AR224111A1 - Derivados de 1-oxido de acido penicilanico,desprovistos de actividad terapeutica,utiles como intermediarios en la preparacion de 1,1-dioxido de acido penicilanico farmaceuticamente activos,procedimiento para preparar dichos intermediarios y procedimiento para preparar los 1,1-dioxidos de acido penicilanico farmaceuticamente activos partiendo de dichos intermediarios - Google Patents

Derivados de 1-oxido de acido penicilanico,desprovistos de actividad terapeutica,utiles como intermediarios en la preparacion de 1,1-dioxido de acido penicilanico farmaceuticamente activos,procedimiento para preparar dichos intermediarios y procedimiento para preparar los 1,1-dioxidos de acido penicilanico farmaceuticamente activos partiendo de dichos intermediarios

Info

Publication number: AR224111A1
Authority: AR; Argentina
Prior art keywords: intermediaries; procedure; pharmaceutically active; penicilanic acid; lost
Prior art date: 1977-06-07

Application number

AR272228A

Other languages

English (en)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-06-07

Filing date

1978-08-18

Publication date

1981-10-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27122691&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR224111(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1978-08-18 Application filed by Pfizer filed Critical Pfizer

1981-10-30 Application granted granted Critical

1981-10-30 Publication of AR224111A1 publication Critical patent/AR224111A1/es

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AR272228A 1977-06-07 1978-08-18 Derivados de 1-oxido de acido penicilanico,desprovistos de actividad terapeutica,utiles como intermediarios en la preparacion de 1,1-dioxido de acido penicilanico farmaceuticamente activos,procedimiento para preparar dichos intermediarios y procedimiento para preparar los 1,1-dioxidos de acido penicilanico farmaceuticamente activos partiendo de dichos intermediarios AR224111A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US80432077A	1977-06-07	1977-06-07
US87938178A	1978-02-21	1978-02-21

Publications (1)

Publication Number	Publication Date
AR224111A1 true AR224111A1 (es)	1981-10-30

Family

ID=27122691

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AR272228A AR224111A1 (es)	1977-06-07	1978-08-18	Derivados de 1-oxido de acido penicilanico,desprovistos de actividad terapeutica,utiles como intermediarios en la preparacion de 1,1-dioxido de acido penicilanico farmaceuticamente activos,procedimiento para preparar dichos intermediarios y procedimiento para preparar los 1,1-dioxidos de acido penicilanico farmaceuticamente activos partiendo de dichos intermediarios

Country Status (35)

Country	Link
AR (1)	AR224111A1 (es)
AT (2)	AT360649B (es)
AU (1)	AU513636B2 (es)
BE (1)	BE867859A (es)
BG (2)	BG34615A3 (es)
CH (1)	CH634073A5 (es)
CS (1)	CS208472B2 (es)
DD (2)	DD140888A5 (es)
DE (2)	DE2857263C3 (es)
DK (1)	DK155740C (es)
EG (1)	EG13869A (es)
FI (1)	FI66003C (es)
FR (2)	FR2393804A1 (es)
GB (1)	GB2000138B (es)
GR (1)	GR72255B (es)
HK (1)	HK13184A (es)
HU (1)	HU180042B (es)
IE (1)	IE47079B1 (es)
IL (2)	IL54867A (es)
IN (1)	IN149747B (es)
IT (1)	IT1096381B (es)
KE (1)	KE3355A (es)
LU (1)	LU79774A1 (es)
MY (1)	MY8500092A (es)
NL (2)	NL180009C (es)
NO (2)	NO151746C (es)
NZ (1)	NZ187476A (es)
OA (1)	OA05964A (es)
PH (3)	PH26810A (es)
PL (1)	PL114501B1 (es)
PT (1)	PT68146A (es)
SE (2)	SE436206B (es)
SG (1)	SG65383G (es)
SU (1)	SU860706A1 (es)
YU (1)	YU41829B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU77306A1 (es) *	1977-05-09	1979-01-18
DE2912511C2 (de) *	1977-06-07	1982-06-24	Pfizer Inc., 10017 New York, N.Y.	Pharmazeutische Zusammensetzung, enthaltend Penicillansäure
DK155942C (da) *	1977-12-23	1989-10-23	Pfizer	Analogifremgangsmaade til fremstilling af 6-aminopenicillansyre-1,1-dioxid og fysiologisk acceptable syreadditions- og basesalte deraf.
JPS54126735A (en) *	1978-03-24	1979-10-02	Toyama Chem Co Ltd	Bactericidal composition for medical use
US4241050A (en) *	1978-09-01	1980-12-23	Pfizer Inc.	Penam 1,1-dioxides as beta-lactamase inhibitors
CA1158639A (en) *	1978-12-11	1983-12-13	Eric M. Gordon	6-bromopenicillanic acid sulfone
IE49881B1 (en) *	1979-02-13	1986-01-08	Leo Pharm Prod Ltd	B-lactam intermediates
US4714761A (en) *	1979-03-05	1987-12-22	Pfizer Inc.	6,6-dihalopenicillanic acid 1,1-dioxides and process
US4420426A (en)	1979-03-05	1983-12-13	Pfizer Inc.	6-Alpha-halopenicillanic acid 1,1-dioxides
SE449103B (sv) *	1979-03-05	1987-04-06	Pfizer	Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
GB2045236A (en) *	1979-03-26	1980-10-29	Hoechst Uk Ltd	Oxapenem derivatives
US4244951A (en) *	1979-05-16	1981-01-13	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4309347A (en) *	1979-05-16	1982-01-05	Pfizer Inc.	Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
IL59948A0 (en) *	1979-05-21	1980-06-30	Rech Applications Therap	Penicillanic acid derivatives,their production and pharmaceutical compositions containing them
DE3051044C2 (es) *	1979-06-19	1989-03-30	Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk
US4256733A (en) *	1979-09-26	1981-03-17	Pfizer Inc.	Acetoxymethyl penam compounds as β-lactamase inhibitors
US4432970A (en) *	1979-11-23	1984-02-21	Pfizer Inc.	6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
IL61880A (en) *	1980-01-21	1984-11-30	Bristol Myers Co	2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
US4488994A (en) *	1980-09-08	1984-12-18	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4432903A (en) *	1980-09-08	1984-02-21	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4474698A (en) *	1980-12-11	1984-10-02	Pfizer Inc.	Process for preparing esters of penicillanic acid sulfone
US4419284A (en) *	1981-03-23	1983-12-06	Pfizer Inc.	Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
DE3261759D1 (en) *	1981-07-15	1985-02-14	Kanebo Ltd	Novel ester of 1,1-dioxopenicillanic acid, process for production thereof, and use thereof as beta-lactamase inhibitor
PT76527B (en) *	1982-04-19	1985-12-09	Gist Brocades Nv	A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof
US4502988A (en) *	1983-08-08	1985-03-05	Eli Lilly And Company	Oxidation process
EP0139047A1 (en) *	1983-10-18	1985-05-02	Gist-Brocades N.V.	Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4647457A (en) *	1983-12-16	1987-03-03	Hoffmann-La Roche Inc.	Penicillanic acid derivatives
WO1987006230A1 (en) *	1986-04-10	1987-10-22	Leo Pharmaceutical Products Ltd. A/S	Method for preparing penicillanic acid derivatives
GB8808701D0 (en) *	1988-04-13	1988-05-18	Erba Carlo Spa	Beta-lactam derivatives
CN102977120B (zh) *	2012-12-14	2015-05-27	江西富祥药业股份有限公司	一种舒巴坦匹酯制备及结晶方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3197466A (en) *	1961-10-30	1965-07-27	Smith Kline French Lab	Penicillin sulfoxides and process
LU77306A1 (es) *	1977-05-09	1979-01-18
AU3796278A (en) *	1977-07-13	1980-01-17	Glaxo Group Ltd	Penams and azetidinones

1978
- 1978-05-04 IN IN327/DEL/78A patent/IN149747B/en unknown
- 1978-05-09 PH PH21116A patent/PH26810A/en unknown
- 1978-05-16 YU YU1170/78A patent/YU41829B/xx unknown
- 1978-05-18 OA OA56500A patent/OA05964A/xx unknown
- 1978-05-20 EG EG322/78A patent/EG13869A/xx active
- 1978-05-30 BG BG042176A patent/BG34615A3/xx unknown
- 1978-05-30 BG BG039910A patent/BG34614A3/xx unknown
- 1978-06-01 CS CS783579A patent/CS208472B2/cs unknown
- 1978-06-02 AU AU36838/78A patent/AU513636B2/en not_active Ceased
- 1978-06-02 GB GB7826308A patent/GB2000138B/en not_active Expired
- 1978-06-05 GR GR56439A patent/GR72255B/el unknown
- 1978-06-05 DE DE2857263A patent/DE2857263C3/de not_active Expired
- 1978-06-05 DE DE2824535A patent/DE2824535C3/de not_active Expired
- 1978-06-06 IT IT24270/78A patent/IT1096381B/it active Protection Beyond IP Right Term
- 1978-06-06 LU LU79774A patent/LU79774A1/fr unknown
- 1978-06-06 IL IL54867A patent/IL54867A/xx unknown
- 1978-06-06 FI FI781800A patent/FI66003C/fi not_active IP Right Cessation
- 1978-06-06 AT AT411278A patent/AT360649B/de active Protection Beyond IP Right Term
- 1978-06-06 BE BE188352A patent/BE867859A/xx not_active IP Right Cessation
- 1978-06-06 DK DK251478A patent/DK155740C/da not_active IP Right Cessation
- 1978-06-06 PT PT68146A patent/PT68146A/pt unknown
- 1978-06-06 SE SE7806628A patent/SE436206B/sv not_active IP Right Cessation
- 1978-06-06 PL PL1978207396A patent/PL114501B1/pl unknown
- 1978-06-06 NO NO781970A patent/NO151746C/no unknown
- 1978-06-06 NL NLAANVRAGE7806126,A patent/NL180009C/xx not_active IP Right Cessation
- 1978-06-06 HU HU78PI630A patent/HU180042B/hu unknown
- 1978-06-06 CH CH618078A patent/CH634073A5/fr not_active IP Right Cessation
- 1978-06-06 IE IE1140/78A patent/IE47079B1/en not_active IP Right Cessation
- 1978-06-06 NZ NZ187476A patent/NZ187476A/xx unknown
- 1978-06-06 FR FR787816893A patent/FR2393804A1/fr active Granted
- 1978-06-06 SU SU782624408A patent/SU860706A1/ru active
- 1978-06-07 DD DD78205839A patent/DD140888A5/de unknown
- 1978-06-07 DD DD78218400A patent/DD148585A5/de unknown
- 1978-08-18 AR AR272228A patent/AR224111A1/es active
- 1978-09-08 PH PH21586A patent/PH21116A/en unknown
- 1978-09-08 PH PH21587A patent/PH16465A/en unknown
- 1978-09-19 FR FR787826789A patent/FR2393805A1/fr active Granted
1980
- 1980-03-07 AT AT0128580A patent/AT364084B/de not_active IP Right Cessation
1981
- 1981-02-19 IL IL62168A patent/IL62168A0/xx unknown
1982
- 1982-09-15 NO NO823126A patent/NO152448C/no unknown
1983
- 1983-10-27 SE SE8305916A patent/SE447995B/xx not_active IP Right Cessation
- 1983-11-02 SG SG653/83A patent/SG65383G/en unknown
- 1983-11-22 KE KE3355A patent/KE3355A/xx unknown
1984
- 1984-02-16 HK HK131/84A patent/HK13184A/xx not_active IP Right Cessation
1985
- 1985-12-30 MY MY92/85A patent/MY8500092A/xx unknown
1993
- 1993-06-11 NL NL930064C patent/NL930064I2/nl unknown

Also Published As

Publication number	Publication date
NO151746B (no)	1985-02-18
IT7824270A0 (it)	1978-06-06
NZ187476A (en)	1982-08-17
DE2857263B2 (de)	1981-04-23
DD140888A5 (de)	1980-04-02
DK155740C (da)	1989-10-23
SU860706A1 (ru)	1981-08-30
CH634073A5 (en)	1983-01-14
NL7806126A (nl)	1978-12-11
MY8500092A (en)	1985-12-31
DE2857263C3 (de)	1981-12-17
GB2000138A (en)	1979-01-04
PH21116A (en)	1987-07-16
YU41829B (en)	1988-02-29
DE2824535A1 (de)	1978-12-14
NO781970L (no)	1978-12-08
IT1096381B (it)	1985-08-26
AT360649B (de)	1981-01-26
SE8305916L (sv)	1983-10-27
ATA411278A (de)	1980-06-15
FI66003C (fi)	1984-08-10
YU117078A (en)	1983-01-21
NL930064I1 (nl)	1993-09-01
IE781140L (en)	1978-12-07
FI66003B (fi)	1984-04-30
NL180009C (nl)	1986-12-16
FR2393805B1 (es)	1984-02-24
BG34615A3 (en)	1983-10-15
FR2393804B1 (es)	1980-11-07
EG13869A (en)	1983-03-31
BE867859A (fr)	1978-12-06
FR2393804A1 (fr)	1979-01-05
PH26810A (en)	1992-11-05
HK13184A (en)	1984-02-24
IN149747B (es)	1982-04-03
DK251478A (da)	1978-12-08
FR2393805A1 (fr)	1979-01-05
SE7806628L (sv)	1978-12-08
IL62168A0 (en)	1981-03-31
HU180042B (en)	1983-01-28
NO152448B (no)	1985-06-24
PL114501B1 (en)	1981-02-28
AT364084B (de)	1981-09-25
GR72255B (es)	1983-10-06
NL930064I2 (nl)	1994-04-18
CS208472B2 (en)	1981-09-15
AU3683878A (en)	1979-12-06
IL54867A (en)	1981-11-30
KE3355A (en)	1983-12-16
DD148585A5 (de)	1981-06-03
DK155740B (da)	1989-05-08
SE8305916D0 (sv)	1983-10-27
NO823126L (no)	1978-12-08
SE436206B (sv)	1984-11-19
FI781800A (fi)	1978-12-08
OA05964A (fr)	1981-06-30
PH16465A (en)	1983-10-20
DE2824535C3 (de)	1981-01-22
AU513636B2 (en)	1980-12-11
NO152448C (no)	1985-10-02
SE447995B (sv)	1987-01-12
PT68146A (en)	1978-07-01
GB2000138B (en)	1982-03-03
IL54867A0 (en)	1978-08-31
LU79774A1 (fr)	1980-01-22
ATA128580A (de)	1981-02-15
SG65383G (en)	1985-03-29
BG34614A3 (en)	1983-10-15
PL207396A1 (pl)	1979-06-04
NO151746C (no)	1985-06-05
DE2824535B2 (de)	1980-05-14
IE47079B1 (en)	1983-12-14

Publication	Publication Date	Title
AR224111A1 (es)	1981-10-30	Derivados de 1-oxido de acido penicilanico,desprovistos de actividad terapeutica,utiles como intermediarios en la preparacion de 1,1-dioxido de acido penicilanico farmaceuticamente activos,procedimiento para preparar dichos intermediarios y procedimiento para preparar los 1,1-dioxidos de acido penicilanico farmaceuticamente activos partiendo de dichos intermediarios
NO782127L (no)	1978-12-21	Fremgangsmaate for fremstilling av fysiologisk aktive isoksazolo-pyridin-derivater
NO149035C (no)	1984-02-01	Analogifremgangsmaate for fremstilling av fysiologisk aktive acylanilid-derivater
NO148148C (no)	1983-08-17	Fremgangsmaate til fremstilling av terapeutisk aktive 4-hydroksy-2-pyrrolidinonderivater
NO803136L (no)	1981-04-23	Fremgangsmaate for fremstilling av farmakologisk aktive 6beta-hydroksyalkylpenicillansyrederivater
NO784231L (no)	1979-06-19	Analogifremgangsmaate for fremstilling av fysiologisk aktive benzotiazinderivater
NO155055C (no)	1987-02-04	Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater.
NO782756L (no)	1979-02-16	Fremgangsmaate for fremstilling av terapeutisk aktive antrakinonderivater
NO802015L (no)	1981-01-07	Fremgangsmaate for fremstilling av fysiologisk aktive indolizin-derivater.
NO151287C (no)	1985-03-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive 9-hydrazono-6,7,8,9-tetrahydro-4h-pyrido(1,2-a)-pyrimidinderivater
AR219561A1 (es)	1980-08-29	Procedimiento para la preparacion de nuevos derivados de 1-piperidino-6,7-dialcoxi-ftalazina utiles como agentes terapeuticos
IT1105054B (it)	1985-10-28	Derivati alfa-acetilenici di ammine con attivita' farmaceutica e procedimento per la loro preparazione
AR221051A1 (es)	1980-12-30	Procedimiento para la preparacion de derivados del acido aminodesoxiclavulanico
IT7820957A0 (it)	1978-03-07	Derivati di acido 1-azaxantone-3-carbossilico eprocedimento per la loro preparazione.
MX6206E (es)	1984-12-14	Procedimiento para la preparacion de acido 4-aril-5-tiazol-carboxilico 2-substituido y derivados del mismo
AR215666A1 (es)	1979-10-31	Derivados de oleandomicina,desprovistos de actividad terapeutica,aplicables como intermediarios para la preparacion de oleandomicinas terapeuticamente activas;procedimiento para preparar dichos derivados intermediarios;y procedimiento para preparar compuestos 4"-amino epimericos con propiedades terapeuticas,partiendo de dichos derivados
NO780743L (no)	1978-09-06	Fremgangsmaate for fremstilling av farmakologisk aktive benzylpyrimidiner
MX6032E (es)	1984-10-04	Procedimiento para la preparacion de 1,1-dioxido de acido penicilanico y esters del mismo
NO780644L (no)	1978-08-25	Fremgangsmaate til fremstilling av terapeutisk virksomme 9-hydroksyetoksymetylguanin-derivater
IT7852073A0 (it)	1978-11-27	Antracene-9,10-bis-carbonil-idrazoni e loro derivati dotati di attivi ta' farmacologica e procedure di preparazione
IT1162395B (it)	1987-03-25	Derivati auronici dotati di attivita' farmacologica e procedimento per la loro preparazione
NO145656C (no)	1982-05-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-fenyletanolaminderivater
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