12-15 | Neopharm, Inc. | Cationic cardiolipin analoges and its use thereof |
WO2006073430A2 (en) * | 2004-04-20 | 2006-07-13 | The University Of Chicago | Therapeutic delivery system comprising a high molecular weight peg-like compound |
US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
US7282224B1 (en) | 2006-06-09 | 2007-10-16 | Guthy-Renker Corporation | Pain relief composition |
US20080107747A1 (en) * | 2006-10-23 | 2008-05-08 | Roederer Joy E | Pain relief composition |
WO2008109887A1 (en) * | 2007-03-08 | 2008-09-12 | Biozone Laboratories Inc. | Dressing formulations to prevent and reduce scarring |
WO2009105294A2 (en) * | 2008-02-20 | 2009-08-27 | Elc Management Llc | Topical compositions and methods for whitening skin |
BR112012001098A2 (pt) * | 2009-07-09 | 2015-09-01 | Crescendo Therapeutics Llc | Método de cicatrização de feridas e modulação de cicatriz |
CN106290351A (zh) * | 2015-06-03 | 2017-01-04 | 舒泰神(北京)生物制药股份有限公司 | 一种磷脂酶a2的活性测定方法 |
US10702475B2 (en) | 2017-09-05 | 2020-07-07 | Richard Rigg | Liposome containing compositions and their use in personal care and food products |
JP6805385B1 (ja) * | 2020-08-31 | 2020-12-23 | ジェイ−ネットワーク,インコーポレイテッド | 表皮内の保湿関連物質の発現増強剤 |
JP6860739B1 (ja) * | 2020-11-20 | 2021-04-21 | ジェイ−ネットワーク,インコーポレイテッド | 表皮内の抗酸化物質の発現増強剤 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5001234A (en) | 1987-04-16 | 1991-03-19 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
US5659049A (en) | 1988-02-18 | 1997-08-19 | Virginia Commonwealth University | Antioxidant, antiphospholipase derivatives of ricinoleic acid |
US5122536A (en) | 1989-10-12 | 1992-06-16 | Perricone Nicholas V | Method for the topical treatment of psoriasis |
JPH04134077A (ja) | 1990-09-21 | 1992-05-07 | Taiho Yakuhin Kogyo Kk | イソオキサゾール化合物 |
SG48108A1 (en) | 1991-11-22 | 1998-04-17 | Lipogenenics Inc | Tocotrienols and tocotrienol-like compounds and methods for their use |
US5451686A (en) | 1994-04-15 | 1995-09-19 | Allergan, Inc. | 3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents |
FR2750426B1 (fr) | 1996-06-28 | 1998-08-07 | Cird Galderma | Nouveaux composes biaryles heterocycliques et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetique |
US5863560A (en) | 1996-09-11 | 1999-01-26 | Virotex Corporation | Compositions and methods for topical application of therapeutic agents |
US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
DE19909552C1 (de) * | 1999-03-04 | 2000-07-27 | Goldwell Gmbh | Haarwaschmittel |
-
2001
- 2001-06-07 US US09/877,334 patent/US6495596B1/en not_active Expired - Lifetime
-
2002
- 2002-03-22 WO PCT/US2002/011155 patent/WO2002102757A1/en not_active Application Discontinuation
- 2002-03-22 AT AT02756086T patent/ATE448189T1/de not_active IP Right Cessation
- 2002-03-22 DE DE60234329T patent/DE60234329D1/de not_active Expired - Lifetime
- 2002-03-22 EP EP02756086A patent/EP1381587B1/de not_active Expired - Lifetime
- 2002-03-22 CA CA2447811A patent/CA2447811C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1381587B1 (de) | 2009-11-11 |
CA2447811A1 (en) | 2002-12-27 |
US6495596B1 (en) | 2002-12-17 |
WO2002102757A1 (en) | 2002-12-27 |
CA2447811C (en) | 2011-11-29 |
DE60234329D1 (de) | 2009-12-24 |
EP1381587A1 (de) | 2004-01-21 |
US20020198260A1 (en) | 2002-12-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |