[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE447965T1 - Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren - Google Patents

Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren

Info

Publication number
ATE447965T1
ATE447965T1 AT01973008T AT01973008T ATE447965T1 AT E447965 T1 ATE447965 T1 AT E447965T1 AT 01973008 T AT01973008 T AT 01973008T AT 01973008 T AT01973008 T AT 01973008T AT E447965 T1 ATE447965 T1 AT E447965T1
Authority
AT
Austria
Prior art keywords
extracellular domain
compositions
cancer treatment
muc1
methods derived
Prior art date
Application number
AT01973008T
Other languages
English (en)
Inventor
Donald W Kufe
Tsuneya Ohno
Original Assignee
Dana Farber Cancer Inst Inc
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc, Genzyme Corp filed Critical Dana Farber Cancer Inst Inc
Application granted granted Critical
Publication of ATE447965T1 publication Critical patent/ATE447965T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT01973008T 2000-09-11 2001-09-11 Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren ATE447965T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23184100P 2000-09-11 2000-09-11
PCT/US2001/028548 WO2002022685A2 (en) 2000-09-11 2001-09-11 Muc1 extracellular domain and cancer treatment compositions and methods derived therefrom

Publications (1)

Publication Number Publication Date
ATE447965T1 true ATE447965T1 (de) 2009-11-15

Family

ID=22870825

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01973008T ATE447965T1 (de) 2000-09-11 2001-09-11 Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren

Country Status (10)

Country Link
US (3) US20050053606A1 (de)
EP (1) EP1317278B1 (de)
JP (1) JP5165175B2 (de)
KR (1) KR20030068536A (de)
CN (1) CN1455680A (de)
AT (1) ATE447965T1 (de)
AU (1) AU9263101A (de)
CA (1) CA2421751C (de)
DE (1) DE60140461D1 (de)
WO (1) WO2002022685A2 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0111125A (pt) * 2000-05-23 2004-12-28 Cenes Pharmaceuticals Inc Moléculas de ácido nucléico de nrg-2, polipeptìdeos, e métodos diagnóstico e terapêuticos
ATE447965T1 (de) * 2000-09-11 2009-11-15 Dana Farber Cancer Inst Inc Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren
US20040018181A1 (en) * 2000-09-11 2004-01-29 KUFE Donald W. MUC1 interference RNA compositions and methods derived therefrom
CA2430060C (en) 2000-11-27 2015-11-24 Minerva Biotechnologies Corporation Identification and use of cell surface receptor-binding ligands for the diagnosis and treatment of cancer
AU2002246791C1 (en) * 2000-12-22 2008-04-03 Dana-Farber Cancer Institute, Inc. Regulation of cell growth by MUC1
WO2002078598A2 (en) * 2001-03-29 2002-10-10 Ramot University Authority For Applied Research & Industrial Development Ltd. Peptides and antibodies to muc 1 proteins
US8435529B2 (en) * 2002-06-14 2013-05-07 Immunomedics, Inc. Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy
WO2003089451A2 (en) * 2002-04-22 2003-10-30 Dyax Corporation Antibodies specific for mucin polypeptide
US9599619B2 (en) * 2002-06-14 2017-03-21 Immunomedics, Inc. Anti-pancreatic cancer antibodies
US8821868B2 (en) * 2002-06-14 2014-09-02 Immunomedics, Inc. Anti-pancreatic cancer antibodies
CA2491017A1 (en) * 2002-07-03 2004-01-15 Immunogen, Inc. Antibodies to non-shed muc1 and muc16, and uses thereof
CA2537263C (en) * 2002-11-27 2017-05-30 Minerva Biotechnologies Corporation Techniques and compositions for the diagnosis and treatment of cancer (muc1)
WO2004092339A2 (en) * 2003-04-11 2004-10-28 Ilex Products, Inc. Modulation of muc1 mediated signal transduction
US9005613B2 (en) 2003-06-16 2015-04-14 Immunomedics, Inc. Anti-mucin antibodies for early detection and treatment of pancreatic cancer
AU2003904201A0 (en) * 2003-08-11 2003-08-21 Allen, Barry John Mr Alpha-conjugate of C595 for therapy of pancreatic, prostate and other cancers
DK2363410T3 (en) * 2003-08-26 2018-01-15 Minerva Biotechnologies Corp ISOFORMER OF MUC1
WO2005042573A1 (en) 2003-10-24 2005-05-12 Dana-Farber Cancer Institute, Inc. Modulation of the interaction of muc1 with muc1 ligands
US7999071B2 (en) 2003-12-12 2011-08-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human cytotoxic T-lymphoctye epitope and its agonist eptiope from the non-variable number of tandem repeat sequence of MUC-1
JP2007523214A (ja) * 2004-02-23 2007-08-16 ジェンザイム コーポレイション デスレセプターリガンド誘導アポトーシスのｍｕｃ１アンタゴニスト増強方法
CN101175855A (zh) * 2005-01-28 2008-05-07 特拉维夫大学拉莫特有限公司 抗MUC1 α/β抗体
EP1853304A4 (de) * 2005-02-15 2009-11-25 Dana Farber Cancer Inst Inc Modulation der muc1-aktivität
DK1874821T3 (da) 2005-04-26 2013-07-08 Trion Pharma Gmbh Kombination af antistoffer med glykokortikoider til behandling af kræft
EP1946113A4 (de) * 2005-08-22 2010-03-10 Dana Farber Cancer Inst Inc Mitochondriale lokalisierung von muc1
CN101282650A (zh) * 2005-10-11 2008-10-08 华盛顿大学 治疗呼吸道分泌过多的组合物和方法
WO2008111996A2 (en) * 2006-07-20 2008-09-18 Dana-Farber Cancer Institute, Inc. Muc1-ikb kinase complexes and their activities
US20080107661A1 (en) * 2006-07-28 2008-05-08 Dana-Farber Cancer Institute, Inc. MUC1 and ABL
WO2008070171A2 (en) * 2006-12-06 2008-06-12 Minerva Biotechnologies Corp. Method for identifying and manipulating cells
WO2008073817A2 (en) * 2006-12-08 2008-06-19 Dana-Farber Cancer Institute, Inc. Muc1 and galectin-3
US7972870B2 (en) 2007-02-02 2011-07-05 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3
WO2008097844A2 (en) * 2007-02-02 2008-08-14 Dana -Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins
WO2008101121A2 (en) * 2007-02-14 2008-08-21 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to promoter regulation by muc1 and klf proteins
WO2011091113A2 (en) 2010-01-22 2011-07-28 Immunomedics, Inc. Detection of early-stage pancreatic adenocarcinoma
CN102239182B (zh) 2008-10-06 2014-07-09 米纳瓦生物技术公司 Muc1*抗体
CN102245632B (zh) 2008-10-17 2018-10-12 达娜-法勃肿瘤研究所公司 Muc-1胞质结构域肽作为癌症的抑制剂
WO2010138740A1 (en) 2009-05-27 2010-12-02 Dana-Farber Cancer Institute, Inc. Inhibition 0f inflammation using antagonists of muc1
KR20190122749A (ko) * 2009-06-11 2019-10-30 미네르바 바이오테크놀로지 코포레이션 줄기세포 및 전구세포를 배양하는 방법
WO2011100688A1 (en) 2010-02-12 2011-08-18 Dana-Farber Cancer Institute, Inc. Improved antagonists of muc1
US8993525B2 (en) * 2010-10-14 2015-03-31 Amicus Therapeutics, Inc. Compounds and methods for treating or preventing disease conditions associated with α-1-antitrypsin
EP2675485A4 (de) * 2011-02-15 2014-10-15 Immunomedics Inc Anti-mucin-antikörper zur frühen erkennung und behandlung von pankreaskrebs
MX2013009742A (es) * 2011-02-24 2014-01-31 Oncothyreon Inc Vacuna de glicolipopeptidos a base de muc1 con adyuvante.
US20130101664A1 (en) * 2011-08-18 2013-04-25 Donald W. Kufe Muc1 ligand traps for use in treating cancers
US9044421B2 (en) 2012-03-28 2015-06-02 Genus Oncology, Llc Treating MUC1-expressing cancers with combination therapies
WO2013161614A1 (ja) 2012-04-27 2013-10-31 コニカミノルタ株式会社 酵素処理工程を含むレクチンを用いた抗原検出方法
US9382329B2 (en) 2012-08-14 2016-07-05 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to Trop-2 expressing cells
US9452228B2 (en) 2013-04-01 2016-09-27 Immunomedics, Inc. Antibodies reactive with an epitope located in the N-terminal region of MUC5AC comprising cysteine-rich subdomain 2 (Cys2)
US9868764B2 (en) 2013-06-12 2018-01-16 Maruha Nichiro Corporation Dipeptidyl peptidase-IV (DPPIV), inhibitory peptide compound, composition containing the same, and production method for the same
JP6323463B2 (ja) * 2013-12-27 2018-05-16 コニカミノルタ株式会社 診断用情報の分析方法およびそのためのキット
WO2015097862A1 (ja) 2013-12-27 2015-07-02 コニカミノルタ株式会社 診断用情報の分析方法およびそのためのキット
EP3099719B1 (de) 2014-01-29 2020-04-01 Dana-Farber Cancer Institute, Inc. Antikörper gegen die muc1-c/extrazelluläre domäne (/muc1-c/ecd)
CN103880956B (zh) * 2014-03-10 2015-12-30 中国人民解放军第四军医大学 抗muc1单克隆抗体及其轻链和重链可变区
AU2016219350A1 (en) 2015-02-10 2017-08-24 Minerva Biotechnologies Corporation Humanized anti-MUC1* antibodies
IL293719B2 (en) 2015-05-21 2023-07-01 Harpoon Therapeutics Inc Trispecific binding proteins and methods of use
WO2018174544A2 (ko) * 2017-03-21 2018-09-27 주식회사 펩트론 Muc1에 특이적으로 결합하는 항체 및 그의 용도
JP7032425B2 (ja) 2017-03-21 2022-03-08 ペプトロン インコーポレイテッド Ｍｕｃ１に特異的に結合する抗体及びその用途
EP3694871A4 (de) 2017-10-13 2021-11-10 Harpoon Therapeutics, Inc. B-zellreifungs-antigenbindende proteine
JP7411559B2 (ja) 2018-02-26 2024-01-11 ミネルバ バイオテクノロジーズ コーポレーション Ａｎｔｉ－ｍｕｃｉ＊抗体を用いた診断法
CN116536270A (zh) * 2023-01-31 2023-08-04 浙江中医药大学 人卵巢癌细胞系SKOV3-sh-MUC1及其构建方法和应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4497796A (en) * 1980-03-26 1985-02-05 The Regents Of The University Of California Gene transfer in intact mammals
US5080898A (en) * 1982-05-12 1992-01-14 The University Hospital Enzymatically active toxin coupled to a cell-specific ligand
ES522315A0 (es) * 1982-05-12 1984-08-16 Harvard College Un procedimiento para obtener una proteina hibrida.
US4740461A (en) * 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4894227A (en) * 1986-08-01 1990-01-16 Cetus Corporation Composition of immunotoxins with interleukin-2
US6054438A (en) * 1987-01-07 2000-04-25 Imperial Cancer Research Technology Limited Nucleic acid fragments encoding portions of the core protein of the human mammary epithelial mucin
GB8725529D0 (en) * 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
US4963484A (en) * 1988-01-29 1990-10-16 Dana-Farber Cancer Institute, Inc. Genetically engineered polypeptides with determinants of the human DF3 breast carcinoma-associated antigen
US5053489A (en) * 1988-01-29 1991-10-01 Dana-Farber Cancer Institute, Inc. Genetically engineered polypeptides with determinants of the human DF3 breast carcinoma-associated antigen
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
FR2668064B1 (fr) * 1990-10-23 1994-12-16 Transgene Sa Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne.
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
US5660827A (en) * 1992-03-05 1997-08-26 Board Of Regents, The University Of Texas System Antibodies that bind to endoglin
WO1993020841A1 (en) * 1992-04-13 1993-10-28 Dana-Farber Cancer Institute, Inc. Antibodies specific for carcinoma-associated antigens
WO1994016057A1 (en) * 1992-12-31 1994-07-21 Dana-Farber Cancer Institute, Inc. Enhancer sequence for modulating expression in epithelial cells
US5801154A (en) * 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
GB9404270D0 (en) * 1994-03-05 1994-04-20 Delta Biotechnology Ltd Yeast strains and modified albumins
DE69532127T2 (de) * 1994-07-20 2004-08-26 Genetics Institute, Inc., Cambridge Interaktions-fullensysteme zum nachweis von protein-interaktionen
DE69524304T2 (de) * 1994-07-29 2002-07-25 Dainippon Ink And Chemicals, Inc. Verfahren zur Herstellung von Negativbildern mit ultrahohem Kontrast und photographisches Silberhalogenidmaterial und Entwickler dafür
JPH08176138A (ja) * 1994-12-19 1996-07-09 Mercian Corp イソクマリン誘導体
US6074841A (en) * 1996-08-19 2000-06-13 Millennium Biotherapeutics, Inc. Don-1 gene and polypeptides and uses therefor
WO2000000828A1 (en) * 1998-06-26 2000-01-06 Biomira Inc. Method of detecting t-cell activation
IT1303683B1 (it) * 1998-10-30 2001-02-23 Menarini Ricerche Spa Composizione farmaceutiche ad azione antitumorale contenente dnacodificante per frammenti di una proteina antigenica.
WO2000034468A2 (en) * 1998-12-11 2000-06-15 Biomira Inc. Muc-1 antagonists and methods of treating immune disorders
IL144559A0 (en) * 1999-03-01 2002-05-23 Genentech Inc Antibodies for cancer therapy and diagnosis
AU2935900A (en) * 1999-03-26 2000-10-16 Firmenich S.A. Cyclic compounds and their use as precursors of fragrant alcohols
US5998148A (en) * 1999-04-08 1999-12-07 Isis Pharmaceuticals Inc. Antisense modulation of microtubule-associated protein 4 expression
US6589981B2 (en) * 2000-02-29 2003-07-08 Ilex Oncology, Inc. Tumor radiosensitization and/or chemopotentiation using isocoumarin derivatives
ATE447965T1 (de) * 2000-09-11 2009-11-15 Dana Farber Cancer Inst Inc Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren
US20040018181A1 (en) * 2000-09-11 2004-01-29 KUFE Donald W. MUC1 interference RNA compositions and methods derived therefrom
AU2002246791C1 (en) * 2000-12-22 2008-04-03 Dana-Farber Cancer Institute, Inc. Regulation of cell growth by MUC1
US20040209832A1 (en) * 2001-11-30 2004-10-21 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US6716627B2 (en) * 2001-12-20 2004-04-06 Isis Pharmaceuticals, Inc. Antisense modulation of mucin 1, transmembrane expression
WO2004092339A2 (en) * 2003-04-11 2004-10-28 Ilex Products, Inc. Modulation of muc1 mediated signal transduction

Also Published As

Publication number Publication date
US20090232812A1 (en) 2009-09-17
CA2421751C (en) 2014-02-11
JP5165175B2 (ja) 2013-03-21
US20050042209A1 (en) 2005-02-24
DE60140461D1 (de) 2009-12-24
WO2002022685A2 (en) 2002-03-21
JP2004515472A (ja) 2004-05-27
CA2421751A1 (en) 2002-03-21
EP1317278B1 (de) 2009-11-11
WO2002022685A3 (en) 2002-09-26
KR20030068536A (ko) 2003-08-21
EP1317278A2 (de) 2003-06-11
CN1455680A (zh) 2003-11-12
US20050053606A1 (en) 2005-03-10
AU9263101A (en) 2002-03-26

Similar Documents

Publication Publication Date Title
ATE447965T1 (de) Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren
DE602004015811D1 (de) Verfahren zur inhibierung der proliferation von tumorzellen, bei dem platinkomplexe eingesetzt werden
ATE459653T1 (de) Monoklonale anti-cd71-antikörper und deren verwendung zur behandlung maligner tumorzellen
ATE443724T1 (de) Antikrebs-antikörper mit reduzierter komplementfixierung
IL179904A0 (en) Compounds and methods for inhibiting the interaction of bcl proteins with binding partners
DK1214292T3 (da) Tyrosinderivater
TR199902194T2 (xx) +p38 protein kinaz inhibit�rleri olarak ikameli azot ihtiva eden heterosikler.
TR200102029T2 (tr) 1-Heterosiklil ikameli diarilaminler.
TN2009000255A1 (en) Quinazolines for pdk1 inhibition
DE60011755D1 (de) Calciumkanalblocker als antikrebsmittel
WO2006113483A3 (en) Methods and compositions for treating or preventing cancer
ATE295735T1 (de) Verwendung von interleukin-6 antagonisten zur behandlung von oestrogen-abhängigen krebs
DE602006005084D1 (de) Verfahren zur vorhersage und verhinderung der resistenz gegen taxoid-verbindungen
MY153232A (en) Compounds and methods for inhibiting the interaction of bcl proteins with binding partners
DE69940320D1 (de) Betulinsäurederivate zur inhibierung des krebswach
TW200700089A (en) Recombinant protein comprising starch binding domain and use thereof
MXPA05006507A (es) Inhibidores de ccxckr2 expresado en tumor humano.
ATE339208T1 (de) Verwendung von progesteronrezeptorhemmern zur behandlung von steroid-resistentem brustkrebs
ATE423129T1 (de) Inhibitoren von lyn-verbundener signaltransduktion (last) und deren verwendung zur behandlung von prostatakrebs
ATE445408T1 (de) Verwendung von prolactin in der prophylaktischen krebstherapie
PL1776103T3 (pl) Kompleksy rutenu do leczenia raków
ATE397003T1 (de) Ruthenium(ii)-komplexe zur behandlung von tumoren
DE60212415D1 (de) Die verwendung von einer 4-pyridylmethylphtalazine enthaltenden kombination zur behandlung von tumoren
MXPA02010813A (es) Fosforamidatos de bis-(n,n'-bis-(2-haloetil)amino) como agentes antitumor.
ATE480237T1 (de) Tumorhemmende nitroacridin-zusammensetzungen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties