ATE124417T1 - 2,19-methylenoxy- und 2,19-methylenthiogebrückte steroide und ihre verwendung als inhibitoren von aromatase und 19-hydroxylase. - Google Patents

2,19-methylenoxy- und 2,19-methylenthiogebrückte steroide und ihre verwendung als inhibitoren von aromatase und 19-hydroxylase.

Info

Publication number: ATE124417T1
Authority: AT; Austria
Prior art keywords: methylenthio; methyleneoxy; aromatase; hydroxylase; inhibitors
Prior art date: 1989-12-20

Application number

AT90124739T

Other languages

English (en)

Inventor

Norton P Peet

J O'neil Johnston

Joseph P Burkhart

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-20

Filing date

1990-12-19

Publication date

1995-07-15

1990-12-19 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1995-07-15 Application granted granted Critical

1995-07-15 Publication of ATE124417T1 publication Critical patent/ATE124417T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0073—Sulfur-containing hetero ring
- C07J71/0078—Sulfur-containing hetero ring containing only sulfur
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT90124739T 1989-12-20 1990-12-19 2,19-methylenoxy- und 2,19-methylenthiogebrückte steroide und ihre verwendung als inhibitoren von aromatase und 19-hydroxylase. ATE124417T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US45344189A	1989-12-20	1989-12-20

Publications (1)

Publication Number	Publication Date
ATE124417T1 true ATE124417T1 (de)	1995-07-15

Family

ID=23800602

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90124739T ATE124417T1 (de)	1989-12-20	1990-12-19	2,19-methylenoxy- und 2,19-methylenthiogebrückte steroide und ihre verwendung als inhibitoren von aromatase und 19-hydroxylase.

Country Status (20)

Country	Link
EP (1)	EP0434020B1 (de)
JP (1)	JP2922653B2 (de)
KR (1)	KR100187781B1 (de)
CN (1)	CN1035768C (de)
AR (1)	AR248410A1 (de)
AT (1)	ATE124417T1 (de)
AU (1)	AU630008B2 (de)
CA (1)	CA2032311C (de)
DE (1)	DE69020520T2 (de)
DK (1)	DK0434020T3 (de)
ES (1)	ES2076286T3 (de)
FI (1)	FI107925B (de)
GR (1)	GR3017136T3 (de)
HU (1)	HU208024B (de)
IE (1)	IE67557B1 (de)
IL (1)	IL96695A (de)
NO (1)	NO177676C (de)
NZ (1)	NZ236473A (de)
PT (1)	PT96258B (de)
ZA (1)	ZA9010082B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5491136A (en) *	1989-12-20	1996-02-13	Merrell Dow Pharmaceuticals Inc.	2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, 19-hydroxylaser inhibitors and methods of their use in the treatment of estrogen mediated disorders
US5126488A (en) *	1990-11-30	1992-06-30	Merrell Dow Pharmaceuticals Inc.	2β,19-methyleneamino bridged steroids as aromatase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3627756A (en) *	1970-04-23	1971-12-14	Searle & Co	N-dialkylaminoalkyl-n-(2{62 ,19-epoxy-5{60 -androstan-17{62 -yl)amines/formamides and 3{60 -halo derivatives thereof
US3954980A (en) *	1971-10-19	1976-05-04	Derek Harold Richard Barton	Chemical compounds
US4814324A (en) *	1987-03-06	1989-03-21	Merck & Co., Inc.	Sterol inhibitors of testosterone 5α-reductase

1990
- 1990-12-14 ZA ZA9010082A patent/ZA9010082B/xx unknown
- 1990-12-14 AU AU68083/90A patent/AU630008B2/en not_active Ceased
- 1990-12-14 CA CA002032311A patent/CA2032311C/en not_active Expired - Fee Related
- 1990-12-14 NZ NZ236473A patent/NZ236473A/xx unknown
- 1990-12-17 IL IL9669590A patent/IL96695A/en not_active IP Right Cessation
- 1990-12-17 HU HU908299A patent/HU208024B/hu not_active IP Right Cessation
- 1990-12-18 KR KR1019900020871A patent/KR100187781B1/ko not_active Expired - Fee Related
- 1990-12-19 NO NO905494A patent/NO177676C/no not_active IP Right Cessation
- 1990-12-19 ES ES90124739T patent/ES2076286T3/es not_active Expired - Lifetime
- 1990-12-19 AT AT90124739T patent/ATE124417T1/de not_active IP Right Cessation
- 1990-12-19 JP JP2411707A patent/JP2922653B2/ja not_active Expired - Fee Related
- 1990-12-19 FI FI906269A patent/FI107925B/fi not_active IP Right Cessation
- 1990-12-19 DE DE69020520T patent/DE69020520T2/de not_active Expired - Fee Related
- 1990-12-19 IE IE459790A patent/IE67557B1/en not_active IP Right Cessation
- 1990-12-19 EP EP90124739A patent/EP0434020B1/de not_active Expired - Lifetime
- 1990-12-19 PT PT96258A patent/PT96258B/pt not_active IP Right Cessation
- 1990-12-19 DK DK90124739.5T patent/DK0434020T3/da active
- 1990-12-19 CN CN90110133A patent/CN1035768C/zh not_active Expired - Fee Related
- 1990-12-20 AR AR90318689A patent/AR248410A1/es active
1995
- 1995-08-16 GR GR950402256T patent/GR3017136T3/el unknown

Also Published As

Publication number	Publication date
IL96695A (en)	1996-08-04
KR100187781B1 (ko)	1999-06-01
CN1035768C (zh)	1997-09-03
PT96258B (pt)	1998-09-30
HU208024B (en)	1993-07-28
IE67557B1 (en)	1996-04-17
HU908299D0 (en)	1991-06-28
NO177676C (no)	1995-11-01
DK0434020T3 (da)	1995-08-28
ZA9010082B (en)	1991-10-30
NZ236473A (en)	1993-04-28
FI906269L (fi)	1991-06-21
DE69020520T2 (de)	1995-11-30
EP0434020B1 (de)	1995-06-28
AU630008B2 (en)	1992-10-15
DE69020520D1 (de)	1995-08-03
HUT56380A (en)	1991-08-28
NO177676B (no)	1995-07-24
KR910011888A (ko)	1991-08-07
CN1052678A (zh)	1991-07-03
JP2922653B2 (ja)	1999-07-26
NO905494L (no)	1991-06-21
FI107925B (fi)	2001-10-31
AR248410A1 (es)	1995-08-18
PT96258A (pt)	1991-09-30
CA2032311A1 (en)	1991-06-21
NO905494D0 (no)	1990-12-19
FI906269A0 (fi)	1990-12-19
IL96695A0 (en)	1991-09-16
IE904597A1 (en)	1991-07-03
CA2032311C (en)	2002-08-27
EP0434020A1 (de)	1991-06-26
JPH04128297A (ja)	1992-04-28
AU6808390A (en)	1991-10-17
ES2076286T3 (es)	1995-11-01
GR3017136T3 (en)	1995-11-30

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Legal Events

Date	Code	Title	Description
1996-01-15	UEP	Publication of translation of european patent specification
2004-09-15	REN	Ceased due to non-payment of the annual fee