[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE239917T1 - Metall-chelat enthaltende zusammensetzungen zur verwendung in chemilumineszierenden assays - Google Patents

Metall-chelat enthaltende zusammensetzungen zur verwendung in chemilumineszierenden assays

Info

Publication number
ATE239917T1
ATE239917T1 AT95901921T AT95901921T ATE239917T1 AT E239917 T1 ATE239917 T1 AT E239917T1 AT 95901921 T AT95901921 T AT 95901921T AT 95901921 T AT95901921 T AT 95901921T AT E239917 T1 ATE239917 T1 AT E239917T1
Authority
AT
Austria
Prior art keywords
analyte
compositions
metal chelated
chemiluminescent assay
composition
Prior art date
Application number
AT95901921T
Other languages
English (en)
Inventor
Edwin F Ullman
Sharat Singh
Original Assignee
Dade Behring Marburg Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Marburg Gmbh filed Critical Dade Behring Marburg Gmbh
Application granted granted Critical
Publication of ATE239917T1 publication Critical patent/ATE239917T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT95901921T 1993-11-22 1994-11-21 Metall-chelat enthaltende zusammensetzungen zur verwendung in chemilumineszierenden assays ATE239917T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/156,181 US5578498A (en) 1991-05-22 1993-11-22 Metal chelate containing compositions for use in chemiluminescent assays
PCT/US1994/013193 WO1995014928A1 (en) 1993-11-22 1994-11-21 Metal chelate containing compositions for use in chemiluminescent assays

Publications (1)

Publication Number Publication Date
ATE239917T1 true ATE239917T1 (de) 2003-05-15

Family

ID=22558459

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95901921T ATE239917T1 (de) 1993-11-22 1994-11-21 Metall-chelat enthaltende zusammensetzungen zur verwendung in chemilumineszierenden assays

Country Status (7)

Country Link
US (9) US5578498A (de)
EP (2) EP0730738B1 (de)
JP (1) JP3426241B2 (de)
AT (1) ATE239917T1 (de)
CA (1) CA2177143C (de)
DE (1) DE69432640T2 (de)
WO (1) WO1995014928A1 (de)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395506B1 (en) * 1991-04-18 2002-05-28 Becton, Dickinson And Company Device for monitoring cells
US6251581B1 (en) * 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US6002000A (en) * 1992-07-20 1999-12-14 Dade Behring Marburg Gmbh Chemiluminescent compounds and methods of use
WO1994002486A1 (en) * 1992-07-20 1994-02-03 Syntex (U.S.A.) Inc. Novel chemiluminescent compounds and methods of use
JPH09503660A (ja) * 1993-09-23 1997-04-15 ゼネカ・リミテッド エネルギー移動による核酸検出
JP2000505439A (ja) * 1996-02-19 2000-05-09 シャファー、モシェ 感光性組成物
WO1997041442A1 (en) * 1996-05-01 1997-11-06 Behringwerke Aktiengesellschaft Chemiluminescent compositions and their use in the detection of hydrogen peroxide
US6028025A (en) * 1996-10-21 2000-02-22 Massachusetts Institute Of Technology Metalloporphyrin oxidation catalyst covalently coupled to an inorganic surface and method making same
US6753191B2 (en) 1996-11-06 2004-06-22 University Of Pittsburgh Polymerized crystalline colloidal array chemical sensing materials for use in high ionic strength solutions
US5898004A (en) * 1996-11-06 1999-04-27 University Of Pittsburgh Of The Commonwealth System Of Higher Education Polymerized crystalline colloidal array sensors
US5854078A (en) 1996-11-06 1998-12-29 University Of Pittsburgh Polymerized crystalline colloidal array sensor methods
US5772926A (en) * 1997-05-13 1998-06-30 Lumigen, Inc. Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates
EP1000345B1 (de) * 1997-08-01 2003-05-07 PreSens Precision Sensing GmbH Verfahren und vorrichtung zur referenzierung von fluoreszenzintensitätssignalen
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
DE19933104A1 (de) 1999-07-15 2001-01-18 Ingo Klimant Phosphoreszierende Mikro- und Nanopartikel als Referenzstandard und Phosphoreszenzmarker
US6329205B1 (en) 1999-08-31 2001-12-11 Molecular Probes, Inc. Detection method using luminescent europium-based protein stains
AU3791301A (en) * 1999-11-01 2001-05-14 Fluorrx, Inc. New ruthenium metal ligand complexes
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
EP1264181B1 (de) 2000-03-06 2007-06-06 Dade Behring Marburg GmbH Mit polysacchariden beschichtete träger, deren herstellung und verwendung
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US7635571B2 (en) * 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
SG92833A1 (en) * 2001-03-27 2002-11-19 Sumitomo Chemical Co Polymeric light emitting substance and polymer light emitting device using the same
US7354733B2 (en) * 2001-03-29 2008-04-08 Cellect Technologies Corp. Method for sorting and separating living cells
AU2002305658A1 (en) 2001-05-21 2002-12-03 Aclara Biosciences, Inc. Analyzing phosphorylated proteins
CA2445053A1 (en) * 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
AU2002344221A1 (en) * 2001-05-26 2002-12-09 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
EP1419211A1 (de) * 2001-08-23 2004-05-19 Honeywell International Inc. Vierzähnige europium-ammonium-chelate
US7045311B2 (en) * 2001-10-25 2006-05-16 Monogram Biosciences, Inc. Whole cell assay systems for cell surface proteases
CN1166422C (zh) * 2001-11-05 2004-09-15 北京源德生物医学工程股份有限公司 用于体外高能聚焦超声波治疗机的坐位架
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
AU2003222253A1 (en) * 2002-03-05 2003-09-22 Monogram Biosciences, Inc. Multiplex analysis using membrane-bound sensitizers
US20040229299A1 (en) * 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US7105308B2 (en) 2002-07-25 2006-09-12 Monogram Biosciences, Inc. Detecting receptor oligomerization
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040175765A1 (en) * 2002-07-05 2004-09-09 Sharat Singh Cell-screening assay and composition
US6783699B2 (en) 2002-10-17 2004-08-31 Medgene, Inc. Europium-containing fluorescent nanoparticles and methods of manufacture thereof
JPWO2004040305A1 (ja) * 2002-10-31 2006-03-02 株式会社リバース・プロテオミクス研究所 化合物の固相担体への固定化方法
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
US7179542B2 (en) 2003-05-20 2007-02-20 Canon Kabushiki Kaisha Thiazole- and imidazole-fused phenanthroline molecules in organic light-emitting devices
CN1795252A (zh) * 2003-05-22 2006-06-28 三菱化学株式会社 发光器件和荧光材料
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
EP1673399B1 (de) * 2003-08-11 2017-04-05 Monogram BioSciences, Inc. Nachweis und erstellung des profils eines molekularen komplexes
CA2543830A1 (en) * 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
EP1695083A1 (de) 2003-12-01 2006-08-30 Dade Behring Marburg GmbH Homogenes nachweisverfahren
US7722842B2 (en) * 2003-12-31 2010-05-25 The Ohio State University Carbon dioxide sequestration using alkaline earth metal-bearing minerals
JP4786656B2 (ja) * 2004-06-09 2011-10-05 パーキンエルマー エルエーエス，インク． シデロホアおよび関連組成物を使用する標的分子検出の方法
US7964407B2 (en) * 2004-07-21 2011-06-21 Bates Lynn S Methods of marking products using natural materials having genetically controlled micromorphological structures as markers
US7807468B2 (en) * 2004-07-21 2010-10-05 Bates Lynn S Methods of marking and testing pharmaceutical products
US20060040258A1 (en) * 2004-08-23 2006-02-23 Huiyan Guo Water-soluble conjugates and methods of preparation
EP1807530A2 (de) * 2004-09-17 2007-07-18 Novartis Vaccines and Diagnostics, Inc. Dreiwertiger metallvermittelter homogener lumineszenz-proximity-assay
US7939267B2 (en) * 2004-11-04 2011-05-10 Laboratory Corporation Of America Holdings Detection of activation of endothelial cells as surrogate marker for angiogenesis
US20060166376A1 (en) * 2005-01-21 2006-07-27 Craig Alan R Compositions for use as a signal generation component and methods of using same
CN100429197C (zh) * 2005-02-04 2008-10-29 博阳生物科技（上海）有限公司 双丁二酮化合物、铕配合物、含该配合物的组合物及其用途
US20060205090A1 (en) * 2005-03-14 2006-09-14 Newton Michael W Water-soluble conjugates for electrochemical detection
CN100445744C (zh) * 2005-04-25 2008-12-24 博阳生物科技（上海）有限公司 用于免疫分析的微球组合物或组件及免疫分析方法
WO2007008472A2 (en) * 2005-07-08 2007-01-18 Colorado Seminary, Which Owns And Operates The University Of Denver Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers
WO2007070761A2 (en) * 2005-12-12 2007-06-21 Colorado Seminary, Which Owns And Operates The University Of Denver Method for encoding and screening combinatorial libraries
US20080220434A1 (en) * 2007-02-07 2008-09-11 Perscitus Biosciences, Llc Detection Of Molecule Proximity
WO2009026313A1 (en) * 2007-08-20 2009-02-26 Colorado Seminary, Which Owns And Operates The University Of Denver Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers and photoamplified fluorescence turn-off system
CA2706763C (en) * 2007-11-27 2013-07-30 Laboratory Corporation Of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample
EP2235536A4 (de) * 2007-12-20 2011-05-04 Lab Corp America Holdings Her-2-diagnoseverfahren
CN101251540B (zh) * 2008-03-26 2012-12-05 博阳生物科技（上海）有限公司 乙型肝炎病毒e抗原检测微粒、其制备及应用
ES2735985T3 (es) 2008-09-26 2019-12-23 Univ Ohio State Conversión de combustibles carbonosos en portadores de energía libre de carbono
US8470542B2 (en) 2008-12-01 2013-06-25 Laboratory Corporation Of America Holdings Methods and assays for measuring p95 and/or p95 complexes in a sample and antibodies specific for p95
US20120295259A1 (en) 2011-05-19 2012-11-22 Laboratory Corporation Of America Holdings Methods for Determining the Likelihood of Survival and for Predicting Likelihood of Metastasis in Cancer Patients
SG172983A1 (en) 2009-01-15 2011-08-29 Lab Corp America Holdings Methods of determining patient response by measurement of her-3
EP2398868B1 (de) 2009-02-20 2016-06-15 Perkinelmer Biosignal, Inc. Multiplex-assayverfahren und zusammensetzungen
US9347947B2 (en) 2009-03-12 2016-05-24 Siemens Healthcare Diagnostics Inc. Immunoassays employing non-particulate chemiluminescent reagent
JP5311662B2 (ja) * 2009-08-24 2013-10-09 キッコーマン株式会社 ペルオキシダーゼ化学発光反応の発光増強方法及びペルオキシダーゼ化学発光反応用発光増強剤
CN102597173A (zh) 2009-09-08 2012-07-18 俄亥俄州立大学研究基金会 具有原位co2捕集的合成燃料和化学品生产
CN105762386A (zh) 2009-09-08 2016-07-13 俄亥俄州国家创新基金会 具有集成的碳捕集的重整/水裂解和用于发电的电化学系统的集成
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
US20110306148A1 (en) 2010-06-14 2011-12-15 Siemens Healthcare Diagnostics Inc. Composition for use as an assay reagent
US10088490B2 (en) 2010-08-20 2018-10-02 Siemens Healthcare Diagnostics Inc. Assay for analytes using multiple receptors
US10010847B2 (en) 2010-11-08 2018-07-03 Ohio State Innovation Foundation Circulating fluidized bed with moving bed downcomers and gas sealing between reactors
DE102011007546A1 (de) 2011-04-15 2012-10-18 Humboldt-Universität Zu Berlin Messvorrichtung für eine Messung einer Singulettsauerstoff-Lumineszenz
EP2707350A4 (de) 2011-05-11 2015-12-23 Ohio State Innovation Foundation Systeme zum umwandeln von brennstoffen
EP2707583B1 (de) 2011-05-11 2019-07-10 Ohio State Innovation Foundation Sauerstoffträgermaterialien
ES2671238T3 (es) 2011-08-12 2018-06-05 Siemens Healthcare Diagnostics Inc. Detección de esteroides sexuales
US9244083B2 (en) 2012-11-30 2016-01-26 Siemens Healthcare Diagnostics Inc. Compositions and methods for detecting vitamin D
CN109536210B (zh) 2013-02-05 2020-12-18 俄亥俄州国家创新基金会 用于碳质燃料转化的方法
US9616403B2 (en) 2013-03-14 2017-04-11 Ohio State Innovation Foundation Systems and methods for converting carbonaceous fuels
CN105264382A (zh) 2013-04-05 2016-01-20 美国控股实验室公司 基于检测her3活化辅助癌症的诊断、预后和治疗的系统和方法
US20140308751A1 (en) 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
US10124072B2 (en) 2013-09-18 2018-11-13 Caliper Life Sciences, Inc. In-vivo reactive species imaging
US20150238915A1 (en) 2014-02-27 2015-08-27 Ohio State Innovation Foundation Systems and methods for partial or complete oxidation of fuels
KR102309377B1 (ko) 2014-06-27 2021-10-05 지멘스 헬쓰케어 다이아그노스틱스 인크. 비타민 d 에피머에 특이적인 결합 파트너
EP3161005B1 (de) 2014-06-27 2020-11-25 Siemens Healthcare Diagnostics Inc. Spezifische bindungspartner für vitamin d in epimeren in vitamin-d-assays
BR112018017336A2 (pt) 2016-03-07 2018-12-26 Hoffmann La Roche método in vitro para detectar um anticorpo para p53 (anticorpo anti-p53) em uma amostra e polipeptídeo de fusão
CA3016914C (en) 2016-03-15 2019-08-27 Laboratory Corporation Of America Holdings Methods of assessing protein interactions between cells
EP3429738B1 (de) 2016-04-12 2024-07-17 Ohio State Innovation Foundation Chemical-looping-verfahren zur herstellung von synthesegas aus kohlenstoffhaltigen brennstoffen
AU2017292172A1 (en) 2016-07-06 2019-01-03 Prothena Biosciences Limited Assay for detecting total and S129 phosphorylated alpha-synuclein
WO2019027972A1 (en) 2017-07-31 2019-02-07 Ohio State Innovation Foundation REACTOR SYSTEM WITH UNEQUAL OPERATING PRESSURE OF REACTOR ASSEMBLY
US10933146B2 (en) 2017-12-12 2021-03-02 Massachusetts Institute Of Technology Cell-permeable imaging sensors and uses thereof
US10549236B2 (en) 2018-01-29 2020-02-04 Ohio State Innovation Foundation Systems, methods and materials for NOx decomposition with metal oxide materials
US20210208080A1 (en) 2018-05-21 2021-07-08 Beyond Diagnostics (Shanghai) Co., Ltd Chemiluminescence analytical method and system and kit using same
KR102281252B1 (ko) * 2018-05-21 2021-07-23 (주)인벤티지랩 두타스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법
CN110514651A (zh) 2018-05-21 2019-11-29 博阳生物科技（上海）有限公司 一种化学发光免疫分析测定方法及使用该方法的系统、试剂盒
JP7122454B2 (ja) 2018-07-30 2022-08-19 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド ビオチンアッセイを実施するためのキット、マイクロ流体デバイス、および方法
US11413574B2 (en) 2018-08-09 2022-08-16 Ohio State Innovation Foundation Systems, methods and materials for hydrogen sulfide conversion
WO2020150438A1 (en) 2019-01-17 2020-07-23 Ohio State Innovation Foundation Systems, methods and materials for stable phase syngas generation
AU2020271068A1 (en) 2019-04-09 2021-09-30 Ohio State Innovation Foundation Alkene generation using metal sulfide particles
CN112500434B (zh) * 2020-11-20 2021-10-22 复旦大学 基于铱配合物的光扳机分子及应用
CN115947714B (zh) * 2022-11-01 2024-05-14 上海泰辉生物科技有限公司 光化学缓存剂的合成方法

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340716A (en) * 1964-11-10 1967-09-12 Reynolds Metals Co Method of producing wrought structure
US3720622A (en) * 1970-01-02 1973-03-13 American Cyanamid Co Generation of light from the decomposition of dioxetaneones in the presence of a fluorescer
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US4043792A (en) * 1974-04-09 1977-08-23 Uniroyal, Inc. Plant growth regulation using certain substituted 2,3-dihydro-1,4-oxathiins
US3947264A (en) * 1974-04-09 1976-03-30 Uniroyal, Inc. Substituted 2,3-dihydro-,4-oxathiin plant growth stunting agents
US4199559A (en) 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4383031A (en) 1975-04-28 1983-05-10 Miles Laboratories, Inc. Homogeneous chemiluminescent specific binding assay
US4174384A (en) 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
CA1121647A (en) 1977-11-09 1982-04-13 Norman L. Betz Feed intake limiting acidulated fat for animals
US4529561A (en) 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4220450A (en) 1978-04-05 1980-09-02 Syva Company Chemically induced fluorescence immunoassay
US4380580A (en) 1978-04-10 1983-04-19 Miles Laboratories, Inc. Heterogenous chemiluminescent specific binding assay
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
AU517292B2 (en) 1978-06-20 1981-07-23 Syva Co. Fluorescence quenching system
US4226993A (en) 1978-07-24 1980-10-07 Miles Laboratories, Inc. Amino-functionalized phthalhydrazides
US4318707A (en) 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4576912A (en) 1978-11-30 1986-03-18 Technicon Instruments Corporation Fluoroimmunoassaying
US4261968A (en) 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4299916A (en) 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
CA1130297A (en) * 1980-05-02 1982-08-24 Michael A. Puttock Method of making 2,3-dihydro-5,6-diphenyl- 1,4-oxathiin
US4483921A (en) 1981-01-12 1984-11-20 Collaborative Research, Inc. Immunoassay with antigen or antibody labeled liposomes sequestering enzyme
US4650770A (en) 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4654300A (en) 1982-04-02 1987-03-31 Syntex (U.S.A.) Inc. Fluorescent microbead quenching assay
US4483929A (en) 1982-05-03 1984-11-20 Liposome Technology Incorporated Liposomes with glycolipid-linked antibodies
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4568649A (en) 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
US4588578A (en) 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4652533A (en) 1983-04-28 1987-03-24 Pandex Laboratories, Inc. Method of solid phase immunoassay incorporating a luminescent label
JPS6036962A (ja) 1983-08-09 1985-02-26 Toray Ind Inc 生物学的検査用微粒子
EP0144914A3 (de) 1983-12-12 1986-08-13 Miles Inc. Hybridisierungstest mittels markierter Paare von hybridbindenden Reagenzien
CA1273552A (en) 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
DE3785591T2 (de) 1986-01-10 1993-09-02 Amoco Corp Kompetitiver homogener test.
WO1987005334A1 (en) 1986-03-04 1987-09-11 Angenics, Inc. Nucleic acid detection using particle agglutination
US5254477A (en) 1986-06-25 1993-10-19 Trustees Of Tufts College Flourescence intramolecular energy transfer conjugate compositions and detection methods
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US5616729A (en) 1986-07-17 1997-04-01 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
US5004565A (en) 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US4959182A (en) 1986-07-17 1990-09-25 Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US4857652A (en) * 1986-07-17 1989-08-15 Board Of Governors Of Wayne State University Chemiluminescent 1,2-dioxetane compounds
JP2506396B2 (ja) 1986-07-24 1996-06-12 トロピックス・インコーポレーテッド ジオキセタン類の酵素的に誘導される分解を使用する物質検出法
US4978614A (en) 1988-10-26 1990-12-18 Tropix, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
US4891324A (en) 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
US4806485A (en) * 1987-02-27 1989-02-21 Cooperative Institute For Research In Environmental Sciences Univers. Of Colorado Method of improving the detection limits of UV-VIS absorbing compounds in HPLC by the use of a singlet oxygen trap
US5070158A (en) 1987-03-12 1991-12-03 Hewlett-Packard Company Covalently labeled siloxane polymers
US5017473A (en) 1987-05-26 1991-05-21 Becton, Dickinson And Company Homogeneous chemiluminescence immunoassay using a light absorbing material
US4822878A (en) 1987-06-30 1989-04-18 Viomedics, Inc. Cyclic anhydride derivatives of chromophors
SE8703682L (sv) * 1987-09-24 1989-03-25 Wallac Oy Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner
US4943525A (en) 1987-11-02 1990-07-24 Bioventures, Inc. Simultaneous immunoassay for the determination of antigens and antibodies
US4910303A (en) * 1988-05-26 1990-03-20 Texaco Chemical Company Process for preparing oxazine derivatives
WO1989012232A1 (en) 1988-06-08 1989-12-14 London Diagnostics, Inc. Assays utilizing sensitizer-induced production of detectable signals
WO1990002205A1 (en) 1988-08-25 1990-03-08 Angenics, Inc. Detection of nucleic acid sequences using particle agglutination
US5061445A (en) 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
US5019496A (en) 1989-02-17 1991-05-28 Gerald Oster Photopolymerization diagnostic test composition and method for immunoassay and nucleic acid assay
WO1991003479A1 (en) 1989-09-06 1991-03-21 Tropix, Inc. Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
JP3184894B2 (ja) 1989-10-05 2001-07-09 エックスオックスエミス， インコーポレイテッド ハロペルオキシターゼ酸至適化学的発光分析系
DE69125992T2 (de) 1990-09-14 1997-08-21 Tosoh Corp Verfahren und Kit für Immunoassay
FI88654C (fi) * 1991-03-15 1993-06-10 Datacity Center Oy Fluorescenshoejningsmetod
US5578498A (en) * 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
ATE246360T1 (de) * 1991-05-22 2003-08-15 Dade Behring Marburg Gmbh Partikel, die eine zusammensetzung beinhalten, die eine chemilumineszierende verbindung umfassen
US5257970A (en) 1992-04-09 1993-11-02 Health Research, Inc. In situ photodynamic therapy
WO1994003812A1 (en) 1992-07-31 1994-02-17 Syntex (U.S.A.) Inc. Photoactivatable chemiluminescent matrices
FR2707658B1 (fr) 1993-07-12 1995-11-24 Prolabo Sa Latex fluorescent comportant au moins deux fluorochromes, procédé d'obtention et application dudit latex comme marqueur, notamment en biologie.
EP0716746B1 (de) 1993-09-03 1999-03-17 Behringwerke Ag Fluoreszenz-sauerstoffkanalisation-immunteste

Also Published As

Publication number Publication date
US5536834A (en) 1996-07-16
US20040121490A1 (en) 2004-06-24
CA2177143C (en) 2007-09-18
JPH09505888A (ja) 1997-06-10
WO1995014928A1 (en) 1995-06-01
US5578498A (en) 1996-11-26
US20050214875A1 (en) 2005-09-29
US6692975B2 (en) 2004-02-17
DE69432640T2 (de) 2004-03-25
JP3426241B2 (ja) 2003-07-14
US20020058280A1 (en) 2002-05-16
US7229842B2 (en) 2007-06-12
EP0730738A1 (de) 1996-09-11
US5811311A (en) 1998-09-22
US6916667B2 (en) 2005-07-12
CA2177143A1 (en) 1995-06-01
EP1091211A1 (de) 2001-04-11
EP0730738B1 (de) 2003-05-07
US6340599B1 (en) 2002-01-22
US6180354B1 (en) 2001-01-30
US5780646A (en) 1998-07-14
DE69432640D1 (de) 2003-06-12

Similar Documents

Publication Publication Date Title
ATE239917T1 (de) Metall-chelat enthaltende zusammensetzungen zur verwendung in chemilumineszierenden assays
CA2002101A1 (en) Electrochemiluminescent assays
PT984282E (pt) Particulas que tem incorporada uma composicao que compreende um composto quimioluminescente
ES462576A1 (es) Procedimiento para la estabilizacion de composiciones que contienen peroxidas.
ATE386814T1 (de) Gemischte g-proteinzusammensetzung und ihre verwendung
ATE279089T1 (de) Leuchtstoffanordnung wellenlängenkonvertierende vergussmasse und lichtquelle
AU667131B2 (en) Cyanoacrylate adhesives with cured thermal properties utilizing substituted aromatic additive
DE69823845D1 (de) Neue verbindungen zur erzeugung von chemilumineszenz mit hilfe einer peroxidase
CA2179823A1 (en) Method of assay using two distinguishable types of particles
ATE333522T1 (de) Verfahren zur bestimmung von mehrere analyten
TR199902796T2 (xx) Toz deterjan bile�imleri.
ATE92510T1 (de) Verfahren zur herstellung von polymeren.
EP0078703A3 (de) Markierte Pyroglu-L-Phe-L-Arg-Derivate, Substrate und Methoden zur Bestimmung von Kallikrein
DE3382380D1 (de) Aktivierte 'aryl-beendete' fluoreszierende verbindungen und testverfahren und systeme in denen dieselben als fluorogenische ausgangsmaterialien verwendet werden.
AU573277B2 (en) Cyanoacrylate and silacrown compound adhesive composition
KR910012542A (ko) 플론 134a 냉매 압축기
DK0556906T3 (da) Kalibrator og dens anvendelse til en immunanalyse
JPS5712420A (en) Magnetic recording medium
KR880005584A (ko) 광학 기록 매체와 그 제조방법
JPS57177054A (en) Synthetic resin composition having improved durability of fluorescence
ATE364716T1 (de) Stabilisiertes reagenz und verfahren zur bestimmung von creatin-kinase
DE3774906D1 (de) Substituierte 2,3-naphthalencarboxaldehyde.
JPS5712417A (en) Magnetic recording medium
JPS5712414A (en) Magnetic recording medium
JPS5712418A (en) Magnetic recording medium

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0730738

Country of ref document: EP