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ATE225174T1 - Selbstemulgierende formulierung enthaltend saure lipophile verbindungen - Google Patents

Selbstemulgierende formulierung enthaltend saure lipophile verbindungen

Info

Publication number
ATE225174T1
ATE225174T1 AT98936888T AT98936888T ATE225174T1 AT E225174 T1 ATE225174 T1 AT E225174T1 AT 98936888 T AT98936888 T AT 98936888T AT 98936888 T AT98936888 T AT 98936888T AT E225174 T1 ATE225174 T1 AT E225174T1
Authority
AT
Austria
Prior art keywords
self
emulsifying formulation
pharmaceutically acceptable
formulation containing
containing acidic
Prior art date
Application number
AT98936888T
Other languages
English (en)
Inventor
Walter Morozowich
Ping Gao
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE225174T1 publication Critical patent/ATE225174T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
AT98936888T 1997-07-29 1998-07-27 Selbstemulgierende formulierung enthaltend saure lipophile verbindungen ATE225174T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5401297P 1997-07-29 1997-07-29
PCT/US1998/014817 WO1999006044A1 (en) 1997-07-29 1998-07-27 Pharmaceutical composition for acidic lipophilic compounds in a form of a self-emulsifying formulation

Publications (1)

Publication Number Publication Date
ATE225174T1 true ATE225174T1 (de) 2002-10-15

Family

ID=21988155

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98936888T ATE225174T1 (de) 1997-07-29 1998-07-27 Selbstemulgierende formulierung enthaltend saure lipophile verbindungen

Country Status (25)

Country Link
US (1) US6231887B1 (de)
EP (1) EP0989851B1 (de)
JP (1) JP4524367B2 (de)
KR (1) KR100509131B1 (de)
CN (1) CN1112927C (de)
AT (1) ATE225174T1 (de)
AU (1) AU728626B2 (de)
BR (1) BR9810729B1 (de)
CA (1) CA2294033C (de)
CY (1) CY2006002I2 (de)
CZ (1) CZ296957B6 (de)
DE (1) DE69808463T2 (de)
DK (1) DK0989851T3 (de)
ES (1) ES2184310T3 (de)
FI (1) FI20000172A (de)
HK (1) HK1028879A1 (de)
HU (1) HU228923B1 (de)
NO (1) NO323425B1 (de)
NZ (1) NZ502566A (de)
PL (1) PL192865B1 (de)
PT (1) PT989851E (de)
RU (1) RU2202346C2 (de)
SI (1) SI0989851T1 (de)
SK (1) SK284616B6 (de)
WO (1) WO1999006044A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
ES2234582T3 (es) * 1999-03-31 2005-07-01 PHARMACIA & UPJOHN COMPANY LLC Emulsiones farmaceuticas para inhibidores de proteasas retrovirales.
US6956048B2 (en) 1999-03-31 2005-10-18 Pharmacia & Upjohn Company Pharmaceutical emulsions for retroviral protease inhibitors
SE0000773D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000774D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
PL365627A1 (en) * 2000-10-31 2005-01-10 Boehringer Ingelheim Pharmaceuticals, Inc. Oral dosage self-emulsifying formulations of pyranone protease inhibitors
SE0102993D0 (sv) * 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
US20030165545A1 (en) * 2002-01-30 2003-09-04 Allergan, Inc. Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same
DE60320940D1 (de) * 2002-02-01 2008-06-26 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
US6828301B2 (en) * 2002-02-07 2004-12-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for hepatitis C viral protease inhibitors
US20040191332A1 (en) * 2003-03-27 2004-09-30 Allergan, Inc. Preserved ophthalmic compositions
RS20050741A (en) * 2003-04-02 2007-06-04 Boehringer Ingelheim International Gmbh., Pharmaceutical compositions for hepatitis c viral protease inhibitors
WO2005011635A2 (en) 2003-08-04 2005-02-10 Pfizer Products Inc. Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials
JP2007507226A (ja) * 2003-10-07 2007-03-29 イーライ リリー アンド カンパニー ラクトパミンの液状製剤
EP1814549A2 (de) * 2004-11-19 2007-08-08 Boehringer Ingelheim International GmbH Verfahren zur behandlung von hiv-infektionen mittels gemeinsamer verabreichung von tipranavir und uk-427, 857
CA2583195A1 (en) * 2004-11-19 2006-05-26 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and reverset
JP2008521896A (ja) * 2004-12-01 2008-06-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チプラナビル及びｇｗ６９５６３４を共に投与することを含むｈｉｖ感染症の治療方法
JP5028885B2 (ja) * 2006-07-04 2012-09-19 大正製薬株式会社 ユビデカレノン含有自己乳化組成物
CA2679482C (en) 2007-03-12 2015-04-21 Nektar Therapeutics Oligomer-protease inhibitor conjugates
US9095620B2 (en) * 2008-03-12 2015-08-04 Nektar Therapeutics Reagents
WO2010144869A2 (en) 2009-06-12 2010-12-16 Nektar Therapeutics Protease inhibitors
CN102470103B (zh) 2009-07-07 2016-09-07 贝林格尔.英格海姆国际有限公司 用作丙型肝炎病毒蛋白酶抑制剂的药物组合物
US9717703B2 (en) 2009-10-16 2017-08-01 Glaxosmithkline Llc Emulsion and emulsion preconcentrate compositions comprising omega-3 fatty acids and uses thereof are disclosed
RU2419426C1 (ru) * 2010-04-26 2011-05-27 Всеволод Иванович Киселев Лекарственное средство на основе дииндолилметана (dim) с повышенной биодоступностью и его использование в лечении гиперпластических и воспалительных заболеваний человека
SG10201503234SA (en) 2010-05-03 2015-06-29 Teikoku Pharma Usa Inc Non-Aqueous Taxane Pro-Emulsion Formulations and Methods of Making and Using the Same
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
CN104968330A (zh) * 2013-01-14 2015-10-07 因佛斯特医疗有限公司 用于治疗剧痛的组合物及方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230702A (en) 1978-01-09 1980-10-28 Kali-Chemie Pharma Gmbh Readily enterally absorbable pharmaceutical compositions of per se poorly enterally absorbable pharmacologically active agents
DE3300793A1 (de) * 1983-01-12 1984-07-12 Bayer Ag, 5090 Leverkusen Coccidiosemittel
GB8903804D0 (en) 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US5071643A (en) 1986-10-17 1991-12-10 R. P. Scherer Corporation Solvent system enhancing the solubility of pharmaceuticals for encapsulation
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
IL102236A0 (en) * 1991-06-27 1993-01-14 Ltt Inst Co Ltd Topical preparations containing cyclosporin
GB9113872D0 (en) 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
GB9208712D0 (en) * 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates
US5376688A (en) 1992-12-18 1994-12-27 R. P. Scherer Corporation Enhanced solubility pharmaceutical solutions
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
JPH10504291A (ja) * 1994-07-22 1998-04-28 ジー．ディー．サール アンド カンパニー 自己乳化性ドラッグデリバリーシステム
WO1996033697A1 (fr) * 1995-04-24 1996-10-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Formulation auto-emulsionnable formant une emulsion huile dans l'eau
CA2224125C (en) 1995-06-06 2004-09-28 F. Hoffmann-La Roche Ag Pharmaceutical composition comprising a proteinase inhibitor and a monoglyceride
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.

Also Published As

Publication number Publication date
KR100509131B1 (ko) 2005-08-18
HUP0002440A3 (en) 2001-10-29
JP4524367B2 (ja) 2010-08-18
SK284616B6 (sk) 2005-07-01
WO1999006044A1 (en) 1999-02-11
SI0989851T1 (en) 2003-04-30
NO323425B1 (no) 2007-04-30
BR9810729A (pt) 2000-08-08
NO20000466L (no) 2000-03-28
CN1112927C (zh) 2003-07-02
KR20010022369A (ko) 2001-03-15
NZ502566A (en) 2002-03-28
CZ2000156A3 (cs) 2000-05-17
CA2294033C (en) 2007-01-09
EP0989851A1 (de) 2000-04-05
EP0989851B1 (de) 2002-10-02
AU728626B2 (en) 2001-01-11
AU8573898A (en) 1999-02-22
BR9810729B1 (pt) 2010-07-13
RU2202346C2 (ru) 2003-04-20
DE69808463D1 (de) 2002-11-07
SK162000A3 (en) 2000-12-11
HU228923B1 (en) 2013-06-28
HUP0002440A2 (hu) 2001-09-28
PL192865B1 (pl) 2006-12-29
DE69808463T2 (de) 2003-06-26
CY2006002I1 (el) 2011-02-02
DK0989851T3 (da) 2003-01-27
HK1028879A1 (en) 2001-03-09
CN1261796A (zh) 2000-08-02
NO20000466D0 (no) 2000-01-28
US6231887B1 (en) 2001-05-15
FI20000172A (fi) 2000-01-28
CY2006002I2 (el) 2012-01-25
ES2184310T3 (es) 2003-04-01
CZ296957B6 (cs) 2006-08-16
JP2002510330A (ja) 2002-04-02
PT989851E (pt) 2002-12-31
PL338335A1 (en) 2000-10-23
CA2294033A1 (en) 1999-02-11

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