ATE381531T1 - Nitroderivate als arzneimittel für auf entzündungen beruhende erkrankungen - Google Patents
Nitroderivate als arzneimittel für auf entzündungen beruhende erkrankungenInfo
- Publication number
- ATE381531T1 ATE381531T1 AT01986670T AT01986670T ATE381531T1 AT E381531 T1 ATE381531 T1 AT E381531T1 AT 01986670 T AT01986670 T AT 01986670T AT 01986670 T AT01986670 T AT 01986670T AT E381531 T1 ATE381531 T1 AT E381531T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammatory
- nitroderivatives
- medicinal products
- based diseases
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI002202A IT1319202B1 (it) | 2000-10-12 | 2000-10-12 | Farmaci per le malattie a base infiammatoria. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE381531T1 true ATE381531T1 (de) | 2008-01-15 |
Family
ID=11445950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01986670T ATE381531T1 (de) | 2000-10-12 | 2001-10-09 | Nitroderivate als arzneimittel für auf entzündungen beruhende erkrankungen |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7465803B2 (de) |
| EP (1) | EP1339665B1 (de) |
| JP (1) | JP4451595B2 (de) |
| AT (1) | ATE381531T1 (de) |
| AU (1) | AU2002215932A1 (de) |
| CA (1) | CA2425649A1 (de) |
| DE (1) | DE60132011T2 (de) |
| ES (1) | ES2298280T3 (de) |
| IT (1) | IT1319202B1 (de) |
| WO (1) | WO2002030866A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20011240A1 (it) * | 2001-06-13 | 2002-12-13 | Nicox Sa | Farmaci per le vasculopatie |
| ITMI20011308A1 (it) | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per il dolore cronico |
| ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
| EP1336602A1 (de) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrat-Prodrugs zur Freisetzung von Stickstoffmonoxid in kontrollierter und selektiver Weise sowie deren Verwendung zur Prävention und Behandlung inflammatorischer, ischämischer und proliferativer Erkrankungen |
| CA2487414A1 (en) | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| ITMI20021391A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Nitroderivati di inibitori della cicloossigenasi-2 |
| ITMI20021399A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Inibitori della cicloossigenasi 2 |
| CA2492066A1 (en) * | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| JP2005539089A (ja) | 2002-07-03 | 2005-12-22 | ニトロメッド インコーポレーティッド | ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法 |
| AU2003261281A1 (en) | 2002-07-29 | 2004-02-16 | Nicox S.A. | Cyclooxygenase- 2 selective inhibitors, compositions and methods of use |
| CA2546807A1 (en) | 2003-11-20 | 2005-06-16 | Nicox S.A. | New process for the preparation of nitrooxyderivatives of paracetamol |
| BRPI0515218A (pt) | 2004-08-26 | 2008-07-08 | Nicholas Piramal India Ltd | composto, composição farmacêutica, método para o tratamento de um mamìfero ou ser humano, método de uso do composto, novos intermediários, uso dos novos intermediários, processo para a preparação de um composto |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| WO2008062466A2 (en) * | 2006-10-13 | 2008-05-29 | Reliance Life Sciences Pvt. Ltd. | Cinnamic acid, vanillic acid and benzofuran derivatives for use in the treatment of inflammation and cancer |
| EP2188245B1 (de) | 2007-08-17 | 2013-11-06 | Council of Scientific & Industrial Research | Stickoxidfreisetzende Derivate von Paracetamol |
| US20100286264A1 (en) * | 2008-01-10 | 2010-11-11 | Nicox S.A. | Composition comprising a nitrooxyderivative of acetaminophen and a anticonvulsant drug for the treatment of neuropathic pain |
| KR101717145B1 (ko) | 2008-05-20 | 2017-03-16 | 노이로제스엑스, 인코포레이티드 | 간보호제 아세트아미노펜 공통 프로드러그 |
| US8062653B2 (en) * | 2009-02-18 | 2011-11-22 | Bezwada Biomedical, Llc | Controlled release of nitric oxide and drugs from functionalized macromers and oligomers |
| WO2010108843A1 (en) | 2009-03-27 | 2010-09-30 | Nicox S.A. | Use of nitrooxyderivative of paracetamol for the treatment of muscular dystrophies |
| WO2011133385A2 (en) * | 2010-04-16 | 2011-10-27 | The Research Foundation Of State University Of New York | Novel ether-based compounds and their use |
| CN111087301B (zh) * | 2019-12-23 | 2022-05-20 | 河南中医药大学 | 布洛芬咖啡酸酯的合成方法及其在制备免疫抑制药物中的应用 |
| CN111087302B (zh) * | 2019-12-23 | 2022-05-20 | 河南中医药大学 | 布洛芬阿魏酸酯的合成方法及其在制备免疫抑制药物中的应用 |
| WO2023142996A1 (zh) | 2022-01-28 | 2023-08-03 | 上海岸阔医药科技有限公司 | 预防或治疗与抗肿瘤剂相关的疾病或病症的方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5418261B2 (de) | 1971-08-23 | 1979-07-06 | ||
| US4721709A (en) | 1984-07-26 | 1988-01-26 | Pyare Seth | Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions |
| IT1256345B (it) | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
| IT1256450B (it) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
| HU218923B (hu) * | 1993-10-06 | 2000-12-28 | Nicox S.A. | Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására |
| EP0759899B1 (de) | 1994-05-10 | 1999-09-15 | Nicox S.A. | Nitroverbindingen und ihre zubereitungen mit entzündungsremmenden, schmertzlindernden und antithrombotischen wirkungen |
| ES2092962B1 (es) | 1995-04-19 | 1997-07-16 | Prodes Sa | Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion. |
| DE19515970A1 (de) | 1995-05-02 | 1996-11-07 | Bayer Ag | Acetylsalicylsäurenitrate |
| US6057139A (en) | 1995-06-29 | 2000-05-02 | Mcneil-Ppc, Inc. | Preblend of microcrystalline cellulose and lactase for making tablets |
| JP4286332B2 (ja) * | 1995-07-27 | 2009-06-24 | 富士通株式会社 | Ｄｎａ塩基配列に含まれるベクター部の自動除去方法および装置 |
| IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
| IT1288123B1 (it) | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| SE9704401D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | Matrix pellets for greasy, oily or sticky drug substances |
| SE9704400D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | Porous inorganic particles as carriers for drug substances |
| AU763000B2 (en) * | 1998-10-30 | 2003-07-10 | Nicox S.A. | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| IT1307928B1 (it) | 1999-01-26 | 2001-11-29 | Nicox Sa | Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina. |
| IT1308633B1 (it) | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
| IT1311923B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1311924B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| DE19926500C2 (de) | 1999-06-10 | 2001-09-20 | Infineon Technologies Ag | Nichtflüchtige Halbleiter-Speicherzelle mit einer eine hohe relative Dielektrizitätskonstante aufweisenden dielektrischen Schicht und Verfahren zu deren Herstellung |
| IT1312115B1 (it) * | 1999-06-24 | 2002-04-04 | Nicox Sa | Composti amorfi e relative composizioni farmaceutiche |
| ITMI991517A1 (it) * | 1999-07-09 | 2001-01-09 | Nicox Sa | Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| AP2002002582A0 (en) * | 1999-12-23 | 2002-09-30 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| SE0000773D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
| SE0000774D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
| US6538033B2 (en) | 2000-08-29 | 2003-03-25 | Huntington Medical Research Institutes | Nitric oxide donor compounds |
| SE0102993D0 (sv) | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
| SE0200895D0 (sv) | 2002-03-22 | 2002-03-22 | Astrazeneca Ab | New pharmaceutical composition |
| BR0314365A (pt) | 2002-09-20 | 2005-07-19 | Nicox Sa | Processos para a fabricação de compostos doadores de no e para a produção da forma a do composto iva, compostos, usos do processo, dos compostos, e da forma a do composto iva, e, formulação farmacêutica |
-
2000
- 2000-10-12 IT IT2000MI002202A patent/IT1319202B1/it active
-
2001
- 2001-10-09 EP EP01986670A patent/EP1339665B1/de not_active Expired - Lifetime
- 2001-10-09 JP JP2002534255A patent/JP4451595B2/ja not_active Expired - Fee Related
- 2001-10-09 AT AT01986670T patent/ATE381531T1/de not_active IP Right Cessation
- 2001-10-09 US US10/398,289 patent/US7465803B2/en not_active Expired - Fee Related
- 2001-10-09 AU AU2002215932A patent/AU2002215932A1/en not_active Abandoned
- 2001-10-09 ES ES01986670T patent/ES2298280T3/es not_active Expired - Lifetime
- 2001-10-09 WO PCT/EP2001/011664 patent/WO2002030866A1/en active IP Right Grant
- 2001-10-09 DE DE60132011T patent/DE60132011T2/de not_active Expired - Lifetime
- 2001-10-09 CA CA002425649A patent/CA2425649A1/en not_active Abandoned
-
2008
- 2008-04-08 US US12/099,636 patent/US7629368B2/en not_active Expired - Fee Related
- 2008-11-14 US US12/271,440 patent/US20090075952A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI20002202A1 (it) | 2002-04-12 |
| JP4451595B2 (ja) | 2010-04-14 |
| EP1339665A1 (de) | 2003-09-03 |
| EP1339665B1 (de) | 2007-12-19 |
| US20040023933A1 (en) | 2004-02-05 |
| WO2002030866A1 (en) | 2002-04-18 |
| US20090075952A1 (en) | 2009-03-19 |
| AU2002215932A1 (en) | 2002-04-22 |
| IT1319202B1 (it) | 2003-09-26 |
| DE60132011T2 (de) | 2009-01-22 |
| US7629368B2 (en) | 2009-12-08 |
| CA2425649A1 (en) | 2002-04-18 |
| US20080194651A1 (en) | 2008-08-14 |
| JP2004511455A (ja) | 2004-04-15 |
| DE60132011D1 (de) | 2008-01-31 |
| ES2298280T3 (es) | 2008-05-16 |
| US7465803B2 (en) | 2008-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |