[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE398448T1 - Herstellung von weichgelatinekapseln - Google Patents

Herstellung von weichgelatinekapseln

Info

Publication number
ATE398448T1
ATE398448T1 AT00103110T AT00103110T ATE398448T1 AT E398448 T1 ATE398448 T1 AT E398448T1 AT 00103110 T AT00103110 T AT 00103110T AT 00103110 T AT00103110 T AT 00103110T AT E398448 T1 ATE398448 T1 AT E398448T1
Authority
AT
Austria
Prior art keywords
soft gelatin
gelatin capsules
production
solvent
capsules
Prior art date
Application number
AT00103110T
Other languages
English (en)
Inventor
Werner Brox
Horst Zande
Armin Meinzer
Original Assignee
Scherer Gmbh R P
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6498793&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE398448(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scherer Gmbh R P, Novartis Ag filed Critical Scherer Gmbh R P
Application granted granted Critical
Publication of ATE398448T1 publication Critical patent/ATE398448T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Cosmetics (AREA)
AT00103110T 1993-09-28 1994-09-24 Herstellung von weichgelatinekapseln ATE398448T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4332931 1993-09-28

Publications (1)

Publication Number Publication Date
ATE398448T1 true ATE398448T1 (de) 2008-07-15

Family

ID=6498793

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00103110T ATE398448T1 (de) 1993-09-28 1994-09-24 Herstellung von weichgelatinekapseln
AT94115081T ATE198041T1 (de) 1993-09-28 1994-09-24 Herstellung von weichgelatinekapseln

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT94115081T ATE198041T1 (de) 1993-09-28 1994-09-24 Herstellung von weichgelatinekapseln

Country Status (31)

Country Link
US (4) US5985321A (de)
EP (3) EP1033128B2 (de)
JP (1) JP3071642B2 (de)
KR (1) KR100200174B1 (de)
CN (2) CN100473377C (de)
AT (2) ATE398448T1 (de)
AU (1) AU690571B2 (de)
CA (3) CA2302963C (de)
CZ (1) CZ290314B6 (de)
DE (2) DE69426408T2 (de)
DK (2) DK0649651T3 (de)
ES (2) ES2308955T5 (de)
FI (1) FI120718B (de)
FR (1) FR2710532B1 (de)
GB (1) GB2282586B (de)
GR (1) GR3035179T3 (de)
HK (1) HK1078478A1 (de)
HU (2) HU228201B1 (de)
IL (1) IL111067A (de)
IT (1) IT1274931B (de)
NO (1) NO312334B1 (de)
NZ (1) NZ264536A (de)
PE (1) PE31295A1 (de)
PL (1) PL178884B1 (de)
PT (2) PT649651E (de)
RU (1) RU2140783C1 (de)
SG (1) SG46531A1 (de)
SI (2) SI0649651T1 (de)
SK (2) SK285204B6 (de)
TW (1) TW438609B (de)
ZA (1) ZA947567B (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013761A1 (de) * 1992-01-17 1993-07-22 Alfatec-Pharma Gmbh Verfahren zur herstellung von weichgelatinekapseln nach einem tropfverfahren
US6204243B1 (en) 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
ATE398448T1 (de) 1993-09-28 2008-07-15 Scherer Gmbh R P Herstellung von weichgelatinekapseln
US7205279B2 (en) * 1995-10-25 2007-04-17 Novartis Ag Pharmaceutical compositions
MY129435A (en) * 1994-10-26 2007-04-30 Novartis Ag Pharmaceutical microemulsion preconcentrates
GB2308545B (en) * 1994-10-26 1999-06-02 Novartis Ag Pharmaceutical microemulsion preconcentrates
US5603951A (en) * 1994-11-09 1997-02-18 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin-containing soft capsule compositions
NZ280689A (en) * 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
JPH1071186A (ja) * 1996-08-29 1998-03-17 Shionogi & Co Ltd カプセルのバンドシール形成方法
TR199901686T2 (xx) * 1997-01-30 1999-09-21 Norvartis Ag Esasen ya�s�z farmakolojik kompozisyonlar� i�eren sert jelatin kaps�ller.
PT982035E (pt) * 1998-08-18 2004-08-31 Panacea Biotec Ltd Composicao de ciclosporina compreendendo um veiculo hidrofilo
EP1131037B1 (de) * 1998-11-17 2004-09-01 F. Hoffmann-La Roche Ag Verfahren zur herstellung von flüssigkeitsgefüllten kapseln
PT1154759E (pt) 1998-12-30 2008-11-20 Dexcel Ltd Concentrado dispersível para administração de ciclosporina
US20030104048A1 (en) * 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
AU4491200A (en) * 1999-08-03 2001-02-19 Lilly Icos Llc Beta-carboline pharmaceutical compositions
JP4601100B2 (ja) * 1999-11-08 2010-12-22 三生医薬株式会社 マスティックの油液を内包した軟カプセル
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
WO2002022158A1 (en) * 2000-09-18 2002-03-21 Rpg Life Sciences Limited Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities
RS50197B (sr) * 2000-10-12 2009-05-06 Boehringer Ingelheim Pharma Gmbh. & Co.Kg., Novi tiotropiumski preparati- koji sadrže prah za inhaliranje
YU32103A (sh) * 2000-10-31 2006-05-25 Boehringer Ingelheim Pharmaceuticals Inc. Samo-emulgujući preparati za oralnu primenu piranonskih inhibitora proteaze
JP4214350B2 (ja) * 2001-01-15 2009-01-28 日本電気株式会社 携帯電話のｓｉｍカード取り付け構造
US20030138483A1 (en) * 2001-05-25 2003-07-24 Sergio Petriconi Soft elastic capsules and compositions thereof
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US20040052852A1 (en) * 2001-09-25 2004-03-18 Michael Farber Carbohydrate-based delivery system for creatine and other bioactive ingredients
PT1435910E (pt) * 2001-10-19 2009-09-07 Isotechnika Inc Novos pré-concentrados de microemulsão de análogos da ciclosporina
US6752953B2 (en) * 2001-12-03 2004-06-22 Yung Shin Pharmaceutical Co., Ltd. Method for manufacturing hard non-gelatin pharmaceutical capsules
KR20030062894A (ko) * 2002-01-21 2003-07-28 주식회사 보창 소프트젤라틴캡슐제조기의 성형드럼 냉각장치
US7067150B2 (en) 2002-04-16 2006-06-27 Scepter Holdings, Inc. Delivery systems for functional ingredients
ES2293039T3 (es) * 2002-07-29 2008-03-16 Alza Corporation Procedimiento y formas de dosificacion para el suministro controlado de paliperidona.
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
KR100525234B1 (ko) * 2003-02-19 2005-10-28 한국유나이티드제약 주식회사 사이클로스포린 함유 연질캅셀제 및 그 제조방법
US7134978B2 (en) * 2003-07-28 2006-11-14 Sagittarius Life Science Corporation Seamless BB paintball
US7247010B2 (en) * 2003-10-01 2007-07-24 Technophar Equipment & Service Limited Servo control for capsule making machine
FR2861992B1 (fr) * 2003-11-10 2007-07-20 Sanofi Synthelabo Composition pharmaceutique destinee a l'administration orale d'un derive de pyrazole-3-carboxamide.
CA2546004C (en) 2003-11-12 2010-09-14 National Paintball Supply, Inc. Projectile, projectile core, and method of making
US20050175686A1 (en) * 2004-02-11 2005-08-11 Ramachandran Radhakrishnan Drug delivery system using a solubilized gelatin shell composition and unit dose drug delivery using a special shape soft gelatin capsule
JP2005255677A (ja) * 2004-02-12 2005-09-22 Nof Corp シクロスポリン製剤
US20080160086A1 (en) * 2004-02-19 2008-07-03 Scepter Holdings, Inc. Delivery Systems For Calcium
US20060153824A1 (en) * 2005-01-13 2006-07-13 Everett Laboratories, Inc. Methods and kits for co-administration of nutritional supplements
HUE029192T2 (en) * 2005-03-21 2017-02-28 Teva Czech Ind S R O Anti-crystallization and its use in gelatin capsules
US20060275361A1 (en) * 2005-06-03 2006-12-07 Cadbury Adams Usa Llc. Rapidly dissolving gelatin compositions and products made therefrom
EA015922B1 (ru) 2005-11-14 2011-12-30 Ариад Фармасьютикалз, Инк. ВВЕДЕНИЕ ИНГИБИТОРА mTOR ДЛЯ ЛЕЧЕНИЯ ПАЦИЕНТОВ СО ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛЬЮ
CN1919194A (zh) * 2006-08-17 2007-02-28 刘瑜玲 西罗莫司的液体组合物
US20100055175A1 (en) * 2007-03-06 2010-03-04 James Nugent Soft gelatin capsule shells containing oil soluble flavoring and methods of making the same
US20090110724A1 (en) * 2007-10-31 2009-04-30 Everett Laboratories, Inc. Compositions and methods for treatment of pain
MY153093A (en) 2008-09-16 2014-12-31 Boehringer Ingelheim Int Crystalline forms of a 2-thiazolyl-4-quinolinyl-oxy derivative, a potent hcv inhibitor
CA2937492C (en) 2008-11-11 2019-08-13 The Board Of Regents Of The University Of Texas System Inhibition of mammalian target of rapamycin
BR112012000287B8 (pt) 2009-07-07 2021-05-25 Boehringer Ingelheim Int composição farmacêutica para um inibidor de protease viral de hepatite c
US9283211B1 (en) 2009-11-11 2016-03-15 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
US8530497B2 (en) 2010-03-11 2013-09-10 Boehringer Ingelheim International Gmbh Crystalline salts of a potent HCV inhibitor
GB201006012D0 (en) * 2010-04-09 2010-05-26 Ayanda As Composition
EP2595610A4 (de) * 2010-07-19 2015-10-28 Procaps S A Verbesserte vorrichtung und verfahren zur herstellung weicher gelkapseln
KR20130108326A (ko) 2010-09-30 2013-10-02 베링거 인겔하임 인터내셔날 게엠베하 효능이 강한 ｈｃｖ 억제제의 고체 상태 형태
US20120107395A1 (en) * 2010-11-01 2012-05-03 Viva Pharmaceutical Inc. Probiotic Soft Gel Compositions
US8621764B2 (en) 2011-03-16 2014-01-07 John PUCKETT Gelatin capsule formulation and drying system
WO2012138669A1 (en) 2011-04-04 2012-10-11 Gilead Sciences, Inc. Solid state forms of hiv inhibitor
CN103732255B (zh) * 2011-09-02 2016-04-06 富士胶片株式会社 软胶囊制剂、软胶囊制剂用组合物及软胶囊制剂的制造方法
US20130261134A1 (en) 2012-03-30 2013-10-03 Boehringer Ingelheim International Gmbh Mesylate salt forms of a potent hcv inhibitor
US20140094485A1 (en) 2012-10-03 2014-04-03 Gilead Sciences, Inc. Solid state forms of hiv inhibitor
US20160030401A1 (en) 2013-03-13 2016-02-04 The Board Of Regents Of The University Of Texas System Use of mtor inhibitors for prevention of intestinal polyp growth and cancer
CN103315975B (zh) * 2013-06-05 2015-09-02 天津科技大学 一种明胶-CaCO3矿物质胶囊壳及其制备方法
WO2015013397A2 (en) * 2013-07-25 2015-01-29 Neuren Pharmaceuticals Limited Neuroprotective bicyclic compounds and methods for their use in treating autism spectrum disorders and neurodevelopmental disorders
US9700544B2 (en) 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
DK3089737T3 (da) 2013-12-31 2021-12-13 Rapamycin Holdings Llc Orale rapamycin-nanopartikelpræparater og anvendelse.
CA2994859A1 (en) * 2015-08-19 2017-02-23 Vivus, Inc. Pharmaceutical formulations
CN112240659A (zh) * 2020-10-17 2021-01-19 温州桑盾信息科技有限公司 一种胶囊机安全防护用自动降温机构

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198391A (en) * 1973-07-20 1980-04-15 R. P. Scherer Ltd. Pharmaceutical compositions
US3870547A (en) 1974-01-24 1975-03-11 Owens Corning Fiberglass Corp Starch coated fibers for embedding in resin matrix forming materials and composites so formed
BE825842A (fr) * 1974-02-22 1975-08-21 Compositions pharmaceutiques comprenant de la digoxine
GB1508770A (en) 1974-04-01 1978-04-26 Scherer Ltd R Pharmaceutical compositions
US4067960A (en) * 1975-06-20 1978-01-10 R. P. Scherer Limited Pharmaceutical compositions containing cardiac glycoside
SE445174B (sv) * 1978-03-07 1986-06-09 Sandoz Ag Farmaceutisk komposition innehallande en cyklosporin och en berarsubstans
JPS5933018B2 (ja) * 1980-03-17 1984-08-13 森下仁丹株式会社 高融点物質のマイクロカプセル製造方法とその製造装置
DE3237814A1 (de) * 1982-10-12 1984-04-12 Warner-Lambert Co., 07950 Morris Plains, N.J. Wasserfreie emulsionen und verwendung derselben
DE3307353C2 (de) 1983-03-02 1985-01-31 R.P. Scherer GmbH, 6930 Eberbach Polyethylenglykolhaltige Weichgelatinekapsel und Verfahren zu ihrer Herstellung
GB8305693D0 (en) * 1983-03-02 1983-04-07 Scherer Ltd R P Pharmaceutical compositions
DE3406497A1 (de) 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4609403A (en) * 1984-03-12 1986-09-02 Warner-Lambert Company Foam soft gelatin capsules and their method of manufacture
US4713246A (en) 1984-03-19 1987-12-15 Bristol-Myers Company Etoposide oral dosage form
EP0169398B1 (de) * 1984-07-24 1990-08-29 R.P. Scherer GmbH Oxytetracyclin-HC1-Weichgelatinekapseln und Verfahren zu ihrer Herstellung
DE3445237C1 (de) * 1984-12-12 1986-06-05 R.P. Scherer GmbH, 6930 Eberbach Weichgelatinekapseln und Verfahren zu ihrer Herstellung
DE3529694A1 (de) 1985-08-20 1987-02-26 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
JPS62207460A (ja) 1986-03-07 1987-09-11 株式会社三協 ゼラチンカプセルの製造装置におけるゼラチンシ−ト成型装置
DE3676491D1 (de) 1986-04-05 1991-02-07 Scherer Gmbh R P Gelatinekapseln mit gesteuerter wirkstofffreisetzung und verfahren zur herstellung derselben.
DE3629386A1 (de) * 1986-08-29 1988-03-03 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
US4927638A (en) * 1986-10-08 1990-05-22 Bristol-Myers Company Etoposide solutions
US5154930A (en) * 1987-03-05 1992-10-13 The Liposome Company, Inc. Pharmacological agent-lipid solution preparation
JPS63309264A (ja) 1987-06-10 1988-12-16 Kamata Seisakusho:Kk ソフトカプセル製造機
US4817367A (en) * 1987-08-10 1989-04-04 Sankyo Co., Ltd. Apparatus for manufacturing gelatin capsule and method therefor
GB8721455D0 (en) 1987-09-11 1987-10-21 Lilly Industries Ltd Capsules
HU205010B (en) * 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
DE68900991D1 (de) * 1988-01-29 1992-04-23 Sankyo Co Cyclosporin-zusammensetzungen.
US5376381A (en) * 1988-02-25 1994-12-27 The Liposome Company, Inc. Integrity protected gelatin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US4935293A (en) 1988-10-25 1990-06-19 Unifi, Inc. Continuous multi-filament polyester substrate readily adherable to a vinyl sheet
US4935243A (en) * 1988-12-19 1990-06-19 Pharmacaps, Inc. Chewable, edible soft gelatin capsule
CA2063791C (en) * 1989-08-17 2000-12-19 Michael John Story Hard gelatine capsule containing fat-soluble nutrients.
US5532002A (en) * 1989-08-17 1996-07-02 Cortecs Limited Gelatin pharmaceutical formulations
US5178877A (en) * 1991-01-04 1993-01-12 Abbott Laboratories Encapsulated renin inhibitor composition
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US6262022B1 (en) * 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
US5224294A (en) * 1991-07-25 1993-07-06 E. I. Du Pont De Nemours And Company Hydroponic growth system
US5200191A (en) * 1991-09-11 1993-04-06 Banner Gelatin Products Corp. Softgel manufacturing process
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
DE4201178C2 (de) * 1992-01-17 1995-12-07 Alfatec Pharma Gmbh Verfahren zur Herstellung von Weichgelatinekapseln nach einem Tropfverfahren
EP0573978B1 (de) * 1992-06-12 1999-04-21 Kao Corporation Badezusatzzusammensetzung enthaltend oberflächenaktive Mittel enthaltende nahtlose Kapsel und Verfahren zur Herrstellung der Kapsel
US5626872A (en) * 1992-06-16 1997-05-06 Roemmers S.A.I.C.F. Pharmaceutical soft capsules containing lysine clonixinate and a process for their preparation
CZ278863B6 (en) 1992-09-07 1994-07-13 Galena Medicinal preparations with n-methylated cyclic undecapeptides
US5376293A (en) * 1992-09-14 1994-12-27 State Of South Dakota As Represented By The Department Of Transportation Deicer
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
JPH06157916A (ja) 1992-11-30 1994-06-07 Warner Lambert Kk カプセル硬皮膜組成物
US5376688A (en) * 1992-12-18 1994-12-27 R. P. Scherer Corporation Enhanced solubility pharmaceutical solutions
US5431916A (en) * 1993-04-29 1995-07-11 The Procter & Gamble Company Pharmaceutical compositions and process of manufacture thereof
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
CN1077800C (zh) 1993-07-01 2002-01-16 韩美药品工业株式会社 环孢菌素软胶囊组合物
US5505961A (en) * 1993-08-05 1996-04-09 R. P. Scherer Corporation Gelatin capsules containing a highly concentrated acetaminophen solution
US6204243B1 (en) * 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
IL110752A (en) * 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
ATE398448T1 (de) * 1993-09-28 2008-07-15 Scherer Gmbh R P Herstellung von weichgelatinekapseln
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
US5641512A (en) * 1995-03-29 1997-06-24 The Procter & Gamble Company Soft gelatin capsule compositions
US5614217A (en) * 1995-06-07 1997-03-25 R.P. Scherer Corporation Capsule shell formulation to produce brittle capsules
NZ280689A (en) * 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
US5958876A (en) 1996-06-19 1999-09-28 Novartis Ag Cyclosporin-containing pharmaceutical compositions
PT1208847E (pt) * 1996-07-30 2007-07-24 Novartis Ag Composições farmacêuticas para o tratamento da rejeição de transplantes, doenças autoimunes ou inflamatórias compreendendo ciclosporina a e 40-0-(2-hidroxietil)-rapamicina
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
FR2755368B1 (fr) * 1996-11-04 1999-03-19 Oreal Composition rincable pour le soin de la peau

Also Published As

Publication number Publication date
PL178884B1 (pl) 2000-06-30
ES2308955T3 (es) 2008-12-16
RU94034106A (ru) 1996-11-10
IT1274931B (it) 1997-07-29
PL305188A1 (en) 1995-04-03
HK1078478A1 (en) 2006-03-17
IL111067A (en) 1999-12-31
US20030206930A1 (en) 2003-11-06
CZ290314B6 (cs) 2002-07-17
DE69426408T2 (de) 2001-07-12
DK1033128T4 (da) 2012-03-19
CA2332631C (en) 2002-11-19
IL111067A0 (en) 1994-12-29
EP0649651A1 (de) 1995-04-26
CA2132933C (en) 2000-07-18
US7078054B2 (en) 2006-07-18
GR3035179T3 (en) 2001-04-30
EP1033128A3 (de) 2001-02-28
AU690571B2 (en) 1998-04-30
SK285204B6 (sk) 2006-08-03
US6555132B1 (en) 2003-04-29
EP0649651B1 (de) 2000-12-13
FI944452A (fi) 1995-03-29
SI0649651T1 (en) 2001-02-28
EP1029538A2 (de) 2000-08-23
CZ236094A3 (en) 1995-04-12
PT1033128E (pt) 2008-08-08
SG46531A1 (en) 1998-02-20
GB9419353D0 (en) 1994-11-09
DE69435104D1 (de) 2008-07-31
SI1033128T2 (sl) 2012-02-29
CA2132933A1 (en) 1995-03-29
JP3071642B2 (ja) 2000-07-31
PE31295A1 (es) 1995-10-16
AU7423794A (en) 1995-04-13
GB2282586A (en) 1995-04-12
ITRM940613A0 (it) 1994-09-26
CN1636554A (zh) 2005-07-13
NO943563L (no) 1995-03-29
TW438609B (en) 2001-06-07
EP1033128A2 (de) 2000-09-06
SI1033128T1 (sl) 2009-02-28
US6589536B1 (en) 2003-07-08
DE69426408D1 (de) 2001-01-18
FR2710532B1 (fr) 1997-06-20
ZA947567B (en) 1996-06-28
CN100473377C (zh) 2009-04-01
HU228201B1 (en) 2013-01-28
CA2332631A1 (en) 1995-03-29
PT649651E (pt) 2001-03-30
NO943563D0 (no) 1994-09-26
RU2140783C1 (ru) 1999-11-10
KR950007820A (ko) 1995-04-15
SK284268B6 (sk) 2004-12-01
KR100200174B1 (ko) 1999-06-15
HU221681B1 (hu) 2002-12-28
DK1033128T3 (da) 2008-10-20
GB2282586B (en) 1998-04-22
FI944452A0 (fi) 1994-09-26
HUT70417A (en) 1995-10-30
ITRM940613A1 (it) 1996-03-26
JPH07149625A (ja) 1995-06-13
CN1182842C (zh) 2005-01-05
EP1033128B2 (de) 2011-11-23
FI120718B (fi) 2010-02-15
CA2302963C (en) 2001-10-23
HU9402772D0 (en) 1994-12-28
FR2710532A1 (fr) 1995-04-07
ES2308955T5 (es) 2012-04-03
NO312334B1 (no) 2002-04-29
SK115794A3 (en) 1995-05-10
EP1029538A3 (de) 2003-10-15
DK0649651T3 (da) 2001-02-26
HU0105382D0 (en) 2002-02-28
CA2302963A1 (en) 1995-03-29
CN1108930A (zh) 1995-09-27
US5985321A (en) 1999-11-16
ATE198041T1 (de) 2000-12-15
NZ264536A (en) 1996-09-25
ES2152281T3 (es) 2001-02-01
EP1033128B1 (de) 2008-06-18

Similar Documents

Publication Publication Date Title
ATE198041T1 (de) Herstellung von weichgelatinekapseln
FI892762A0 (fi) Foerfarande foer framstaellning av estrogenprodukt.
DE3650339D1 (de) Herstellung von Urandioxid-Material.
DE3876913D1 (de) Herstellung von kohlenstoffhaltigen pulvern und ihre granulierung.
YU46641B (sh) Postupak za dobijanje dvodelnih tvrdih želatinskih kapsula
DE3770889D1 (de) Herstellung von kubischem bornitrid.
DE3877713D1 (de) Herstellung von gelatinegelee-konfekten.
ATE73643T1 (de) Kapsel und verfahren zu ihrer herstellung.
AT381090B (de) Herstellung von neuen (4r*,5as*)2,4,5-trialkylch8204132231/8

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1033128

Country of ref document: EP

UEP Publication of translation of european patent specification

Ref document number: 1033128

Country of ref document: EP