ATE225806T1 - D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet - Google Patents

D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet

Info

Publication number: ATE225806T1
Authority: AT; Austria
Prior art keywords: growth hormone; alkyltryptophane; hormone releasing; containing polypeptides; releasing activity
Prior art date: 1994-09-27

Application number

AT95932735T

Other languages

English (en)

Inventor

Bioscience Limited Ardana

Original Assignee

Bioscience Limited Ardana

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-27

Filing date

1995-09-13

Publication date

2002-10-15

1994-09-27 Priority claimed from ITMI941954A external-priority patent/IT1270021B/it

1995-06-16 Priority claimed from IT95MI001293A external-priority patent/IT1276734B1/it

1995-09-13 Application filed by Bioscience Limited Ardana filed Critical Bioscience Limited Ardana

2002-10-15 Application granted granted Critical

2002-10-15 Publication of ATE225806T1 publication Critical patent/ATE225806T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Crystallography & Structural Chemistry (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)

AT95932735T 1994-09-27 1995-09-13 D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet ATE225806T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI941954A IT1270021B (it)	1994-09-27	1994-09-27	"composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare"
IT95MI001293A IT1276734B1 (it)	1995-06-16	1995-06-16	Composti polipeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della
PCT/EP1995/003601 WO1996010040A1 (en)	1994-09-27	1995-09-13	Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Publications (1)

Publication Number	Publication Date
ATE225806T1 true ATE225806T1 (de)	2002-10-15

Family

ID=26331189

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95932735T ATE225806T1 (de)	1994-09-27	1995-09-13	D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet

Country Status (21)

Country	Link
US (1)	US5795957A (de)
EP (1)	EP0783521B8 (de)
JP (1)	JP3810083B2 (de)
KR (1)	KR100369105B1 (de)
CN (1)	CN1121413C (de)
AT (1)	ATE225806T1 (de)
AU (1)	AU700066B2 (de)
CA (1)	CA2201122A1 (de)
CZ (1)	CZ291798B6 (de)
DE (1)	DE69528531T2 (de)
DK (1)	DK0783521T3 (de)
ES (1)	ES2186730T3 (de)
HK (1)	HK1001207A1 (de)
HU (1)	HU221481B (de)
IL (1)	IL115381A (de)
MX (1)	MX9702275A (de)
PL (1)	PL181588B1 (de)
PT (1)	PT783521E (de)
RU (1)	RU2157378C2 (de)
SK (1)	SK284550B6 (de)
WO (1)	WO1996010040A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5798337A (en) *	1994-11-16	1998-08-25	Genentech, Inc.	Low molecular weight peptidomimetic growth hormone secretagogues
US20020111461A1 (en)	1999-05-21	2002-08-15	Todd C. Somers	Low molecular weight peptidomimetic growth hormone secretagogues
IT1277113B1 (it) *	1995-12-20	1997-11-04	Romano Deghenghi	Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
WO1999039730A1 (fr) *	1998-02-09	1999-08-12	Kaken Pharmaceutical Co., Ltd.	Preparation a administration orale contenant des peptides favorisant la secretion d'hormone de croissance
US5932548A (en) *	1998-06-03	1999-08-03	Deghenghi; Romano	Lysine containing peptides for treatment of heart disease
US6696063B1 (en)	1998-12-30	2004-02-24	Applied Research Systems Ars Holding N.V.	Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
US6211156B1 (en) *	1999-11-10	2001-04-03	Asta Medica A.G.	Peptides for treatment of erectile dysfunction
TWI331922B (en)	2002-08-09	2010-10-21	Ipsen Pharma Sas	Growth hormone releasing peptides
WO2006078320A2 (en)	2004-08-04	2006-07-27	Brookwood Pharmaceuticals, Inc.	Methods for manufacturing delivery devices and devices thereof
GB0603295D0 (en)	2006-02-18	2006-03-29	Ardana Bioscience Ltd	Methods and kits
US8728528B2 (en)	2007-12-20	2014-05-20	Evonik Corporation	Process for preparing microparticles having a low residual solvent volume
US9119832B2 (en)	2014-02-05	2015-09-01	The Regents Of The University Of California	Methods of treating mild brain injury
WO2017075535A1 (en)	2015-10-28	2017-05-04	Oxeia Biopharmaceuticals, Inc.	Methods of treating neurodegenerative conditions

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1080470A (en) *	1963-12-31	1967-08-23	Merck & Co Inc	Indole derivatives
US4411890A (en) *	1981-04-14	1983-10-25	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4226857A (en) *	1979-03-30	1980-10-07	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4224316A (en) *	1979-03-30	1980-09-23	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4228156A (en) *	1979-03-30	1980-10-14	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4228155A (en) *	1979-03-30	1980-10-14	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4228158A (en) *	1979-03-30	1980-10-14	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4223020A (en) *	1979-03-30	1980-09-16	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4228157A (en) *	1979-03-30	1980-10-14	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4223021A (en) *	1979-03-30	1980-09-16	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4223019A (en) *	1979-03-30	1980-09-16	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
AU549053B2 (en) *	1981-12-28	1986-01-09	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4410513A (en) *	1981-12-28	1983-10-18	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4410512A (en) *	1981-12-28	1983-10-18	Beckman Instruments, Inc.	Combinations having synergistic pituitary growth hormone releasing activity
US4725577A (en) *	1985-04-25	1988-02-16	Administrators Of The Tulane Educational Fund	Biologically active lysine containing octapeptides
US4839344A (en) *	1987-06-12	1989-06-13	Eastman Kodak Company	Polypeptide compounds having growth hormone releasing activity
AU637316B2 (en) *	1988-01-28	1993-05-27	Eastman Kodak Company	Polypeptide compounds having growth hormone releasing activity
DE3915361A1 (de) *	1989-05-11	1990-11-15	Merck Patent Gmbh	Cyclopeptide
IT1240643B (it) *	1990-05-11	1993-12-17	Mediolanum Farmaceutici Spa	Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
WO1994007519A1 (en) *	1992-09-25	1994-04-14	Smithkline Beecham Corporation	Growth hormone releasing peptides

1995
- 1995-09-13 WO PCT/EP1995/003601 patent/WO1996010040A1/en active IP Right Grant
- 1995-09-13 RU RU97107089/04A patent/RU2157378C2/ru not_active IP Right Cessation
- 1995-09-13 CA CA002201122A patent/CA2201122A1/en not_active Abandoned
- 1995-09-13 AT AT95932735T patent/ATE225806T1/de not_active IP Right Cessation
- 1995-09-13 AU AU35668/95A patent/AU700066B2/en not_active Ceased
- 1995-09-13 SK SK399-97A patent/SK284550B6/sk unknown
- 1995-09-13 CN CN95195323A patent/CN1121413C/zh not_active Expired - Fee Related
- 1995-09-13 CZ CZ1997914A patent/CZ291798B6/cs not_active IP Right Cessation
- 1995-09-13 DK DK95932735T patent/DK0783521T3/da active
- 1995-09-13 KR KR1019970701987A patent/KR100369105B1/ko not_active IP Right Cessation
- 1995-09-13 ES ES95932735T patent/ES2186730T3/es not_active Expired - Lifetime
- 1995-09-13 PT PT95932735T patent/PT783521E/pt unknown
- 1995-09-13 EP EP95932735A patent/EP0783521B8/de not_active Expired - Lifetime
- 1995-09-13 HU HU9800136A patent/HU221481B/hu not_active IP Right Cessation
- 1995-09-13 DE DE69528531T patent/DE69528531T2/de not_active Expired - Fee Related
- 1995-09-13 JP JP51131596A patent/JP3810083B2/ja not_active Expired - Fee Related
- 1995-09-13 PL PL95319382A patent/PL181588B1/pl unknown
- 1995-09-13 MX MX9702275A patent/MX9702275A/es not_active IP Right Cessation
- 1995-09-20 US US08/530,853 patent/US5795957A/en not_active Expired - Fee Related
- 1995-09-21 IL IL11538195A patent/IL115381A/xx not_active IP Right Cessation
1998
- 1998-01-02 HK HK98100002A patent/HK1001207A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUT77525A (hu)	1998-05-28
CN1121413C (zh)	2003-09-17
US5795957A (en)	1998-08-18
SK284550B6 (sk)	2005-06-02
DE69528531D1 (de)	2002-11-14
CZ91497A3 (en)	1997-09-17
CZ291798B6 (cs)	2003-05-14
EP0783521A1 (de)	1997-07-16
AU3566895A (en)	1996-04-19
SK39997A3 (en)	1997-09-10
CN1158622A (zh)	1997-09-03
RU2157378C2 (ru)	2000-10-10
HU221481B (en)	2002-10-28
PL319382A1 (en)	1997-08-04
EP0783521B1 (de)	2002-10-09
JPH10506114A (ja)	1998-06-16
JP3810083B2 (ja)	2006-08-16
DE69528531T2 (de)	2003-06-05
KR970706305A (ko)	1997-11-03
EP0783521B8 (de)	2003-04-09
PL181588B1 (pl)	2001-08-31
PT783521E (pt)	2003-02-28
MX9702275A (es)	1997-06-28
WO1996010040A1 (en)	1996-04-04
KR100369105B1 (ko)	2003-04-07
IL115381A (en)	2000-07-16
HK1001207A1 (en)	1998-06-05
IL115381A0 (en)	1995-12-31
AU700066B2 (en)	1998-12-17
DK0783521T3 (da)	2003-01-27
CA2201122A1 (en)	1996-04-04
ES2186730T3 (es)	2003-05-16

Publication	Publication Date	Title
NZ227788A (en)	1991-10-25	Peptide having growth hormone regulatory effects, and compositions
ATE197307T1 (de)	2000-11-15	Neuroaktive peptide
DE69837264D1 (de)	2007-04-19	Dipeptidderivate zur förderung der sekretion von wachstumshormon
DE69732871D1 (de)	2005-05-04	Basisches Protein Zusammensetzung, basisches Peptid Zusammensetzung und deren Verwendung
AU1750297A (en)	1997-08-11	Humanized green fluorescent protein genes and methods
ATE225806T1 (de)	2002-10-15	D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
DE60030450D1 (de)	2006-10-12	Von MUC-1 abgeleitete Peptide
TR199802534T2 (xx)	1999-03-22	Leptin (OB Protein) fragmanlar�
DK1129186T3 (da)	2008-01-21	Et faktor VIII-polypeptid med faktor VIII:C-aktivitet
EP0875567A3 (de)	1999-12-22	Myc-bindende Zinkfinger-Proteine, ihre Herstellung und ihre Verwendung
DK148085C (da)	1985-08-12	Dipeptidet pyrglu-his(2,4-dinitrophenyl)-oh og fremgangsmaade til fremstilling af lh-rh og lh-rh-analoge peptider under anvendelse af dette dipeptid
ES2087337T3 (es)	1996-07-16	Composiciones de implantes que contienen una proteina, peptido o polipeptido biologicamente activos.
MX169334B (es)	1993-06-30	Preparacion de liberacion sostenida
DE69002881D1 (de)	1993-09-30	Peptide und deren Benutzung.
EP0490383A3 (en)	1993-06-30	Peptides of the hiv-gag protein, their preparation and use
NO891926D0 (no)	1989-05-11	Fremgangsmaate for fremstilling av stabile protein- eller peptidpreparater.
DE3869939D1 (de)	1992-05-14	Biologisch wirksame peptide.
GB9604518D0 (en)	1996-05-01	Novel compounds
DE69030316D1 (de)	1997-04-30	Schrittweiser c-terminaler abbau von peptiden und proteinen
DE68914057D1 (de)	1994-04-28	Peptide.
DE60044468D1 (de)	2010-07-08	Herstellung von sekretierten polypeptiden
NO893572L (no)	1989-09-05	Lunge-overflateaktivt protein og beslektet polypeptid.
IT8847737A0 (it)	1988-03-16	Procedimento per ottenere amminoacidi da sostanze proteiche per uso fertilizzante
NO912072D0 (no)	1991-05-29	Rekombinante proteiner med adipsin- og komplement-d-aktiviteter.

Legal Events

Date	Code	Title	Description
2003-05-15	UEP	Publication of translation of european patent specification	Ref document number: 0783521 Country of ref document: EP
2009-06-15	REN	Ceased due to non-payment of the annual fee

Date

Code

Title

Description

2003-05-15

UEP

Publication of translation of european patent specification

Ref document number: 0783521

Country of ref document: EP

2009-06-15

REN

Ceased due to non-payment of the annual fee