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ATE138925T1 - Erythromycinderivate, herstellung und verwendung davon - Google Patents

Erythromycinderivate, herstellung und verwendung davon

Info

Publication number
ATE138925T1
ATE138925T1 AT93104504T AT93104504T ATE138925T1 AT E138925 T1 ATE138925 T1 AT E138925T1 AT 93104504 T AT93104504 T AT 93104504T AT 93104504 T AT93104504 T AT 93104504T AT E138925 T1 ATE138925 T1 AT E138925T1
Authority
AT
Austria
Prior art keywords
hemiacetal
salt
erythromycin derivative
positions
hydroxyl group
Prior art date
Application number
AT93104504T
Other languages
English (en)
Inventor
Setsuo Harada
Yasunori Funabashi
Nobuhiro Inatomi
Shigeharu Tanayama
Seiichi Tanida
Original Assignee
Takeda Chemical Industries Ltd
Kitasato Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd, Kitasato Inst filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE138925T1 publication Critical patent/ATE138925T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT93104504T 1992-03-19 1993-03-19 Erythromycinderivate, herstellung und verwendung davon ATE138925T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6424392 1992-03-19
JP15246792 1992-06-11

Publications (1)

Publication Number Publication Date
ATE138925T1 true ATE138925T1 (de) 1996-06-15

Family

ID=26405362

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93104504T ATE138925T1 (de) 1992-03-19 1993-03-19 Erythromycinderivate, herstellung und verwendung davon

Country Status (5)

Country Link
US (2) US5470961A (de)
EP (1) EP0561413B1 (de)
AT (1) ATE138925T1 (de)
CA (1) CA2092045C (de)
DE (1) DE69302938T2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE138925T1 (de) * 1992-03-19 1996-06-15 Takeda Chemical Industries Ltd Erythromycinderivate, herstellung und verwendung davon
US6077943A (en) * 1996-03-01 2000-06-20 Takeda Chemical Industries, Ltd. Method of producing erythromycin derivative
WO2001060833A2 (en) * 2000-02-18 2001-08-23 Kosan Biosciences, Inc. Motilide compounds
EP1365726A2 (de) 2001-02-15 2003-12-03 Kosan Biosciences, Inc. Verfahern zur beurteilung der therapeutischen wirksamkeit
EP1633774B1 (de) 2003-06-18 2010-02-17 Tranzyme Pharma Inc. Makrozyklische motilin rezeptorantagonisten
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
US7582611B2 (en) 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
JP2009518396A (ja) * 2005-12-08 2009-05-07 ファイザー・インク エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法
US9133235B2 (en) 2006-09-11 2015-09-15 Ocera Therapeutics, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
WO2008068593A2 (en) * 2006-12-05 2008-06-12 Pfizer Inc. Motilide polymorphs
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2926959A1 (de) * 1979-07-04 1981-01-22 Hoechst Ag Vorrichtung zur fluessig-fluessig- extraktion
EP0215355B1 (de) * 1985-08-31 1994-04-06 Kitasato Kenkyusho Erythromycinderivat und Verfahren zu dessen Herstellung
US5008249A (en) * 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
US4672056A (en) * 1985-11-12 1987-06-09 Abbott Laboratories Erythromycin A derivatives and method of use
JPH0633312B2 (ja) * 1986-05-02 1994-05-02 大正製薬株式会社 １４−ハイドロキシエリスロマイシン誘導体およびその製造方法
US5106961A (en) * 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
US4920102A (en) * 1988-04-18 1990-04-24 Eli Lilly And Company Method for treating gastrointestinal disorders
ATE138925T1 (de) * 1992-03-19 1996-06-15 Takeda Chemical Industries Ltd Erythromycinderivate, herstellung und verwendung davon

Also Published As

Publication number Publication date
EP0561413B1 (de) 1996-06-05
US5854407A (en) 1998-12-29
CA2092045C (en) 2004-08-10
EP0561413A1 (de) 1993-09-22
DE69302938D1 (de) 1996-07-11
DE69302938T2 (de) 1996-10-17
CA2092045A1 (en) 1993-09-20
US5470961A (en) 1995-11-28

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties