ATA291279A - Verfahren zur herstellung von neuen 4-desacetyl vincaleucoblastin-c3-carbonsaeurehydraziden - Google Patents

Verfahren zur herstellung von neuen 4-desacetyl vincaleucoblastin-c3-carbonsaeurehydraziden

Info

Publication number: ATA291279A
Authority: AT; Austria
Prior art keywords: vincaleucoblastin; desacetyl; carbonic acid; producing new; acid hydrazides
Prior art date: 1978-04-20

Application number

AT792912A

Other languages

English (en)

Other versions

AT369010B (de

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-18

Publication date

1982-04-15

1979-04-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1981-12-14 Priority to AT533781A priority Critical patent/AT377764B/de

1981-12-14 Priority to AT533881A priority patent/AT377765B/de

1982-04-15 Publication of ATA291279A publication Critical patent/ATA291279A/de

1982-11-25 Application granted granted Critical

1982-11-25 Publication of AT369010B publication Critical patent/AT369010B/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT0291279A 1978-04-20 1979-04-18 Verfahren zur herstellung von neuen 4-desacetyl -vincaleucoblastin-c3-carbonsaeurehydraziden AT369010B (de)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
AT533781A AT377764B (de)	1978-04-20	1981-12-14	Verfahren zur herstellung von neuen 4-desacetyl-vincaleucoblastin-c3carbons\|urehydraziden
AT533881A AT377765B (de)	1978-04-20	1981-12-14	Verfahren zur herstellung von neuen 4-desacetyl-vincaleucoblastin-c3carbons\|urehydraziden

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (2)

Publication Number	Publication Date
ATA291279A true ATA291279A (de)	1982-04-15
AT369010B AT369010B (de)	1982-11-25

Family

ID=25410402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0291279A AT369010B (de)	1978-04-20	1979-04-18	Verfahren zur herstellung von neuen 4-desacetyl -vincaleucoblastin-c3-carbonsaeurehydraziden

Country Status (32)

Country	Link
US (1)	US4166810A (de)
EP (1)	EP0005051B1 (de)
JP (1)	JPS54141798A (de)
AR (1)	AR228940A1 (de)
AT (1)	AT369010B (de)
AU (1)	AU527109B2 (de)
BE (1)	BE875652A (de)
BG (3)	BG33296A3 (de)
CA (1)	CA1097629A (de)
CH (1)	CH643269A5 (de)
CS (3)	CS218583B2 (de)
DD (1)	DD143075A5 (de)
DE (1)	DE2964130D1 (de)
DK (1)	DK147484C (de)
EG (1)	EG14867A (de)
ES (2)	ES479753A1 (de)
FI (1)	FI791286A (de)
FR (1)	FR2423495A1 (de)
GB (1)	GB2019396B (de)
GR (1)	GR69987B (de)
HU (1)	HU181431B (de)
IE (1)	IE48213B1 (de)
IL (1)	IL57168A (de)
LU (1)	LU81166A1 (de)
NZ (1)	NZ190213A (de)
PH (1)	PH14163A (de)
PL (3)	PL125470B1 (de)
PT (1)	PT69496A (de)
RO (3)	RO81037A (de)
SU (3)	SU1225490A3 (de)
YU (1)	YU93179A (de)
ZA (1)	ZA791856B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DE3483336D1 (de) *	1983-03-30	1990-11-08	Lilly Industries Ltd	Vincaleukoblastin-derivate.
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
WO2002085908A1 (en)	2001-04-24	2002-10-31	Purdue Research Foundation	Folate mimetics and folate-receptor binding conjugates thereof
JP4814520B2 (ja) *	2002-05-15	2011-11-16	エンドサイト，インコーポレイテッド	ビタミン−マイトマイシン結合体
EP2517729A3 (de)	2003-01-27	2013-01-02	Endocyte, Inc.	Vitaminrezeptorbindende Wirkstofffreisetzungskonjugate
WO2006012527A1 (en)	2004-07-23	2006-02-02	Endocyte, Inc.	Bivalent linkers and conjugates thereof
US8044200B2 (en) *	2005-03-16	2011-10-25	Endocyte, Inc.	Synthesis and purification of pteroic acid and conjugates thereof
EP1948240A2 (de)	2005-08-19	2008-07-30	Endocyte, Inc.	Liganden-konjugate von vinca-alkaloiden, analoga und derivaten
WO2007022494A2 (en) *	2005-08-19	2007-02-22	Endocyte, Inc.	Multi-drug ligand conjugates
US20100087370A1 (en) *	2007-02-14	2010-04-08	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
US20100104626A1 (en) *	2007-02-16	2010-04-29	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
NZ580132A (en) *	2007-03-14	2012-11-30	Endocyte Inc	Binding ligand linked drug delivery conjugates of tubulysins to vitamins
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
EP3569251A1 (de)	2007-06-25	2019-11-20	Endocyte, Inc.	Konjugate mit hydrophilen spacern/linkern
EP2209374B1 (de) *	2007-10-25	2014-12-03	Endocyte, Inc.	Tubulysine und verfahren zu ihrer herstellung
EP2476414B1 (de) *	2009-09-07	2015-03-04	NIPRO Patch Co., Ltd.	Transdermal absorbierbares präparat
WO2013126797A1 (en)	2012-02-24	2013-08-29	Purdue Research Foundation	Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
KR20150070318A (ko)	2012-10-16	2015-06-24	엔도사이트, 인코포레이티드	비천연 아미노산을 함유하는 약물 전달 컨쥬게이트 및 사용 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en)	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 EP EP79300638A patent/EP0005051B1/de not_active Expired
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 FI FI791286A patent/FI791286A/fi not_active Application Discontinuation
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 BG BG056469A patent/BG33296A3/xx unknown
- 1979-04-20 BG BG043323A patent/BG33294A3/xx unknown
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 BG BG056470A patent/BG33297A3/xx unknown
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
PH14163A (en)	1981-03-19
CS218585B2 (en)	1983-02-25
IL57168A (en)	1983-10-31
AT369010B (de)	1982-11-25
BG33296A3 (en)	1983-01-14
RO81037B (ro)	1983-01-30
AU527109B2 (en)	1983-02-17
CS218584B2 (en)	1983-02-25
US4166810A (en)	1979-09-04
SU893135A3 (ru)	1981-12-23
YU93179A (en)	1983-01-21
IE790795L (en)	1979-10-20
DK160679A (da)	1979-10-21
ES479754A1 (es)	1980-08-16
EG14867A (en)	1986-09-30
CH643269A5 (fr)	1984-05-30
AU4609779A (en)	1979-10-25
CS218583B2 (en)	1983-02-25
LU81166A1 (fr)	1979-09-07
EP0005051B1 (de)	1982-12-01
FR2423495A1 (fr)	1979-11-16
GR69987B (de)	1982-07-22
IE48213B1 (en)	1984-10-31
JPS54141798A (en)	1979-11-05
GB2019396B (en)	1982-09-15
RO81114A (ro)	1983-02-01
PL119416B1 (en)	1981-12-31
RO80084A (ro)	1983-02-01
BE875652A (fr)	1979-10-18
IL57168A0 (en)	1979-07-25
RO81114B (ro)	1983-01-30
JPS6245873B2 (de)	1987-09-29
BG33294A3 (en)	1983-01-14
RO81037A (ro)	1983-02-01
DK147484B (da)	1984-08-27
EP0005051A1 (de)	1979-10-31
DE2964130D1 (en)	1983-01-05
FI791286A (fi)	1979-10-21
NZ190213A (en)	1982-12-21
FR2423495B1 (de)	1983-02-11
DD143075A5 (de)	1980-07-30
BG33297A3 (en)	1983-01-14
ES479753A1 (es)	1980-08-16
PT69496A (en)	1979-05-01
AR228940A1 (es)	1983-05-13
PL215911A1 (de)	1980-03-24
CA1097629A (en)	1981-03-17
PL125470B1 (en)	1983-05-31
RO80084B (ro)	1983-01-30
DK147484C (da)	1985-03-25
ZA791856B (en)	1980-11-26
HU181431B (en)	1983-07-28
SU1225490A3 (ru)	1986-04-15
SU1061698A3 (ru)	1983-12-15
GB2019396A (en)	1979-10-31

Publication	Publication Date	Title
AT368168B (de)	1982-09-27	Verfahren zur herstellung von neuen thioetiansaeurederivaten
AT369010B (de)	1982-11-25	Verfahren zur herstellung von neuen 4-desacetyl -vincaleucoblastin-c3-carbonsaeurehydraziden
AT366689B (de)	1982-04-26	Verfahren zur herstellung von neuen spirooxazolidindionen
ATA590580A (de)	1982-06-15	Verfahren zur herstellung von neuen cephalosporinantibiotika
AT376684B (de)	1984-12-27	Verfahren zur herstellung von neuen bor-silicium- verbindungen
AT366365B (de)	1982-04-13	Verfahren zur herstellung von neuen 4-nitro-2trichlormethylphenyldisulfiden
AT369377B (de)	1982-12-27	Verfahren zur herstellung von neuen cephalosporinantibiotika
AT362872B (de)	1981-06-25	Verfahren zur herstellung von neuen demethylmaytansinoiden
AT367397B (de)	1982-06-25	Verfahren zur herstellung von neuen n-phenaethyl- glycinamiden
AT365564B (de)	1982-01-25	Verfahren zur herstellung von neuen alpha-phenylbenzylidenaminoalkansaeurederivaten
AT367052B (de)	1982-05-25	Verfahren zur herstellung von neuen modifizierten azulminsaeuren
ATA291979A (de)	1981-03-15	Verfahren zur herstellung von neuen ver- bindungen
AT368516B (de)	1982-10-25	Verfahren zur herstellung von neuen nitrosoharnstoff-verbindungen
AT364347B (de)	1981-10-12	Verfahren zur herstellung von neuen 1beta-hydroxy-2beta-alkenyl-3-methylencyclopentan-4 beta-yl-cyclopropancarboxylaten
AT362067B (de)	1981-04-27	Verfahren zur herstellung von neuen deoxyanthracyclinen
AT368517B (de)	1982-10-25	Verfahren zur herstellung von neuen nitrosoharnstoffverbindungen
AT368155B (de)	1982-09-27	Verfahren zur herstellung von neuen vincamonsalzen
AT371475B (de)	1983-06-27	Verfahren zur herstellung von neuen cephalosporinantibiotika
AT366698B (de)	1982-04-26	Verfahren zur herstellung von neuen cephalosporinantibiotika
ATA491481A (de)	1984-01-15	Verfahren zur herstellung von neuen cephalosporinantibiotika
ATA491581A (de)	1984-01-15	Verfahren zur herstellung von neuen cephalosporinantibiotika
ATA831278A (de)	1980-01-15	Verfahren zur herstellung von neuen 3-di-n- -propyl-acetoxy-benzodiazepin-2-onen
ATA246881A (de)	1982-11-15	Verfahren zur herstellung von neuen cephalosporinantibiotika
ATA330681A (de)	1982-10-15	Verfahren zur herstellung von neuen cephalosporinantibiotika
AT369368B (de)	1982-12-27	Verfahren zur herstellung von neuen modifizierten azulminsaeuren

Legal Events

Date	Code	Title	Description
1985-01-15	ELJ	Ceased due to non-payment of the annual fee