ATE107278T1 - Enantioselektives verfahren zur herstellung von 1-beta-methylcarbapenem- antibiotikumzwischenprodukten. - Google Patents
Enantioselektives verfahren zur herstellung von 1-beta-methylcarbapenem- antibiotikumzwischenprodukten.Info
- Publication number
- ATE107278T1 ATE107278T1 AT86104146T AT86104146T ATE107278T1 AT E107278 T1 ATE107278 T1 AT E107278T1 AT 86104146 T AT86104146 T AT 86104146T AT 86104146 T AT86104146 T AT 86104146T AT E107278 T1 ATE107278 T1 AT E107278T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- alkyl
- chem
- beta
- preparation
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- YKMONJZIUAOVEM-WDSKDSINSA-N 1beta-methylcarbapenem Chemical compound C[C@H]1C=CN2C(=O)C[C@@H]12 YKMONJZIUAOVEM-WDSKDSINSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract 1
- 125000002587 enol group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000011968 lewis acid catalyst Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71774285A | 1985-03-29 | 1985-03-29 | |
| US71734285A | 1985-03-29 | 1985-03-29 | |
| US71774685A | 1985-03-29 | 1985-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE107278T1 true ATE107278T1 (de) | 1994-07-15 |
Family
ID=27418970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86104146T ATE107278T1 (de) | 1985-03-29 | 1986-03-26 | Enantioselektives verfahren zur herstellung von 1-beta-methylcarbapenem- antibiotikumzwischenprodukten. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0197432B1 (de) |
| JP (2) | JPH05320159A (de) |
| AT (1) | ATE107278T1 (de) |
| CA (3) | CA1276156C (de) |
| DE (1) | DE3689911D1 (de) |
| DK (1) | DK141786A (de) |
| ES (1) | ES8800215A1 (de) |
| IE (1) | IE860840L (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE109764T1 (de) * | 1985-12-28 | 1994-08-15 | Sumitomo Pharma | Beta-lactamverbindungen und deren herstellung. |
| US5231179A (en) * | 1986-01-27 | 1993-07-27 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds and their production |
| JP2789190B2 (ja) * | 1986-01-27 | 1998-08-20 | 住友製薬株式会社 | 新規なβ−ラクタム誘導体およびその製造法 |
| GB8607921D0 (en) * | 1986-04-01 | 1986-05-08 | Fujisawa Pharmaceutical Co | 3,4-disubstituted-2-azetidinone derivatives |
| EP0241200B1 (de) * | 1986-04-07 | 1990-12-27 | Merck & Co. Inc. | Verfahren zur Herstellung von 1-Betamethylcarbapenem-Antibiotikum-Zwischenprodukten |
| US5550229A (en) * | 1993-06-23 | 1996-08-27 | Tanabe Seiyaku Co., Ltd. | Alkylation process for preparing azetidinone compound and starting compound therefor |
| DE69405922T2 (de) * | 1993-06-30 | 1998-01-29 | Nippon Soda Co | Verfahren zur Herstellung von 4-substituierten Azetidinon-Derivaten |
| JP3450193B2 (ja) * | 1998-07-24 | 2003-09-22 | 高砂香料工業株式会社 | ４−置換アゼチジノン誘導体の製造方法 |
| CN113817299B (zh) * | 2021-08-18 | 2022-12-13 | 安徽建筑大学 | 一种具有离子和化学双重交联结构的pla基共混复合材料及其制备方法 |
| CN113970500B (zh) * | 2021-10-27 | 2023-08-29 | 北京新风航天装备有限公司 | 一种油污固废含油率快速测定方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2399118A (en) | 1942-02-13 | 1946-04-23 | Mallinckrodt Chemical Works | 2-oxazolidone compounds and method for preparing the same |
| US3950357A (en) | 1974-11-25 | 1976-04-13 | Merck & Co., Inc. | Antibiotics |
| US4194047A (en) | 1975-11-21 | 1980-03-18 | Merck & Co., Inc. | Substituted N-methylene derivatives of thienamycin |
| US4383946A (en) | 1980-03-27 | 1983-05-17 | Merck & Co., Inc. | Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals |
| ES8404184A1 (es) * | 1981-08-03 | 1984-04-16 | Merck & Co Inc | Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados. |
| JPS6019763A (ja) | 1983-07-13 | 1985-01-31 | Sankyo Co Ltd | アゼチジノンチオエステル類の製造法 |
-
1986
- 1986-03-26 DK DK141786A patent/DK141786A/da not_active Application Discontinuation
- 1986-03-26 AT AT86104146T patent/ATE107278T1/de not_active IP Right Cessation
- 1986-03-26 ES ES553461A patent/ES8800215A1/es not_active Expired
- 1986-03-26 EP EP86104146A patent/EP0197432B1/de not_active Expired - Lifetime
- 1986-03-26 DE DE3689911T patent/DE3689911D1/de not_active Expired - Lifetime
- 1986-03-26 CA CA000505211A patent/CA1276156C/en not_active Expired - Fee Related
- 1986-03-27 IE IE860840A patent/IE860840L/xx unknown
-
1990
- 1990-01-04 CA CA000615590A patent/CA1319697C/en not_active Expired - Fee Related
- 1990-01-04 CA CA000615589A patent/CA1279649C/en not_active Expired - Fee Related
-
1992
- 1992-06-03 JP JP4185649A patent/JPH05320159A/ja active Pending
- 1992-06-03 JP JP4185650A patent/JPH05320171A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1319697C (en) | 1993-06-29 |
| EP0197432B1 (de) | 1994-06-15 |
| JPH05320171A (ja) | 1993-12-03 |
| DK141786A (da) | 1986-09-30 |
| ES8800215A1 (es) | 1987-10-16 |
| DE3689911D1 (de) | 1994-07-21 |
| ES553461A0 (es) | 1987-10-16 |
| JPH05320159A (ja) | 1993-12-03 |
| EP0197432A2 (de) | 1986-10-15 |
| CA1276156C (en) | 1990-11-13 |
| CA1279649C (en) | 1991-01-29 |
| EP0197432A3 (en) | 1987-01-21 |
| DK141786D0 (da) | 1986-03-26 |
| IE860840L (en) | 1986-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |