AR241657A1 - Un procedimiento para la preparacion de benanomicina a y benanomicina b y/o dexilosilbenanomicina b, sus sales y alquil(c1-c4) esteres de los mismos. - Google Patents
Un procedimiento para la preparacion de benanomicina a y benanomicina b y/o dexilosilbenanomicina b, sus sales y alquil(c1-c4) esteres de los mismos.Info
- Publication number
- AR241657A1 AR241657A1 AR88312367A AR31236788A AR241657A1 AR 241657 A1 AR241657 A1 AR 241657A1 AR 88312367 A AR88312367 A AR 88312367A AR 31236788 A AR31236788 A AR 31236788A AR 241657 A1 AR241657 A1 AR 241657A1
- Authority
- AR
- Argentina
- Prior art keywords
- benanomycin
- temperature
- acid
- medium
- products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/826—Actinomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
PREAPARACION DE BENANOMICINA A Y BENANOMICINA B Y/O DEXILOSILBENANOMICINA B DE FORMULA (I) O SUS SALES Y ALQUIL ESTERES , SIENDO R -OH O AMINO Y R1 ES H O XILOXILO, A CONDICION DE QUE CUANDO R ES-OH, R1 NO ES H, Y UNA SAL O UN ESTER DE (I). CULTIVAR UNA CEPA PRODUCTORA DE BENAOMICINA A Y BENANOMICINA B, MH193-16F4 (FER1BP-2051) DE ACTINOMICETES EN UN MEDIO DE CULTIVO QUE TIENE FUENTESRBONO NITROGENO ASIMILABLES, BAJO CONDICIONES AEROBICAS, PARA PRODUCIR BENANOMICINA A Y/O BENANOMICINA B EN EL CUTILVO, Y LUEGO RECUPERAR ESTOS PRODUCTOS O UNO DE ELLOS DEL CULTIVO. SI SE DESEA HIDROLIZAR LA BENANOMICINA B EN UN MEDIO ACIDO, O CON UN ALCOHOL QUE CONTIENE UN ACIDO INORGANICO PARA LA ALCOHOLISIS, NEUTRALIZANDO LUEGO CON UN MEDIO ALCALINO, PARA OBTENER DEXILOSILBENANOMICINAB. TAMBIEN SE PUEDE HACERLOS REACCIONAR CON UN ALCOHOL PARA OBTENER LOS ALQUIL ESTERES, HACIENDO LA HIDROLISIS EN MEDIO ACIDO A UNA TEMPERATURA ENTRE 60° Y 110°C Y LA ALCOHOLISIS DE LA BANANOMICINA B CON ALCOHOLES A UN A TEMPERATURA ENTRE 60° Y 120°C, SEGUIDA DE LA SUBSIGUIENTE HIDROLISIS DE LOS ALQUIL CARBOXILATOS DE LA DEXILOXILBENANOMICINA B, CON HIDROXIDOS O CARBONATOS DE METILO ALCALINOS EN MEDIO ACUOSO, PARA OBTENER DESILOXILBENANOMICINA B. ESTOS PRODUCTOS SON ANTIBIOTICOS CON PROPIEDADES ANTIFUNGICIDAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62277692A JP2592468B2 (ja) | 1987-11-02 | 1987-11-02 | 新規抗生物質ベナノマイシンaおよびbならびにその製造法 |
JP32716387A JP2512050B2 (ja) | 1987-12-25 | 1987-12-25 | 新規抗かび性抗生物質デキシロシルベナノマイシンbならびにその製造法 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR241657A1 true AR241657A1 (es) | 1992-10-30 |
Family
ID=26552521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR88312367A AR241657A1 (es) | 1987-11-02 | 1988-11-02 | Un procedimiento para la preparacion de benanomicina a y benanomicina b y/o dexilosilbenanomicina b, sus sales y alquil(c1-c4) esteres de los mismos. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5055453A (es) |
EP (1) | EP0315147B1 (es) |
AR (1) | AR241657A1 (es) |
AU (1) | AU612189B2 (es) |
CA (1) | CA1339016C (es) |
DE (1) | DE3887820T2 (es) |
DK (1) | DK170029B1 (es) |
ES (1) | ES2063015T3 (es) |
FI (1) | FI98739C (es) |
MX (1) | MX9201563A (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4990497A (en) * | 1987-02-02 | 1991-02-05 | Toshikazu Oki | Antifungal antibiotics |
US5110960A (en) * | 1987-02-02 | 1992-05-05 | Bristol-Myers Company | Antifungal antibiotics |
US5109122A (en) * | 1987-11-02 | 1992-04-28 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Antibiotics, dexylosylbenanomicin B |
US4992425A (en) * | 1988-06-07 | 1991-02-12 | Bristol-Myers Company | Antibiotics BU-3608D and BU-3608E |
US4960755A (en) * | 1988-07-19 | 1990-10-02 | Bristol-Myers Company | BU-3608 derivatives |
JP2643340B2 (ja) * | 1988-08-22 | 1997-08-20 | 財団法人微生物化学研究会 | ヒト後天性免疫不全症候群ウイルス感染阻害剤 |
JP2643404B2 (ja) * | 1989-01-13 | 1997-08-20 | 財団法人微生物化学研究会 | 新抗生物質n―アセチルベナノマイシンbならびにその製造法 |
EP0420552B1 (en) * | 1989-09-26 | 1994-06-15 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | New antifungal antibiotic, and the production and uses of same |
FI92207C (fi) * | 1989-11-14 | 1994-10-10 | Squibb Bristol Myers Co | Menetelmä terapeuttisesti käyttökelpoisten pradimisiinijohdannaisten valmistamiseksi |
US5227370A (en) * | 1989-11-14 | 1993-07-13 | Bristol-Myers Squibb Company | Pradimicin derivatives |
CA2030166C (en) * | 1989-11-22 | 1997-10-07 | Shimpei Aburaki | Pradimicin derivatives |
US5696096A (en) * | 1990-09-28 | 1997-12-09 | Bristol-Myers Squibb Company | Pradimicin derivatives |
US5091418A (en) * | 1990-09-28 | 1992-02-25 | Bristol-Myers Squibb Company | Novel alpha-glucosidase inhibitor, pradimicin Q |
US5217877A (en) * | 1990-09-28 | 1993-06-08 | Bristol-Myers Squibb Company | Process for the preparation of α-glucosidase inhibitor, pradimicin Q |
JP3134010B2 (ja) * | 1991-11-26 | 2001-02-13 | 財団法人微生物化学研究会 | デスアラニンベナノマイシンa誘導体およびそれらの製造法 |
US5837828A (en) * | 1992-04-08 | 1998-11-17 | Bristol-Myers Squibb Co. | Pradimicin derivatives |
US5326867A (en) * | 1992-07-16 | 1994-07-05 | Bristol-Myers Squibb Company | Pradimic acids, amides, and pradimicin derivatives |
EP1934327B8 (en) * | 2005-09-13 | 2013-02-27 | OrganoBalance GmbH | Microorganisms inhibiting the formation of axillary malodor |
KR20080045713A (ko) * | 2005-09-19 | 2008-05-23 | 바스프 에스이 | 발 악취 형성을 저해하는 미생물 |
US9877494B2 (en) * | 2014-08-21 | 2018-01-30 | Shantung HSU | Active fermentation process and fermented liquid and drinks made by using the same |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4870165A (en) * | 1987-02-02 | 1989-09-26 | Bristol-Myers Company | Antifungal antibiotics |
-
1988
- 1988-10-31 US US07/264,888 patent/US5055453A/en not_active Expired - Lifetime
- 1988-11-01 DK DK608288A patent/DK170029B1/da not_active IP Right Cessation
- 1988-11-01 FI FI885039A patent/FI98739C/fi not_active IP Right Cessation
- 1988-11-02 AR AR88312367A patent/AR241657A1/es active
- 1988-11-02 ES ES88118253T patent/ES2063015T3/es not_active Expired - Lifetime
- 1988-11-02 CA CA000581994A patent/CA1339016C/en not_active Expired - Fee Related
- 1988-11-02 AU AU24579/88A patent/AU612189B2/en not_active Ceased
- 1988-11-02 EP EP88118253A patent/EP0315147B1/en not_active Expired - Lifetime
- 1988-11-02 DE DE3887820T patent/DE3887820T2/de not_active Expired - Lifetime
-
1991
- 1991-06-14 US US07/715,770 patent/US5278052A/en not_active Expired - Lifetime
-
1992
- 1992-04-06 MX MX9201563A patent/MX9201563A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA1339016C (en) | 1997-03-25 |
FI98739B (fi) | 1997-04-30 |
US5055453A (en) | 1991-10-08 |
US5278052A (en) | 1994-01-11 |
EP0315147A3 (en) | 1991-05-15 |
MX9201563A (es) | 1993-10-01 |
DK608288D0 (da) | 1988-11-01 |
EP0315147A2 (en) | 1989-05-10 |
AU612189B2 (en) | 1991-07-04 |
AU2457988A (en) | 1989-05-25 |
FI98739C (fi) | 1997-08-11 |
FI885039A0 (fi) | 1988-11-01 |
EP0315147B1 (en) | 1994-02-16 |
DE3887820T2 (de) | 1994-05-19 |
DK170029B1 (da) | 1995-05-01 |
DK608288A (da) | 1989-05-03 |
DE3887820D1 (de) | 1994-03-24 |
FI885039A (fi) | 1989-05-03 |
ES2063015T3 (es) | 1995-01-01 |
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