[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE388713T1 - 4-amino-6-phenyl-pyrrolo(2,3-d)pyrimidin derivate - Google Patents

4-amino-6-phenyl-pyrrolo(2,3-d)pyrimidin derivate

Info

Publication number
ATE388713T1
ATE388713T1 AT02758437T AT02758437T ATE388713T1 AT E388713 T1 ATE388713 T1 AT E388713T1 AT 02758437 T AT02758437 T AT 02758437T AT 02758437 T AT02758437 T AT 02758437T AT E388713 T1 ATE388713 T1 AT E388713T1
Authority
AT
Austria
Prior art keywords
pyrrolo
phenyl
amino
pyrimidine derivatives
pyrimidine
Prior art date
Application number
AT02758437T
Other languages
English (en)
Inventor
Guido Bold
Hans-Georg Capraro
Giorgio Caravatti
Peter Traxler
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE388713T1 publication Critical patent/ATE388713T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02758437T 2001-08-07 2002-08-06 4-amino-6-phenyl-pyrrolo(2,3-d)pyrimidin derivate ATE388713T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0119249.1A GB0119249D0 (en) 2001-08-07 2001-08-07 Organic compounds

Publications (1)

Publication Number Publication Date
ATE388713T1 true ATE388713T1 (de) 2008-03-15

Family

ID=9919959

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02758437T ATE388713T1 (de) 2001-08-07 2002-08-06 4-amino-6-phenyl-pyrrolo(2,3-d)pyrimidin derivate

Country Status (32)

Country Link
US (2) US7244729B2 (de)
EP (1) EP1416935B8 (de)
JP (1) JP4147184B2 (de)
KR (1) KR100597505B1 (de)
CN (2) CN1538847A (de)
AR (1) AR036213A1 (de)
AT (1) ATE388713T1 (de)
AU (1) AU2002324029B2 (de)
BR (1) BR0211801A (de)
CA (1) CA2453881C (de)
CY (1) CY1108129T1 (de)
DE (1) DE60225563T2 (de)
DK (1) DK1416935T3 (de)
EC (1) ECSP034444A (de)
ES (1) ES2302830T3 (de)
GB (1) GB0119249D0 (de)
HK (1) HK1065483A1 (de)
HU (1) HUP0401083A3 (de)
IL (2) IL159832A0 (de)
MX (1) MXPA04001191A (de)
MY (1) MY140398A (de)
NO (1) NO328791B1 (de)
NZ (1) NZ530824A (de)
PE (1) PE20030349A1 (de)
PL (1) PL365783A1 (de)
PT (1) PT1416935E (de)
RU (1) RU2318826C2 (de)
SG (1) SG156521A1 (de)
SI (1) SI1416935T1 (de)
TW (1) TWI324159B (de)
WO (1) WO2003013541A1 (de)
ZA (1) ZA200400271B (de)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL359563A1 (en) * 2000-06-26 2004-08-23 Pfizer Products Inc. Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents
EP1435959A2 (de) * 2001-10-09 2004-07-14 University of Cincinnati Egf rezeptor hemmer zur behandlung von schilddrüsentumoren
EP1944026B1 (de) 2002-05-16 2013-06-26 Novartis AG Verwendung von EDG-Rezeptorbindemitteln bei Krebs
KR101471732B1 (ko) 2003-08-27 2014-12-16 옵쏘테크 코포레이션 안구의 혈관신생성 장애를 치료하기 위한 조합 치료법
EP1689407A1 (de) * 2003-11-25 2006-08-16 Pfizer Products Inc. Verfahren zur behandlung von atherosklerose
PE20051092A1 (es) * 2004-01-29 2006-01-20 Novartis Ag Derivados de pirrolo-pirimidina utiles para el tratamiento de enfermedades proliferativas
GB0403606D0 (en) * 2004-02-18 2004-03-24 Novartis Ag Organic compounds
WO2005095419A1 (ja) * 2004-04-01 2005-10-13 Takeda Pharmaceutial Company Limited チアゾロピリミジン誘導体
CN1964970B (zh) 2004-04-07 2011-08-03 诺瓦提斯公司 Iap的抑制剂
KR101194622B1 (ko) 2004-06-02 2012-10-29 다케다 야쿠힌 고교 가부시키가이샤 접합 헤테로시클릭 화합물
WO2006010264A1 (en) * 2004-07-30 2006-02-02 Methylgene, Inc. Inhibitors of vegf receptor and hgf receptor signaling
JO2596B1 (en) * 2004-11-30 2011-02-27 نوفارتيس ايه جي Compositions include epothelones and tyrosine protein kinase inhibitors and their pharmaceutical uses
DK1827437T3 (da) 2004-12-15 2012-02-13 Sigma Tau Ind Farmaceuti Kombinationer af terapeutiske midler til cancerbehandling
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US20080219977A1 (en) * 2005-07-27 2008-09-11 Isaiah Josh Fidler Combinations Comprising Gemcitabine and Tyrosine Kinase Inhibitors for the Treatment of Pancreatic Cancer
US20080227980A1 (en) * 2005-08-05 2008-09-18 Novartis Ag Preparation of a 7H-Pyrrolo [2,3-D] Pyrimidine Derivative
CN103446138A (zh) 2005-11-21 2013-12-18 诺瓦提斯公司 利用mTOR抑制剂治疗神经内分泌肿瘤
CN101370814A (zh) * 2006-01-23 2009-02-18 诺瓦提斯公司 固体形式的吡咯并嘧啶衍生物及其作为抗肿瘤剂的用途
GB0605120D0 (en) 2006-03-14 2006-04-26 Novartis Ag Organic Compounds
KR20080108516A (ko) * 2006-04-05 2008-12-15 노파르티스 아게 암을 치료하기 위한 치료제의 조합물
AU2007240548A1 (en) 2006-04-05 2007-11-01 Novartis Ag Combinations of therapeutic agents for treating cancer
US20090233905A1 (en) 2006-04-05 2009-09-17 Gregory Peter Burke Combinations comprising bcr-abl/c-kit/pdgf-r tk inhibitors for treating cancer
KR20090007635A (ko) 2006-05-09 2009-01-19 노파르티스 아게 철 킬레이터 및 항-신생물 약제를 포함하는 조합물 및 그의용도
US20090286779A1 (en) 2006-09-29 2009-11-19 Novartis Ag Pyrazolopyrimidines as lipid kinase inhibitors
CA2667487C (en) * 2006-11-06 2017-04-04 Supergen, Inc. Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
EP2359818A1 (de) 2007-02-15 2011-08-24 Novartis AG Kombinationen von LB589 mit HSP 90 Inhibitoren zur Krebsbehandlung
AR068054A1 (es) * 2007-08-08 2009-11-04 Smithkline Beecham Corp Compuestos de pirrolopirimidina
WO2009118292A1 (en) 2008-03-24 2009-10-01 Novartis Ag Arylsulfonamide-based matrix metalloprotease inhibitors
ES2519474T3 (es) 2008-03-26 2014-11-07 Novartis Ag Inhibidores de las desacetilasas B basados en hidroxamato
CN102131812B (zh) 2008-08-20 2014-04-09 硕腾有限责任公司 吡咯并[2，3-d]嘧啶化合物
WO2010083617A1 (en) 2009-01-21 2010-07-29 Oncalis Ag Pyrazolopyrimidines as protein kinase inhibitors
SI2391366T1 (sl) 2009-01-29 2013-01-31 Novartis Ag Substituirani benzimidazoli za zdravljenje astrocitomov
WO2010099139A2 (en) 2009-02-25 2010-09-02 Osi Pharmaceuticals, Inc. Combination anti-cancer therapy
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
EP2401613A2 (de) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Verfahren zur identifizierung von mesenchymähnlichen tumorzellen oder deren bildung hemmenden stoffen
WO2010099363A1 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
JO2892B1 (en) 2009-06-26 2015-09-15 نوفارتيس ايه جي CYP inhibitors 17
WO2011013656A1 (ja) * 2009-07-28 2011-02-03 第一三共株式会社 ピロロ［２，３－ｄ］ピリミジン誘導体
US8497368B2 (en) 2009-08-12 2013-07-30 Novartis Ag Heterocyclic hydrazone compounds
ES2709108T3 (es) 2009-08-17 2019-04-15 Intellikine Llc Compuestos heterocíclicos y usos de los mismos
EA201200318A1 (ru) 2009-08-20 2012-09-28 Новартис Аг Гетероциклические оксимы
JP2013503129A (ja) 2009-08-26 2013-01-31 ノバルティス アーゲー テトラ−置換ヘテロアリール化合物ならびにｍｄｍ２および／またはｍｄｍ４モジュレーターとしてのそれらの使用
CN102596951B (zh) 2009-11-04 2015-04-15 诺华股份有限公司 用作mek抑制剂的杂环磺酰胺衍生物
WO2011063421A1 (en) 2009-11-23 2011-05-26 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
AU2012265844A1 (en) 2009-12-08 2013-05-02 Novartis Ag Heterocyclic sulfonamide derivatives
MX2012006561A (es) 2009-12-08 2012-07-04 Novartis Ag Derivados de sulfonamida heterociclicos.
CU24130B1 (es) 2009-12-22 2015-09-29 Novartis Ag Isoquinolinonas y quinazolinonas sustituidas
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
US20110178287A1 (en) 2010-01-19 2011-07-21 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
JP2013537966A (ja) 2010-08-31 2013-10-07 ジェネンテック， インコーポレイテッド バイオマーカー及び治療の方法
US8946260B2 (en) 2010-09-16 2015-02-03 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
CA2822565A1 (en) 2010-12-21 2012-06-28 Novartis Ag Bi-heteroaryl compounds as vps34 inhibitors
US20130324526A1 (en) 2011-02-10 2013-12-05 Novartis Ag [1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
WO2012116237A2 (en) 2011-02-23 2012-08-30 Intellikine, Llc Heterocyclic compounds and uses thereof
WO2012149014A1 (en) 2011-04-25 2012-11-01 OSI Pharmaceuticals, LLC Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
CA2834224A1 (en) 2011-04-28 2012-11-01 Novartis Ag 17.alpha.-hydroxylase/c17,20-lyase inhibitors
US8859586B2 (en) 2011-06-20 2014-10-14 Novartis Ag Cyclohexyl isoquinolinone compounds
WO2012175520A1 (en) 2011-06-20 2012-12-27 Novartis Ag Hydroxy substituted isoquinolinone derivatives
SG195067A1 (en) 2011-06-27 2013-12-30 Novartis Ag Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives
EA201490229A1 (ru) * 2011-07-08 2014-05-30 Новартис Аг Новые пирролопиримидиновые производные
EA026655B1 (ru) 2011-09-15 2017-05-31 Новартис Аг 6-ЗАМЕЩЕННЫЕ 3-(ХИНОЛИН-6-ИЛТИО)[1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ c-MET ТИРОЗИНКИНАЗЫ
CN104080787B (zh) 2011-11-29 2016-09-14 诺华股份有限公司 吡唑并吡咯烷化合物
SG11201402237WA (en) 2011-12-22 2014-09-26 Novartis Ag Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
WO2013093850A1 (en) 2011-12-22 2013-06-27 Novartis Ag Quinoline derivatives
EA201491260A1 (ru) 2011-12-23 2014-11-28 Новартис Аг Соединения и композиции для ингибирования взаимодействия bcl2 с партнерами по связыванию
BR112014015442A8 (pt) 2011-12-23 2017-07-04 Novartis Ag compostos e composições para inibir a interação de bcl2 com parceiros de ligação
BR112014015308A8 (pt) 2011-12-23 2017-06-13 Novartis Ag compostos para inibição da interação de bcl2 com contrapartes de ligação
US20130178520A1 (en) 2011-12-23 2013-07-11 Duke University Methods of treatment using arylcyclopropylamine compounds
CN104125954A (zh) 2011-12-23 2014-10-29 诺华股份有限公司 用于抑制bcl2与结合配偶体相互作用的化合物
US9126980B2 (en) 2011-12-23 2015-09-08 Novartis Ag Compounds for inhibiting the interaction of BCL2 with binding partners
UY34591A (es) 2012-01-26 2013-09-02 Novartis Ag Compuestos de imidazopirrolidinona
EP3964513A1 (de) 2012-04-03 2022-03-09 Novartis AG Kombinationsprodukte mit tyrosinkinaseinhibitoren und deren verwendung
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
JP6171003B2 (ja) 2012-05-24 2017-07-26 ノバルティス アーゲー ピロロピロリジノン化合物
AU2013274101B2 (en) 2012-06-15 2017-09-07 The Brigham And Women's Hospital, Inc. Compositions for treating cancer and methods for making the same
US9738643B2 (en) 2012-08-06 2017-08-22 Duke University Substituted indazoles for targeting Hsp90
US20150252047A1 (en) 2012-09-26 2015-09-10 Bayer Pharma Aktiengesellschaft Substituted indazol-pyrrolopyrimidines useful in the treatment of hyperproliferative diseases
US20150218173A1 (en) 2012-09-26 2015-08-06 Bayer Pharma Aktiengesellschaft Substituted indazol-pyrrolopyrimidines useful in the treatment of hyperfoliferative disorders
CN102936251A (zh) * 2012-11-05 2013-02-20 上海毕得医药科技有限公司 一种吡咯并[2,3-d]嘧啶衍生物的制备方法
TW201422625A (zh) 2012-11-26 2014-06-16 Novartis Ag 二氫－吡啶并－□衍生物之固體形式
US9556180B2 (en) 2013-01-22 2017-01-31 Novartis Ag Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
WO2014115077A1 (en) 2013-01-22 2014-07-31 Novartis Ag Substituted purinone compounds
WO2014128612A1 (en) 2013-02-20 2014-08-28 Novartis Ag Quinazolin-4-one derivatives
CA2900097A1 (en) 2013-02-22 2014-08-28 F. Hoffmann-La Roche Ag Methods of treating cancer and preventing drug resistance
JP2016510751A (ja) 2013-03-06 2016-04-11 ジェネンテック， インコーポレイテッド 抗がん剤耐性を治療及び予防する方法
CA2905070A1 (en) 2013-03-14 2014-09-25 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
JP2016512835A (ja) 2013-03-15 2016-05-09 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせ及びそれらの使用
WO2014144850A1 (en) 2013-03-15 2014-09-18 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
WO2014155268A2 (en) 2013-03-25 2014-10-02 Novartis Ag Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity
US20150018376A1 (en) 2013-05-17 2015-01-15 Novartis Ag Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
EA201690212A8 (ru) 2013-07-12 2016-08-31 Офтотек Корпорейшн Способы лечения или профилактики офтальмологических патологических состояний
UY35675A (es) 2013-07-24 2015-02-27 Novartis Ag Derivados sustituidos de quinazolin-4-ona
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
WO2015022663A1 (en) 2013-08-14 2015-02-19 Novartis Ag Compounds and compositions as inhibitors of mek
WO2015022664A1 (en) 2013-08-14 2015-02-19 Novartis Ag Compounds and compositions as inhibitors of mek
EP3046563B1 (de) 2013-09-22 2019-05-29 Calitor Sciences, LLC Substituierte aminopyrimidinverbindungen als pi3-kinase inhibitoren
WO2015084804A1 (en) 2013-12-03 2015-06-11 Novartis Ag Combination of mdm2 inhibitor and braf inhibitor and their use
KR20160137599A (ko) 2014-03-24 2016-11-30 제넨테크, 인크. C-met 길항제로의 암 치료 및 이것과 hgf 발현과의 상관관계
WO2015148714A1 (en) 2014-03-25 2015-10-01 Duke University Heat shock protein 70 (hsp-70) receptor ligands
WO2015145388A2 (en) 2014-03-27 2015-10-01 Novartis Ag Methods of treating colorectal cancers harboring upstream wnt pathway mutations
US9394281B2 (en) 2014-03-28 2016-07-19 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
MX2016012893A (es) 2014-04-03 2017-05-12 Invictus Oncology Pvt Ltd Sustancias terapéuticas combinadas supramoleculares.
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
CN108064274A (zh) 2014-07-30 2018-05-22 耶达研究及发展有限公司 用于培养多能干细胞的培养基
US10195208B2 (en) 2014-07-31 2019-02-05 Novartis Ag Combination therapy
EP3347097B1 (de) 2015-09-11 2021-02-24 Sunshine Lake Pharma Co., Ltd. Substituierte aminopyrimidin-derivate als modulatoren der kinasen jak, flt3 und aurora
SG11201809223PA (en) * 2016-04-19 2018-11-29 Univ California Erbb inhibitors and uses thereof
US11261187B2 (en) 2016-04-22 2022-03-01 Duke University Compounds and methods for targeting HSP90
US10207998B2 (en) 2016-09-29 2019-02-19 Duke University Substituted benzimidazole and substituted benzothiazole inhibitors of transforming growth factor-β kinase and methods of use thereof
US10927083B2 (en) 2016-09-29 2021-02-23 Duke University Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase
EP3559006A4 (de) 2016-12-23 2021-03-03 Arvinas Operations, Inc. Verbindungen und verfahren zum gezielten abbau von fetalen leberkinasepolypeptiden
MX2019007646A (es) 2016-12-23 2019-09-06 Arvinas Operations Inc Moleculas quimericas dirigidas a la proteolisis del egfr y metodos asociados de uso.
EP3710006A4 (de) 2017-11-19 2021-09-01 Sunshine Lake Pharma Co., Ltd. Substituierte heteroarylverbindungen und verfahren zur verwendung
WO2019119486A1 (zh) 2017-12-21 2019-06-27 中国科学院合肥物质科学研究院 一类嘧啶类衍生物激酶抑制剂
AU2019209960B2 (en) 2018-01-20 2023-11-23 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
US20210353651A1 (en) 2018-07-24 2021-11-18 Hygia Pharmaceuticals, Llc Compounds, derivatives, and analogs for cancer
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
EP3914698A1 (de) 2019-01-23 2021-12-01 Yeda Research and Development Co. Ltd Kulturmedien für pluripotente stammzellen
WO2021233534A1 (en) 2020-05-20 2021-11-25 Pvac Medical Technologies Ltd Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof
WO2021185844A1 (en) 2020-03-16 2021-09-23 Pvac Medical Technologies Ltd Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof
EP4192509A1 (de) 2020-08-05 2023-06-14 Ellipses Pharma Ltd Behandlung von krebs mit einem cyclodextrinhaltigen polymer-topoisomerase-inhibitor-konjugat und einem parp-inhibitor
US11999964B2 (en) 2020-08-28 2024-06-04 California Institute Of Technology Synthetic mammalian signaling circuits for robust cell population control
US11814388B1 (en) 2020-08-28 2023-11-14 Ferris State University Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers
GB2617409B (en) 2022-04-27 2024-06-26 Cancertain Ltd Method for predicting responsiveness to therapy
WO2024030441A1 (en) 2022-08-02 2024-02-08 National University Corporation Hokkaido University Methods of improving cellular therapy with organelle complexes
WO2024091370A1 (en) * 2022-10-26 2024-05-02 Acerand Therapeutics (Usa) Limited 5,6-fused bicyclic heteroaromatic compounds

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877178A (en) * 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5958930A (en) * 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
ATE159257T1 (de) * 1994-05-03 1997-11-15 Ciba Geigy Ag Pyrrolopyrimidinderivate mit antiproliferativer wirkung
TW530047B (en) 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
MX9800215A (es) * 1995-07-06 1998-03-31 Novartis Ag Pirrolopirimidas y procesos para su preparacion.
JPH09218320A (ja) * 1996-02-14 1997-08-19 Fujitsu Ltd 光海底中継器
GB9604361D0 (en) 1996-02-29 1996-05-01 Pharmacia Spa 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors
AU2980797A (en) 1996-06-11 1998-01-07 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and medicinal uses thereof
AU4054197A (en) 1996-08-14 1998-03-06 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists
JP4242928B2 (ja) * 1996-08-23 2009-03-25 ノバルティス アクチエンゲゼルシャフト 置換ピロロピリミジンおよびその製造方法
AU7210398A (en) 1997-03-27 1998-10-22 Novartis Ag Intermediate products and method for the production of pyrimidine derivatives
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
BR9911365A (pt) 1998-06-19 2001-03-13 Pfizer Prod Inc Compostos pirrolo[2,3-d]pirimidina
EP1040831A3 (de) 1999-04-02 2003-05-02 Pfizer Products Inc. Verwendung von Corticotropin Releasing Factor (CRF) Antagonisten zur Prophylaxe des plötzlichen Todes
CA2379640C (en) 1999-09-30 2006-11-28 Neurogen Corporation Certain alkylene diamine-substituted heterocycles
ITMI992711A1 (it) 1999-12-27 2001-06-27 Novartis Ag Composti organici
CZ20022353A3 (cs) 2000-01-07 2003-02-12 Universitaire Instelling Antwerpen Deriváty purinu, způsob jejich přípravy a jejich použití
AU779995B2 (en) 2000-01-18 2005-02-24 Pfizer Products Inc. Corticotropin releasing factor antagonists
DK1415987T3 (da) 2000-10-20 2007-07-02 Eisai R&D Man Co Ltd Nitrogenholdige aromatiske ringforbindelser til anvendelse som midler mod cancer

Also Published As

Publication number Publication date
PT1416935E (pt) 2008-06-18
DK1416935T3 (da) 2008-07-07
IL159832A0 (en) 2004-06-20
EP1416935B8 (de) 2008-08-27
PL365783A1 (en) 2005-01-10
RU2318826C2 (ru) 2008-03-10
RU2004106783A (ru) 2005-07-27
DE60225563D1 (de) 2008-04-24
ZA200400271B (en) 2004-11-01
NZ530824A (en) 2005-08-26
JP2005501077A (ja) 2005-01-13
US20040242600A1 (en) 2004-12-02
KR100597505B1 (ko) 2006-07-10
CN101560214A (zh) 2009-10-21
EP1416935A1 (de) 2004-05-12
CA2453881C (en) 2010-09-28
HK1065483A1 (en) 2005-02-25
TWI324159B (en) 2010-05-01
NO20040540L (no) 2004-02-05
CY1108129T1 (el) 2014-02-12
AR036213A1 (es) 2004-08-18
WO2003013541A1 (en) 2003-02-20
MY140398A (en) 2009-12-31
KR20040023730A (ko) 2004-03-18
BR0211801A (pt) 2004-08-31
WO2003013541A8 (en) 2004-02-26
US7244729B2 (en) 2007-07-17
US7390805B2 (en) 2008-06-24
PE20030349A1 (es) 2003-05-29
HUP0401083A2 (hu) 2004-09-28
CA2453881A1 (en) 2003-02-20
GB0119249D0 (en) 2001-10-03
CN1538847A (zh) 2004-10-20
US20070161632A1 (en) 2007-07-12
ES2302830T3 (es) 2008-08-01
DE60225563T2 (de) 2009-03-26
EP1416935B1 (de) 2008-03-12
SI1416935T1 (sl) 2008-08-31
ECSP034444A (es) 2004-08-27
HUP0401083A3 (en) 2007-12-28
CN101560214B (zh) 2011-05-25
IL159832A (en) 2012-09-24
MXPA04001191A (es) 2005-02-17
AU2002324029B2 (en) 2005-01-27
NO328791B1 (no) 2010-05-18
JP4147184B2 (ja) 2008-09-10
SG156521A1 (en) 2009-11-26

Similar Documents

Publication Publication Date Title
ATE388713T1 (de) 4-amino-6-phenyl-pyrrolo(2,3-d)pyrimidin derivate
ATE309245T1 (de) 5-amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3- d)pyrimidin-derivate
ATE284404T1 (de) Pyrazolo(4,3-d)pyrimidinderivate
NO20022738L (no) Pyrrolo(2,3-d)pyrimidinforbindelser
DK1419152T3 (da) HIV-hæmmende pyrimidin-derivater
DE69905306D1 (de) HIV hemmende Pyrimidin Derivate
DE69943247D1 (de) HIV hemmende Pyrimidin Derivate
NO20006454L (no) Pyrrolo(2,3-d)pyrimidinforbindelser
NO20006453D0 (no) Pyrrolo(2,3-d)pyrimidinforbindelser
IS7287A (is) Pýrimídín efnasambönd
AU2003292007A1 (en) 4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO(2,3-d)PYRIMIDINE DERIVATIVES
ATE452892T1 (de) Substituierte 8-perfluoro-6,7,8,9- tetrahydropyrimido-(1,2a) pyrimidin-4-on derivate
DE60205921D1 (de) SUBSTITUIERTE 2-PYRIDINYL-6,7,8,9-TETRAHYDROPYRIMIDOç1,2-A!PYRIMIDIN-4-ON- UND 7-PYRIDINYL-2,3-DIHYDROIMIDAZO-ç1,2-A!PYRIMIDIN-5(1H)ONDERIVATE
ATE231866T1 (de) Pyrazolo(4, 3-d)pyrimidine
GB0112802D0 (en) Pyrimidine derivatives
DE60215804D1 (de) 4-aminopyrimidine derivate
GB0112803D0 (en) Pyrimidine derivatives
ATE276260T1 (de) 2-aminoalkyl-thieno(2,3-d)pyrimidine
ATE297927T1 (de) Substituierte 3,4-dihydro-pyrido(1,2-a)pyrimidine
GB0119477D0 (en) Pyrimidine derivatives
GB0112809D0 (en) Pyrimidine derivatives
GB0119475D0 (en) Pyrimidine derivatives
GB0112804D0 (en) Pyrimidine derivatives
GB0112805D0 (en) Pyrimidine derivatives
GB0112807D0 (en) Pyrimidine derivatives

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1416935

Country of ref document: EP