ATE326697T1 - Sensor und methode zur messung der flächendichte von magnetischen nanopartikeln auf einem mikroarray - Google Patents
Sensor und methode zur messung der flächendichte von magnetischen nanopartikeln auf einem mikroarrayInfo
- Publication number
- ATE326697T1 ATE326697T1 AT02790607T AT02790607T ATE326697T1 AT E326697 T1 ATE326697 T1 AT E326697T1 AT 02790607 T AT02790607 T AT 02790607T AT 02790607 T AT02790607 T AT 02790607T AT E326697 T1 ATE326697 T1 AT E326697T1
- Authority
- AT
- Austria
- Prior art keywords
- nanoparticles
- magnetoresistive sensor
- measuring
- magnetic nanoparticles
- target sample
- Prior art date
Links
- 239000002122 magnetic nanoparticle Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000002493 microarray Methods 0.000 title abstract 2
- 239000002105 nanoparticle Substances 0.000 abstract 2
- 238000000018 DNA microarray Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/0656—Investigating concentration of particle suspensions using electric, e.g. electrostatic methods or magnetic methods
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
- G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
- G01R33/09—Magnetoresistive devices
- G01R33/093—Magnetoresistive devices using multilayer structures, e.g. giant magnetoresistance sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
- G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
- G01R33/09—Magnetoresistive devices
- G01R33/096—Magnetoresistive devices anisotropic magnetoresistance sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
- G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/143—Magnetism, e.g. magnetic label
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/155—Particles of a defined size, e.g. nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10N—ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10N50/00—Galvanomagnetic devices
- H10N50/10—Magnetoresistive devices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Dispersion Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Ecology (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Measuring Magnetic Variables (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01205152 | 2001-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE326697T1 true ATE326697T1 (de) | 2006-06-15 |
Family
ID=8181541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02790607T ATE326697T1 (de) | 2001-12-21 | 2002-12-17 | Sensor und methode zur messung der flächendichte von magnetischen nanopartikeln auf einem mikroarray |
Country Status (10)
Country | Link |
---|---|
US (2) | US7048890B2 (de) |
EP (1) | EP1456658B1 (de) |
JP (1) | JP2005513475A (de) |
KR (1) | KR20040068968A (de) |
CN (1) | CN100343670C (de) |
AT (1) | ATE326697T1 (de) |
AU (1) | AU2002366904A1 (de) |
DE (1) | DE60211555T2 (de) |
TW (1) | TWI295323B (de) |
WO (1) | WO2003054523A2 (de) |
Families Citing this family (151)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003067258A1 (fr) * | 2002-01-29 | 2003-08-14 | Asahi Kasei Kabushiki Kaisha | Biocapteur, procede de mesure de molecules magnetiques et procede de mesure de l'objet mesure |
CN1829922B (zh) * | 2003-07-30 | 2010-06-16 | 皇家飞利浦电子股份有限公司 | 具有改进信噪比的芯片内磁性粒子传感器 |
CN1829908B (zh) * | 2003-07-30 | 2010-04-28 | 皇家飞利浦电子股份有限公司 | 去除磁阻纳米颗粒传感器中噪声的电路、生物芯片、方法 |
EP1697755A1 (de) * | 2003-07-30 | 2006-09-06 | Koninklijke Philips Electronics N.V. | On-chip magnetischefühleranordnung mit übersprechsunterdruckung |
US7906345B2 (en) * | 2003-11-12 | 2011-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules |
JP2007519000A (ja) * | 2004-01-26 | 2007-07-12 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | オンチップ磁気共鳴分光法のための方法及びデバイス |
JP4433820B2 (ja) * | 2004-02-20 | 2010-03-17 | Tdk株式会社 | 磁気検出素子およびその形成方法ならびに磁気センサ、電流計 |
JP2005315678A (ja) * | 2004-04-28 | 2005-11-10 | Canon Inc | 検出方法、検出デバイス及び検出用キット |
GB0410980D0 (en) * | 2004-05-17 | 2004-06-16 | Randox Lab Ltd | Magnetic particle detector system and method of performing binding assay |
GB0410976D0 (en) * | 2004-05-17 | 2004-06-16 | Randox Lab Ltd | Magnetic particle detector system |
US7892817B2 (en) * | 2004-05-18 | 2011-02-22 | Koninklijke Philips Electronics, N.V. | Magnetic rotation to improve signal-over-background in biosensing |
WO2005116661A1 (en) * | 2004-05-24 | 2005-12-08 | Koninklijke Philips Electronics N.V. | Magneto-resistive sensor for high sensitivity depth probing |
PT1781820T (pt) * | 2004-08-20 | 2018-07-10 | Magnomics Sa | Um dispositivo bioeletrónico |
CA2520670A1 (en) * | 2004-09-23 | 2006-03-23 | National Research Council Of Canada | Nanocrystal coated surfaces |
US20090224755A1 (en) | 2004-11-30 | 2009-09-10 | Koninklijke Philips Electronics, N.V. | Means and method for sensing a magnetic stray field in biosensors |
JP4756868B2 (ja) * | 2005-01-31 | 2011-08-24 | キヤノン株式会社 | 検出方法 |
JP4731927B2 (ja) * | 2005-01-31 | 2011-07-27 | キヤノン株式会社 | 磁性体センサおよび検出キット |
US8828740B2 (en) | 2005-01-31 | 2014-09-09 | Koninklijke Philips N.V. | Rapid and sensitive biosensing |
JP4728012B2 (ja) * | 2005-02-28 | 2011-07-20 | 旭化成株式会社 | バイオセンサ |
CN100360939C (zh) * | 2005-05-26 | 2008-01-09 | 上海交通大学 | 利用生物磁控压电传感芯片探针探测癌细胞 |
EP1893774A2 (de) * | 2005-06-09 | 2008-03-05 | Koninklijke Philips Electronics N.V. | Amplifizierung von nukleinsäuren mit magnetischer detektion |
US20080206104A1 (en) * | 2005-06-17 | 2008-08-28 | Koninklijke Philips Electronics, N.V. | Accurate Magnetic Biosensor |
JP2009501929A (ja) * | 2005-07-21 | 2009-01-22 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 短距離相互作用を有するマイクロチップアセンブリ |
WO2007014322A2 (en) * | 2005-07-27 | 2007-02-01 | University Of Houston | Nanomagnetic detector array for biomolecular recognition |
US8143073B2 (en) * | 2005-08-12 | 2012-03-27 | Siemens Aktiengesellschaft | Apparatus for carrying out an analysis process, in particular for identification of biochemical molecules, and analysis processes which can be carried out using this apparatus |
DE102006037739B4 (de) * | 2005-08-12 | 2011-09-15 | Siemens Ag | Vorrichtung zur Durchführung eines Analyseverfahrens, insbesondere zur Erkennung biochemischer Moleküle, und mit dieser Vorrichtung ausführbare Analyseverfahren |
US8283184B2 (en) * | 2005-09-21 | 2012-10-09 | Siemens Aktiengesellschaft | Method for measurement of very small local magnetic fields, in particular for measurement of local magnetic stray fields produced by magnetic beads, and an associated device for carrying out the method |
DE102006042044B4 (de) * | 2005-09-21 | 2020-02-06 | Siemens Aktiengesellschaft | Verfahren zum Messen kleinster lokaler Magnetfelder, insbesondere zur Messung von durch magnetische Beads erzeugten lokalen magnetischen Streufeldern, und zugehörige Einrichtung zur Durchführung des Verfahrens |
EP1938084A2 (de) * | 2005-10-12 | 2008-07-02 | Koninklijke Philips Electronics N.V. | Magnetsensorvorrichtung mit verschiedenen internen betriebsfrequenzen |
US20080311598A1 (en) * | 2005-11-25 | 2008-12-18 | Koninklijke Philips Electronics, N.V. | Magnetic Biosensor For Determination of Enzymic Activity |
DE102006003177A1 (de) * | 2006-01-23 | 2007-08-02 | Siemens Ag | Vorrichtung und Verfahren zum Nachweis eines Analyten |
ES2393758T3 (es) | 2006-03-15 | 2012-12-27 | Micronics, Inc. | Ensayos integrados de ácidos nucleicos |
JP2009529908A (ja) | 2006-03-21 | 2009-08-27 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | センサアレイを有するマイクロエレクトロニクスセンサデバイス |
JP4837410B2 (ja) * | 2006-03-22 | 2011-12-14 | 富士フイルム株式会社 | 標的化合物の検出方法 |
US8945946B2 (en) * | 2006-03-31 | 2015-02-03 | Canon Kabushiki Kaisha | Sensor element and detection method of magnetic particles using this element, and detection method of target substance |
DE102006016334B4 (de) * | 2006-04-06 | 2018-11-15 | Boehringer Ingelheim Vetmedica Gmbh | Verfahren und Vorrichtung zur Detektion magnetisierbarer Partikel |
FI121248B (fi) * | 2006-04-21 | 2010-08-31 | Magnasense Technologies Oy | Laite magneettisten partikkelien mittaamiseksi ja vastaava menetelmä |
CN101467059A (zh) | 2006-05-09 | 2009-06-24 | 皇家飞利浦电子股份有限公司 | 具有磁场发生器和传感器的磁传感器设备 |
JP2009536340A (ja) * | 2006-05-09 | 2009-10-08 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 濃度測定用のマイクロエレクトロニクスセンサデバイス |
CN101438179A (zh) * | 2006-05-09 | 2009-05-20 | 皇家飞利浦电子股份有限公司 | 感测磁性粒子的磁传感器设备和方法 |
WO2007129284A1 (en) | 2006-05-10 | 2007-11-15 | Koninklijke Philips Electronics N.V. | System and methods for actuation on magnetoresistive sensors |
EP2018537B1 (de) * | 2006-05-10 | 2013-07-17 | Koninklijke Philips Electronics N.V. | Schneller magnetsensor |
CN101479617A (zh) * | 2006-06-28 | 2009-07-08 | 皇家飞利浦电子股份有限公司 | 具有场发生器和传感器元件的磁传感器设备 |
WO2008091364A2 (en) * | 2006-06-30 | 2008-07-31 | Intel Corporation | Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance |
WO2008007291A2 (en) * | 2006-07-11 | 2008-01-17 | Koninklijke Philips Electronics N. V. | Magnetic sensor device |
US8133439B2 (en) * | 2006-08-01 | 2012-03-13 | Magic Technologies, Inc. | GMR biosensor with enhanced sensitivity |
EP2052245A2 (de) * | 2006-08-09 | 2009-04-29 | Koninklijke Philips Electronics N.V. | Magnetische sensorvorrichtung und mikrochip |
JP2010521649A (ja) * | 2006-10-09 | 2010-06-24 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 検出ユニットの対を有する磁気センサ装置 |
US8372344B2 (en) | 2006-10-11 | 2013-02-12 | University Of South Carolina | Nanoscale spintronic chemical sensor |
EP2078199B1 (de) | 2006-10-12 | 2013-03-06 | Koninklijke Philips Electronics N.V. | Nachweissystem und verfahren mit hilfe eines magnetischen und/oder elektrischen etiketts |
JP2010508404A (ja) * | 2006-10-30 | 2010-03-18 | エスティーシー. ユーエヌエム | 磁気感受性粒子およびその混合装置 |
EP2115467A1 (de) * | 2007-02-23 | 2009-11-11 | Koninklijke Philips Electronics N.V. | Magnetsensorvorrichtung mit feldgenerator und sensorelement |
US8114683B2 (en) | 2007-03-05 | 2012-02-14 | Headway Technologies, Inc. | Low temperature method to enhance detection of magnetic beads |
CN101622533B (zh) * | 2007-03-06 | 2012-11-07 | 皇家飞利浦电子股份有限公司 | 用于生物传感器的电磁系统 |
EP1967855A1 (de) * | 2007-03-08 | 2008-09-10 | Koninklijke Philips Electronics N.V. | Magnetsensorvorrichtung |
DE102007015543A1 (de) * | 2007-03-30 | 2008-10-09 | Siemens Ag | Verfahren und Anordnung zur Detektion biologischer Reaktionsprodukte |
US8283912B2 (en) | 2007-04-03 | 2012-10-09 | Koninklijke Philips Electronics N.V. | Sensor device with magnetic washing means |
US7705591B2 (en) * | 2007-06-29 | 2010-04-27 | The Boeing Company | Radio frequency sensor systems, electromagnetic sensor arrays, and methods of manufacture |
EP2017619A1 (de) * | 2007-07-20 | 2009-01-21 | Koninklijke Philips Electronics N.V. | Magnetsensorvorrichtung |
FR2919390B1 (fr) | 2007-07-27 | 2009-10-30 | Bertin Technologies Soc Par Ac | Procede de dosage d'un analyte dans un milieu liquide |
EP2728357B1 (de) * | 2007-09-20 | 2017-02-22 | Magarray, Inc. | Nachweis von Analyten mit magnetischen Sensoren |
EP2193375A1 (de) * | 2007-09-21 | 2010-06-09 | Koninklijke Philips Electronics N.V. | Sensor mit hochfrequenz-wechselstrom-magnetfeld |
EP2060637A1 (de) * | 2007-11-14 | 2009-05-20 | Koninklijke Philips Electronics N.V. | Mittel und Verfahren zum Erkennen von Nukleinsäuren |
CN101952725B (zh) * | 2007-12-03 | 2014-12-10 | 多摩川精机株式会社 | 使用了包覆磁性微粒的生物传感方法以及用于该方法的生物传感装置 |
US9656271B2 (en) * | 2007-12-04 | 2017-05-23 | Headway Technologies, Inc. | Guided transport of magnetically labeled biological molecules and cells |
WO2009072078A1 (en) * | 2007-12-07 | 2009-06-11 | Koninklijke Philips Electronics N.V. | Magnetic washing for biosensor |
KR100949804B1 (ko) * | 2007-12-14 | 2010-03-30 | 한국전자통신연구원 | 자기장 감지소자 |
KR100952468B1 (ko) * | 2007-12-14 | 2010-04-13 | 한국전자통신연구원 | 자기장 감지소자의 제조방법 |
US20100277160A1 (en) * | 2007-12-18 | 2010-11-04 | Koninklijke Philips Electronics N.V. | Magnetic sensor device |
US20110001472A1 (en) * | 2007-12-20 | 2011-01-06 | Koninklijke Philips Electronics N.V. | Positioning of magnetic coils in a sensor device |
EP2073016A1 (de) * | 2007-12-20 | 2009-06-24 | Koninklijke Philips Electronics N.V. | Magnetetikett-basierte Detektion |
WO2009091926A2 (en) | 2008-01-17 | 2009-07-23 | The Regents Of The University Of California | Integrated magnetic field generation and detection platform |
WO2009138897A1 (en) * | 2008-05-14 | 2009-11-19 | Koninklijke Philips Electronics, N.V. | Oxygen concentration measurement with gmr |
JP2009031303A (ja) * | 2008-09-22 | 2009-02-12 | Canon Inc | 検出デバイス及び検出用キット |
EP2338052B1 (de) * | 2008-10-16 | 2019-11-20 | Koninklijke Philips N.V. | Verfahren und vorrichtung zur bestimmung der anzahl an magnetisch markierten zielkomponenten |
EP2340434B1 (de) | 2008-10-17 | 2014-03-19 | Koninklijke Philips N.V. | Gepulste magnetische betätigung für sensitive tests |
US8859059B2 (en) * | 2008-11-03 | 2014-10-14 | Yeda Research And Development Co., Ltd. | Magnetic patterning method and system |
KR101181697B1 (ko) * | 2008-12-22 | 2012-09-19 | 한국전자통신연구원 | 정십자형 자기비드 감지 어레이 소자 |
US9121887B2 (en) | 2009-02-26 | 2015-09-01 | Regents Of The University Of Minnesota | High magnetic moment particle detection |
US9599591B2 (en) | 2009-03-06 | 2017-03-21 | California Institute Of Technology | Low cost, portable sensor for molecular assays |
US8405385B2 (en) * | 2009-03-10 | 2013-03-26 | The Board Of Trustees Of The Leland Stanford Junior University | Temperature and drift compensation in magnetoresistive sensors |
KR101034273B1 (ko) * | 2009-04-07 | 2011-05-16 | 최철원 | 마그네틱 비드를 이용한 마이크로어레이 분석 방법 및 시스템 |
JP2012523576A (ja) * | 2009-04-13 | 2012-10-04 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 試料中の分析物の存在を検出するための方法および装置 |
WO2010121223A2 (en) * | 2009-04-17 | 2010-10-21 | California Institute Of Technology | Electromagnetic molecular sensors and methods of using same |
KR101009802B1 (ko) * | 2009-05-11 | 2011-01-19 | 금오공과대학교 산학협력단 | 입자밀도 측정 시스템 및 방법 |
EP2435817B1 (de) * | 2009-05-25 | 2017-06-28 | Insplorion AB | Sensor für lokalisierte oberflächenplasmonenresonanz |
CN102472749B (zh) * | 2009-06-30 | 2015-03-25 | 皇家飞利浦电子股份有限公司 | 磁性传感器装置、操作该装置的方法以及样品 |
WO2011007310A1 (en) | 2009-07-17 | 2011-01-20 | Koninklijke Philips Electronics N.V. | Apparatus for the enrichment of magnetic particles |
US20110076782A1 (en) * | 2009-09-28 | 2011-03-31 | International Business Machines Corporation | Read-after-write detection of analytes via nanoparticle-labeled substances |
WO2011036638A1 (en) * | 2009-09-28 | 2011-03-31 | Koninklijke Philips Electronics N.V. | Substance determining apparatus |
CA2780148C (en) * | 2009-11-06 | 2017-02-28 | Scientific Nanomedicine, Inc. | Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof |
JP5765907B2 (ja) | 2009-11-09 | 2015-08-19 | 株式会社フェローテック | 磁性部材および電子部品 |
US9132423B2 (en) | 2010-01-29 | 2015-09-15 | Micronics, Inc. | Sample-to-answer microfluidic cartridge |
JP5937019B2 (ja) * | 2010-03-12 | 2016-06-22 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 磁気センサに基づく結合反応速度の定量的な分析 |
DE102010020784A1 (de) * | 2010-05-18 | 2011-11-24 | Siemens Aktiengesellschaft | Verfahren zum Erkennen von magnetisch gekennzeichneten Objekten sowie entsprechende Vorrichtung |
KR101157997B1 (ko) * | 2010-08-19 | 2012-06-25 | 주식회사 엘지생명과학 | 자기저항센서를 이용한 검출시스템 |
DE102010040391B4 (de) * | 2010-09-08 | 2015-11-19 | Siemens Aktiengesellschaft | Magnetische Durchflusszytometrie zur Einzelzelldetektion |
GB201016484D0 (en) | 2010-09-30 | 2010-11-17 | Geneseque As | Method |
US8815610B2 (en) * | 2010-10-15 | 2014-08-26 | International Business Machines Corporation | Magnetic nanoparticle detection across a membrane |
WO2012068146A1 (en) | 2010-11-15 | 2012-05-24 | Regents Of The University Of Minnesota | Search coil |
CN102487118B (zh) * | 2010-12-05 | 2014-04-30 | 北京德锐磁星科技有限公司 | 一种磁性生物传感器及其制备方法 |
US9304130B2 (en) | 2010-12-16 | 2016-04-05 | International Business Machines Corporation | Trenched sample assembly for detection of analytes with electromagnetic read-write heads |
US9151763B2 (en) | 2011-03-09 | 2015-10-06 | Magarray, Inc. | Systems and methods for high-throughput detection of an analyte in a sample |
US9040311B2 (en) | 2011-05-03 | 2015-05-26 | International Business Machines Corporation | Calibration assembly for aide in detection of analytes with electromagnetic read-write heads |
US8855957B2 (en) | 2011-05-03 | 2014-10-07 | International Business Machines Corporation | Method for calibrating read sensors of electromagnetic read-write heads |
US9229071B2 (en) * | 2011-06-01 | 2016-01-05 | International Business Machines Corporation | Identification of molecules based on frequency responses using electromagnetic write-heads and magneto-resistive sensors |
DE102011080945A1 (de) * | 2011-08-15 | 2013-02-21 | Siemens Aktiengesellschaft | Dynamische Zustandsbestimmung von Analyten mittels magnetischer Durchflussmessung |
CN102393453B (zh) * | 2011-08-22 | 2013-09-18 | 中国科学院宁波材料技术与工程研究所 | 一种磁标记生物传感器、其制备方法以及检测方法 |
US9927431B2 (en) | 2011-09-14 | 2018-03-27 | Regents Of The University Of Minnesota | External field—free magnetic biosensor |
US9823316B2 (en) | 2011-10-19 | 2017-11-21 | Regents Of The University Of Minnesota | Magnetic biomedical sensors and sensing system for high-throughput biomolecule testing |
EP2800970B1 (de) | 2012-01-04 | 2016-09-28 | Magnomics, S.A. | Monolithische vorrichtung zur kombination von cmos mit magnetoresistiven sensoren |
US9435800B2 (en) | 2012-09-14 | 2016-09-06 | International Business Machines Corporation | Sample assembly with an electromagnetic field to accelerate the bonding of target antigens and nanoparticles |
KR102102123B1 (ko) | 2012-12-21 | 2020-04-20 | 퍼킨엘머 헬스 사이언시즈, 아이엔씨. | 유체 공학 회로 및 관련 제조 방법 |
WO2014100725A1 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Portable fluorescence detection system and microassay cartridge |
KR20150096788A (ko) | 2012-12-21 | 2015-08-25 | 마이크로닉스 인코포레이티드. | 마이크로 유체공학 용도를 위한 저탄성 막 |
CN104919612B (zh) | 2013-03-15 | 2019-08-09 | 马格雷股份有限公司 | 磁隧道结传感器及使用方法 |
AU2014262726B2 (en) | 2013-05-07 | 2019-09-19 | Perkinelmer Health Sciences, Inc. | Device for preparation and analysis of nucleic acids |
AU2014262710B2 (en) | 2013-05-07 | 2019-09-12 | Perkinelmer Health Sciences, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
US10386377B2 (en) | 2013-05-07 | 2019-08-20 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
US9767943B2 (en) | 2013-11-07 | 2017-09-19 | University Of South Carolina | Patterned nanoparticle assembly methodology |
AU2015213248B2 (en) * | 2014-01-31 | 2019-03-28 | University Of South Australia | Sensor for detection of magnetic particles |
US20160011182A1 (en) * | 2014-07-09 | 2016-01-14 | Zepto Life Technology, LLC | Method and system for substance detection with a magnetic sensor |
US9678169B2 (en) * | 2014-07-09 | 2017-06-13 | Voltafield Technology Corp. | Testing assembly for testing magnetic sensor and method for testing magnetic sensor |
GB201413929D0 (en) | 2014-08-06 | 2014-09-17 | Geneseque As | Method |
WO2016029943A1 (en) * | 2014-08-27 | 2016-03-03 | Siemens Aktiengesellschaft | Method for determining at least one physiological parameter of a biological sample |
CN105092879B (zh) * | 2015-08-06 | 2019-08-13 | 德惠市北方汽车底盘零部件有限公司 | 复合电子元件 |
US10605775B2 (en) * | 2015-11-10 | 2020-03-31 | Tdk Corporation | Biosensor, method for detecting biomolecules, and biochip |
CN109073597A (zh) | 2016-03-28 | 2018-12-21 | Tdk株式会社 | 化学传感器 |
US10799863B2 (en) | 2016-03-28 | 2020-10-13 | Tdk Corporation | Chemical sensor |
JPWO2017170230A1 (ja) * | 2016-03-28 | 2019-02-07 | Tdk株式会社 | バイオセンサ及びバイオチップ |
JP6668176B2 (ja) * | 2016-06-16 | 2020-03-18 | 株式会社東芝 | センサ |
CN107796865B (zh) | 2016-09-05 | 2021-05-25 | 财团法人工业技术研究院 | 生物分子磁传感器 |
US10060880B2 (en) * | 2016-09-15 | 2018-08-28 | Qualcomm Incorporated | Magnetoresistive (MR) sensors employing dual MR devices for differential MR sensing |
WO2018156920A1 (en) * | 2017-02-24 | 2018-08-30 | Nano Theranostics, Inc | Doped magnetic nanoparticles |
DE102017114537A1 (de) * | 2017-06-29 | 2019-01-03 | Endress+Hauser Conducta Gmbh+Co. Kg | Sensormembran, Sensorkappe und optischer Sensor |
CN107394062B (zh) * | 2017-07-20 | 2019-02-05 | 京东方科技集团股份有限公司 | 一种有机发光二极管显示面板及其制作方法、显示装置 |
CA3178002A1 (en) | 2018-07-27 | 2020-01-30 | Zepto Life Technology, LLC | System and method for sensing analytes in gmr-based detection of biomarkers |
US10738342B2 (en) | 2018-08-30 | 2020-08-11 | Urinary Technologies, Inc. | System for microbial species detection, quantification and antibiotic susceptibility identification |
US10978376B2 (en) * | 2019-01-18 | 2021-04-13 | Electronics And Telecommunications Research Institute | Sensing device and method for fabricating the same |
US11609208B2 (en) | 2019-04-12 | 2023-03-21 | Western Digital Technologies, Inc. | Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles |
US11112468B2 (en) * | 2019-04-12 | 2021-09-07 | Western Digital Technologies, Inc. | Magnetoresistive sensor array for molecule detection and related detection schemes |
CN113905822B (zh) | 2019-04-12 | 2023-09-22 | 西部数据技术公司 | 使用磁传感器阵列边合成边核酸测序 |
CN110274951A (zh) * | 2019-05-20 | 2019-09-24 | 青岛大学 | 一种磁标签及其检测系统、检测方法、制备方法 |
CN112082901B (zh) * | 2019-06-13 | 2022-02-22 | 宁德时代新能源科技股份有限公司 | 面密度测量补偿系统 |
CN110302838B (zh) * | 2019-06-20 | 2022-04-15 | 苏州大学 | 表面修饰PNH的磁性Fe2O3纳米小球及其在水处理中的应用 |
JP7136137B2 (ja) * | 2020-01-29 | 2022-09-13 | Tdk株式会社 | 磁気センサ、磁気検出装置及び磁気検出システム |
CN112924906B (zh) * | 2021-01-26 | 2022-04-05 | 西安交通大学 | 基于磁热效应的无线柔性磁传感器及制备方法和检测方法 |
EP4291911A1 (de) | 2021-03-22 | 2023-12-20 | Nearfield Atomics Inc. | Systeme und verfahren zur messung von magnetfeldern aus solvatierten zielmolekülen unter verwendung eines magnetoresistiven sensors |
DE102021115952A1 (de) * | 2021-06-21 | 2022-12-22 | Universidad Complutense Madrid | Sensorvorrichtungen, elektrische Verbindungssysteme und Verfahren zum Detektieren eines genetischen Materials |
US20230243778A1 (en) * | 2022-01-28 | 2023-08-03 | Western Digital Technologies, Inc. | Self-aligned surface modification for magnetochemical sensors |
CN119173780A (zh) * | 2022-04-29 | 2024-12-20 | 亚德诺半导体国际无限责任公司 | 使用一个或多个隔室内的粒子进行比较测量 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252459A (en) * | 1988-09-23 | 1993-10-12 | Abbott Laboratories | Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles |
US5021736A (en) * | 1989-09-19 | 1991-06-04 | Texas Instruments Incorporated | Speed/position sensor calibration method with angular adjustment of a magnetoresistive element |
US5412087A (en) * | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
JPH06220609A (ja) * | 1992-07-31 | 1994-08-09 | Sony Corp | 磁気抵抗効果膜及びその製造方法並びにそれを用いた磁気抵抗効果素子、磁気抵抗効果型磁気ヘッド |
US5569544A (en) * | 1992-11-16 | 1996-10-29 | Nonvolatile Electronics, Incorporated | Magnetoresistive structure comprising ferromagnetic thin films and intermediate layers of less than 30 angstroms formed of alloys having immiscible components |
CN1076784A (zh) * | 1993-03-10 | 1993-09-29 | 北京放射医学研究所 | 磁性微颗粒免疫分离剂及制备 |
US5411814A (en) * | 1994-01-26 | 1995-05-02 | At&T Corp. | Article comprising magnetoresistive oxide of La, Ca, Mn additionally containing either of both of Sr and Ba |
US5739990A (en) * | 1996-11-13 | 1998-04-14 | Read-Rite Corporation | Spin-valve GMR sensor with inbound exchange stabilization |
US5981297A (en) * | 1997-02-05 | 1999-11-09 | The United States Of America As Represented By The Secretary Of The Navy | Biosensor using magnetically-detected label |
US6592820B1 (en) * | 1998-11-05 | 2003-07-15 | Bio-Spectrum Technologies, Inc. | System and method for biochemical assay |
AU4244300A (en) * | 1999-04-13 | 2000-11-14 | Nanogen, Inc. | Magnetic bead-based array for genetic detection |
CA2381732A1 (en) * | 1999-08-21 | 2001-03-01 | John S. Fox | High sensitivity biomolecule detection with magnetic particles |
US6743639B1 (en) * | 1999-10-13 | 2004-06-01 | Nve Corporation | Magnetizable bead detector |
US6468809B1 (en) * | 2000-02-04 | 2002-10-22 | The United States Of America As Represented By The Secretary Of The Navy | High efficiency magnetic sensor for magnetic particles |
US20040219695A1 (en) * | 2002-01-19 | 2004-11-04 | Fox John Stewart | High sensitivity detection of and manipulation of biomolecules and cells with magnetic particles |
US20040033627A1 (en) * | 2002-05-31 | 2004-02-19 | The Regents Of The University Of California | Method and apparatus for detecting substances of interest |
-
2002
- 2002-12-17 JP JP2003555187A patent/JP2005513475A/ja active Pending
- 2002-12-17 EP EP02790607A patent/EP1456658B1/de not_active Expired - Lifetime
- 2002-12-17 WO PCT/IB2002/005567 patent/WO2003054523A2/en active IP Right Grant
- 2002-12-17 AU AU2002366904A patent/AU2002366904A1/en not_active Abandoned
- 2002-12-17 DE DE60211555T patent/DE60211555T2/de not_active Expired - Lifetime
- 2002-12-17 US US10/498,958 patent/US7048890B2/en not_active Expired - Fee Related
- 2002-12-17 AT AT02790607T patent/ATE326697T1/de not_active IP Right Cessation
- 2002-12-17 KR KR10-2004-7009884A patent/KR20040068968A/ko not_active Application Discontinuation
- 2002-12-17 CN CNB02825869XA patent/CN100343670C/zh not_active Expired - Fee Related
- 2002-12-25 TW TW091137286A patent/TWI295323B/zh not_active IP Right Cessation
-
2006
- 2006-01-24 US US11/338,022 patent/US20060128035A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20050087000A1 (en) | 2005-04-28 |
JP2005513475A (ja) | 2005-05-12 |
DE60211555D1 (de) | 2006-06-22 |
EP1456658B1 (de) | 2006-05-17 |
TWI295323B (en) | 2008-04-01 |
CN1608206A (zh) | 2005-04-20 |
EP1456658A2 (de) | 2004-09-15 |
TW200411063A (en) | 2004-07-01 |
KR20040068968A (ko) | 2004-08-02 |
WO2003054523A3 (en) | 2004-03-18 |
DE60211555T2 (de) | 2007-02-22 |
AU2002366904A1 (en) | 2003-07-09 |
CN100343670C (zh) | 2007-10-17 |
WO2003054523A2 (en) | 2003-07-03 |
US20060128035A1 (en) | 2006-06-15 |
US7048890B2 (en) | 2006-05-23 |
AU2002366904A8 (en) | 2003-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE326697T1 (de) | Sensor und methode zur messung der flächendichte von magnetischen nanopartikeln auf einem mikroarray | |
Yang et al. | Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis | |
ATE479775T1 (de) | Hochempfindliche assays für die pathogendetektion unterverwendung der metallverstärkten fluoreszenz | |
DE60319641D1 (de) | Methode zur Anwendung Molekulare Konstrukte zur Detektion biochemischer Reaktionen | |
EP1442142A4 (de) | Nukleinsäuresonden und verfahren zum nachweis und zur quantifizierung von nukleinsäureanalyten | |
ATE312199T1 (de) | Verfahen und zusammensetzungen zur vermehrung von feststellbaren signalen in spezifischen bindungstests | |
DE60318313D1 (de) | Verfahren und einrichtung zur hochempfindlichen detektion der anwesenheit von dna und weitere sonden | |
WO2005026681A3 (en) | Magnetostrictive ligand sensor devices and uses thereof | |
DE60023539D1 (de) | Immunologischer nachweis von rna:dna hybriden auf mikroarrays | |
JP2007500347A (ja) | 改善されたsnrを持つチップ上磁性粒子センサ | |
Shivashakarappa et al. | Nanotechnology for the detection of plant pathogens | |
WO2005027714A3 (en) | Sensitive and rapid biodetection | |
CN1605031A (zh) | 确定流体中的磁性颗粒密度的磁阻传感器、系统和方法 | |
ATE556030T1 (de) | Ultrasensitiver nachweis von analyten | |
DE60133111D1 (de) | Verfahren zur erkennung und zum assay von nukleinsäuresequenzen | |
ATE537271T1 (de) | Toll-like-rezeptor-4-dysfunktion und biologische anwendungen davon | |
EP1431398A1 (de) | Verfahren zum Nachweis die Menge eines Analyten in einer Mischung | |
US20080054896A1 (en) | Magnetic Sensor with Parallel Magnetic Sensor Strips | |
EP1239286A3 (de) | Biochemische Sensoren, Methoden für deren Herstellung und biochemische Methoden und Systeme für das Testen von Substanzen | |
ATE331044T1 (de) | Verfahren zur integrierten integritätsbewertung und analyse von nukleinsäuren | |
DE602005018816D1 (de) | Chemische sensoren, die anilinpolysiloxane als empfindliche substanzen enthalten, und ihre verwendung zum nachweis und zur quantitativen analyse von nitroverbindungen | |
US20240118274A1 (en) | Structure and methods for detection of sample analytes | |
FR2868071B1 (fr) | Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques | |
EP1967855A1 (de) | Magnetsensorvorrichtung | |
ATE515701T1 (de) | Verwendung eines bindungsteil exprimierenden virus zur messung von analyten in einer probe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |