ATE222920T1 - Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung - Google Patents

Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung

Info

Publication number: ATE222920T1
Authority: AT; Austria
Prior art keywords: salt; ump; production; ppi; dpp
Prior art date: 1998-10-02

Application number

AT99970090T

Other languages

English (en)

Inventor

Hideaki Maeda

Toshio Yamada

Hiroshi Sato

Yutaka Noda

Original Assignee

Yamasa Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-02

Filing date

1999-10-01

Publication date

2002-09-15

1999-10-01 Application filed by Yamasa Corp filed Critical Yamasa Corp

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE222920T1 publication Critical patent/ATE222920T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99970090T 1998-10-02 1999-10-01 Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung ATE222920T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP28166398		1998-10-02
JP17068199		1999-06-17
PCT/JP1999/005415 WO2000020430A1 (fr)	1998-10-02	1999-10-01	Cristal de diuridine tetraphosphate ou sel correspondant et procede de fabrication

Publications (1)

Publication Number	Publication Date
ATE222920T1 true ATE222920T1 (de)	2002-09-15

Family

ID=26493605

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99970090T ATE222920T1 (de)	1998-10-02	1999-10-01	Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung

Country Status (21)

Country	Link
US (2)	US6458946B1 (de)
EP (1)	EP1043329B1 (de)
JP (2)	JP3247685B2 (de)
KR (1)	KR100475008B1 (de)
CN (2)	CN1151166C (de)
AT (1)	ATE222920T1 (de)
AU (1)	AU747096C (de)
BR (2)	BRPI9917911B1 (de)
CA (1)	CA2345624C (de)
CZ (1)	CZ300402B6 (de)
DE (1)	DE69902624T2 (de)
EA (2)	EA004513B1 (de)
ES (1)	ES2183650T3 (de)
HU (1)	HU228681B1 (de)
IL (1)	IL142181A (de)
MX (1)	MXPA01003377A (de)
NO (1)	NO317305B1 (de)
NZ (1)	NZ510748A (de)
PL (1)	PL199434B1 (de)
SK (1)	SK283729B6 (de)
WO (1)	WO2000020430A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7078391B2 (en)	1997-02-10	2006-07-18	Inspire Pharmaceuticals, Inc.	Method of treating edematous retinal disorders
US6818629B2 (en)	1997-02-10	2004-11-16	Inspire Pharmaceuticals, Inc.	Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US7223744B2 (en)	1997-02-10	2007-05-29	Inspire Pharmaceuticals, Inc.	Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6872710B2 (en)	1997-07-25	2005-03-29	Inspire Pharmaceuticals, Inc.	Di(uridine 5′)-tetraphosphate and salts thereof
CN1144811C (zh) *	1999-06-30	2004-04-07	雅玛山酱油株式会社	二核苷酸结晶
US6867199B2 (en)	2000-08-21	2005-03-15	Inspire Pharmaceuticals, Inc.	Dinucleoside polyphosphate compositions and their therapeutic use
CN100363376C (zh) *	2006-06-12	2008-01-23	南京工业大学	一种5’-核苷三磷酸钠盐的结晶方法
JPWO2017002827A1 (ja) *	2015-06-29	2018-04-26	ヤマサ醤油株式会社	Ｐ１，ｐ４−ビス（５’−ウリジル）テトラホスフェート結晶の保管方法
US10815263B2 (en)	2016-10-25	2020-10-27	Yamasa Corporation	Method for purifying P1,P4-di(uridine 5′-)tetraphosphate
KR20180091689A (ko)	2017-11-06	2018-08-16	주식회사 종근당	무정형 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법
CN109021049B (zh) *	2018-06-14	2020-12-08	扬子江药业集团北京海燕药业有限公司	一种尿苷5′-二磷酸-苯并咪唑二钠的合成方法
KR20210110055A (ko) *	2020-02-28	2021-09-07	주식회사 종근당바이오	P1, p4-디(우리딘 5'-)테트라포스페이트 나트륨염 4 수화물 결정형 a의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6423694B1 (en) *	1996-02-21	2002-07-23	Inspire Pharmaceuticals, Inc.	Method of treating otitis media with uridine triphosphates and related compounds
AU727314B2 (en) *	1996-03-27	2000-12-07	Inspire Pharmaceuticals, Inc.	Method of treating ciliary dyskinesia with uridine triphosphates and related compounds
US6319908B1 (en) *	1996-07-03	2001-11-20	Inspire Pharmaceuticals, Inc.	Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
US5763447C1 (en) *	1996-07-23	2002-05-07	Inspire Pharmaceuticals	Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
ATE261982T1 (de) *	1997-07-25	2004-04-15	Inspire Pharmaceuticals Inc	Salze von di(uridine 5'-tetraphosphate), verfahren zur herstellung und verwendungen davon

1999
- 1999-10-01 MX MXPA01003377A patent/MXPA01003377A/es active IP Right Grant
- 1999-10-01 DE DE69902624T patent/DE69902624T2/de not_active Expired - Lifetime
- 1999-10-01 BR BRPI9917911A patent/BRPI9917911B1/pt active IP Right Grant
- 1999-10-01 PL PL347070A patent/PL199434B1/pl unknown
- 1999-10-01 ES ES99970090T patent/ES2183650T3/es not_active Expired - Lifetime
- 1999-10-01 EA EA200200695A patent/EA004513B1/ru not_active IP Right Cessation
- 1999-10-01 CN CNB998117137A patent/CN1151166C/zh not_active Expired - Lifetime
- 1999-10-01 AT AT99970090T patent/ATE222920T1/de not_active IP Right Cessation
- 1999-10-01 JP JP2000574541A patent/JP3247685B2/ja not_active Expired - Lifetime
- 1999-10-01 SK SK440-2001A patent/SK283729B6/sk not_active IP Right Cessation
- 1999-10-01 HU HU0103754A patent/HU228681B1/hu unknown
- 1999-10-01 CA CA002345624A patent/CA2345624C/en not_active Expired - Lifetime
- 1999-10-01 BR BR9914453-0A patent/BR9914453A/pt not_active Application Discontinuation
- 1999-10-01 NZ NZ510748A patent/NZ510748A/xx not_active IP Right Cessation
- 1999-10-01 KR KR10-2001-7004083A patent/KR100475008B1/ko active IP Right Grant
- 1999-10-01 CN CNB2003101209181A patent/CN100396692C/zh not_active Expired - Lifetime
- 1999-10-01 EP EP99970090A patent/EP1043329B1/de not_active Expired - Lifetime
- 1999-10-01 AU AU60008/99A patent/AU747096C/en not_active Expired
- 1999-10-01 CZ CZ20011028A patent/CZ300402B6/cs not_active IP Right Cessation
- 1999-10-01 US US09/582,642 patent/US6458946B1/en not_active Expired - Lifetime
- 1999-10-01 WO PCT/JP1999/005415 patent/WO2000020430A1/ja active IP Right Grant
- 1999-10-01 IL IL14218199A patent/IL142181A/xx not_active IP Right Cessation
- 1999-10-01 EA EA200100407A patent/EA003167B1/ru not_active IP Right Cessation
2001
- 2001-03-30 NO NO20011634A patent/NO317305B1/no not_active IP Right Cessation
- 2001-08-06 JP JP2001237293A patent/JP3824894B2/ja not_active Expired - Lifetime
2002
- 2002-04-12 US US10/120,367 patent/US6780988B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU747096C (en)	2003-01-23
EA004513B1 (ru)	2004-04-29
CN1151166C (zh)	2004-05-26
IL142181A (en)	2005-12-18
EA003167B1 (ru)	2003-02-27
WO2000020430A1 (fr)	2000-04-13
EP1043329B1 (de)	2002-08-28
DE69902624T2 (de)	2003-04-03
ES2183650T3 (es)	2003-03-16
EP1043329A4 (de)	2001-03-14
PL199434B1 (pl)	2008-09-30
HUP0103754A3 (en)	2003-01-28
BR9914453A (pt)	2001-05-22
SK4402001A3 (en)	2001-11-06
CA2345624C (en)	2006-12-05
EA200100407A1 (ru)	2001-10-22
NO20011634D0 (no)	2001-03-30
NZ510748A (en)	2002-10-25
SK283729B6 (sk)	2003-12-02
US20020156269A1 (en)	2002-10-24
HUP0103754A2 (hu)	2002-04-29
IL142181A0 (en)	2002-03-10
US6780988B2 (en)	2004-08-24
AU6000899A (en)	2000-04-26
EP1043329A1 (de)	2000-10-11
JP2002053590A (ja)	2002-02-19
PL347070A1 (en)	2002-03-11
MXPA01003377A (es)	2003-06-24
CZ20011028A3 (cs)	2001-08-15
KR20020013471A (ko)	2002-02-20
HU228681B1 (en)	2013-05-28
CN1321163A (zh)	2001-11-07
CZ300402B6 (cs)	2009-05-13
JP3824894B2 (ja)	2006-09-20
NO317305B1 (no)	2004-10-04
US6458946B1 (en)	2002-10-01
JP3247685B2 (ja)	2002-01-21
EA200200695A1 (ru)	2002-10-31
NO20011634L (no)	2001-05-30
DE69902624D1 (de)	2002-10-02
AU747096B2 (en)	2002-05-09
BRPI9917911B1 (pt)	2016-08-23
CA2345624A1 (en)	2000-04-13
CN100396692C (zh)	2008-06-25
KR100475008B1 (ko)	2005-03-08
CN1502622A (zh)	2004-06-09

Publication	Publication Date	Title
ATE222920T1 (de)	2002-09-15	Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung
ATE268788T1 (de)	2004-06-15	Verfahren zur herstellung von polyisocyanaten
DE60231534D1 (de)	2009-04-23	Kristall von oxidiertem glutathion und verfahren zu dessen herstellung
NO20016381L (no)	2002-02-28	Dinukleotidkrystaller
RU94046317A (ru)	1996-10-20	Новое синтетическое промежуточное соединение для получения производных и способы получения производных аминокислот
MY107160A (en)	1995-09-30	N-aryl-3-aryl-4-substituted-4,5-dihydro-1h-pyrazole-1- carboxamides and processes for their production.
ATE273263T1 (de)	2004-08-15	Verfahren zur kontinuierlichen herstellung von glutaraldehyd
DE69629661D1 (de)	2003-10-02	VERFAHREN ZUR HERSTELLUNG VON N-(D-alpha-METHYL-beta-MERCAPTOPROPIONYL)-L-PROLIN UND INTERMEDIATEN DAVON
JPH0641463B2 (ja)	1994-06-01	チオテトロン酸の製造方法
DE69926223D1 (de)	2005-08-25	Verfahren zur herstellung von zwischenprodukten
DE69604565D1 (de)	1999-11-11	Verfahren zur herstellung von polycyanatestern
HUP9801658A2 (hu)	1999-09-28	Eljárás az 1. típusú ranitidin hidroklorid előállítására és az ezzel az eljárással előállítható termék
JP2000229940A (ja)	2000-08-22	高純度ピロリドン類の製造法
KR910021370A (ko)	1991-12-20	방향족 우레탄의 제조방법
JPH02282376A (ja)	1990-11-19	シス―７―デセン―４―オリドの製造方法
JPS63203673A (ja)	1988-08-23	Ｄｌ−パントラクトンの光学分割法
HUP0003490A2 (hu)	2001-02-28	Eljárás ftalidok tisztítására
RU92010801A (ru)	1995-06-19	Способ получения n-карбэтоксиметилпирролидона-2
JPH0616614A (ja)	1994-01-25	ニトリルの製造法
JPS61134368A (ja)	1986-06-21	Ｎ−クロルスルフェニル化合物の製造方法
JPH041164A (ja)	1992-01-06	２―アセトアミドチロイノシトール類およびその製造方法
JPH03197451A (ja)	1991-08-28	５―アミノ―２，４，６―トリヨードイソフタル酸の製造方法
JPS60243057A (ja)	1985-12-03	光学活性有機イソシアネート類の製造法
JPH07149712A (ja)	1995-06-13	ジフェニルジスルホニルフルオライドおよびその合成方法
RU95101529A (ru)	1996-12-20	СПОСОБ ПОЛУЧЕНИЯ N-( α -АЛКОКСИЭТИЛ)КАПРОЛАКТАМОВ

Legal Events

Date	Code	Title	Description
2003-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties